Tpcn1 (two pore segment channel 1) - Rat Genome Database

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Gene: Tpcn1 (two pore segment channel 1) Ictidomys tridecemlineatus
Analyze
Symbol: Tpcn1
Name: two pore segment channel 1
RGD ID: 12514331
Description: ENCODES a protein that exhibits NAADP-sensitive calcium-release channel activity (ortholog); INVOLVED IN calcium-mediated signaling (inferred); endocytosis involved in viral entry into host cell (inferred); monoatomic ion transport (inferred); PARTICIPATES IN calcium transport pathway; calcium/calcium-mediated signaling pathway; ASSOCIATED WITH oligospermia (ortholog); FOUND IN early endosome membrane (inferred); endolysosome (inferred); endosome membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: two pore calcium channel protein 1; two pore segment channel 1, transcript variant X1; two pore segment channel 1, transcript variant X2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118148,612,146 - 148,663,274 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366683,111,002 - 3,163,396 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366683,111,038 - 3,162,163 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Tpcn1Squirreloligospermia  ISORGD:13440849068941CTD Direct Evidence: marker/mechanismCTDPMID:24451262


Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Tpcn1Squirrelcalcium-mediated signaling involved_inIEAGO:0072345150520179 GOCGO_REF:0000108
Tpcn1Squirrelendocytosis involved in viral entry into host cell involved_inIEAUniProtKB:Q9EQJ0|UniProtKB:Q9ULQ1|ensembl:ENSMUSP00000042188|ensembl:ENSP00000335300150520179 EnsemblGO_REF:0000107
Tpcn1Squirrelmonoatomic ion transport involved_inIEAInterPro:IPR005821150520179 InterProGO_REF:0000002
Tpcn1Squirrelpositive regulation of autophagy involved_inIEAUniProtKB:Q9ULQ1|ensembl:ENSP00000335300150520179 EnsemblGO_REF:0000107
Tpcn1Squirrelsodium ion transmembrane transport involved_inIEAUniProtKB:Q9EQJ0|ensembl:ENSMUSP00000042188150520179 EnsemblGO_REF:0000107
Tpcn1Squirreltransmembrane transport involved_inIEAInterPro:IPR005821150520179 InterProGO_REF:0000002

Cellular Component
1 to 12 of 12 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Tpcn1Squirrelearly endosome membrane located_inIEAUniProtKB:Q9EQJ0|ensembl:ENSMUSP00000042188150520179 EnsemblGO_REF:0000107
Tpcn1Squirrelendolysosome located_inIEAUniProtKB:Q9EQJ0|UniProtKB:Q9ULQ1|ensembl:ENSMUSP00000042188|ensembl:ENSP00000335300150520179 EnsemblGO_REF:0000107
Tpcn1Squirrelendosome membrane located_inIEAPANTHER:PTN000004547150520179 TreeGrafterGO_REF:0000118
Tpcn1Squirrelendosome membrane located_inIEAUniProtKB:Q9ULQ1|ensembl:ENSP00000335300150520179 EnsemblGO_REF:0000107
Tpcn1Squirrellysosomal membrane located_inIEAPANTHER:PTN000004547150520179 TreeGrafterGO_REF:0000118
Tpcn1Squirrellysosomal membrane located_inIEAUniProtKB:Q9ULQ1|ensembl:ENSP00000335300150520179 EnsemblGO_REF:0000107
Tpcn1Squirrellysosomal membrane located_inIEAInterPro:IPR028801150520179 InterProGO_REF:0000002
Tpcn1Squirrelmembrane located_inIEAUniProtKB:Q9EQJ0|ensembl:ENSMUSP00000042188150520179 EnsemblGO_REF:0000107
Tpcn1Squirrelmembrane located_inIEAInterPro:IPR005821150520179 InterProGO_REF:0000002
Tpcn1Squirrelmembrane located_inIEAUniProtKB-SubCell:SL-0162150520179 UniProtGO_REF:0000044
Tpcn1Squirrelmembrane located_inIEAUniProtKB-KW:KW-0472150520179 UniProtGO_REF:0000043
Tpcn1Squirrelrecycling endosome membrane located_inIEAUniProtKB:Q9EQJ0|ensembl:ENSMUSP00000042188150520179 EnsemblGO_REF:0000107
1 to 12 of 12 rows

Molecular Function
1 to 15 of 15 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Tpcn1Squirrelidentical protein binding enablesIEAUniProtKB:Q9ULQ1|ensembl:ENSP00000335300150520179 EnsemblGO_REF:0000107
Tpcn1Squirrelintracellularly phosphatidylinositol-3,5-bisphosphate-gated monatomic cation channel activity enablesIEAUniProtKB:Q9EQJ0|UniProtKB:Q9ULQ1|ensembl:ENSMUSP00000042188|ensembl:ENSP00000335300150520179 EnsemblGO_REF:0000107
Tpcn1Squirrelligand-gated sodium channel activity enablesIEAUniProtKB:Q9EQJ0|UniProtKB:Q9ULQ1|ensembl:ENSMUSP00000042188|ensembl:ENSP00000335300150520179 EnsemblGO_REF:0000107
Tpcn1Squirrelmonoatomic ion channel activity enablesIEAInterPro:IPR005821150520179 InterProGO_REF:0000002
Tpcn1SquirrelNAADP-sensitive calcium-release channel activity NOT|enablesISORGD:13440849068941 PMID:24776928UniProtPMID:24776928
Tpcn1SquirrelNAADP-sensitive calcium-release channel activity enablesIEAUniProtKB:Q9ULQ1|ensembl:ENSP00000335300150520179 EnsemblGO_REF:0000107
Tpcn1SquirrelNAADP-sensitive calcium-release channel activity NOT|enablesISORGD:7334449068941 PMID:24776928UniProtPMID:24776928
Tpcn1Squirrelphosphatidylinositol-3,5-bisphosphate binding enablesIEAUniProtKB:Q9EQJ0|ensembl:ENSMUSP00000042188150520179 EnsemblGO_REF:0000107
Tpcn1Squirrelprotein binding enablesISOUniProtKB:O001659068941 PMID:24188827IntActPMID:24188827
Tpcn1Squirrelprotein binding enablesISOUniProtKB:Q8NHX99068941 PMID:21903581IntActPMID:21903581
Tpcn1Squirrelprotein binding enablesISOUniProtKB:Q9H9109068941 PMID:15094197UniProtPMID:15094197
Tpcn1Squirrelprotein homodimerization activity enablesIEAUniProtKB:Q9EQJ0|ensembl:ENSMUSP00000042188150520179 EnsemblGO_REF:0000107
Tpcn1Squirrelsyntaxin binding enablesIEAUniProtKB:Q9EQJ0|ensembl:ENSMUSP00000042188150520179 EnsemblGO_REF:0000107
Tpcn1Squirrelvoltage-gated channel activity enablesIEAInterPro:IPR028801150520179 InterProGO_REF:0000002
Tpcn1Squirrelvoltage-gated sodium channel activity enablesIEAUniProtKB:Q9EQJ0|UniProtKB:Q9ULQ1|ensembl:ENSMUSP00000042188|ensembl:ENSP00000335300150520179 EnsemblGO_REF:0000107
1 to 15 of 15 rows

RGD Manual Annotations


  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Tpcn1Squirrelcalcium transport pathway   ISORGD:13440849068941 RGDPMID:20018950|REF_RGD_ID:7204697
Tpcn1Squirrelcalcium/calcium-mediated signaling pathway   ISORGD:13440849068941 RGDPMID:20018950|REF_RGD_ID:7204697
PMID:22301074   PMID:30032202  



Tpcn1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118148,612,146 - 148,663,274 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366683,111,002 - 3,163,396 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366683,111,038 - 3,162,163 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TPCN1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812113,221,464 - 113,298,585 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12113,221,050 - 113,298,585 (+)EnsemblGRCh38hg38GRCh38
GRCh3712113,659,269 - 113,736,390 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3612112,143,652 - 112,218,317 (+)NCBINCBI36Build 36hg18NCBI36
Build 3412112,121,988 - 112,196,653NCBI
Celera12113,286,083 - 113,363,215 (+)NCBICelera
Cytogenetic Map12q24.13NCBI
HuRef12110,671,978 - 110,748,859 (+)NCBIHuRef
CHM1_112113,627,519 - 113,704,638 (+)NCBICHM1_1
T2T-CHM13v2.012113,198,077 - 113,275,213 (+)NCBIT2T-CHM13v2.0
Tpcn1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395120,672,222 - 120,726,731 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5120,672,218 - 120,726,738 (-)EnsemblGRCm39 Ensembl
GRCm385120,534,157 - 120,588,678 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5120,534,153 - 120,588,673 (-)EnsemblGRCm38mm10GRCm38
MGSCv375120,984,166 - 121,038,622 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365120,794,774 - 120,849,230 (-)NCBIMGSCv36mm8
Celera5117,618,746 - 117,673,755 (-)NCBICelera
Cytogenetic Map5FNCBI
cM Map560.63NCBI
Tpcn1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81241,633,399 - 41,690,200 (+)NCBIGRCr8
mRatBN7.21235,972,813 - 36,029,632 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1235,972,846 - 36,029,626 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1237,152,476 - 37,208,823 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01237,763,694 - 37,820,042 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01236,816,157 - 36,872,506 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01241,507,784 - 41,566,847 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1241,543,696 - 41,566,847 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01243,365,885 - 43,421,373 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41237,140,428 - 37,227,711 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11237,003,822 - 37,091,098 (+)NCBI
Celera1237,634,250 - 37,689,810 (+)NCBICelera
Cytogenetic Map12q16NCBI
Tpcn1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554829,542,079 - 9,592,972 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554829,538,572 - 9,594,739 (+)NCBIChiLan1.0ChiLan1.0
TPCN1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210121,275,876 - 121,387,131 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112121,292,962 - 121,383,532 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v012110,812,587 - 110,903,033 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.112114,209,638 - 114,286,443 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12114,209,638 - 114,286,443 (+)Ensemblpanpan1.1panPan2
TPCN1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12610,599,898 - 10,662,269 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2610,599,780 - 10,660,767 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2610,722,333 - 10,784,680 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02610,844,354 - 10,906,738 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2610,844,324 - 10,906,732 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12610,818,283 - 10,880,655 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02610,880,824 - 10,943,296 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02610,930,100 - 10,992,447 (+)NCBIUU_Cfam_GSD_1.0
TPCN1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1438,683,597 - 38,773,186 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11438,698,680 - 38,773,189 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21441,288,818 - 41,314,324 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TPCN1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111108,459,754 - 108,549,933 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl11108,475,380 - 108,552,374 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037136,539,692 - 136,615,663 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tpcn1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474719,179,575 - 19,236,206 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474719,179,378 - 19,237,799 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Ensembl Acc Id: ENSSTOT00000001991   ⟹   ENSSTOP00000001773
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049366683,111,002 - 3,163,396 (+)Ensembl
RefSeq Acc Id: XM_013363566   ⟹   XP_013219020
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024405118148,612,146 - 148,663,274 (+)NCBI
SpeTri2.0NW_0049366683,111,038 - 3,162,163 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021734261   ⟹   XP_021589936
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024405118148,612,146 - 148,663,274 (+)NCBI
SpeTri2.0NW_0049366683,111,046 - 3,162,163 (+)NCBI
Sequence:
RefSeq Acc Id: XM_040289442   ⟹   XP_040145376
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024405118148,633,216 - 148,663,274 (+)NCBI
Protein RefSeqs XP_013219020 (Get FASTA)   NCBI Sequence Viewer  
  XP_021589936 (Get FASTA)   NCBI Sequence Viewer  
  XP_040145376 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000001773.3
GenBank Protein KAG3278962 (Get FASTA)   NCBI Sequence Viewer  
  KAG3278963 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_013219020   ⟸   XM_013363566
- Peptide Label: isoform X1
- UniProtKB: I3LZK2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_021589936   ⟸   XM_021734261
- Peptide Label: isoform X1
- UniProtKB: I3LZK2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_040145376   ⟸   XM_040289442
- Peptide Label: isoform X2
Ensembl Acc Id: ENSSTOP00000001773   ⟸   ENSSTOT00000001991
Ion transport



1 to 13 of 13 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSSTOG00000001971 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000001991.3 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.70 UniProtKB/TrEMBL
  1.20.120.350 UniProtKB/TrEMBL
InterPro Ion_trans_dom UniProtKB/TrEMBL
  TPC1_animal UniProtKB/TrEMBL
  Volt_channel_dom_sf UniProtKB/TrEMBL
NCBI Gene Tpcn1 ENTREZGENE
PANTHER PTHR46474 UniProtKB/TrEMBL
  TWO PORE CALCIUM CHANNEL PROTEIN 1 UniProtKB/TrEMBL
Pfam Ion_trans UniProtKB/TrEMBL
Superfamily-SCOP Voltage-gated potassium channels UniProtKB/TrEMBL
UniProt I3LZK2 ENTREZGENE, UniProtKB/TrEMBL
1 to 13 of 13 rows