Msh3 (mutS homolog 3) - Rat Genome Database

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Gene: Msh3 (mutS homolog 3) Ictidomys tridecemlineatus
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Symbol: Msh3
Name: mutS homolog 3
RGD ID: 12681165
Description: ENCODES a protein that exhibits centromeric DNA binding (ortholog); damaged DNA binding (ortholog); dinucleotide insertion or deletion binding (ortholog); INVOLVED IN mismatch repair (ortholog); positive regulation of helicase activity (ortholog); somatic hypermutation of immunoglobulin genes (ortholog); PARTICIPATES IN mismatch repair pathway; ASSOCIATED WITH cavernous sinus meningioma (ortholog); colorectal carcinoma (ortholog); Digestive System Neoplasms (ortholog); FOUND IN MutSbeta complex (inferred); nucleus (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: DNA mismatch repair protein Msh3
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213182,351,062 - 182,542,651 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493646983,285 - 273,561 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493646982,967 - 275,772 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Msh3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213182,351,062 - 182,542,651 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493646983,285 - 273,561 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493646982,967 - 275,772 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MSH3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38580,654,652 - 80,876,815 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl580,654,652 - 80,876,815 (+)EnsemblGRCh38hg38GRCh38
GRCh37579,950,471 - 80,172,634 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36579,986,050 - 80,208,390 (+)NCBINCBI36Build 36hg18NCBI36
Build 34579,986,294 - 80,208,389NCBI
Celera575,854,379 - 76,076,910 (+)NCBICelera
Cytogenetic Map5q14.1NCBI
HuRef575,159,370 - 75,381,401 (+)NCBIHuRef
CHM1_1579,383,713 - 79,605,325 (+)NCBICHM1_1
T2T-CHM13v2.0581,139,552 - 81,361,456 (+)NCBIT2T-CHM13v2.0
Msh3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391392,348,387 - 92,491,515 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1392,348,380 - 92,491,511 (-)EnsemblGRCm39 Ensembl
GRCm381392,211,878 - 92,355,004 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1392,211,872 - 92,355,003 (-)EnsemblGRCm38mm10GRCm38
MGSCv371392,981,836 - 93,124,958 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361393,312,634 - 93,455,756 (-)NCBIMGSCv36mm8
Celera1395,828,509 - 95,961,232 (-)NCBICelera
Cytogenetic Map13C3NCBI
cM Map1347.63NCBI
Msh3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8225,179,400 - 25,320,857 (-)NCBIGRCr8
mRatBN7.2223,444,326 - 23,585,777 (-)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx230,479,042 - 30,620,224 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0228,579,397 - 28,720,585 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0223,406,403 - 23,548,408 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0221,790,048 - 21,931,791 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl221,790,044 - 21,931,720 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0240,996,035 - 41,137,686 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4222,462,934 - 22,606,874 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera219,534,848 - 19,675,746 (-)NCBICelera
Cytogenetic Map2q12NCBI
Msh3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541829,150,085 - 29,274,437 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541829,149,595 - 29,274,067 (-)NCBIChiLan1.0ChiLan1.0
MSH3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2434,432,400 - 34,653,426 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1532,582,453 - 32,806,981 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0534,408,469 - 34,663,483 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1534,719,261 - 34,938,521 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl534,719,322 - 34,938,469 (-)Ensemblpanpan1.1panPan2
MSH3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1326,335,788 - 26,520,633 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl326,336,403 - 26,518,521 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha327,571,200 - 27,762,336 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0326,250,075 - 26,441,642 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl326,250,084 - 26,441,647 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1326,190,404 - 26,381,864 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0326,171,404 - 26,356,535 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0326,451,047 - 26,636,178 (-)NCBIUU_Cfam_GSD_1.0
MSH3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl289,250,003 - 89,453,936 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1289,255,647 - 89,456,102 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2291,102,138 - 91,281,732 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MSH3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1474,811,181 - 75,032,067 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl474,811,198 - 75,032,005 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604923,674,149 - 23,899,258 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Msh3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247431,461,077 - 1,581,180 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247431,461,952 - 1,581,524 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSSTOT00000020039   ⟹   ENSSTOP00000017843
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_00493646983,285 - 273,561 (+)Ensembl
Ensembl Acc Id: ENSSTOT00000041011   ⟹   ENSSTOP00000028096
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_004936469240,000 - 273,501 (+)Ensembl
RefSeq Acc Id: XM_040273364   ⟹   XP_040129298
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024407213182,351,062 - 182,542,651 (-)NCBI
Protein Sequences
Protein RefSeqs XP_040129298 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000017843.2
  ENSSTOP00000028096.1
GenBank Protein KAG3266431 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_040129298   ⟸   XM_040273364
- UniProtKB: I3N0E7 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSSTOP00000028096   ⟸   ENSSTOT00000041011
Ensembl Acc Id: ENSSTOP00000017843   ⟸   ENSSTOT00000020039
Protein Domains
DNA mismatch repair proteins mutS family


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000025220 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000020039.2 UniProtKB/TrEMBL
  ENSSTOT00000041011.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.1420.10 UniProtKB/TrEMBL
  3.30.420.110 UniProtKB/TrEMBL
  3.40.1170.10 UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/TrEMBL
InterPro DNA_mismatch_repair_MutS-lik_N UniProtKB/TrEMBL
  DNA_mismatch_repair_MutS/MSH UniProtKB/TrEMBL
  DNA_mismatch_repair_MutS_C UniProtKB/TrEMBL
  DNA_mismatch_repair_MutS_core UniProtKB/TrEMBL
  DNA_mismatch_repair_MutS_N UniProtKB/TrEMBL
  DNA_mismatch_repair_MutS_sf UniProtKB/TrEMBL
  DNA_mmatch_repair_MutS_con_dom UniProtKB/TrEMBL
  MutS_con_dom_sf UniProtKB/TrEMBL
  MutS_family UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
NCBI Gene Msh3 ENTREZGENE
PANTHER DNA MISMATCH REPAIR PROTEIN MSH3 UniProtKB/TrEMBL
  PTHR11361 UniProtKB/TrEMBL
Pfam MutS_I UniProtKB/TrEMBL
  MutS_II UniProtKB/TrEMBL
  MutS_III UniProtKB/TrEMBL
  MutS_V UniProtKB/TrEMBL
PIRSF DNA_mis_repair_Msh6 UniProtKB/TrEMBL
PROSITE DNA_MISMATCH_REPAIR_2 UniProtKB/TrEMBL
SMART MUTSac UniProtKB/TrEMBL
  MUTSd UniProtKB/TrEMBL
Superfamily-SCOP SSF48334 UniProtKB/TrEMBL
  SSF52540 UniProtKB/TrEMBL
  SSF53150 UniProtKB/TrEMBL
  SSF55271 UniProtKB/TrEMBL
UniProt A0A287D3D9_ICTTR UniProtKB/TrEMBL
  I3N0E7 ENTREZGENE, UniProtKB/TrEMBL