PREX1 (phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1) - Rat Genome Database

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Gene: PREX1 (phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1) Sus scrofa
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Symbol: PREX1
Name: phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1
RGD ID: 14018891
Description: ENCODES a protein that exhibits GTPase activator activity (inferred); guanyl-nucleotide exchange factor activity (inferred); phospholipid binding (inferred); INVOLVED IN G protein-coupled receptor signaling pathway (ortholog); neutrophil chemotaxis (ortholog); positive regulation of cell adhesion (ortholog); PARTICIPATES IN insulin responsive facilitative sugar transporter mediated glucose transport pathway; Rho/Rac/Cdc42 mediated signaling pathway; ASSOCIATED WITH autism spectrum disorder (ortholog); genetic disease (ortholog); Lymphatic Metastasis (ortholog); FOUND IN dendritic shaft (ortholog); growth cone (ortholog); perinuclear region of cytoplasm (ortholog); INTERACTS WITH deoxynivalenol
Type: protein-coding
RefSeq Status: MODEL
Previously known as: phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1750,354,775 - 50,550,637 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11750,352,273 - 50,550,402 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:14681463   PMID:17145712   PMID:22301074  


Genomics

Comparative Map Data
PREX1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1750,354,775 - 50,550,637 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11750,352,273 - 50,550,402 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
PREX1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382048,624,252 - 48,888,185 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2048,624,252 - 48,827,999 (-)EnsemblGRCh38hg38GRCh38
GRCh372047,240,790 - 47,444,536 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362046,674,200 - 46,877,827 (-)NCBINCBI36Build 36hg18NCBI36
Celera2043,945,979 - 44,149,646 (-)NCBICelera
Cytogenetic Map20q13.13NCBI
HuRef2043,990,060 - 44,195,320 (-)NCBIHuRef
CHM1_12047,145,458 - 47,349,091 (-)NCBICHM1_1
T2T-CHM13v2.02050,394,065 - 50,597,825 (-)NCBIT2T-CHM13v2.0
Prex1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392166,408,265 - 166,555,752 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2166,408,262 - 166,555,752 (-)EnsemblGRCm39 Ensembl
GRCm382166,566,345 - 166,713,832 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2166,566,342 - 166,713,832 (-)EnsemblGRCm38mm10GRCm38
MGSCv372166,391,845 - 166,539,332 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362166,256,959 - 166,405,037 (-)NCBIMGSCv36mm8
Celera2172,502,260 - 172,653,067 (-)NCBICelera
Cytogenetic Map2H3NCBI
cM Map287.09NCBI
Prex1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83175,724,939 - 175,875,764 (-)NCBIGRCr8
mRatBN7.23155,306,950 - 155,456,688 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3155,306,950 - 155,456,688 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3159,108,046 - 159,257,416 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03167,607,015 - 167,756,375 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03165,348,709 - 165,498,079 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03163,329,580 - 163,477,822 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3163,329,975 - 163,477,715 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03169,494,331 - 169,575,981 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43157,693,897 - 157,863,943 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13157,599,463 - 157,770,600 (-)NCBI
Celera3153,891,483 - 154,040,542 (-)NCBICelera
Cytogenetic Map3q42NCBI
Prex1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554459,229,793 - 9,398,662 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554459,229,775 - 9,401,277 (+)NCBIChiLan1.0ChiLan1.0
PREX1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22154,369,425 - 54,573,462 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12054,362,530 - 54,566,568 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02044,965,850 - 45,169,891 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12046,034,724 - 46,157,984 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2046,033,937 - 46,226,500 (-)Ensemblpanpan1.1panPan2
PREX1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12435,403,078 - 35,503,428 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2435,404,564 - 35,582,041 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2434,646,334 - 34,825,207 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02436,111,037 - 36,287,341 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2436,112,187 - 36,287,722 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12435,349,797 - 35,528,690 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02435,484,549 - 35,662,320 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02436,026,106 - 36,205,507 (-)NCBIUU_Cfam_GSD_1.0
Prex1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640189,903,846 - 189,990,356 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365145,368,629 - 5,444,003 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365145,291,473 - 5,443,999 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PREX1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1215,152,001 - 15,354,556 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl215,152,096 - 15,354,544 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605063,656,144 - 63,859,525 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Prex1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247906,453,066 - 6,637,597 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247906,453,085 - 6,622,179 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in PREX1
7604 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 2 2 3 5 15 1 3
Low 8 2 2 8 2 2
Below cutoff

Sequence


RefSeq Acc Id: ENSSSCT00000053680   ⟹   ENSSSCP00000035207
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1750,354,775 - 50,550,406 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000065142   ⟹   ENSSSCP00000052177
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1750,355,115 - 50,550,637 (-)Ensembl
RefSeq Acc Id: XM_021078040   ⟹   XP_020933699
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11750,352,273 - 50,550,402 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_020933699 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSSCP00000035207
  ENSSSCP00000035207.3
  ENSSSCP00000052177.3
  ENSSSCP00050009081.1
  ENSSSCP00060008750.1
GenBank Protein JAG69259 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_020933699   ⟸   XM_021078040
- UniProtKB: A0A8D1T459 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000052177   ⟸   ENSSSCT00000065142
RefSeq Acc Id: ENSSSCP00000035207   ⟸   ENSSSCT00000053680
Protein Domains
DEP   DH   PDZ   PH


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000031118 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00050015922 UniProtKB/TrEMBL
  ENSSSCG00060015961 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000053680 ENTREZGENE
  ENSSSCT00000053680.3 UniProtKB/TrEMBL
  ENSSSCT00000065142.3 UniProtKB/TrEMBL
  ENSSSCT00050021657.1 UniProtKB/TrEMBL
  ENSSSCT00060021270.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.10 UniProtKB/TrEMBL
  1.20.900.10 UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/TrEMBL
  2.30.42.10 UniProtKB/TrEMBL
InterPro DBL_dom_sf UniProtKB/TrEMBL
  DEP_dom UniProtKB/TrEMBL
  DH-domain UniProtKB/TrEMBL
  GDS_CDC24_CS UniProtKB/TrEMBL
  PDZ UniProtKB/TrEMBL
  PDZ_6 UniProtKB/TrEMBL
  PDZ_sf UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/TrEMBL
  PH_domain UniProtKB/TrEMBL
  WH-like_DNA-bd_sf UniProtKB/TrEMBL
  WH_DNA-bd_sf UniProtKB/TrEMBL
NCBI Gene PREX1 ENTREZGENE
PANTHER DEP DOMAIN PROTEIN UniProtKB/TrEMBL
  PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE-DEPENDENT RAC EXCHANGER 1 PROTEIN UniProtKB/TrEMBL
Pfam DEP UniProtKB/TrEMBL
  PDZ_6 UniProtKB/TrEMBL
  PF00169 UniProtKB/TrEMBL
  RhoGEF UniProtKB/TrEMBL
PROSITE DEP UniProtKB/TrEMBL
  DH_1 UniProtKB/TrEMBL
  DH_2 UniProtKB/TrEMBL
  PDZ UniProtKB/TrEMBL
  PH_DOMAIN UniProtKB/TrEMBL
SMART DEP UniProtKB/TrEMBL
  PDZ UniProtKB/TrEMBL
  RhoGEF UniProtKB/TrEMBL
  SM00233 UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/TrEMBL
  SSF46785 UniProtKB/TrEMBL
  SSF48065 UniProtKB/TrEMBL
  SSF50156 UniProtKB/TrEMBL
UniProt A0A286ZUE0_PIG UniProtKB/TrEMBL
  A0A287B6M9_PIG UniProtKB/TrEMBL
  A0A8D1T459 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:96264 ENTREZGENE