SPINT1 (serine peptidase inhibitor, Kunitz type 1) - Rat Genome Database

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Gene: SPINT1 (serine peptidase inhibitor, Kunitz type 1) Canis lupus familiaris
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Symbol: SPINT1
Name: serine peptidase inhibitor, Kunitz type 1
RGD ID: 12368378
Description: ENCODES a protein that exhibits serine-type endopeptidase inhibitor activity (ortholog); INVOLVED IN branching involved in labyrinthine layer morphogenesis (ortholog); cellular response to BMP stimulus (ortholog); embryonic placenta development (ortholog); ASSOCIATED WITH Alzheimer's disease (ortholog); biliary atresia (ortholog); Bloom syndrome (ortholog); FOUND IN membrane (inferred); plasma membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: kunitz-type protease inhibitor 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1307,976,094 - 7,989,019 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl307,975,235 - 7,988,339 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha308,030,789 - 8,043,874 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0308,104,320 - 8,117,280 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl308,104,237 - 8,117,684 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1308,026,984 - 8,039,921 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0308,134,558 - 8,147,504 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0308,264,088 - 8,277,146 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
membrane  (IEA)
plasma membrane  (IBA,IEA)

Molecular Function

References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
SPINT1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1307,976,094 - 7,989,019 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl307,975,235 - 7,988,339 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha308,030,789 - 8,043,874 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0308,104,320 - 8,117,280 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl308,104,237 - 8,117,684 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1308,026,984 - 8,039,921 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0308,134,558 - 8,147,504 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0308,264,088 - 8,277,146 (+)NCBIUU_Cfam_GSD_1.0
SPINT1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381540,844,048 - 40,858,207 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1540,844,018 - 40,858,207 (+)EnsemblGRCh38hg38GRCh38
GRCh371541,136,246 - 41,150,405 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361538,923,538 - 38,937,145 (+)NCBINCBI36Build 36hg18NCBI36
Celera1517,904,155 - 17,917,761 (+)NCBICelera
Cytogenetic Map15q15.1NCBI
HuRef1517,956,043 - 17,998,087 (+)NCBIHuRef
CHM1_11541,254,190 - 41,267,796 (+)NCBICHM1_1
T2T-CHM13v2.01538,650,076 - 38,664,232 (+)NCBIT2T-CHM13v2.0
Spint1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392119,067,841 - 119,079,995 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2119,067,843 - 119,080,008 (+)EnsemblGRCm39 Ensembl
GRCm382119,237,360 - 119,249,535 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2119,237,362 - 119,249,527 (+)EnsemblGRCm38mm10GRCm38
MGSCv372119,063,096 - 119,075,250 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362118,928,918 - 118,940,633 (+)NCBIMGSCv36mm8
Celera2120,387,921 - 120,400,196 (+)NCBICelera
Cytogenetic Map2E5NCBI
cM Map259.97NCBI
Spint1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83126,685,017 - 126,697,957 (+)NCBIGRCr8
mRatBN7.23106,231,082 - 106,244,121 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3106,231,444 - 106,244,119 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3109,904,232 - 109,916,890 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03118,499,779 - 118,512,434 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03116,160,160 - 116,172,815 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03111,049,132 - 111,061,991 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3111,049,118 - 111,062,011 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03117,599,717 - 117,612,635 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43105,757,666 - 105,770,345 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13105,654,093 - 105,666,772 (+)NCBI
Celera3105,144,668 - 105,157,338 (+)NCBICelera
Cytogenetic Map3q35NCBI
Spint1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554167,715,536 - 7,729,158 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554167,715,536 - 7,728,759 (+)NCBIChiLan1.0ChiLan1.0
SPINT1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21630,086,766 - 30,100,403 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11534,238,095 - 34,251,732 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01519,786,621 - 19,800,297 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11538,036,638 - 38,050,303 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1538,036,638 - 38,050,303 (+)Ensemblpanpan1.1panPan2
Spint1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864086,390,799 - 86,403,274 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364714,238,845 - 4,251,350 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364714,238,883 - 4,251,291 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SPINT1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1130,458,909 - 130,473,783 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11130,458,909 - 130,473,791 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21145,616,937 - 145,631,763 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SPINT1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12642,136,749 - 42,150,125 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2642,134,536 - 42,150,118 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604898,833,369 - 98,846,726 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Spint1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248048,093,346 - 8,106,193 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248048,092,700 - 8,105,478 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in SPINT1
184 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 5 23 22 16 6 6 6 6 33 22 12 14 10

Sequence


Ensembl Acc Id: ENSCAFT00000014907   ⟹   ENSCAFP00000013796
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl307,976,314 - 7,988,339 (+)Ensembl
Ensembl Acc Id: ENSCAFT00000093502   ⟹   ENSCAFP00000049460
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl307,975,235 - 7,988,339 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845051330   ⟹   ENSCAFP00845040265
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl308,104,237 - 8,117,684 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845051344   ⟹   ENSCAFP00845040279
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl308,104,744 - 8,117,684 (+)Ensembl
RefSeq Acc Id: XM_038442004   ⟹   XP_038297932
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0308,104,320 - 8,117,280 (+)NCBI
RefSeq Acc Id: XM_038442005   ⟹   XP_038297933
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0308,104,375 - 8,117,280 (+)NCBI
RefSeq Acc Id: XM_038461521   ⟹   XP_038317449
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha308,030,789 - 8,043,874 (+)NCBI
RefSeq Acc Id: XM_038516494   ⟹   XP_038372422
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1308,026,984 - 8,039,921 (+)NCBI
RefSeq Acc Id: XM_038516495   ⟹   XP_038372423
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1308,027,040 - 8,039,921 (+)NCBI
RefSeq Acc Id: XM_038580085   ⟹   XP_038436013
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0308,264,088 - 8,277,146 (+)NCBI
RefSeq Acc Id: XM_038580086   ⟹   XP_038436014
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0308,264,144 - 8,277,146 (+)NCBI
RefSeq Acc Id: XM_038644366   ⟹   XP_038500294
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0308,134,558 - 8,147,504 (+)NCBI
RefSeq Acc Id: XM_038644367   ⟹   XP_038500295
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0308,134,613 - 8,147,504 (+)NCBI
RefSeq Acc Id: XM_544625   ⟹   XP_544625
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1307,976,094 - 7,989,019 (+)NCBI
Dog10K_Boxer_Tasha308,030,845 - 8,043,874 (+)NCBI
Sequence:
RefSeq Acc Id: XP_544625   ⟸   XM_544625
- UniProtKB: A0A8C0JZY3 (UniProtKB/TrEMBL),   A0A8C0TZ26 (UniProtKB/TrEMBL),   A0A8I3PYU2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCAFP00000013796   ⟸   ENSCAFT00000014907
Ensembl Acc Id: ENSCAFP00000049460   ⟸   ENSCAFT00000093502
RefSeq Acc Id: XP_038372422   ⟸   XM_038516494
RefSeq Acc Id: XP_038372423   ⟸   XM_038516495
RefSeq Acc Id: XP_038500294   ⟸   XM_038644366
RefSeq Acc Id: XP_038500295   ⟸   XM_038644367
RefSeq Acc Id: XP_038297932   ⟸   XM_038442004
- UniProtKB: A0A8C0JZY3 (UniProtKB/TrEMBL),   A0A8C0TZ26 (UniProtKB/TrEMBL),   A0A8I3PYU2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038297933   ⟸   XM_038442005
- UniProtKB: A0A8C0JZY3 (UniProtKB/TrEMBL),   A0A8C0TZ26 (UniProtKB/TrEMBL),   A0A8I3PYU2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038317449   ⟸   XM_038461521
- UniProtKB: A0A8C0JZY3 (UniProtKB/TrEMBL),   A0A8C0TZ26 (UniProtKB/TrEMBL),   A0A8I3PYU2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038436013   ⟸   XM_038580085
- UniProtKB: A0A8C0JZY3 (UniProtKB/TrEMBL),   A0A8C0TZ26 (UniProtKB/TrEMBL),   A0A8I3PYU2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038436014   ⟸   XM_038580086
- UniProtKB: A0A8C0JZY3 (UniProtKB/TrEMBL),   A0A8C0TZ26 (UniProtKB/TrEMBL),   A0A8I3PYU2 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCAFP00845040265   ⟸   ENSCAFT00845051330
Ensembl Acc Id: ENSCAFP00845040279   ⟸   ENSCAFT00845051344
Protein Domains
BPTI/Kunitz inhibitor   MANSC


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000009365 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030023390 UniProtKB/TrEMBL
  ENSCAFG00040025715 UniProtKB/TrEMBL
  ENSCAFG00845029015 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000014907.5 UniProtKB/TrEMBL
  ENSCAFT00000093502.2 UniProtKB/TrEMBL
  ENSCAFT00030042970.1 UniProtKB/TrEMBL
  ENSCAFT00030043032.1 UniProtKB/TrEMBL
  ENSCAFT00040047997.1 UniProtKB/TrEMBL
  ENSCAFT00040048000.1 UniProtKB/TrEMBL
  ENSCAFT00845051330 ENTREZGENE
  ENSCAFT00845051330.1 UniProtKB/TrEMBL
  ENSCAFT00845051344.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
  4.10.400.10 UniProtKB/TrEMBL
  4.10.410.10 UniProtKB/TrEMBL
InterPro Ig-like_fold UniProtKB/TrEMBL
  Kunitz_BPTI UniProtKB/TrEMBL
  Kunitz_BPTI_sf UniProtKB/TrEMBL
  LDL_receptor-like_sf UniProtKB/TrEMBL
  LDLR_class-A_CS UniProtKB/TrEMBL
  LDrepeatLR_classA_rpt UniProtKB/TrEMBL
  MANSC_dom UniProtKB/TrEMBL
  MANSC_N UniProtKB/TrEMBL
  Prtase_inh_Kunz-CS UniProtKB/TrEMBL
NCBI Gene SPINT1 ENTREZGENE
PANTHER KUNITZ-TYPE PROTEASE INHIBITOR 1 UniProtKB/TrEMBL
  PTHR46750 UniProtKB/TrEMBL
Pfam K319L-like_PKD UniProtKB/TrEMBL
  Kunitz_BPTI UniProtKB/TrEMBL
  Ldl_recept_a UniProtKB/TrEMBL
  MANEC UniProtKB/TrEMBL
PRINTS BASICPTASE UniProtKB/TrEMBL
PROSITE BPTI_KUNITZ_1 UniProtKB/TrEMBL
  BPTI_KUNITZ_2 UniProtKB/TrEMBL
  LDLRA_1 UniProtKB/TrEMBL
  LDLRA_2 UniProtKB/TrEMBL
  MANSC UniProtKB/TrEMBL
SMART LDLa UniProtKB/TrEMBL
  MANEC UniProtKB/TrEMBL
  SM00131 UniProtKB/TrEMBL
Superfamily-SCOP SSF57362 UniProtKB/TrEMBL
  SSF57424 UniProtKB/TrEMBL
UniProt A0A8C0JZY3 ENTREZGENE
  A0A8C0P693_CANLF UniProtKB/TrEMBL
  A0A8C0TZ26 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3PYU2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3S6Z5_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:46746 ENTREZGENE