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Gene: Tsr2 (TSR2 ribosome maturation factor) Ictidomys tridecemlineatus

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Symbol:

Tsr2

Name:

TSR2 ribosome maturation factor

RGD ID:

12566245

Description:

INVOLVED IN rRNA processing (inferred); ASSOCIATED WITH Aarskog syndrome (ortholog); Atkin Syndrome (ortholog); autistic disorder (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

pre-rRNA-processing protein TSR2 homolog; TSR2, ribosome maturation factor

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	X	39,010,776 - 39,015,724 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936751	1,350,481 - 1,358,110 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936751	1,350,542 - 1,355,449 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Tsr2	Squirrel	Aarskog syndrome		ISO	TSR2 (Homo sapiens)	8554872	ClinVar more ...	ClinVar	PMID:25741868 and PMID:28492532
Tsr2	Squirrel	Atkin Syndrome		ISO	TSR2 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Atkin Flaitz Patil Smith syndrome	ClinVar	PMID:26059843 and PMID:28492532
Tsr2	Squirrel	autistic disorder		ISO	TSR2 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Autism	ClinVar	PMID:21681106 and PMID:30208311
Tsr2	Squirrel	Cornelia de Lange syndrome 2		ISO	TSR2 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Congenital muscular hypertrophy-cerebral syndrome	ClinVar	PMID:26386245 more ...
Tsr2	Squirrel	Diamond-Blackfan anemia 14 with mandibulofacial dysostosis		ISO	TSR2 (Homo sapiens)	8554872	ClinVar more ...	ClinVar	PMID:11424144 more ...
Tsr2	Squirrel	Diamond-Blackfan anemia 15 with mandibulofacial dysostosis		ISO	TSR2 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Diamond-Blackfan anemia 15 with mandibulofacial dysostosis	ClinVar	PMID:11424144 and PMID:24942156
Tsr2	Squirrel	genetic disease		ISO	TSR2 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Inborn genetic diseases	ClinVar	PMID:24033266 more ...
Tsr2	Squirrel	non-syndromic X-linked intellectual disability 1		ISO	TSR2 (Homo sapiens)	8554872	ClinVar Annotator: match by term: INTELLECTUAL DEVELOPMENTAL DISORDER and X-LINKED 1	ClinVar	PMID:26059843 and PMID:28492532
Tsr2	Squirrel	syndromic X-linked intellectual disability Lubs type		ISO	TSR2 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Syndromic X-linked intellectual disability Lubs type	ClinVar	PMID:25741868
Tsr2	Squirrel	X-linked Aarskog syndrome		ISO	TSR2 (Homo sapiens)	8554872	ClinVar Annotator: match by term: FGD1-Related Disorders	ClinVar	PMID:25741868 and PMID:28492532

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Tsr2	Squirrel	Diamond-Blackfan anemia 14 with mandibulofacial dysostosis		ISO	TSR2 (Homo sapiens)	7240710		OMIM

Biological Process

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Tsr2	Squirrel	rRNA processing	involved_in	IEA	UniProtKB-KW:KW-0698	150520179		UniProt	GO_REF:0000043

Molecular Function

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Tsr2	Squirrel	protein binding	enables	ISO	UniProtKB:P62854	9068941	PMID:16189514 more ...	IntAct	PMID:16189514 more ...
Tsr2	Squirrel	protein binding	enables	ISO	UniProtKB:O75928 more ...	9068941	PMID:25416956	IntAct	PMID:25416956
Tsr2	Squirrel	protein binding	enables	ISO	UniProtKB:A0PJW8 more ...	9068941	PMID:32296183	IntAct	PMID:32296183
Tsr2	Squirrel	protein binding	enables	ISO	UniProtKB:O95166 and UniProtKB:P60520	9068941	PMID:20562859	IntAct	PMID:20562859

PMID:30032202

Tsr2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	X	39,010,776 - 39,015,724 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936751	1,350,481 - 1,358,110 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936751	1,350,542 - 1,355,449 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TSR2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	X	54,440,404 - 54,448,032 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	X	54,440,404 - 54,448,032 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	X	54,466,837 - 54,474,465 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	X	54,483,578 - 54,488,455 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	X	58,299,414 - 58,304,291 (+)	NCBI		Celera
Cytogenetic Map	X	p11.22	NCBI
HuRef	X	51,518,075 - 51,522,307 (+)	NCBI		HuRef
CHM1_1	X	54,457,507 - 54,462,384 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	X	53,731,260 - 53,738,888 (+)	NCBI		T2T-CHM13v2.0

Tsr2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	X	149,870,090 - 149,879,539 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	X	149,870,090 - 149,879,539 (-)	Ensembl		GRCm39 Ensembl
GRCm38	X	151,087,094 - 151,096,543 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	X	151,087,094 - 151,096,543 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	X	147,521,637 - 147,531,086 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	X	146,428,025 - 146,437,234 (-)	NCBI		MGSCv36	mm8
Celera	X	133,307,018 - 133,317,146 (+)	NCBI		Celera
Cytogenetic Map	X	F3	NCBI
cM Map	X	68.46	NCBI

Tsr2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	X	23,507,141 - 23,515,711 (-)	NCBI		GRCr8
mRatBN7.2	X	20,064,102 - 20,072,673 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	X	20,064,103 - 20,072,620 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	X	17,502,402 - 17,510,917 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	X	22,612,665 - 22,621,180 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	X	20,593,349 - 20,601,866 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	X	20,141,406 - 20,146,082 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	X	20,144,432 - 20,232,639 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	X	20,968,908 - 20,977,426 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Celera	X	20,321,354 - 20,329,877 (-)	NCBI		Celera
Cytogenetic Map	X	q12	NCBI

Tsr2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955475	1,698,136 - 1,703,404 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955475	1,698,926 - 1,703,404 (+)	NCBI	ChiLan1.0	ChiLan1.0

TSR2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	X	55,829,012 - 55,833,962 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	X	55,832,617 - 55,837,566 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	X	46,643,659 - 46,648,829 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	X	54,875,679 - 54,883,324 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	X	54,875,696 - 54,880,809 (+)	Ensembl	panpan1.1		panPan2

TSR2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	X	46,189,810 - 46,194,949 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	X	46,189,870 - 46,296,966 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	X	37,578,758 - 37,583,898 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	X	46,511,181 - 46,516,318 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	X	46,511,246 - 46,516,313 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	X	46,008,993 - 46,014,130 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	X	46,459,373 - 46,464,505 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	X	46,526,670 - 46,531,808 (+)	NCBI		UU_Cfam_GSD_1.0

TSR2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	X	47,186,643 - 47,192,452 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	X	47,186,610 - 47,192,465 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	X	53,043,987 - 53,049,415 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

TSR2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	X	50,532,958 - 50,555,179 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666086	4,515,626 - 4,523,216 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Tsr2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624909	2,310,718 - 2,315,538 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624909	2,311,494 - 2,316,358 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.


RefSeq Transcripts	XM_005339783	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000614	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSSTOT00000032692 ⟹ ENSSTOP00000029512

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936751	1,350,481 - 1,358,110 (+)	Ensembl

RefSeq Acc Id:

XM_005339783 ⟹ XP_005339840

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	X	39,010,776 - 39,015,724 (+)	NCBI
SpeTri2.0	NW_004936751	1,350,542 - 1,355,449 (+)	NCBI

Sequence:

show sequence

GGGCCGCCTGGGTTTCACGTGGTACAGACTGGATGATGGCGGGCGCCGGGGAAGATGCACGAGCCCTCTTCAGGGCTGGCGTCCGCGCGGCGTTGGAGGCTTGGCCTGCTTTACAGATCGCTGTAGAG
AATGGATTCGGGGGCGTGCACAGCCAAGAGAAGGCGGAGTGGCTGGGGGGTGCAGTGGAGGATTACTTCATCCGCAATGCTGACTTGGAGCTGGATGAGGTGGAAGACTTCCTTGGGGAGCTGATGAC
AAATGAGTTTGATACAGTTGTGGAGGATGGGAGTCTGCCCCAGGTGAGCCAGCAGTTGCAGACCATGTTCCACCACTTCCAGAAGGGTGATGGGGCTGCTCTGAGGGAGATGGCCTCCCACATCACCC
AAAAAAAGTGCAAAGTCAAAGCCACTGCACTCAAGGCAGCCAAAGAGACTGATGGGGATCAAGATGATGCAGACAGCGTGGAAGAGATGGAGGTCACAGCTACAAATGATGGGGCTACCACAGATGGG
GTCTCCCCCCAGCCTGAACCCTCTGATCCAAACTCCCAGAATATTAAGGAAGAGGATATAGTGGAAGATGGTTGGACCATTGTCCGGAGAAAGAAATGAGTGGGGCTGGAATTGGTTTGGGCCCTTGT
TTTCTAGGTATTCGAAACTTATTTGTAGGGCTTTTATGGAGGGCTATAGACCTCTGGATTGGTTATACTATCCCCACCCTCTTTCTTGTTCCTCTGTGCAGTTCCCTACAGGGGAAGAAAAGCCCTAA
GGTTCTTGGTTTTGGGGGGTCTAAGGCACTTGGTCCAACATACCCCCTTGGGCTTTAAGTTATCTGAGTGATGAGGCCAGTTTTCCCAGCATAGTTCCTCTTGGGTGCAGTCAGTGAAGAGGAGGGAT
GAGTGAATGTGGGCATGGATGGAGGAGCTAGACTCTGGTGGATACTAGACAGGAGGATTATGGAGAGGATGAGCCTGGGGACCAGTACTCAGTGCCAAGAGCTGGCTGGGTCAGGAATGGTGAGATGA
ACATGCAGATGAAAGAAAAGTTGAAGATGTAAGCAAAAGTAGCTGTGGTGCCTCTCCCTTACCCCACCCCACCCGACACATACCAACTCTTATTCCTGCTCAGAGCTTAAAACCTCCCAGGAATGCTC
CCTTCCTCCAGCCCAGCCTCTCACCCCAGGTTCCCTTAGGAATTCTAAGATCTTGGCAAGGTGGTGAGCTTGGAAGAAGAGTTGGGCTATTTTCTGTCTCCTCCAACCTCTTTCCTCATTCTTTATCC
CATCCCATTTAAGTTCAGGGATGAGGCTTATGACCCTAATAAATAATACCCTCTTGTTTAA

hide sequence


Protein RefSeqs	XP_005339840	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000029512.1
GenBank Protein	KAG3272195	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	XP_005339840 ⟸ XM_005339783
- UniProtKB:	A0A287D7G0 (UniProtKB/TrEMBL)
- Sequence:	show sequence MMAGAGEDARALFRAGVRAALEAWPALQIAVENGFGGVHSQEKAEWLGGAVEDYFIRNADLELDEVEDFLGELMTNEFDTVVEDGSLPQVSQQLQTMFHHFQKGDGAALREMASHITQKKCKVKATAL KAAKETDGDQDDADSVEEMEVTATNDGATTDGVSPQPEPSDPNSQNIKEEDIVEDGWTIVRRKK hide sequence

Ensembl Acc Id:

ENSSTOP00000029512 ⟸ ENSSTOT00000032692

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000033612	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000032692.1	UniProtKB/TrEMBL
InterPro	Pre-rRNA_process_TSR2	UniProtKB/TrEMBL
NCBI Gene	Tsr2	ENTREZGENE
PANTHER	PTHR21250	UniProtKB/TrEMBL
Pfam	WGG	UniProtKB/TrEMBL
UniProt	A0A287D7G0	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2019-01-29	Tsr2	TSR2 ribosome maturation factor		TSR2, ribosome maturation factor	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailable


InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailable


Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
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MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable

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