Ndufs4 (NADH:ubiquinone oxidoreductase subunit S4) - Rat Genome Database

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Gene: Ndufs4 (NADH:ubiquinone oxidoreductase subunit S4) Ictidomys tridecemlineatus
Analyze
Symbol: Ndufs4
Name: NADH:ubiquinone oxidoreductase subunit S4
RGD ID: 12624650
Description: ENCODES a protein that exhibits NADH dehydrogenase (ubiquinone) activity (ortholog); INVOLVED IN adult behavior (ortholog); adult walking behavior (ortholog); brain development (ortholog); ASSOCIATED WITH brain disease (ortholog); COVID-19 (ortholog); developmental coordination disorder (ortholog); FOUND IN mitochondrial inner membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213204,892,598 - 204,995,733 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648013,827,743 - 13,932,238 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648013,829,093 - 13,932,202 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ndufs4SquirrelCOVID-19  ISONDUFS4 (Homo sapiens)9068941mRNA:increased expression:peripheral blood mononuclear cell (human)RGDPMID:32228226 and REF_RGD_ID:28912744
Ndufs4SquirrelMetabolic Brain Diseases, Inborn  ISONdufs4 (Mus musculus)9068941 RGDPMID:18396137 and REF_RGD_ID:6484689
Ndufs4SquirrelParkinson's disease  ISONdufs4 (Mus musculus)9068941 RGDPMID:21383081 and REF_RGD_ID:6484691
1 to 9 of 9 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ndufs4Squirrelgenetic disease  ISONDUFS4 (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:11165261 more ...
Ndufs4Squirrellactic acidosis  ISONDUFS4 (Homo sapiens)8554872ClinVar Annotator: match by term: Lactic acidosisClinVarPMID:25741868 and PMID:33093004
Ndufs4SquirrelLeigh disease  ISONDUFS4 (Homo sapiens)8554872ClinVar Annotator: match by term: Leigh syndromeClinVarPMID:10944442 more ...
Ndufs4SquirrelLeigh disease  ISONDUFS4 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10944442 more ...
Ndufs4SquirrelLeigh disease  ISONDUFS4 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10944442 more ...
Ndufs4Squirrelmitochondrial complex I deficiency  ISONDUFS4 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10944442 more ...
Ndufs4SquirrelNeurodevelopmental Disorders  ISONDUFS4 (Homo sapiens)8554872ClinVar Annotator: match by term: Neurodevelopmental disorderClinVarPMID:25741868
Ndufs4Squirrelnuclear type mitochondrial complex I deficiency 1  ISONDUFS4 (Homo sapiens)8554872ClinVar Annotator: match by term: Mitochondrial complex I deficiency and nuclear type 1ClinVarPMID:10944442 more ...
Ndufs4SquirrelSubacute Necrotizing Encephalopathy of Leigh, Infantile  ISONDUFS4 (Homo sapiens)8554872ClinVar Annotator: match by term: Leigh's necrotizing encephalopathyClinVarPMID:25741868 and PMID:28492532
1 to 9 of 9 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ndufs4Squirrelbrain disease  ISONDUFS4 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:24935635
Ndufs4Squirreldevelopmental coordination disorder  ISONDUFS4 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:24935635
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ndufs4Squirrelnuclear type mitochondrial complex I deficiency 1  ISONDUFS4 (Homo sapiens)7240710 OMIM 


Biological Process
1 to 20 of 26 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ndufs4Squirreladult behavior acts_upstream_of_or_withinISOMGI:35271739068941 PMID:28327638MGIPMID:28327638
Ndufs4Squirreladult walking behavior acts_upstream_of_or_withinISOMGI:37937139068941 PMID:26363424MGIPMID:26363424
Ndufs4Squirrelbrain development involved_inIEAUniProtKB:O43181 and ensembl:ENSP00000296684150520179 EnsemblGO_REF:0000107
Ndufs4Squirrelbrain development acts_upstream_of_or_withinISOMGI:37937139068941 PMID:28916769MGIPMID:28916769
Ndufs4Squirrelcellular response to oxygen levels acts_upstream_of_or_withinISOMGI:35271739068941 PMID:26437605MGIPMID:26437605
Ndufs4Squirrelcognition acts_upstream_of_or_withinISOMGI:35271739068941 PMID:28327638MGIPMID:28327638
Ndufs4Squirreldopamine metabolic process acts_upstream_of_or_withinISOMGI:35271739068941 PMID:28327638MGIPMID:28327638
Ndufs4Squirrelelectron transport chain involved_inIEAInterPro:IPR006885150520179 InterProGO_REF:0000002
Ndufs4Squirrelinflammatory response acts_upstream_of_or_withinISOMGI:37937139068941 PMID:25652399MGIPMID:25652399
Ndufs4Squirrelinnate immune response acts_upstream_of_or_withinISOMGI:37937139068941 PMID:25652399MGIPMID:25652399
Ndufs4Squirrelmitochondrial respiratory chain complex I assembly involved_inIEAUniProtKB:O43181 and ensembl:ENSP00000296684150520179 EnsemblGO_REF:0000107
Ndufs4Squirrelmitochondrial respiratory chain complex I assembly acts_upstream_of_or_withinISOMGI:37937139068941 PMID:18396137MGIPMID:18396137
Ndufs4Squirrelneuron apoptotic process acts_upstream_of_or_withinISOMGI:37937139068941 PMID:25652399MGIPMID:25652399
Ndufs4Squirrelneuron development acts_upstream_of_or_withinISOMGI:37937139068941 PMID:26363424MGIPMID:26363424
Ndufs4Squirrelproton transmembrane transport involved_inIEAGO:0008137150520179 GOCGO_REF:0000108
Ndufs4Squirrelpsychomotor behavior acts_upstream_of_or_withinISOMGI:35271739068941 PMID:28327638MGIPMID:28327638
Ndufs4Squirrelreactive oxygen species metabolic process involved_inIEAUniProtKB:O43181 and ensembl:ENSP00000296684150520179 EnsemblGO_REF:0000107
Ndufs4Squirrelreactive oxygen species metabolic process acts_upstream_of_or_withinISOMGI:37937139068941 PMID:29501746MGIPMID:29501746
Ndufs4Squirrelregulation of mitochondrial membrane potential acts_upstream_of_or_withinISOMGI:35271739068941 PMID:26712463MGIPMID:26712463
Ndufs4Squirrelregulation of protein phosphorylation acts_upstream_of_or_withinISONDUFS4 (Homo sapiens)9068941 PMID:11165261MGIPMID:11165261
1 to 20 of 26 rows

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ndufs4Squirrelmembrane located_inIEAUniProtKB-KW:KW-0472150520179 UniProtGO_REF:0000043
Ndufs4Squirrelmitochondrial inner membrane is_active_inISONdufs4 (Mus musculus)9068941 PMID:38575788UniProtPMID:38575788
Ndufs4Squirrelmitochondrial inner membrane located_inIEAUniProtKB-KW:KW-0999150520179 UniProtGO_REF:0000043
Ndufs4Squirrelmitochondrial inner membrane located_inIEAUniProtKB-SubCell:SL-0168150520179 UniProtGO_REF:0000044
Ndufs4Squirrelmitochondrial inner membrane located_inIEAUniProtKB:O43181 and ensembl:ENSP00000296684150520179 EnsemblGO_REF:0000107
Ndufs4Squirrelmitochondrion located_inIEAUniProtKB-KW:KW-0496150520179 UniProtGO_REF:0000043
Ndufs4Squirrelmitochondrion located_inIEAUniProtKB:A0A0S2Z433 more ...150520179 EnsemblGO_REF:0000107
Ndufs4Squirrelrespiratory chain complex I part_ofIEAUniProtKB:O43181 and ensembl:ENSP00000296684150520179 EnsemblGO_REF:0000107

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ndufs4SquirrelNADH dehydrogenase (ubiquinone) activity contributes_toISONDUFS4 (Homo sapiens)9068941 PMID:15038602 and PMID:16870178UniProtKBPMID:15038602 and PMID:16870178
Ndufs4SquirrelNADH dehydrogenase (ubiquinone) activity enablesIEAUniProtKB:O43181 and ensembl:ENSP00000296684150520179 EnsemblGO_REF:0000107
Ndufs4Squirrelprotein binding enablesISOUniProtKB:P515729068941 PMID:31206022UniProtPMID:31206022

PMID:22301074   PMID:30032202  



Ndufs4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213204,892,598 - 204,995,733 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648013,827,743 - 13,932,238 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648013,829,093 - 13,932,202 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NDUFS4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38553,560,639 - 53,683,338 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl553,560,633 - 53,683,338 (+)EnsemblGRCh38hg38GRCh38
GRCh37552,856,469 - 52,979,168 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36552,892,242 - 53,014,925 (+)NCBINCBI36Build 36hg18NCBI36
Build 34552,892,241 - 53,014,924NCBI
Celera549,810,070 - 49,932,765 (+)NCBICelera
Cytogenetic Map5q11.2NCBI
HuRef549,829,192 - 49,951,782 (+)NCBIHuRef
CHM1_1552,859,382 - 52,982,064 (+)NCBICHM1_1
T2T-CHM13v2.0554,388,486 - 54,511,162 (+)NCBIT2T-CHM13v2.0
Ndufs4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3913114,424,331 - 114,524,630 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl13114,424,331 - 114,524,794 (-)EnsemblGRCm39 Ensembl
GRCm3813114,287,795 - 114,388,094 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl13114,287,795 - 114,388,258 (-)EnsemblGRCm38mm10GRCm38
MGSCv3713115,078,003 - 115,178,302 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3613115,409,528 - 115,508,921 (-)NCBIMGSCv36mm8
Celera13118,620,039 - 118,721,271 (-)NCBICelera
Cytogenetic Map13D2.2NCBI
cM Map1364.12NCBI
Ndufs4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8247,684,420 - 47,794,914 (-)NCBIGRCr8
mRatBN7.2245,951,327 - 46,061,829 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl245,951,313 - 46,061,846 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx253,055,093 - 53,165,153 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0251,113,456 - 51,223,515 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0245,988,050 - 46,102,968 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0246,372,488 - 46,476,162 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl246,372,518 - 46,476,203 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0265,403,197 - 65,515,243 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4245,839,236 - 46,479,619 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera241,712,356 - 41,822,320 (-)NCBICelera
Cytogenetic Map2q14NCBI
Ndufs4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544613,764,907 - 13,864,824 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544613,764,907 - 13,864,824 (-)NCBIChiLan1.0ChiLan1.0
NDUFS4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2460,256,021 - 60,378,662 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1558,409,645 - 58,532,287 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0560,344,363 - 60,467,008 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1561,966,124 - 62,088,388 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl561,966,124 - 62,088,375 (-)Ensemblpanpan1.1panPan2
NDUFS4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1461,613,580 - 61,727,219 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl461,613,589 - 61,727,205 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha461,379,036 - 61,492,669 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0462,107,235 - 62,231,743 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1461,884,352 - 61,997,681 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0462,012,344 - 62,126,203 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0462,529,496 - 62,643,162 (-)NCBIUU_Cfam_GSD_1.0
NDUFS4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1632,874,450 - 32,987,828 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11632,874,418 - 32,985,638 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21634,963,225 - 34,992,577 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NDUFS4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1449,851,012 - 49,967,533 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl449,851,014 - 49,967,590 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660821,152,990 - 1,272,340 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ndufs4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247595,630,522 - 5,733,928 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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RefSeq Transcripts XM_005319642 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_040272191 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAESOR010002273 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSSTOT00000005329   ⟹   ENSSTOP00000004777
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_00493648013,827,743 - 13,932,238 (-)Ensembl
RefSeq Acc Id: XM_005319642   ⟹   XP_005319699
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024407213204,892,598 - 204,995,733 (-)NCBI
SpeTri2.0NW_00493648013,829,093 - 13,932,202 (-)NCBI
Sequence:
RefSeq Acc Id: XM_040272191   ⟹   XP_040128125
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024407213204,892,598 - 204,995,412 (-)NCBI
Protein RefSeqs XP_005319699 (Get FASTA)   NCBI Sequence Viewer  
  XP_040128125 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000004777.3
GenBank Protein KAG3266697 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_005319699   ⟸   XM_005319642
- Peptide Label: isoform X2
- UniProtKB: I3M5W5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_040128125   ⟸   XM_040272191
- Peptide Label: isoform X1
Ensembl Acc Id: ENSSTOP00000004777   ⟸   ENSSTOT00000005329



1 to 10 of 10 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSSTOG00000005327 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000005329.3 UniProtKB/TrEMBL
Gene3D-CATH 3.30.160.190 UniProtKB/TrEMBL
InterPro NADH_UbQ_FeS_4_mit UniProtKB/TrEMBL
  NDUFS4-like_sf UniProtKB/TrEMBL
NCBI Gene Ndufs4 ENTREZGENE
PANTHER NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 4, MITOCHONDRIAL UniProtKB/TrEMBL
  PTHR12219 UniProtKB/TrEMBL
Pfam ETC_C1_NDUFA4 UniProtKB/TrEMBL
UniProt I3M5W5 ENTREZGENE, UniProtKB/TrEMBL
1 to 10 of 10 rows