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Gene: Msh3 (mutS homolog 3) Chinchilla lanigera

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Symbol:

Msh3

Name:

mutS homolog 3

RGD ID:

8729622

Description:

ENCODES a protein that exhibits centromeric DNA binding (ortholog); damaged DNA binding (ortholog); dinucleotide insertion or deletion binding (ortholog); INVOLVED IN DNA repair (ortholog); maintenance of DNA repeat elements (ortholog); mismatch repair (ortholog); PARTICIPATES IN mismatch repair pathway; ASSOCIATED WITH cavernous sinus meningioma (ortholog); colorectal carcinoma (ortholog); Digestive System Neoplasms (ortholog); FOUND IN MutSbeta complex (ortholog); nucleus (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

DNA mismatch repair protein Msh3

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	MSH3 (mutS homolog 3)	NCBI	Ortholog
Mus musculus (house mouse):	Msh3 (mutS homolog 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Msh3 (mutS homolog 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	MSH3 (mutS homolog 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	MSH3 (mutS homolog 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Msh3 (mutS homolog 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	MSH3 (mutS homolog 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	MSH3 (mutS homolog 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Msh3 (mutS homolog 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955418	29,150,085 - 29,274,437 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955418	29,149,595 - 29,274,067 (-)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

cavernous sinus meningioma (ISO)

colorectal carcinoma (ISO)

Digestive System Neoplasms (ISO)

endometrial cancer (ISO)

endometrial carcinoma (ISO)

Endometrial Neoplasms (ISO)

familial adenomatous polyposis (ISO)

familial adenomatous polyposis 4 (ISO)

gastrointestinal stromal tumor (ISO)

hepatocellular carcinoma (ISO)

Hereditary Neoplastic Syndromes (ISO)

lung adenocarcinoma (ISO)

lung cancer (ISO)

lung non-small cell carcinoma (ISO)

Megaloblastic Anemia due to Dihydrofolate Reductase Deficiency (ISO)

Microsatellite Instability (ISO)

Neurodevelopmental Disorders (ISO)

Prostatic Neoplasms (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

DNA repair (ISO)

maintenance of DNA repeat elements (ISO)

mismatch repair (ISO)

negative regulation of DNA recombination (ISO)

positive regulation of helicase activity (ISO)

somatic hypermutation of immunoglobulin genes (ISO)

somatic recombination of immunoglobulin gene segments (ISO)

spermatogenesis (ISO)

Cellular Component

MutSbeta complex (ISO)

nucleus (ISO)

Molecular Function

centromeric DNA binding (ISO)

damaged DNA binding (ISO)

dinucleotide insertion or deletion binding (ISO)

dinucleotide repeat insertion binding (ISO)

DNA binding (ISO)

enzyme binding (ISO)

guanine/thymine mispair binding (ISO)

mismatched DNA binding (ISO)

oxidized purine DNA binding (ISO)

protein binding (ISO)

protein homodimerization activity (ISO)

single guanine insertion binding (ISO)

single-stranded DNA binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

mismatch repair pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species
2.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Msh3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955418	29,150,085 - 29,274,437 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955418	29,149,595 - 29,274,067 (-)	NCBI	ChiLan1.0	ChiLan1.0

MSH3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	5	80,654,652 - 80,876,815 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	5	80,654,652 - 80,876,815 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	5	79,950,471 - 80,172,634 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	5	79,986,050 - 80,208,390 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	5	79,986,294 - 80,208,389	NCBI
Celera	5	75,854,379 - 76,076,910 (+)	NCBI		Celera
Cytogenetic Map	5	q14.1	NCBI
HuRef	5	75,159,370 - 75,381,401 (+)	NCBI		HuRef
CHM1_1	5	79,383,713 - 79,605,325 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	5	81,139,552 - 81,361,456 (+)	NCBI		T2T-CHM13v2.0

Msh3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	13	92,348,387 - 92,491,515 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	13	92,348,380 - 92,491,511 (-)	Ensembl		GRCm39 Ensembl
GRCm38	13	92,211,878 - 92,355,004 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	13	92,211,872 - 92,355,003 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	13	92,981,836 - 93,124,958 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	13	93,312,634 - 93,455,756 (-)	NCBI		MGSCv36	mm8
Celera	13	95,828,509 - 95,961,232 (-)	NCBI		Celera
Cytogenetic Map	13	C3	NCBI
cM Map	13	47.63	NCBI

Msh3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	25,179,400 - 25,320,857 (-)	NCBI		GRCr8
mRatBN7.2	2	23,444,326 - 23,585,777 (-)	NCBI	mRatBN7.2	mRatBN7.2
UTH_Rnor_SHR_Utx	2	30,479,042 - 30,620,224 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	28,579,397 - 28,720,585 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	23,406,403 - 23,548,408 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	21,790,048 - 21,931,791 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	21,790,044 - 21,931,720 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	40,996,035 - 41,137,686 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	22,462,934 - 22,606,874 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	2	19,534,848 - 19,675,746 (-)	NCBI		Celera
Cytogenetic Map	2	q12	NCBI

MSH3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	4	34,432,400 - 34,653,426 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	5	32,582,453 - 32,806,981 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	5	34,408,469 - 34,663,483 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	5	34,719,261 - 34,938,521 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	5	34,719,322 - 34,938,469 (-)	Ensembl	panpan1.1		panPan2

MSH3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	3	26,335,788 - 26,520,633 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	3	26,336,403 - 26,518,521 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	3	27,571,200 - 27,762,336 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	3	26,250,075 - 26,441,642 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	3	26,250,084 - 26,441,647 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	3	26,190,404 - 26,381,864 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	3	26,171,404 - 26,356,535 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	3	26,451,047 - 26,636,178 (-)	NCBI		UU_Cfam_GSD_1.0

Msh3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	182,351,062 - 182,542,651 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936469	83,285 - 273,561 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936469	82,967 - 275,772 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

MSH3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	89,250,003 - 89,453,936 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	89,255,647 - 89,456,102 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	91,102,138 - 91,281,732 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

MSH3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	4	74,811,181 - 75,032,067 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	4	74,811,198 - 75,032,005 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666049	23,674,149 - 23,899,258 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Msh3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624743	1,461,077 - 1,581,180 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624743	1,461,952 - 1,581,524 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_013513015	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01019455	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBCE01075042	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCLAT00000008804 ⟹ ENSCLAP00000008676

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955418	29,150,085 - 29,274,437 (-)	Ensembl

RefSeq Acc Id:

XM_013513015 ⟹ XP_013368469

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955418	29,149,595 - 29,274,067 (-)	NCBI

Sequence:

show sequence

GGCCCCATTGGATCAGGCGCGGGCTTGGCCCGCCCCCCGCTCGCGAAGTGTCGGCGTGCTCGCG
CCCGCACGCGCCTGGGGACTCGCTCTCCCACGGGCTACCCGCTTCTCCGCCCCACGATGTCGCG
CCGCAAGCCTGCGTCGGGCGGTGTGGCTGCTGTGGGCCCGGCACCCGGGAGGCAAGCCGTTTTA
AGCCGGTTCTTCCAGCCTGCGAGAAGCCTGAAATCTACCTCGTCCCCCACCGGCGCCGCCGAGC
AGGCAGACCCTGCTTCCACAGCGCCCCCCGCGTCCGCCGCGCCCCCTACGTCAGCGGCGCCGAA
GGCTGCAAAAGCTGACAGAAGGAAGAAGAGACCGGCAGAGCCTGCTGCGCCTCCTAAGAAGAAG
TCGAGGAAGGCCCAGGAACAGGAGAGCGGAGGGGGCCCAGCTCTGTCTGGCGGCCCTGAGCCAA
AGCGATGTCTGAGGACCGGAATTGCTTTACAGTCTCTGGAAAAACTGAAAGAATTCTGCTGTGA
TTCTGCCCTCCCTCAAAATAGAGCCCAGACAGAGCCTCGTCAAGGGAGATTCGAAGTTCTGCCG
AAATGCACTGATTTTGAGGACATCACTCTTCAGCGTGCTAAGAATGCTGTTTGTTCTGAAGATT
CCAGATCTCAAAGTAGTCAAAAGGACAGCGCGTTTGGGAGTCCCGAGAGTTCCCGGAAGCCTCC
TGACCCGAAAGCAGCCGGCAAGCGCTCGGAGCGCGTCTACACGCCGCTGGAGCTGCAGTACCTG
GAGGTGAAGCGGCAGCACCCAGACGCGGTTCTGTGCGTGGAGTGTGGGTACAAGTACAGATTCT
TCGGGGAAGACGCAGAGATCGCTGCCCGGGAGCTCAATATCTACTGCCACCTGGACCACAGCTT
CATGACGGCCAGCGTCCCCACGCACAGGCTCTTCGTGCACGTGCGCCGCCTGGTGGCCAAGGGC
TACAAGGTGGGGGTTGTGAAGCAGACGGAGACGGCAGCCCTGAAGGCGGCTGGCGAGAACAGAG
GCTCCGTGTTTGCGCGGAAGTTGACTGCTCTGTACACCAAGTCCACGCTCATTGGGGAAGATGT
GAACCCTCTAGTCAAGCTGGACGATGCCGTCAGTGTGGATGAGATAACGACCGACACCTCCACT
GGGTATCTCCTGTGCATCTGCGAAGACAAGGAAGGCGTTAAGGACAGGGAGAGGGGCAGCGTTT
CCATGGGCCTGGTGGCTGTGCAGCCCGCCACCGGGGAGGTGCTGCTGGACGGCTTCTGCGACGC
GGCGCCCCGCCTGGAGCTGGAGACGCGGGTGCGCAGCCTGCAGCCCGCCGAGCTGCTGCTCCCC
CAGTGCCTGTCGGAGCCCACCGAGGCGCTGGTGCGCAGAGCCGCCACCGCAGGTGTGCGGGATG
ACAGGATTCGCGTGGAGAGGATGGATAACGTTTATTTTGAGCATAGCCATGCTTTCCAGGTGGT
CACAGAGTTCTACGCAAAGGACCCAGTGGATGTCCGAGGGTCTCAAAGTTTTTCAGACATCATT
AATTTGGAGAAACCTGTGATTTGCTGTTTGGCTGCCATAATAAGATACCTCAAGGAGTTCAACT
TGGAAAAAATACTTTCTAAACCTGAGAATTTTAAACAGCTGTCGAGTGAGATGGTGTTTATGAC
GATGAACGGAACAACCCTGAGGAATCTGGAGATCCTGCAGAATCAGACTGACGGGAAGAAAAGA
GGAAGTTTGCTGTGGGTGTTAGACCACACAAAAACTGCGTTCGGGAGACGGGAGCTCAAGAAGT
GGGTGACCCAGCCACTGCTTAAATTAAGTGAGATCAACGCCCGACTCGACGCTGTCTCCGAAGT
GCTACACTCAGAGTCCAGTGTGTTTGGTCAGCTCGAAAGCCAGCTGCAGAAGCTGCCCGACATC
GAGAGAGGACTCGGCAGCATTTACCACAAAAAATGTTCCACCCAGGAGTTCTTCTTGATCGTCA
AAACCCTCTATCACCTGAAGTCCGAGTTACAAGCATTGATGCCCGTGGTGAATTCGCATGTACA
GTCCGACTTGCTCCAGAAGTGTATTTTAGAAATCCCTGAGCTGCTTGGTCCTGTGGAACACTAT
TTAAAGATACTTAACGAACCAGCTGCCAAGATTGGGGATAAAACTGAATTATTCAAAGATCTTT
CTGACTTCCCTTTAATAAAAAAGAGGAAGGATGAAATTCAAGAAGTCATTGTCAAGATCCAAAC
ACATTTGCAAGAAATACGAAAAATACTAAAAAACCCTTCAGCACAATATGTGACCGTTTCAGGA
CAGGAGTTCATGATTGAAGTGAAGAACACCGCAGTGTCTTGCATCCCTGCTGACTGGGTTAAGG
TTGGAAGCACGAAGGCTGTGAGCCGCTTCCACTCCCCGCTGGTCGTGGAGAACTACAGACGCCT
GCAGCAGCTCCGTGAGCAGCTCGTCCTTGACTGCAGTGCCGAGTGGCTCGGCTTTCTCACGAGC
TTCAGTGAACATTATCACTGTCTGTGCAAAGCGGTACGTCACCTAGCAACCGTTGATTGTATTT
TCTCCCTGGCCAAGGTCGCTAAGCAAGGAGATTACTGCAGGCCAACCGTAAAAGAAGAAAGGAA
AATCATAATAAAGAATGGAAGGCACCCCGTGATTGACGTGCTGCTGGGAGAACACGATCAGTAC
GTCCCCAACGGCACCAGTCTGTCAGGGGACTCGGAGAGAGTCATGATCATCACTGGCCCCAACA
TGGGTGGGAAGAGCTCCTACATCAAGCAGGTGGCCCTGATCACCCTCATGGCCCAGGTGGGCTC
CTACGTCCCTGCGGAGGAGGCGACCATCGGCATCGTGGACGGCATTTACACGAGGATGGGTGCT
GCGGACAATATCTACCAAGGACGGAGCACCTTTATGGAAGAACTGACGGACACTGCAGAAATCA
TCCGGAAGGCGACCCCGCGCTCCCTGGTGATCCTGGACGAGCTGGGCAGAGGGACGAGCACGCA
CGACGGGATCGCCATCGCCTACGCCACCCTGGAGTACTTCATCAGAGACGTGAAATCCTTGACC
CTGTTCGTCACCCACTACCCCCCAGTGTGCGAGCTGGAAAGGAGCTACCCGGGGCAGGTGGGGA
ATTACCACATGGGCTTCCTGGTGACCGAGGAGGAGGACGAGGCGGAGCCAGGCAAAGAGAGAGT
CCCTGATTTTGTCACGTTTCTCTATCAAATAACCAGAGGAATTGCAGCGAGGAGCTATGGCCTA
AATGTGGCTAAGCTGGCAGATGTTCCCGGAGAAATCCTGAAGAAAGCCGCTGTCAAGTCCAAAG
AGCTGGAAGGATTAGTAAACATGAAAAGGAAAAGGCTGAAGTCTTTTGTGAAGTTATGGACGAC
ATGTAGCGCAGACGACCTGCAGGAGTGGATGGCCGAGCTGGGAGCAGAAGAAACACAGACGCCT
TCTCCCGACTGACGTGCAAACTGCACTTCCGGAGAAGCACTGCGCCCGAGTGAGCGCTGCTCGG
GGCTGGTGGCTCCCTTGGGAAGCAGCTTTCTTCCTTTTGTGGAGGAAATGATGCTCGGTTCCTT
CCCCTCCGCCTTCTCCCGTATCCAGGCTGCCACGGTGACGGGGACTCCCCTGGCCAGTGGGTCT
CACAAGTGGAAACCGTTTTAGTAGAGCCCAAAGTGGTGGCTGCAGTACATGCACCCTTGACAGG
GACGTGGTTGAACTTCTGTTCCATGTGCGCTGAGAGAATGTCAAAAGCCACTAACTTATTCATC
ATGTGCATAAGAATTTTTATAAAAATAGAATCATGAAGCTTTTAGAAACCAGTGCCCGGGAGGA
ATGAGGTCCTATGAAATGTGAAGAGTCAAACATGGCTCTAGTGTGAAGCGGTTCGAATACTGTT
GGATGGAATGATTTTGGCACTCTTTGAAGTAATAAATATTTAACGCACACTCGC

hide sequence

Protein Sequences


Protein RefSeqs	XP_013368469	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000008676
	ENSCLAP00000008676.1

RefSeq Acc Id:

XP_013368469 ⟸ XM_013513015

- UniProtKB:

A0A8C2YM35 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MSRRKPASGGVAAVGPAPGRQAVLSRFFQPARSLKSTSSPTGAAEQADPASTAPPASAAPPTSA
APKAAKADRRKKRPAEPAAPPKKKSRKAQEQESGGGPALSGGPEPKRCLRTGIALQSLEKLKEF
CCDSALPQNRAQTEPRQGRFEVLPKCTDFEDITLQRAKNAVCSEDSRSQSSQKDSAFGSPESSR
KPPDPKAAGKRSERVYTPLELQYLEVKRQHPDAVLCVECGYKYRFFGEDAEIAARELNIYCHLD
HSFMTASVPTHRLFVHVRRLVAKGYKVGVVKQTETAALKAAGENRGSVFARKLTALYTKSTLIG
EDVNPLVKLDDAVSVDEITTDTSTGYLLCICEDKEGVKDRERGSVSMGLVAVQPATGEVLLDGF
CDAAPRLELETRVRSLQPAELLLPQCLSEPTEALVRRAATAGVRDDRIRVERMDNVYFEHSHAF
QVVTEFYAKDPVDVRGSQSFSDIINLEKPVICCLAAIIRYLKEFNLEKILSKPENFKQLSSEMV
FMTMNGTTLRNLEILQNQTDGKKRGSLLWVLDHTKTAFGRRELKKWVTQPLLKLSEINARLDAV
SEVLHSESSVFGQLESQLQKLPDIERGLGSIYHKKCSTQEFFLIVKTLYHLKSELQALMPVVNS
HVQSDLLQKCILEIPELLGPVEHYLKILNEPAAKIGDKTELFKDLSDFPLIKKRKDEIQEVIVK
IQTHLQEIRKILKNPSAQYVTVSGQEFMIEVKNTAVSCIPADWVKVGSTKAVSRFHSPLVVENY
RRLQQLREQLVLDCSAEWLGFLTSFSEHYHCLCKAVRHLATVDCIFSLAKVAKQGDYCRPTVKE
ERKIIIKNGRHPVIDVLLGEHDQYVPNGTSLSGDSERVMIITGPNMGGKSSYIKQVALITLMAQ
VGSYVPAEEATIGIVDGIYTRMGAADNIYQGRSTFMEELTDTAEIIRKATPRSLVILDELGRGT
STHDGIAIAYATLEYFIRDVKSLTLFVTHYPPVCELERSYPGQVGNYHMGFLVTEEEDEAEPGK
ERVPDFVTFLYQITRGIAARSYGLNVAKLADVPGEILKKAAVKSKELEGLVNMKRKRLKSFVKL
WTTCSADDLQEWMAELGAEETQTPSPD

hide sequence

Ensembl Acc Id:

ENSCLAP00000008676 ⟸ ENSCLAT00000008804

Protein Domains

DNA mismatch repair proteins mutS family

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000006074	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000008804	ENTREZGENE
	ENSCLAT00000008804.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.1420.10	UniProtKB/TrEMBL
	3.30.420.110	UniProtKB/TrEMBL
	3.40.1170.10	UniProtKB/TrEMBL
	3.40.50.300	UniProtKB/TrEMBL
InterPro	DNA_mismatch_repair_MutS-lik_N	UniProtKB/TrEMBL
	DNA_mismatch_repair_MutS_C	UniProtKB/TrEMBL
	DNA_mismatch_repair_MutS_core	UniProtKB/TrEMBL
	DNA_mismatch_repair_MutS_N	UniProtKB/TrEMBL
	DNA_mismatch_repair_MutS_sf	UniProtKB/TrEMBL
	DNA_mmatch_repair_MutS_con_dom	UniProtKB/TrEMBL
	MutS_con_dom_sf	UniProtKB/TrEMBL
	MutS_family	UniProtKB/TrEMBL
	P-loop_NTPase	UniProtKB/TrEMBL
NCBI Gene	Msh3	ENTREZGENE
PANTHER	DNA MISMATCH REPAIR PROTEIN MSH3	UniProtKB/TrEMBL
	PTHR11361	UniProtKB/TrEMBL
Pfam	MutS_I	UniProtKB/TrEMBL
	MutS_II	UniProtKB/TrEMBL
	MutS_III	UniProtKB/TrEMBL
	MutS_V	UniProtKB/TrEMBL
PROSITE	DNA_MISMATCH_REPAIR_2	UniProtKB/TrEMBL
SMART	MUTSac	UniProtKB/TrEMBL
	MUTSd	UniProtKB/TrEMBL
Superfamily-SCOP	SSF48334	UniProtKB/TrEMBL
	SSF52540	UniProtKB/TrEMBL
	SSF53150	UniProtKB/TrEMBL
	SSF55271	UniProtKB/TrEMBL
UniProt	A0A8C2YM35	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2015-08-25	Msh3	mutS homolog 3		mutS homolog 3 (E. coli)	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations