Npbwr1 (neuropeptides B and W receptor 1) - Rat Genome Database

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Gene: Npbwr1 (neuropeptides B and W receptor 1) Rattus norvegicus
Analyze
Symbol: Npbwr1
Name: neuropeptides B and W receptor 1
RGD ID: 1305917
Description: Predicted to enable G protein-coupled receptor activity and neuropeptide binding activity. Predicted to be involved in neuropeptide signaling pathway. Predicted to act upstream of or within regulation of metabolic process. Predicted to be active in neuron projection and plasma membrane. Orthologous to human NPBWR1 (neuropeptides B and W receptor 1); INTERACTS WITH bisphenol A; C60 fullerene; gentamycin.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: G protein-coupled receptor 7; G-protein coupled receptor 7; Gpr7; LOC297795; Nbpwr1; neuropeptides B/W receptor 1; neuropeptides B/W receptor type 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2513,495,426 - 13,496,415 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl513,495,426 - 13,496,415 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx515,661,002 - 15,661,991 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0517,305,633 - 17,306,622 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0516,995,703 - 16,996,692 (+)NCBIRnor_WKY
Rnor_6.0513,379,772 - 13,380,761 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl513,379,772 - 13,380,761 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0518,149,038 - 18,150,027 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4513,637,094 - 13,638,083 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1513,637,093 - 13,638,082 (+)NCBI
Celera512,903,127 - 12,904,116 (+)NCBICelera
Cytogenetic Map5q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12401809   PMID:12925742   PMID:16736466   PMID:33105700  


Genomics

Comparative Map Data
Npbwr1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2513,495,426 - 13,496,415 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl513,495,426 - 13,496,415 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx515,661,002 - 15,661,991 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0517,305,633 - 17,306,622 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0516,995,703 - 16,996,692 (+)NCBIRnor_WKY
Rnor_6.0513,379,772 - 13,380,761 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl513,379,772 - 13,380,761 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0518,149,038 - 18,150,027 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4513,637,094 - 13,638,083 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1513,637,093 - 13,638,082 (+)NCBI
Celera512,903,127 - 12,904,116 (+)NCBICelera
Cytogenetic Map5q12NCBI
NPBWR1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38852,939,182 - 52,943,734 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl852,939,182 - 52,943,734 (+)EnsemblGRCh38hg38GRCh38
GRCh37853,851,742 - 53,856,294 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36854,015,021 - 54,016,007 (+)NCBINCBI36Build 36hg18NCBI36
Build 34854,015,020 - 54,016,007NCBI
Celera849,843,313 - 49,844,299 (+)NCBICelera
Cytogenetic Map8q11.23NCBI
HuRef849,319,868 - 49,320,854 (+)NCBIHuRef
CHM1_1853,904,190 - 53,905,176 (+)NCBICHM1_1
T2T-CHM13v2.0853,315,605 - 53,320,157 (+)NCBIT2T-CHM13v2.0
Npbwr1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3915,983,926 - 5,987,617 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl15,983,926 - 5,987,617 (-)EnsemblGRCm39 Ensembl
GRCm3815,913,707 - 5,917,398 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl15,913,707 - 5,917,398 (-)EnsemblGRCm38mm10GRCm38
MGSCv3715,903,788 - 5,907,479 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3615,903,788 - 5,907,479 (-)NCBIMGSCv36mm8
Celera15,903,854 - 5,907,545 (-)NCBICelera
Cytogenetic Map1A1NCBI
Npbwr1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495545412,453,047 - 12,453,676 (+)NCBIChiLan1.0ChiLan1.0
NPBWR1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1846,745,428 - 46,746,949 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl846,745,428 - 46,746,414 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0849,363,390 - 49,368,499 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
NPBWR1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1294,772,851 - 4,774,412 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl294,773,409 - 4,774,404 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha295,213,096 - 5,214,096 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0294,843,580 - 4,844,580 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl294,843,585 - 4,844,580 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1294,776,129 - 4,777,129 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0294,997,715 - 4,998,715 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0295,078,264 - 5,079,264 (+)NCBIUU_Cfam_GSD_1.0
Npbwr1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530374,810,294 - 74,849,609 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493659036,377 - 38,899 (-)EnsemblSpeTri2.0
SpeTri2.0NW_00493659038,185 - 38,899 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NPBWR1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl477,539,087 - 77,540,079 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1477,539,000 - 77,540,691 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2484,561,705 - 84,562,872 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NPBWR1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1849,049,142 - 49,053,037 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl849,049,238 - 49,050,224 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603992,938,770 - 92,945,140 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Npbwr1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247352,574,026 - 2,575,018 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247352,573,992 - 2,576,509 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:46
Count of miRNA genes:45
Interacting mature miRNAs:45
Transcripts:ENSRNOT00000010032
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331756Rf34Renal function QTL 344.16275kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)5190450412Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51131345958Rat
1331771Rf35Renal function QTL 354.36965kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)572947086724018Rat
2312562Pur18Proteinuria QTL 182.60.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)5213896532656739Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
8662454Vetf3Vascular elastic tissue fragility QTL 327.4artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)5228222669540447Rat
2313085Bss59Bone structure and strength QTL 592.90.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)5384401826141981Rat
1300117Hrtrt8Heart rate QTL 83.49heart pumping trait (VT:2000009)heart rate (CMO:0000002)5384401847869213Rat
61462Niddm10Non-insulin dependent diabetes mellitus QTL 103.90.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)5511215947171491Rat
631827Alc4Alcohol consumption QTL 43.5consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)5818750118616199Rat
2293666Bmd38Bone mineral density QTL 384.4femur size trait (VT:1000369)femoral neck cortical cross-sectional area (CMO:0001702)5894822853948228Rat
7394712Emca13Estrogen-induced mammary cancer QTL 13mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)5982326699753708Rat
1641903Alcrsp3Alcohol response QTL 3response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)51268928557689285Rat
634305Mamtr1Mammary tumor resistance QTL 10.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)512789751113558310Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

nervous system renal system reproductive system respiratory system
High
Medium
Low 22 9
Below cutoff 33 4 20 5

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000010032   ⟹   ENSRNOP00000010032
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl513,495,426 - 13,496,415 (+)Ensembl
Rnor_6.0 Ensembl513,379,772 - 13,380,761 (+)Ensembl
RefSeq Acc Id: NM_001014784   ⟹   NP_001014784
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2513,495,426 - 13,496,415 (+)NCBI
Rnor_6.0513,379,772 - 13,380,761 (+)NCBI
Rnor_5.0518,149,038 - 18,150,027 (+)NCBI
RGSC_v3.4513,637,094 - 13,638,083 (+)RGD
Celera512,903,127 - 12,904,116 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001014784 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAT72915 (Get FASTA)   NCBI Sequence Viewer  
  EDM11578 (Get FASTA)   NCBI Sequence Viewer  
  Q56UD9 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001014784   ⟸   NM_001014784
- UniProtKB: Q56UD9 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000010032   ⟸   ENSRNOT00000010032

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q56UD9-F1-model_v2 AlphaFold Q56UD9 1-329 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305917 AgrOrtholog
BioCyc Gene G2FUF-42163 BioCyc
Ensembl Genes ENSRNOG00000007640 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000010032 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000010032 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot
  Neuropept_B/W_rcpt UniProtKB/Swiss-Prot
  NPBW1 UniProtKB/Swiss-Prot
KEGG Report rno:297795 UniProtKB/Swiss-Prot
NCBI Gene 297795 ENTREZGENE
PANTHER PTHR24229:SF47 UniProtKB/Swiss-Prot
Pfam 7tm_1 UniProtKB/Swiss-Prot
PhenoGen Npbwr1 PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot
  NRPEPTIDEWR UniProtKB/Swiss-Prot
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot
UniProt NPBW1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-02-01 Npbwr1  neuropeptides B and W receptor 1  Npbwr1  neuropeptides B/W receptor 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-04 Npbwr1  neuropeptides B/W receptor 1  Nbpwr1  neuropeptides B/W receptor 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Nbpwr1  neuropeptides B/W receptor 1  Gpr7  G protein-coupled receptor 7  Symbol and Name updated 1299863 APPROVED
2005-12-06 Gpr7  G protein-coupled receptor 7  Gpr7_predicted  G protein-coupled receptor 7 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Gpr7_predicted  G protein-coupled receptor 7 (predicted)      Symbol and Name status set to approved 70820 APPROVED