Gpr7 (G protein-coupled receptor 7) - Rat Genome Database

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Gene: Gpr7 (G protein-coupled receptor 7) Mus musculus
Analyze
Symbol: Gpr7 (Ensembl: Npbwr1)
Name: G protein-coupled receptor 7 (Ensembl:neuropeptides B/W receptor 1)
RGD ID: 1622979
MGI Page MGI
Description: Predicted to enable G protein-coupled receptor activity and neuropeptide binding activity. Acts upstream of or within regulation of metabolic process. Predicted to be located in membrane. Predicted to be active in neuron projection and plasma membrane. Orthologous to human NPBWR1 (neuropeptides B and W receptor 1); INTERACTS WITH 4,4'-sulfonyldiphenol; all-trans-retinoic acid; mono(2-ethylhexyl) phthalate.
Type: protein-coding
Previously known as: G-protein coupled receptor 7; Gp; Nbpwr1; neuropeptides B/W receptor 1; neuropeptides B/W receptor type 1; Npbwr1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3915,983,926 - 5,987,617 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl15,983,926 - 5,987,617 (-)EnsemblGRCm39 Ensembl
GRCm3815,913,707 - 5,917,398 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl15,913,707 - 5,917,398 (-)EnsemblGRCm38mm10GRCm38
MGSCv3715,903,788 - 5,907,479 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3615,903,788 - 5,907,479 (-)NCBIMGSCv36mm8
Celera15,903,854 - 5,907,545 (-)NCBICelera
Cytogenetic Map1A1NCBI
cM Map11.89NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Mouse MP Annotation Import Pipeline RGD automated import pipeline
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:7590751   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12925742   PMID:16141072   PMID:16141073  


Genomics

Comparative Map Data
Gpr7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3915,983,926 - 5,987,617 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl15,983,926 - 5,987,617 (-)EnsemblGRCm39 Ensembl
GRCm3815,913,707 - 5,917,398 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl15,913,707 - 5,917,398 (-)EnsemblGRCm38mm10GRCm38
MGSCv3715,903,788 - 5,907,479 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3615,903,788 - 5,907,479 (-)NCBIMGSCv36mm8
Celera15,903,854 - 5,907,545 (-)NCBICelera
Cytogenetic Map1A1NCBI
cM Map11.89NCBI
NPBWR1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38852,939,182 - 52,943,734 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl852,939,182 - 52,943,734 (+)EnsemblGRCh38hg38GRCh38
GRCh37853,851,742 - 53,856,294 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36854,015,021 - 54,016,007 (+)NCBINCBI36Build 36hg18NCBI36
Build 34854,015,020 - 54,016,007NCBI
Celera849,843,313 - 49,844,299 (+)NCBICelera
Cytogenetic Map8q11.23NCBI
HuRef849,319,868 - 49,320,854 (+)NCBIHuRef
CHM1_1853,904,190 - 53,905,176 (+)NCBICHM1_1
T2T-CHM13v2.0853,315,605 - 53,320,157 (+)NCBIT2T-CHM13v2.0
Npbwr1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8518,282,180 - 18,285,622 (+)NCBIGRCr8
mRatBN7.2513,495,319 - 13,498,761 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl513,495,426 - 13,496,415 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx515,661,002 - 15,661,991 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0517,305,633 - 17,306,622 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0516,995,703 - 16,996,692 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0513,379,772 - 13,380,761 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl513,379,772 - 13,380,761 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0518,149,038 - 18,150,027 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4513,637,094 - 13,638,083 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1513,637,093 - 13,638,082 (+)NCBI
Celera512,903,127 - 12,904,116 (+)NCBICelera
Cytogenetic Map5q12NCBI
Npbwr1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495545412,453,047 - 12,453,676 (+)NCBIChiLan1.0ChiLan1.0
NPBWR1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2768,574,398 - 68,579,711 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1844,299,388 - 44,301,866 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0849,363,390 - 49,368,499 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1846,745,428 - 46,746,949 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl846,745,428 - 46,746,414 (+)Ensemblpanpan1.1panPan2
NPBWR1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1294,772,851 - 4,774,412 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl294,773,409 - 4,774,404 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha295,213,096 - 5,214,096 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0294,843,580 - 4,844,580 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl294,843,585 - 4,844,580 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1294,776,129 - 4,777,129 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0294,997,715 - 4,998,715 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0295,078,264 - 5,079,264 (+)NCBIUU_Cfam_GSD_1.0
Npbwr1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530374,810,294 - 74,849,609 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493659036,377 - 38,899 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493659038,185 - 38,899 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NPBWR1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl477,539,087 - 77,540,079 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1477,539,000 - 77,540,691 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2484,561,705 - 84,562,872 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NPBWR1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1849,049,142 - 49,053,037 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl849,049,238 - 49,050,224 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603992,938,770 - 92,945,140 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Npbwr1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247352,574,026 - 2,575,018 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247352,573,992 - 2,576,509 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gpr7
76 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:842
Count of miRNA genes:516
Interacting mature miRNAs:613
Transcripts:ENSMUST00000044180
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
11039528Ccc3_mcolitis susceptibility in the Collaborative Cross 3 (mouse)13680142195051546Mouse
1301275Sle10_msystematic lupus erythematosus susceptibility 10 (mouse)Not determined1288219436882352Mouse
15092046Wngrme1_mweek nine growth rate, maternal effect 1 (mouse)1328014237782236Mouse
1301370Adip1_madiposity 1 (mouse)Not determined1288219436882352Mouse
13824984Twq5_mtestis weight QTL 5 (mouse)13069992184732197Mouse
15092044Wtgrme1_mweek ten growth rate, maternal effect 1 (mouse)1328014237782236Mouse
1301471Obq2_mobesity QTL 2 (mouse)Not determined1394162037941887Mouse
1301891Alcp25_malcohol preference locus 25 (mouse)Not determined1125203185Mouse
1300834Cia20_mcollagen induced arthritis 20 (mouse)Not determined1125203185Mouse
15092055Lgrme1_mlate growth rate, maternal effect 1 (mouse)1328014237782236Mouse
15092050Wsegrme1_mweek seven growth rate, maternal effect 1 (mouse)1328014237782236Mouse
15092051Wegrme1_mweek eight growth rate, maternal effect 1 (mouse)1328014237782236Mouse
15092048Wsigrme1_mweek six growth rate, maternal effect 1 (mouse)1328014237782236Mouse
1301482Morph1_mmorphine antinociception 1 (mouse)Not determined1130367747Mouse
10043970Obq23_mobesity QTL 23 (mouse)Not determined1501266539012665Mouse
10412226Alpq4_malcohol preference QTL 4 (mouse)Not determined1122976684Mouse


Expression


Sequence


Ensembl Acc Id: ENSMUST00000044180   ⟹   ENSMUSP00000046233
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl15,983,926 - 5,987,617 (-)Ensembl
GRCm38.p6 Ensembl15,913,707 - 5,917,398 (-)Ensembl
RefSeq Acc Id: NM_010342   ⟹   NP_034472
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3915,983,926 - 5,987,617 (-)NCBI
GRCm3815,913,707 - 5,917,398 (-)ENTREZGENE
MGSCv3715,903,788 - 5,907,479 (-)RGD
Celera15,903,854 - 5,907,545 (-)RGD
cM Map1 ENTREZGENE
Sequence:
Protein Sequences
GenBank Protein AAA86386 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000046233.5
GenBank Protein P49681 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_034472   ⟸   NM_010342
- Sequence:
Ensembl Acc Id: ENSMUSP00000046233   ⟸   ENSMUST00000044180

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P49681-F1-model_v2 AlphaFold P49681 1-329 view protein structure

Promoters
RGD ID:6818178
Promoter ID:MM_KWN:32
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Spleen
Transcripts:NM_010342
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3615,906,476 - 5,906,976 (-)MPROMDB
RGD ID:6873144
Promoter ID:EPDNEW_M12
Type:single initiation site
Name:Npbwr1_1
Description:Mus musculus neuropeptides B/W receptor 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3815,917,458 - 5,917,518EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:891989 AgrOrtholog
Ensembl Genes ENSMUSG00000033774 Ensembl, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000044180.5 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot
  Neuropept_B/W_rcpt UniProtKB/Swiss-Prot
KEGG Report mmu:226304 UniProtKB/Swiss-Prot
MGD MGI:891989 ENTREZGENE
NCBI Gene Gpr7 ENTREZGENE
PANTHER NEUROPEPTIDES RECEPTOR UniProtKB/Swiss-Prot
  PTHR24229:SF47 UniProtKB/Swiss-Prot
Pfam 7tm_1 UniProtKB/Swiss-Prot
PhenoGen Gpr7 PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot
  NRPEPTIDEWR UniProtKB/Swiss-Prot
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot
UniProt NPBW1_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2024-08-21 Gpr7  G protein-coupled receptor 7  Npbwr1  neuropeptides B/W receptor 1  Symbol and/or name change 5135510 APPROVED