Prex1 (phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Prex1 (phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1) Ictidomys tridecemlineatus
Analyze
Symbol: Prex1
Name: phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1
RGD ID: 12583155
Description: ENCODES a protein that exhibits GTPase activator activity (inferred); guanyl-nucleotide exchange factor activity (inferred); phospholipid binding (inferred); INVOLVED IN G protein-coupled receptor signaling pathway (ortholog); neutrophil chemotaxis (ortholog); positive regulation of cell adhesion (ortholog); PARTICIPATES IN insulin responsive facilitative sugar transporter mediated glucose transport pathway; Rho/Rac/Cdc42 mediated signaling pathway; ASSOCIATED WITH autism spectrum disorder (ortholog); Lymphatic Metastasis (ortholog); prostate cancer (ortholog); FOUND IN dendritic shaft (ortholog); growth cone (ortholog); perinuclear region of cytoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640189,903,846 - 189,990,356 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365145,368,629 - 5,444,003 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365145,291,473 - 5,443,999 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
Prex1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640189,903,846 - 189,990,356 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365145,368,629 - 5,444,003 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365145,291,473 - 5,443,999 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PREX1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382048,624,252 - 48,888,185 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2048,624,252 - 48,827,999 (-)EnsemblGRCh38hg38GRCh38
GRCh372047,240,790 - 47,444,536 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362046,674,200 - 46,877,827 (-)NCBINCBI36Build 36hg18NCBI36
Celera2043,945,979 - 44,149,646 (-)NCBICelera
Cytogenetic Map20q13.13NCBI
HuRef2043,990,060 - 44,195,320 (-)NCBIHuRef
CHM1_12047,145,458 - 47,349,091 (-)NCBICHM1_1
T2T-CHM13v2.02050,394,065 - 50,597,825 (-)NCBIT2T-CHM13v2.0
Prex1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392166,408,265 - 166,555,752 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2166,408,262 - 166,555,752 (-)EnsemblGRCm39 Ensembl
GRCm382166,566,345 - 166,713,832 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2166,566,342 - 166,713,832 (-)EnsemblGRCm38mm10GRCm38
MGSCv372166,391,845 - 166,539,332 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362166,256,959 - 166,405,037 (-)NCBIMGSCv36mm8
Celera2172,502,260 - 172,653,067 (-)NCBICelera
Cytogenetic Map2H3NCBI
cM Map287.09NCBI
Prex1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83175,724,939 - 175,875,764 (-)NCBIGRCr8
mRatBN7.23155,306,950 - 155,456,688 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3155,306,950 - 155,456,688 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3159,108,046 - 159,257,416 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03167,607,015 - 167,756,375 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03165,348,709 - 165,498,079 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03163,329,580 - 163,477,822 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3163,329,975 - 163,477,715 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03169,494,331 - 169,575,981 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43157,693,897 - 157,863,943 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13157,599,463 - 157,770,600 (-)NCBI
Celera3153,891,483 - 154,040,542 (-)NCBICelera
Cytogenetic Map3q42NCBI
Prex1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554459,229,793 - 9,398,662 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554459,229,775 - 9,401,277 (+)NCBIChiLan1.0ChiLan1.0
PREX1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22154,369,425 - 54,573,462 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12054,362,530 - 54,566,568 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02044,965,850 - 45,169,891 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12046,034,724 - 46,157,984 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2046,033,937 - 46,226,500 (-)Ensemblpanpan1.1panPan2
PREX1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12435,403,078 - 35,503,428 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2435,404,564 - 35,582,041 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2434,646,334 - 34,825,207 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02436,111,037 - 36,287,341 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2436,112,187 - 36,287,722 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12435,349,797 - 35,528,690 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02435,484,549 - 35,662,320 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02436,026,106 - 36,205,507 (-)NCBIUU_Cfam_GSD_1.0
PREX1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1750,354,775 - 50,550,637 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11750,352,273 - 50,550,402 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
PREX1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1215,152,001 - 15,354,556 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl215,152,096 - 15,354,544 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605063,656,144 - 63,859,525 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Prex1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247906,453,066 - 6,637,597 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247906,453,085 - 6,622,179 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSSTOT00000020137   ⟹   ENSSTOP00000022721
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049365145,368,629 - 5,443,226 (+)Ensembl
Ensembl Acc Id: ENSSTOT00000035413   ⟹   ENSSTOP00000027987
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049365145,406,618 - 5,444,003 (+)Ensembl
RefSeq Acc Id: XM_040275443   ⟹   XP_040131377
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024408640189,903,846 - 189,990,356 (+)NCBI
Protein Sequences
Protein RefSeqs XP_040131377 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000022721.2
  ENSSTOP00000027987.1
GenBank Protein KAG3263472 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_040131377   ⟸   XM_040275443
- UniProtKB: I3NEC4 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSSTOP00000022721   ⟸   ENSSTOT00000020137
Ensembl Acc Id: ENSSTOP00000027987   ⟸   ENSSTOT00000035413
Protein Domains
DEP   DH   PDZ   PH


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000024458 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000020137.2 UniProtKB/TrEMBL
  ENSSTOT00000035413.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.10 UniProtKB/TrEMBL
  1.20.900.10 UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/TrEMBL
  2.30.42.10 UniProtKB/TrEMBL
InterPro DBL_dom_sf UniProtKB/TrEMBL
  DEP_dom UniProtKB/TrEMBL
  DH-domain UniProtKB/TrEMBL
  GDS_CDC24_CS UniProtKB/TrEMBL
  mTOR-Rac_regulators UniProtKB/TrEMBL
  PDZ UniProtKB/TrEMBL
  PDZ_sf UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/TrEMBL
  PH_domain UniProtKB/TrEMBL
  WH-like_DNA-bd_sf UniProtKB/TrEMBL
  WH_DNA-bd_sf UniProtKB/TrEMBL
NCBI Gene Prex1 ENTREZGENE
PANTHER DEP DOMAIN PROTEIN UniProtKB/TrEMBL
  PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE-DEPENDENT RAC EXCHANGER 1 PROTEIN UniProtKB/TrEMBL
Pfam DEP UniProtKB/TrEMBL
  RhoGEF UniProtKB/TrEMBL
  SOS1_NGEF_PH UniProtKB/TrEMBL
PROSITE DEP UniProtKB/TrEMBL
  DH_1 UniProtKB/TrEMBL
  DH_2 UniProtKB/TrEMBL
  PDZ UniProtKB/TrEMBL
  PH_DOMAIN UniProtKB/TrEMBL
SMART DEP UniProtKB/TrEMBL
  PDZ UniProtKB/TrEMBL
  RhoGEF UniProtKB/TrEMBL
  SM00233 UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/TrEMBL
  SSF46785 UniProtKB/TrEMBL
  SSF48065 UniProtKB/TrEMBL
  SSF50156 UniProtKB/TrEMBL
UniProt A0A287D386_ICTTR UniProtKB/TrEMBL
  I3NEC4 ENTREZGENE, UniProtKB/TrEMBL