Pak4 (p21 (RAC1) activated kinase 4) - Rat Genome Database

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Gene: Pak4 (p21 (RAC1) activated kinase 4) Ictidomys tridecemlineatus
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Symbol: Pak4
Name: p21 (RAC1) activated kinase 4
RGD ID: 12494398
Description: ENCODES a protein that exhibits protein serine/threonine kinase activity (ortholog); INVOLVED IN dendritic spine development (ortholog); negative regulation of endothelial cell apoptotic process (ortholog); positive regulation of angiogenesis (ortholog); PARTICIPATES IN fibroblast growth factor signaling pathway; ASSOCIATED WITH clear cell renal cell carcinoma (ortholog); Experimental Mammary Neoplasms (ortholog); hereditary breast ovarian cancer syndrome (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: serine/threonine-protein kinase PAK 4
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934913,584,379 - 13,620,454 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049366612,012,439 - 2,048,523 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Pak4Squirrelclear cell renal cell carcinoma disease_progressionISOPAK4 (Homo sapiens)9068941 RGDPMID:25744653 and REF_RGD_ID:13504816
Pak4SquirrelExperimental Mammary Neoplasms  ISOPAK4 (Homo sapiens)9068941 RGDPMID:20697354 and REF_RGD_ID:7775027
Pak4Squirrelretinal degeneration  ISOPak4 (Mus musculus)9068941mRNA:increased expression:retinaRGDPMID:16505058 and REF_RGD_ID:7775028
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Pak4Squirrelhereditary breast ovarian cancer syndrome  ISOPAK4 (Homo sapiens)8554872ClinVar Annotator: match by term: Hereditary breast ovarian cancer syndromeClinVarPMID:25741868
Pak4Squirrelmaturity-onset diabetes of the young type 1  ISOPAK4 (Homo sapiens)8554872ClinVar Annotator: match by term: Type 2 diabetes mellitusClinVarPMID:28492532
Pak4Squirrelprostate cancer  ISOPAK4 (Homo sapiens)8554872ClinVar Annotator: match by term: Malignant tumor of prostateClinVar 
Pak4Squirreltype 2 diabetes mellitus  ISOPAK4 (Homo sapiens)8554872ClinVar Annotator: match by term: Type 2 diabetes mellitusClinVarPMID:28492532
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Pak4Squirrelneuroblastoma  ISOPAK4 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:29048629


Biological Process

  

Molecular Function
1 to 18 of 18 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Pak4SquirrelATP binding enablesIEAInterPro:IPR000719150520179 InterProGO_REF:0000002
Pak4Squirrelprotein binding enablesISOUniProtKB:P609539068941 PMID:20936779 more ...IntActPMID:20936779 more ...
Pak4Squirrelprotein binding enablesISOUniProtKB:P60953 more ...9068941 PMID:32707033IntActPMID:32707033
Pak4Squirrelprotein binding enablesISOUniProtKB:O00401 more ...9068941 PMID:29100370IntActPMID:29100370
Pak4Squirrelprotein binding enablesISOUniProtKB:P31947 more ...9068941 PMID:36931259IntActPMID:36931259
Pak4Squirrelprotein binding enablesISOUniProtKB:P319479068941 PMID:15778465IntActPMID:15778465
Pak4Squirrelprotein binding enablesISOUniProtKB:P631049068941 PMID:15161933 and PMID:28514442IntActPMID:15161933 and PMID:28514442
Pak4Squirrelprotein binding enablesISOUniProtKB:Q96EL19068941 PMID:32296183IntActPMID:32296183
Pak4Squirrelprotein binding enablesISOUniProtKB:P05067 and UniProtKB:P378409068941 PMID:32814053IntActPMID:32814053
Pak4Squirrelprotein binding enablesISOUniProtKB:Q96EL1 and UniProtKB:Q9NTI79068941 PMID:26607847UniProtPMID:26607847
Pak4Squirrelprotein binding enablesISOUniProtKB:P542749068941 PMID:21044950IntActPMID:21044950
Pak4Squirrelprotein binding enablesISOUniProtKB:Q9P2589068941 PMID:25074804UniProtPMID:25074804
Pak4Squirrelprotein binding enablesISOUniProtKB:Q8TEC59068941 PMID:24130170UniProtPMID:24130170
Pak4Squirrelprotein binding enablesISOUniProtKB:P62258 and UniProtKB:P631049068941 PMID:35271311IntActPMID:35271311
Pak4Squirrelprotein binding enablesISOUniProtKB:P63104 and UniProtKB:Q96EL19068941 PMID:33961781IntActPMID:33961781
Pak4Squirrelprotein kinase activity enablesIEAInterPro:IPR000719150520179 InterProGO_REF:0000002
Pak4Squirrelprotein serine/threonine kinase activity enablesISOPAK4 (Homo sapiens)9068941 PMID:26607847UniProtPMID:26607847
Pak4Squirrelprotein serine/threonine kinase activity enablesISOPAK4 (Homo sapiens)9068941 PMID:21788589BHF-UCLPMID:21788589
1 to 18 of 18 rows

Imported Annotations - PID (archival)

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Pak4Squirrelfibroblast growth factor signaling pathway  ISOPAK4 (Homo sapiens)9068941 PIDPID:200220
PMID:22301074   PMID:30032202  



Pak4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934913,584,379 - 13,620,454 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049366612,012,439 - 2,048,523 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PAK4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381939,125,786 - 39,182,816 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1939,125,770 - 39,182,816 (+)EnsemblGRCh38hg38GRCh38
GRCh371939,616,426 - 39,673,456 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361944,308,260 - 44,361,886 (+)NCBINCBI36Build 36hg18NCBI36
Build 341944,308,301 - 44,361,882NCBI
Celera1936,418,829 - 36,473,610 (+)NCBICelera
Cytogenetic Map19q13.2NCBI
HuRef1936,063,360 - 36,116,946 (+)NCBIHuRef
CHM1_11939,617,306 - 39,670,871 (+)NCBICHM1_1
T2T-CHM13v2.01941,929,765 - 41,986,971 (+)NCBIT2T-CHM13v2.0
Pak4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39728,258,244 - 28,297,609 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl728,258,244 - 28,297,610 (-)EnsemblGRCm39 Ensembl
GRCm38728,558,819 - 28,598,184 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl728,558,819 - 28,598,185 (-)EnsemblGRCm38mm10GRCm38
MGSCv37729,343,838 - 29,383,203 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36728,267,579 - 28,306,906 (-)NCBIMGSCv36mm8
Celera723,123,936 - 23,163,272 (-)NCBICelera
Cytogenetic Map7A3- B1NCBI
cM Map716.84NCBI
Pak4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8192,977,437 - 93,016,721 (-)NCBIGRCr8
mRatBN7.2183,849,904 - 83,889,188 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl183,849,904 - 83,859,413 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx189,259,841 - 89,299,237 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0197,718,978 - 97,758,274 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0191,015,714 - 91,055,110 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0185,162,462 - 85,201,746 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl185,162,452 - 85,201,757 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0186,378,296 - 86,417,580 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4183,670,786 - 83,710,070 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1183,749,728 - 83,797,056 (-)NCBI
Celera178,244,198 - 78,283,501 (-)NCBICelera
Cytogenetic Map1q21NCBI
Pak4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955468367,971 - 378,271 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955468368,721 - 417,614 (-)NCBIChiLan1.0ChiLan1.0
PAK4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22045,421,628 - 45,475,524 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11947,292,159 - 47,346,128 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01936,224,442 - 36,278,371 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11944,773,098 - 44,826,651 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1944,816,601 - 44,825,827 (+)Ensemblpanpan1.1panPan2
PAK4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11114,009,573 - 114,052,100 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1114,009,711 - 114,018,191 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1113,410,153 - 113,453,319 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01114,608,125 - 114,651,302 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1114,608,128 - 114,651,260 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11114,166,259 - 114,201,907 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01113,799,180 - 113,842,525 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01114,794,554 - 114,837,946 (-)NCBIUU_Cfam_GSD_1.0
PAK4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl647,869,577 - 47,914,182 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1647,869,604 - 47,914,185 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2643,357,961 - 43,402,756 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PAK4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1633,715,695 - 33,769,272 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl633,759,462 - 33,770,497 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607311,743,338 - 11,796,584 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pak4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462479412,457,010 - 12,499,366 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462479412,457,029 - 12,498,839 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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RefSeq Transcripts XM_021734021 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAESOR010004409 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: XM_021734021   ⟹   XP_021589696
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440934913,584,379 - 13,620,454 (+)NCBI
SpeTri2.0NW_0049366612,012,439 - 2,048,523 (+)NCBI
Sequence:
Protein RefSeqs XP_021589696 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000020612.2
GenBank Protein KAG3256008 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_021589696   ⟸   XM_021734021
- Sequence:
Protein kinase



1 to 15 of 15 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSSTOG00000028802 UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000024111.2 UniProtKB/TrEMBL
Gene3D-CATH Phosphorylase Kinase, domain 1 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Kinase-like_dom_sf UniProtKB/TrEMBL
  PAK3-like UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
NCBI Gene Pak4 ENTREZGENE
PANTHER NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE UniProtKB/TrEMBL
  SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/TrEMBL
PIRSF Integrin-linked_kinase UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_DOM UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/TrEMBL
UniProt I3N8B6_ICTTR UniProtKB/TrEMBL
1 to 15 of 15 rows