CIB1 (calcium and integrin binding 1) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: CIB1 (calcium and integrin binding 1) Sus scrofa
Analyze
Symbol: CIB1
Name: calcium and integrin binding 1
RGD ID: 14274648
Description: ENCODES a protein that exhibits protein kinase binding (ortholog); INVOLVED IN angiogenesis (inferred); apoptotic process (inferred); cell adhesion (inferred); ASSOCIATED WITH Alzheimer's disease (ortholog); Bloom syndrome (ortholog); colorectal cancer (ortholog); FOUND IN axon (ortholog); dendrite (ortholog); neuronal cell body (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: calcium and integrin-binding protein 1; calmyrin; DNA-PK interaction-like protein
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl755,794,836 - 55,798,590 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1755,794,834 - 55,798,666 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2760,656,933 - 60,659,823 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (IEA)
apoptotic process  (IEA)
cell adhesion  (IEA)
cell differentiation  (IEA)
cell division  (IEA)
cellular response to growth factor stimulus  (IBA,IEA)
cellular response to nerve growth factor stimulus  (IEA)
cellular response to tumor necrosis factor  (IEA)
cytoplasmic microtubule organization  (IEA)
DNA damage response  (IEA)
endomitotic cell cycle  (IEA)
integrin-mediated signaling pathway  (IEA)
negative regulation of apoptotic process  (IEA)
negative regulation of cell population proliferation  (IEA)
negative regulation of megakaryocyte differentiation  (IEA)
negative regulation of microtubule depolymerization  (IEA)
negative regulation of neuron projection development  (IEA)
negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IEA)
negative regulation of protein phosphorylation  (IEA)
platelet formation  (IEA)
positive regulation of calcineurin-NFAT signaling cascade  (IBA,IEA)
positive regulation of cell adhesion mediated by integrin  (IEA)
positive regulation of cell growth  (IEA)
positive regulation of cell migration  (IEA)
positive regulation of cell migration involved in sprouting angiogenesis  (IEA)
positive regulation of cell population proliferation  (IEA)
positive regulation of cell-matrix adhesion  (IEA)
positive regulation of ERK1 and ERK2 cascade  (IEA)
positive regulation of male germ cell proliferation  (IEA)
positive regulation of protein localization to plasma membrane  (IBA,IEA)
positive regulation of protein phosphorylation  (IEA)
positive regulation of protein targeting to membrane  (IEA)
positive regulation of substrate adhesion-dependent cell spreading  (IEA)
regulation of cell division  (IEA)
regulation of cell population proliferation  (IEA)
response to ischemia  (IEA)
spermatid development  (IEA)
spermatogenesis  (IEA)
thrombopoietin-mediated signaling pathway  (IEA)

Cellular Component

References
Additional References at PubMed
PMID:15679890   PMID:22301074  


Genomics

Comparative Map Data
CIB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl755,794,836 - 55,798,590 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1755,794,834 - 55,798,666 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2760,656,933 - 60,659,823 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CIB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381590,229,975 - 90,265,759 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1590,229,975 - 90,234,047 (-)EnsemblGRCh38hg38GRCh38
GRCh371590,773,207 - 90,808,991 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361588,574,481 - 88,578,168 (-)NCBINCBI36Build 36hg18NCBI36
Build 341588,574,481 - 88,578,164NCBI
Celera1567,177,856 - 67,181,658 (-)NCBICelera
Cytogenetic Map15q26.1NCBI
HuRef1566,885,466 - 66,920,950 (-)NCBIHuRef
CHM1_11590,615,325 - 90,650,739 (-)NCBICHM1_1
T2T-CHM13v2.01587,985,982 - 88,021,749 (-)NCBIT2T-CHM13v2.0
Cib1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39779,876,904 - 79,882,367 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl779,876,895 - 79,882,561 (-)EnsemblGRCm39 Ensembl
GRCm38780,227,156 - 80,232,805 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl780,227,147 - 80,232,813 (-)EnsemblGRCm38mm10GRCm38
MGSCv37787,372,046 - 87,377,502 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36780,100,673 - 80,106,129 (-)NCBIMGSCv36mm8
Celera777,628,499 - 77,633,950 (-)NCBICelera
Cytogenetic Map7D2NCBI
cM Map745.55NCBI
Cib1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81143,587,591 - 143,593,153 (-)NCBIGRCr8
mRatBN7.21134,178,331 - 134,183,895 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1134,178,331 - 134,213,423 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1142,087,063 - 142,092,596 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01149,256,463 - 149,261,996 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01142,174,501 - 142,180,032 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01142,014,962 - 142,020,461 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1142,014,958 - 142,020,525 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01142,969,357 - 142,974,856 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41136,031,865 - 136,045,153 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11136,110,270 - 136,123,559 (-)NCBI
Celera1126,238,471 - 126,243,970 (-)NCBICelera
Cytogenetic Map1q31NCBI
Cib1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541615,102,632 - 15,106,372 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541615,102,632 - 15,106,372 (+)NCBIChiLan1.0ChiLan1.0
CIB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21679,778,580 - 79,782,540 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11583,478,015 - 83,481,975 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01568,919,377 - 68,923,213 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11588,121,309 - 88,125,120 (-)NCBIpanpan1.1PanPan1.1panPan2
CIB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1353,184,713 - 53,209,195 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl353,184,714 - 53,188,224 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha355,822,517 - 55,847,781 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0353,600,749 - 53,626,017 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl353,600,750 - 53,625,109 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1353,120,852 - 53,146,101 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0353,331,988 - 53,357,228 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0353,672,463 - 53,697,717 (-)NCBIUU_Cfam_GSD_1.0
Cib1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640130,366,977 - 130,370,657 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648315,960,036 - 15,968,094 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648315,963,863 - 15,967,458 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CIB1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1298,777,202 - 8,781,027 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl298,777,436 - 8,781,030 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605937,949,545 - 37,953,393 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cib1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476817,209,639 - 17,213,114 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476817,209,639 - 17,212,996 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in CIB1
51 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 8 2 5 1 1 2 2 3
Low 2 2 3 1 22 1
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000002083   ⟹   ENSSSCP00000002033
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl755,794,836 - 55,798,590 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000066733   ⟹   ENSSSCP00000068079
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl755,794,843 - 55,798,562 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000078124   ⟹   ENSSSCP00000069269
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl755,794,839 - 55,798,570 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000087191   ⟹   ENSSSCP00000067090
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl755,794,841 - 55,797,486 (-)Ensembl
RefSeq Acc Id: XM_021098979   ⟹   XP_020954638
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1755,794,834 - 55,798,666 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_020954638   ⟸   XM_021098979
- UniProtKB: A0A8D0J5H4 (UniProtKB/TrEMBL),   F1SJX5 (UniProtKB/TrEMBL),   A0A8D1SK58 (UniProtKB/TrEMBL),   A0A8D0USI3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000069269   ⟸   ENSSSCT00000078124
RefSeq Acc Id: ENSSSCP00000002033   ⟸   ENSSSCT00000002083
RefSeq Acc Id: ENSSSCP00000068079   ⟸   ENSSSCT00000066733
RefSeq Acc Id: ENSSSCP00000067090   ⟸   ENSSSCT00000087191
Protein Domains
EF-hand


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000001858 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00005022786 UniProtKB/TrEMBL
  ENSSSCG00015063077 UniProtKB/TrEMBL
  ENSSSCG00025045653 UniProtKB/TrEMBL
  ENSSSCG00030042007 UniProtKB/TrEMBL
  ENSSSCG00035027095 UniProtKB/TrEMBL
  ENSSSCG00040039501 UniProtKB/TrEMBL
  ENSSSCG00045028616 UniProtKB/TrEMBL
  ENSSSCG00050064915 UniProtKB/TrEMBL
  ENSSSCG00055013024 UniProtKB/TrEMBL
  ENSSSCG00060008936 UniProtKB/TrEMBL
  ENSSSCG00065038278 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000002083 ENTREZGENE
  ENSSSCT00000002083.5 UniProtKB/TrEMBL
  ENSSSCT00000066733.2 UniProtKB/TrEMBL
  ENSSSCT00000078124.2 UniProtKB/TrEMBL
  ENSSSCT00000087191.2 UniProtKB/TrEMBL
  ENSSSCT00005036272.1 UniProtKB/TrEMBL
  ENSSSCT00005036389.1 UniProtKB/TrEMBL
  ENSSSCT00015084722.1 UniProtKB/TrEMBL
  ENSSSCT00025061987.1 UniProtKB/TrEMBL
  ENSSSCT00025062092.1 UniProtKB/TrEMBL
  ENSSSCT00025062242.1 UniProtKB/TrEMBL
  ENSSSCT00025062331.1 UniProtKB/TrEMBL
  ENSSSCT00030058442.1 UniProtKB/TrEMBL
  ENSSSCT00030058468.1 UniProtKB/TrEMBL
  ENSSSCT00030058528.1 UniProtKB/TrEMBL
  ENSSSCT00035035829.1 UniProtKB/TrEMBL
  ENSSSCT00040053238.1 UniProtKB/TrEMBL
  ENSSSCT00045048795.1 UniProtKB/TrEMBL
  ENSSSCT00045048869.1 UniProtKB/TrEMBL
  ENSSSCT00045049000.1 UniProtKB/TrEMBL
  ENSSSCT00045049065.1 UniProtKB/TrEMBL
  ENSSSCT00050088397.1 UniProtKB/TrEMBL
  ENSSSCT00055025637.1 UniProtKB/TrEMBL
  ENSSSCT00055025856.1 UniProtKB/TrEMBL
  ENSSSCT00060011510.1 UniProtKB/TrEMBL
  ENSSSCT00065052342.1 UniProtKB/TrEMBL
Gene3D-CATH EF-hand UniProtKB/TrEMBL
InterPro EF-hand-dom_pair UniProtKB/TrEMBL
  EF_Hand_1_Ca_BS UniProtKB/TrEMBL
  EF_hand_dom UniProtKB/TrEMBL
NCBI Gene CIB1 ENTREZGENE
PANTHER CALCIUM AND INTEGRIN BINDING FAMILY MEMBER 2 UniProtKB/TrEMBL
  CALCIUM AND INTEGRIN-BINDING PROTEIN 1 UniProtKB/TrEMBL
Pfam EF-hand_7 UniProtKB/TrEMBL
PROSITE EF_HAND_1 UniProtKB/TrEMBL
  EF_HAND_2 UniProtKB/TrEMBL
SMART EFh UniProtKB/TrEMBL
Superfamily-SCOP SSF47473 UniProtKB/TrEMBL
UniProt A0A5G2QSI6_PIG UniProtKB/TrEMBL
  A0A5G2QWE2_PIG UniProtKB/TrEMBL
  A0A5G2RBT4_PIG UniProtKB/TrEMBL
  A0A8D0J5H4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0S4R1_PIG UniProtKB/TrEMBL
  A0A8D0USI3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1IKV0_PIG UniProtKB/TrEMBL
  A0A8D1SK58 ENTREZGENE, UniProtKB/TrEMBL
  F1SJX5 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:86695 ENTREZGENE