Cib1 (calcium and integrin binding 1) - Rat Genome Database

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Gene: Cib1 (calcium and integrin binding 1) Ictidomys tridecemlineatus
Analyze
Symbol: Cib1
Name: calcium and integrin binding 1
RGD ID: 12708323
Description: ENCODES a protein that exhibits protein kinase binding (ortholog); INVOLVED IN negative regulation of protein phosphorylation (ortholog); positive regulation of catalytic activity (ortholog); positive regulation of NF-kappaB transcription factor activity (ortholog); ASSOCIATED WITH Alzheimer's disease (ortholog); Bloom syndrome (ortholog); colorectal cancer (ortholog); FOUND IN axon (ortholog); dendrite (ortholog); neuronal cell body (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: calcium and integrin-binding protein 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640130,366,977 - 130,370,657 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648315,960,036 - 15,968,094 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648315,963,863 - 15,967,458 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (IEA)
apoptotic process  (IEA)
cell adhesion  (IEA)
cell differentiation  (IEA)
cell division  (IEA)
cellular response to growth factor stimulus  (IEA)
cellular response to nerve growth factor stimulus  (IEA)
cellular response to tumor necrosis factor  (IEA)
cytoplasmic microtubule organization  (IEA)
DNA damage response  (IEA)
endomitotic cell cycle  (IEA)
negative regulation of apoptotic process  (IEA)
negative regulation of cell population proliferation  (IEA)
negative regulation of megakaryocyte differentiation  (IEA)
negative regulation of microtubule depolymerization  (IEA)
negative regulation of neuron projection development  (IEA)
negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IEA)
negative regulation of protein phosphorylation  (ISO)
platelet formation  (IEA)
positive regulation of calcineurin-NFAT signaling cascade  (IEA)
positive regulation of catalytic activity  (ISO)
positive regulation of cell adhesion mediated by integrin  (IEA)
positive regulation of cell growth  (IEA)
positive regulation of cell migration  (IEA)
positive regulation of cell migration involved in sprouting angiogenesis  (IEA)
positive regulation of cell population proliferation  (IEA)
positive regulation of cell-matrix adhesion  (IEA)
positive regulation of ERK1 and ERK2 cascade  (IEA)
positive regulation of male germ cell proliferation  (IEA)
positive regulation of NF-kappaB transcription factor activity  (ISO)
positive regulation of protein localization to plasma membrane  (IEA)
positive regulation of protein phosphorylation  (ISO)
positive regulation of protein serine/threonine kinase activity  (ISO)
positive regulation of protein targeting to membrane  (IEA)
positive regulation of substrate adhesion-dependent cell spreading  (IEA)
regulation of cell division  (IEA)
regulation of cell population proliferation  (IEA)
response to ischemia  (IEA)
spermatid development  (IEA)
spermatogenesis  (IEA)
thrombopoietin-mediated signaling pathway  (IEA)

Cellular Component

References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
Cib1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640130,366,977 - 130,370,657 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648315,960,036 - 15,968,094 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648315,963,863 - 15,967,458 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CIB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381590,229,975 - 90,265,759 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1590,229,975 - 90,234,047 (-)EnsemblGRCh38hg38GRCh38
GRCh371590,773,207 - 90,808,991 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361588,574,481 - 88,578,168 (-)NCBINCBI36Build 36hg18NCBI36
Build 341588,574,481 - 88,578,164NCBI
Celera1567,177,856 - 67,181,658 (-)NCBICelera
Cytogenetic Map15q26.1NCBI
HuRef1566,885,466 - 66,920,950 (-)NCBIHuRef
CHM1_11590,615,325 - 90,650,739 (-)NCBICHM1_1
T2T-CHM13v2.01587,985,982 - 88,021,749 (-)NCBIT2T-CHM13v2.0
Cib1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39779,876,904 - 79,882,367 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl779,876,895 - 79,882,561 (-)EnsemblGRCm39 Ensembl
GRCm38780,227,156 - 80,232,805 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl780,227,147 - 80,232,813 (-)EnsemblGRCm38mm10GRCm38
MGSCv37787,372,046 - 87,377,502 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36780,100,673 - 80,106,129 (-)NCBIMGSCv36mm8
Celera777,628,499 - 77,633,950 (-)NCBICelera
Cytogenetic Map7D2NCBI
cM Map745.55NCBI
Cib1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81143,587,591 - 143,593,153 (-)NCBIGRCr8
mRatBN7.21134,178,331 - 134,183,895 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1134,178,331 - 134,213,423 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1142,087,063 - 142,092,596 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01149,256,463 - 149,261,996 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01142,174,501 - 142,180,032 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01142,014,962 - 142,020,461 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1142,014,958 - 142,020,525 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01142,969,357 - 142,974,856 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41136,031,865 - 136,045,153 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11136,110,270 - 136,123,559 (-)NCBI
Celera1126,238,471 - 126,243,970 (-)NCBICelera
Cytogenetic Map1q31NCBI
Cib1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541615,102,632 - 15,106,372 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541615,102,632 - 15,106,372 (+)NCBIChiLan1.0ChiLan1.0
CIB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21679,778,580 - 79,782,540 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11583,478,015 - 83,481,975 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01568,919,377 - 68,923,213 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11588,121,309 - 88,125,120 (-)NCBIpanpan1.1PanPan1.1panPan2
CIB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1353,184,713 - 53,209,195 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl353,184,714 - 53,188,224 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha355,822,517 - 55,847,781 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0353,600,749 - 53,626,017 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl353,600,750 - 53,625,109 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1353,120,852 - 53,146,101 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0353,331,988 - 53,357,228 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0353,672,463 - 53,697,717 (-)NCBIUU_Cfam_GSD_1.0
CIB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl755,794,836 - 55,798,590 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1755,794,834 - 55,798,666 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2760,656,933 - 60,659,823 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CIB1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1298,777,202 - 8,781,027 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl298,777,436 - 8,781,030 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605937,949,545 - 37,953,393 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cib1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476817,209,639 - 17,213,114 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476817,209,639 - 17,212,996 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005320148 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAESOR010003700 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSSTOT00000010012   ⟹   ENSSTOP00000008982
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_00493648315,964,089 - 15,967,354 (-)Ensembl
Ensembl Acc Id: ENSSTOT00000041026   ⟹   ENSSTOP00000026855
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_00493648315,960,036 - 15,968,094 (-)Ensembl
RefSeq Acc Id: XM_005320148   ⟹   XP_005320205
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024408640130,366,977 - 130,370,657 (+)NCBI
SpeTri2.0NW_00493648315,963,863 - 15,967,458 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005320205 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000008982.3
  ENSSTOP00000026855.1
GenBank Protein KAG3262562 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_005320205   ⟸   XM_005320148
- UniProtKB: A0A287CZT6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSTOP00000008982   ⟸   ENSSTOT00000010012
Ensembl Acc Id: ENSSTOP00000026855   ⟸   ENSSTOT00000041026
Protein Domains
EF-hand


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000010017 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000010012.3 UniProtKB/TrEMBL
  ENSSTOT00000041026.1 UniProtKB/TrEMBL
Gene3D-CATH EF-hand UniProtKB/TrEMBL
InterPro CIBP UniProtKB/TrEMBL
  EF-hand-dom_pair UniProtKB/TrEMBL
  EF_Hand_1_Ca_BS UniProtKB/TrEMBL
  EF_hand_dom UniProtKB/TrEMBL
NCBI Gene Cib1 ENTREZGENE
PANTHER CALCIUM AND INTEGRIN BINDING FAMILY MEMBER 2 UniProtKB/TrEMBL
  CALCIUM AND INTEGRIN-BINDING PROTEIN 1 UniProtKB/TrEMBL
Pfam EF-hand_7 UniProtKB/TrEMBL
PROSITE EF_HAND_1 UniProtKB/TrEMBL
  EF_HAND_2 UniProtKB/TrEMBL
SMART EFh UniProtKB/TrEMBL
Superfamily-SCOP SSF47473 UniProtKB/TrEMBL
UniProt A0A287CZT6 ENTREZGENE, UniProtKB/TrEMBL
  I3MEN3_ICTTR UniProtKB/TrEMBL