Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 1,2-dimethylhydrazine | decreases expression | ISO | Pnisr (Mus musculus) | 6480464 | 1 and 2-Dimethylhydrazine results in decreased expression of SFRS18 mRNA | CTD | PMID:22206623 | 1,2-dimethylhydrazine | multiple interactions | ISO | Pnisr (Mus musculus) | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in increased expression of PNISR mRNA | CTD | PMID:22206623 | 17alpha-ethynylestradiol | affects expression | ISO | Pnisr (Mus musculus) | 6480464 | Ethinyl Estradiol affects the expression of PNISR mRNA | CTD | PMID:17555576 | 17beta-estradiol | decreases expression | ISO | PNISR (Homo sapiens) | 6480464 | Estradiol results in decreased expression of PNISR mRNA | CTD | PMID:19167446 | 17beta-estradiol | decreases expression | EXP | | 6480464 | Estradiol results in decreased expression of PNISR mRNA | CTD | PMID:32145629 and PMID:35192832 | 2,2',4,4',5,5'-hexachlorobiphenyl | multiple interactions | ISO | Pnisr (Mus musculus) | 6480464 | [2 more ... | CTD | PMID:25510870 | 2,2',5,5'-tetrachlorobiphenyl | multiple interactions | ISO | Pnisr (Mus musculus) | 6480464 | [2 more ... | CTD | PMID:25510870 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of PNISR mRNA | CTD | PMID:34747641 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of PNISR mRNA | CTD | PMID:33387578 | 4-hydroxyphenyl retinamide | increases expression | ISO | Pnisr (Mus musculus) | 6480464 | Fenretinide results in increased expression of PNISR mRNA | CTD | PMID:28973697 | 7,12-dimethyltetraphene | increases expression | EXP | | 6480464 | 9 more ... | CTD | PMID:19480007 | aflatoxin B1 | increases expression | ISO | Pnisr (Mus musculus) | 6480464 | Aflatoxin B1 results in increased expression of PNISR mRNA | CTD | PMID:19770486 | aflatoxin B1 | decreases methylation | ISO | PNISR (Homo sapiens) | 6480464 | Aflatoxin B1 results in decreased methylation of PNISR gene | CTD | PMID:27153756 | atrazine | increases expression | EXP | | 6480464 | Atrazine results in increased expression of PNISR mRNA | CTD | PMID:36841081 | avobenzone | increases expression | ISO | PNISR (Homo sapiens) | 6480464 | avobenzone results in increased expression of PNISR mRNA | CTD | PMID:31016361 | benzo[a]pyrene | decreases expression | ISO | Pnisr (Mus musculus) | 6480464 | Benzo(a)pyrene results in decreased expression of PNISR mRNA | CTD | PMID:19770486 | benzo[a]pyrene | decreases methylation | ISO | Pnisr (Mus musculus) | 6480464 | Benzo(a)pyrene results in decreased methylation of SFRS18 exon | CTD | PMID:27901495 | benzo[a]pyrene diol epoxide I | decreases expression | ISO | PNISR (Homo sapiens) | 6480464 | 7 more ... | CTD | PMID:19150397 and PMID:20018196 | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of PNISR mRNA | CTD | PMID:25181051 | bisphenol A | decreases expression | ISO | Pnisr (Mus musculus) | 6480464 | bisphenol A results in decreased expression of PNISR mRNA | CTD | PMID:32156529 | bisphenol A | decreases expression | ISO | PNISR (Homo sapiens) | 6480464 | bisphenol A results in decreased expression of PNISR protein | CTD | PMID:33376534 | bisphenol A | affects expression | EXP | | 6480464 | bisphenol A affects the expression of PNISR mRNA | CTD | PMID:32145629 | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of PNISR mRNA | CTD | PMID:30816183 and PMID:35192832 | bisphenol A | increases methylation | EXP | | 6480464 | bisphenol A results in increased methylation of PNISR gene | CTD | PMID:28505145 | bortezomib | increases expression | ISO | PNISR (Homo sapiens) | 6480464 | Bortezomib results in increased expression of PNISR mRNA | CTD | PMID:20977926 | butanal | decreases expression | ISO | PNISR (Homo sapiens) | 6480464 | butyraldehyde results in decreased expression of PNISR mRNA | CTD | PMID:26079696 | cadmium dichloride | decreases methylation | EXP | | 6480464 | Cadmium Chloride results in decreased methylation of PNISR promoter | CTD | PMID:22457795 | caffeine | decreases phosphorylation | ISO | PNISR (Homo sapiens) | 6480464 | Caffeine results in decreased phosphorylation of PNISR protein | CTD | PMID:35688186 | capsaicin | increases expression | EXP | | 6480464 | Capsaicin results in increased expression of PNISR mRNA | CTD | PMID:20349343 | carbon nanotube | decreases expression | ISO | Pnisr (Mus musculus) | 6480464 | Nanotubes more ... | CTD | PMID:25554681 and PMID:25620056 | chloroprene | increases expression | EXP | | 6480464 | Chloroprene results in increased expression of PNISR mRNA | CTD | PMID:23125180 | cisplatin | decreases expression | ISO | PNISR (Homo sapiens) | 6480464 | Cisplatin results in decreased expression of PNISR mRNA | CTD | PMID:27594783 | copper atom | increases expression | EXP | | 6480464 | Copper results in increased expression of PNISR mRNA | CTD | PMID:30556269 | copper(0) | increases expression | EXP | | 6480464 | Copper results in increased expression of PNISR mRNA | CTD | PMID:30556269 | copper(II) sulfate | increases expression | ISO | PNISR (Homo sapiens) | 6480464 | Copper Sulfate results in increased expression of PNISR mRNA | CTD | PMID:19549813 | cyclosporin A | decreases expression | ISO | Pnisr (Mus musculus) | 6480464 | Cyclosporine results in decreased expression of PNISR mRNA | CTD | PMID:19770486 | cyclosporin A | decreases methylation | ISO | PNISR (Homo sapiens) | 6480464 | Cyclosporine results in decreased methylation of PNISR promoter | CTD | PMID:27989131 | cyclosporin A | decreases expression | ISO | PNISR (Homo sapiens) | 6480464 | Cyclosporine results in decreased expression of PNISR mRNA | CTD | PMID:25562108 | decabromodiphenyl ether | increases expression | EXP | | 6480464 | decabromobiphenyl ether results in increased expression of PNISR mRNA | CTD | PMID:23914054 | diazinon | increases expression | EXP | | 6480464 | Diazinon results in increased expression of PNISR mRNA | CTD | PMID:29108742 | dibutyl phthalate | decreases expression | EXP | | 6480464 | Dibutyl Phthalate results in decreased expression of PNISR mRNA | CTD | PMID:24893172 | dicrotophos | decreases expression | ISO | PNISR (Homo sapiens) | 6480464 | dicrotophos results in decreased expression of PNISR mRNA | CTD | PMID:28302478 | dimethylarsinous acid | decreases expression | ISO | PNISR (Homo sapiens) | 6480464 | dimethylarsinous acid results in decreased expression of PNISR mRNA | CTD | PMID:23487506 | diuron | decreases expression | EXP | | 6480464 | Diuron results in decreased expression of PNISR mRNA | CTD | PMID:25152437 | diuron | decreases expression | ISO | PNISR (Homo sapiens) | 6480464 | Diuron results in decreased expression of PNISR mRNA | CTD | PMID:35967413 | dorsomorphin | multiple interactions | ISO | PNISR (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | doxorubicin | increases expression | ISO | PNISR (Homo sapiens) | 6480464 | Doxorubicin results in increased expression of PNISR mRNA | CTD | PMID:29803840 | elemental selenium | decreases expression | ISO | PNISR (Homo sapiens) | 6480464 | Selenium results in decreased expression of PNISR mRNA | CTD | PMID:19244175 | entinostat | decreases expression | ISO | PNISR (Homo sapiens) | 6480464 | entinostat results in decreased expression of PNISR mRNA | CTD | PMID:27188386 | ethanol | affects expression | ISO | Pnisr (Mus musculus) | 6480464 | Ethanol affects the expression of PNISR mRNA | CTD | PMID:26730594 | ethyl methanesulfonate | increases expression | ISO | PNISR (Homo sapiens) | 6480464 | Ethyl Methanesulfonate results in increased expression of PNISR mRNA | CTD | PMID:23649840 | folic acid | multiple interactions | ISO | Pnisr (Mus musculus) | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in increased expression of PNISR mRNA | CTD | PMID:22206623 | formaldehyde | decreases expression | ISO | PNISR (Homo sapiens) | 6480464 | Formaldehyde results in decreased expression of PNISR mRNA | CTD | PMID:20655997 | FR900359 | affects phosphorylation | ISO | PNISR (Homo sapiens) | 6480464 | FR900359 affects the phosphorylation of PNISR protein | CTD | PMID:37730182 | gentamycin | increases expression | EXP | | 6480464 | Gentamicins results in increased expression of PNISR mRNA | CTD | PMID:22061828 and PMID:33387578 | glyphosate | increases expression | EXP | | 6480464 | Glyphosate results in increased expression of PNISR mRNA | CTD | PMID:26302742 | hydrogen peroxide | multiple interactions | ISO | Pnisr (Mus musculus) | 6480464 | [Hydrogen Peroxide co-treated with N-(oxo-5 more ... | CTD | PMID:31494107 | lead(0) | affects splicing | ISO | PNISR (Homo sapiens) | 6480464 | Lead affects the splicing of PNISR mRNA | CTD | PMID:28903495 | leflunomide | decreases expression | ISO | PNISR (Homo sapiens) | 6480464 | leflunomide results in decreased expression of PNISR mRNA | CTD | PMID:28988120 | methylmercury chloride | decreases expression | ISO | PNISR (Homo sapiens) | 6480464 | methylmercuric chloride results in decreased expression of PNISR mRNA | CTD | PMID:28001369 | microcystin-LR | decreases expression | ISO | PNISR (Homo sapiens) | 6480464 | cyanoginosin LR results in decreased expression of PNISR mRNA | CTD | PMID:27796937 | nefazodone | decreases expression | EXP | | 6480464 | nefazodone results in decreased expression of PNISR mRNA | CTD | PMID:24136188 | nickel dichloride | decreases expression | ISO | PNISR (Homo sapiens) | 6480464 | nickel chloride results in decreased expression of PNISR mRNA | CTD | PMID:17312168 | nimesulide | decreases expression | EXP | | 6480464 | nimesulide results in decreased expression of PNISR mRNA | CTD | PMID:24136188 | paracetamol | decreases expression | ISO | PNISR (Homo sapiens) | 6480464 | Acetaminophen results in decreased expression of PNISR mRNA | CTD | PMID:21420995 | paracetamol | decreases expression | EXP | | 6480464 | Acetaminophen results in decreased expression of PNISR mRNA | CTD | PMID:33387578 | PCB138 | multiple interactions | ISO | Pnisr (Mus musculus) | 6480464 | [2 more ... | CTD | PMID:25510870 | perfluorooctane-1-sulfonic acid | decreases expression | ISO | PNISR (Homo sapiens) | 6480464 | perfluorooctane sulfonic acid results in decreased expression of PNISR mRNA | CTD | PMID:27153767 | perfluorooctane-1-sulfonic acid | multiple interactions | ISO | Pnisr (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Pectins] results in decreased expression of PNISR mRNA | CTD | PMID:36331819 | phenobarbital | affects expression | ISO | Pnisr (Mus musculus) | 6480464 | Phenobarbital affects the expression of PNISR mRNA | CTD | PMID:23091169 | phenylmercury acetate | decreases expression | ISO | PNISR (Homo sapiens) | 6480464 | Phenylmercuric Acetate results in decreased expression of PNISR mRNA | CTD | PMID:26272509 | phenylmercury acetate | multiple interactions | ISO | PNISR (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PNISR mRNA | CTD | PMID:27188386 | resorcinol | increases expression | ISO | PNISR (Homo sapiens) | 6480464 | resorcinol results in increased expression of PNISR mRNA | CTD | PMID:22623647 | SB 431542 | multiple interactions | ISO | PNISR (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | selenium atom | decreases expression | ISO | PNISR (Homo sapiens) | 6480464 | Selenium results in decreased expression of PNISR mRNA | CTD | PMID:19244175 | sodium arsenate | increases expression | ISO | Pnisr (Mus musculus) | 6480464 | sodium arsenate results in increased expression of PNISR mRNA | CTD | PMID:21795629 | sodium arsenate | decreases expression | ISO | Pnisr (Mus musculus) | 6480464 | sodium arsenate results in decreased expression of PNISR mRNA | CTD | PMID:21795629 | sodium arsenite | decreases expression | ISO | PNISR (Homo sapiens) | 6480464 | sodium arsenite results in decreased expression of PNISR mRNA | CTD | PMID:34032870 | sodium arsenite | decreases expression | ISO | Pnisr (Mus musculus) | 6480464 | sodium arsenite results in decreased expression of PNISR mRNA | CTD | PMID:36209798 | succimer | multiple interactions | ISO | Pnisr (Mus musculus) | 6480464 | [Succimer binds to Magnetite Nanoparticles] which results in decreased expression of PNISR mRNA | CTD | PMID:21641980 | tetrachloromethane | affects expression | ISO | Pnisr (Mus musculus) | 6480464 | Carbon Tetrachloride affects the expression of PNISR mRNA | CTD | PMID:17484886 | tetraphene | affects expression | ISO | Pnisr (Mus musculus) | 6480464 | benz(a)anthracene affects the expression of PNISR mRNA | CTD | PMID:26377693 | thioacetamide | decreases expression | EXP | | 6480464 | Thioacetamide results in decreased expression of PNISR mRNA | CTD | PMID:34492290 | trichloroethene | decreases expression | EXP | | 6480464 | Trichloroethylene results in decreased expression of PNISR mRNA | CTD | PMID:33387578 | trichostatin A | affects expression | ISO | PNISR (Homo sapiens) | 6480464 | trichostatin A affects the expression of PNISR mRNA | CTD | PMID:28542535 | triptonide | decreases expression | ISO | Pnisr (Mus musculus) | 6480464 | triptonide results in decreased expression of PNISR mRNA | CTD | PMID:33045310 | tris(2-butoxyethyl) phosphate | affects expression | ISO | PNISR (Homo sapiens) | 6480464 | tris(2-butoxyethyl) phosphate affects the expression of PNISR mRNA | CTD | PMID:29024780 | troglitazone | decreases expression | ISO | Pnisr (Mus musculus) | 6480464 | troglitazone results in decreased expression of PNISR mRNA | CTD | PMID:28973697 | tungsten | decreases expression | ISO | Pnisr (Mus musculus) | 6480464 | Tungsten results in decreased expression of SFRS18 mRNA | CTD | PMID:30912803 | urethane | increases expression | ISO | PNISR (Homo sapiens) | 6480464 | Urethane results in increased expression of PNISR mRNA | CTD | PMID:28818685 | valproic acid | affects expression | ISO | PNISR (Homo sapiens) | 6480464 | Valproic Acid affects the expression of PNISR mRNA | CTD | PMID:25979313 | valproic acid | affects splicing | EXP | | 6480464 | Valproic Acid affects the splicing of PNISR mRNA | CTD | PMID:29427782 | valproic acid | decreases expression | ISO | PNISR (Homo sapiens) | 6480464 | Valproic Acid results in decreased expression of PNISR mRNA | CTD | PMID:23179753 more ... | valproic acid | multiple interactions | ISO | PNISR (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PNISR mRNA | CTD | PMID:27188386 | vinclozolin | increases expression | EXP | | 6480464 | vinclozolin results in increased expression of PNISR mRNA | CTD | PMID:20566332 and PMID:23034163 | vincristine | decreases expression | ISO | PNISR (Homo sapiens) | 6480464 | Vincristine results in decreased expression of PNISR mRNA | CTD | PMID:23649840 | vitamin E | decreases expression | ISO | PNISR (Homo sapiens) | 6480464 | Vitamin E results in decreased expression of PNISR mRNA | CTD | PMID:19244175 | vorinostat | decreases expression | ISO | PNISR (Homo sapiens) | 6480464 | vorinostat results in decreased expression of PNISR mRNA | CTD | PMID:27188386 | |