SCN2A (sodium voltage-gated channel alpha subunit 2) - Rat Genome Database

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Gene: SCN2A (sodium voltage-gated channel alpha subunit 2) Canis lupus familiaris
Analyze
Symbol: SCN2A
Name: sodium voltage-gated channel alpha subunit 2
RGD ID: 12178861
Description: ENCODES a protein that exhibits leucine zipper domain binding (ortholog); sodium ion binding (ortholog); voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential (ortholog); INVOLVED IN axon development (ortholog); cellular response to hypoxia (ortholog); cerebral cortex development (ortholog); ASSOCIATED WITH asphyxiating thoracic dystrophy (ortholog); asphyxiating thoracic dystrophy 1 (ortholog); autism spectrum disorder (ortholog); FOUND IN axon (ortholog); axon initial segment (ortholog); glutamatergic synapse (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: LOC478773; sodium channel protein type 2 subunit alpha; sodium channel, voltage-gated, type II, alpha subunit
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13610,472,496 - 10,605,055 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3610,472,361 - 10,602,685 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3610,615,273 - 10,749,736 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03610,604,046 - 10,738,882 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3610,604,041 - 10,738,874 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13610,686,329 - 10,820,763 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03610,658,084 - 10,792,902 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03610,770,872 - 10,905,712 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
asphyxiating thoracic dystrophy  (ISO)
asphyxiating thoracic dystrophy 1  (ISO)
autism spectrum disorder  (ISO)
autistic disorder  (ISO)
benign epilepsy with centrotemporal spikes  (ISO)
benign familial infantile epilepsy  (ISO)
benign familial infantile seizures 1  (ISO)
benign familial infantile seizures 3  (ISO)
benign familial neonatal epilepsy  (ISO)
benign neonatal seizures  (ISO)
bipolar disorder  (ISO)
developmental and epileptic encephalopathy  (ISO)
developmental and epileptic encephalopathy 11  (ISO)
developmental and epileptic encephalopathy 14  (ISO)
developmental and epileptic encephalopathy 30  (ISO)
Developmental Disabilities  (ISO)
Developmental Disease  (ISO)
Dravet syndrome  (ISO)
dystonia 12  (ISO)
early infantile epileptic encephalopathy  (ISO)
early-onset vitamin B6-dependent epilepsy 4  (ISO)
epilepsy  (ISO)
episodic ataxia  (ISO)
Episodic Ataxia Type 9  (ISO)
Febrile Seizures  (ISO)
focal epilepsy  (ISO)
Generalized Epilepsy  (ISO)
generalized epilepsy with febrile seizures plus  (ISO)
generalized epilepsy with febrile seizures plus 7  (ISO)
genetic disease  (ISO)
hemiplegia  (ISO)
hereditary sensory and autonomic neuropathy type 2A  (ISO)
hereditary sensory neuropathy  (ISO)
intellectual disability  (ISO)
Lennox-Gastaut syndrome  (ISO)
long QT syndrome  (ISO)
Marfanoid Mental Retardation Syndrome, Autosomal  (ISO)
myoclonic-atonic epilepsy  (ISO)
Myoclonus  (ISO)
nephronophthisis  (ISO)
nephronophthisis 1  (ISO)
NEURODEVELOPMENTAL DISORDER WITH MICROCEPHALY, ARTHROGRYPOSIS, AND STRUCTURAL BRAIN ANOMALIES  (ISO)
Neurodevelopmental Disorders  (ISO)
non-syndromic intellectual disability  (ISO)
pyridoxine-dependent epilepsy  (ISO)
spastic ataxia  (ISO)
West syndrome  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
SCN2A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13610,472,496 - 10,605,055 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3610,472,361 - 10,602,685 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3610,615,273 - 10,749,736 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03610,604,046 - 10,738,882 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3610,604,041 - 10,738,874 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13610,686,329 - 10,820,763 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03610,658,084 - 10,792,902 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03610,770,872 - 10,905,712 (+)NCBIUU_Cfam_GSD_1.0
SCN2A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382165,239,414 - 165,392,304 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2165,194,993 - 165,392,310 (+)EnsemblGRCh38hg38GRCh38
GRCh372166,095,924 - 166,248,814 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362165,804,158 - 165,957,066 (+)NCBINCBI36Build 36hg18NCBI36
Build 342165,976,098 - 166,072,046NCBI
Celera2159,706,512 - 159,859,384 (+)NCBICelera
Cytogenetic Map2q24.3NCBI
HuRef2157,978,323 - 158,131,089 (+)NCBIHuRef
CHM1_12166,101,845 - 166,254,789 (+)NCBICHM1_1
T2T-CHM13v2.02165,696,714 - 165,849,575 (+)NCBIT2T-CHM13v2.0
Scn2a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39265,451,108 - 65,597,791 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl265,451,115 - 65,597,791 (+)EnsemblGRCm39 Ensembl
GRCm38265,620,764 - 65,767,447 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl265,620,771 - 65,767,447 (+)EnsemblGRCm38mm10GRCm38
MGSCv37265,508,502 - 65,605,504 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36265,471,335 - 65,568,290 (+)NCBIMGSCv36mm8
Celera267,347,826 - 67,445,379 (+)NCBICelera
Cytogenetic Map2C1.3NCBI
cM Map238.61NCBI
Scn2a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8370,710,862 - 70,845,569 (+)NCBIGRCr8
mRatBN7.2350,302,781 - 50,437,504 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl350,302,877 - 50,437,214 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx353,646,466 - 53,788,492 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0362,230,075 - 62,372,108 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0360,013,503 - 60,148,019 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0351,687,910 - 51,822,008 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl351,687,809 - 51,822,250 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0358,322,640 - 58,456,658 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4347,588,413 - 47,722,800 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1347,484,784 - 47,619,172 (+)NCBI
Celera349,896,043 - 50,030,402 (+)NCBICelera
RH 3.4 Map3613.5RGD
Cytogenetic Map3q21NCBI
Scn2a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554498,721,784 - 8,846,200 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554498,722,043 - 8,846,165 (-)NCBIChiLan1.0ChiLan1.0
SCN2A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21367,900,817 - 68,052,848 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B67,915,794 - 68,067,823 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B52,514,918 - 52,667,225 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B169,873,992 - 170,026,392 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B169,928,323 - 170,027,509 (+)Ensemblpanpan1.1panPan2
Scn2a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303127,536,296 - 127,745,013 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493646913,872,701 - 13,971,005 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493646913,872,701 - 14,019,170 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SCN2A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1571,864,784 - 71,999,211 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11571,864,753 - 71,999,219 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21580,349,224 - 80,429,339 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SCN2A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11050,717,264 - 50,886,079 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1050,717,271 - 50,888,145 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040148,625,514 - 148,788,747 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in SCN2A
1195 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 1 7
Low 6 5 8 1
Below cutoff 5 5 14 5 6 5 6 4 9 6

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_014110824 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_014110825 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022414740 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022414741 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022414742 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038446929 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038446930 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038446931 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038446932 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038463415 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038521005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038521006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038521007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038521008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038584698 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038584699 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038584700 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038584701 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038649116 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038649117 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038649118 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038649119 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_535939 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000036 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000354 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000082 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000197 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000036 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCAFT00000017733   ⟹   ENSCAFP00000016416
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl3610,472,361 - 10,602,685 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000068235   ⟹   ENSCAFP00000048736
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl3610,472,361 - 10,602,685 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000068896   ⟹   ENSCAFP00000057716
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl3610,472,361 - 10,602,685 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000073386   ⟹   ENSCAFP00000064030
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl3610,472,361 - 10,602,685 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845029009   ⟹   ENSCAFP00845022818
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl3610,604,041 - 10,738,874 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845029123   ⟹   ENSCAFP00845022905
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl3610,604,041 - 10,738,874 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845029212   ⟹   ENSCAFP00845022975
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl3610,604,041 - 10,738,874 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845029357   ⟹   ENSCAFP00845023077
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl3610,651,843 - 10,686,495 (+)Ensembl
RefSeq Acc Id: XM_014110824   ⟹   XP_013966299
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.13610,472,496 - 10,605,055 (+)NCBI
Dog10K_Boxer_Tasha3610,615,273 - 10,749,736 (+)NCBI
Sequence:
RefSeq Acc Id: XM_022414742   ⟹   XP_022270450
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.13610,551,136 - 10,605,055 (+)NCBI
Dog10K_Boxer_Tasha3610,696,200 - 10,749,736 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038446929   ⟹   XP_038302857
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.03610,604,046 - 10,738,882 (+)NCBI
RefSeq Acc Id: XM_038446930   ⟹   XP_038302858
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.03610,651,842 - 10,738,882 (+)NCBI
RefSeq Acc Id: XM_038446931   ⟹   XP_038302859
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.03610,666,473 - 10,738,882 (+)NCBI
RefSeq Acc Id: XM_038446932   ⟹   XP_038302860
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.03610,685,003 - 10,738,882 (+)NCBI
RefSeq Acc Id: XM_038463415   ⟹   XP_038319343
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha3610,677,667 - 10,749,736 (+)NCBI
RefSeq Acc Id: XM_038521005   ⟹   XP_038376933
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.13610,686,329 - 10,820,763 (+)NCBI
RefSeq Acc Id: XM_038521006   ⟹   XP_038376934
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.13610,734,100 - 10,820,763 (+)NCBI
RefSeq Acc Id: XM_038521007   ⟹   XP_038376935
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.13610,748,716 - 10,820,763 (+)NCBI
RefSeq Acc Id: XM_038521008   ⟹   XP_038376936
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.13610,767,259 - 10,820,763 (+)NCBI
RefSeq Acc Id: XM_038584698   ⟹   XP_038440626
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.03610,770,872 - 10,905,712 (+)NCBI
RefSeq Acc Id: XM_038584699   ⟹   XP_038440627
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.03610,818,645 - 10,905,712 (+)NCBI
RefSeq Acc Id: XM_038584700   ⟹   XP_038440628
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.03610,833,268 - 10,905,712 (+)NCBI
RefSeq Acc Id: XM_038584701   ⟹   XP_038440629
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.03610,851,813 - 10,905,712 (+)NCBI
RefSeq Acc Id: XM_038649116   ⟹   XP_038505044
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.03610,658,084 - 10,792,902 (+)NCBI
RefSeq Acc Id: XM_038649117   ⟹   XP_038505045
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.03610,705,881 - 10,792,902 (+)NCBI
RefSeq Acc Id: XM_038649118   ⟹   XP_038505046
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.03610,720,497 - 10,792,902 (+)NCBI
RefSeq Acc Id: XM_038649119   ⟹   XP_038505047
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.03610,738,982 - 10,792,902 (+)NCBI
RefSeq Acc Id: XM_535939   ⟹   XP_535939
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.13610,517,725 - 10,605,055 (+)NCBI
Dog10K_Boxer_Tasha3610,663,054 - 10,749,736 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_013966299 (Get FASTA)   NCBI Sequence Viewer  
  XP_022270450 (Get FASTA)   NCBI Sequence Viewer  
  XP_038302857 (Get FASTA)   NCBI Sequence Viewer  
  XP_038302858 (Get FASTA)   NCBI Sequence Viewer  
  XP_038302859 (Get FASTA)   NCBI Sequence Viewer  
  XP_038302860 (Get FASTA)   NCBI Sequence Viewer  
  XP_038319343 (Get FASTA)   NCBI Sequence Viewer  
  XP_038376933 (Get FASTA)   NCBI Sequence Viewer  
  XP_038376934 (Get FASTA)   NCBI Sequence Viewer  
  XP_038376935 (Get FASTA)   NCBI Sequence Viewer  
  XP_038376936 (Get FASTA)   NCBI Sequence Viewer  
  XP_038440626 (Get FASTA)   NCBI Sequence Viewer  
  XP_038440627 (Get FASTA)   NCBI Sequence Viewer  
  XP_038440628 (Get FASTA)   NCBI Sequence Viewer  
  XP_038440629 (Get FASTA)   NCBI Sequence Viewer  
  XP_038505044 (Get FASTA)   NCBI Sequence Viewer  
  XP_038505045 (Get FASTA)   NCBI Sequence Viewer  
  XP_038505046 (Get FASTA)   NCBI Sequence Viewer  
  XP_038505047 (Get FASTA)   NCBI Sequence Viewer  
  XP_535939 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCAFP00000016416.4
  ENSCAFP00000057716.1
  ENSCAFP00000064030.1
  ENSCAFP00000071967.1
  ENSCAFP00030031168.1
  ENSCAFP00030031312.1
  ENSCAFP00030031346.1
  ENSCAFP00040039572.1
  ENSCAFP00040039625.1
  ENSCAFP00040039642.1
  ENSCAFP00845022818
  ENSCAFP00845022818.1
  ENSCAFP00845022905.1
  ENSCAFP00845022975.1
  ENSCAFP00845023077.1
Reference Protein Sequences
RefSeq Acc Id: XP_013966299   ⟸   XM_014110824
- Peptide Label: isoform X1
- UniProtKB: A0A8C0TTQ7 (UniProtKB/TrEMBL),   A0A8I3NWP9 (UniProtKB/TrEMBL),   A0A8I3NV34 (UniProtKB/TrEMBL),   A0A8P0TFJ4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_535939   ⟸   XM_535939
- Peptide Label: isoform X1
- UniProtKB: A0A8C0TTQ7 (UniProtKB/TrEMBL),   A0A8I3NWP9 (UniProtKB/TrEMBL),   A0A8I3NV34 (UniProtKB/TrEMBL),   A0A8P0TFJ4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_022270450   ⟸   XM_022414742
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: ENSCAFP00000057716   ⟸   ENSCAFT00000068896
RefSeq Acc Id: ENSCAFP00000064030   ⟸   ENSCAFT00000073386
RefSeq Acc Id: ENSCAFP00000048736   ⟸   ENSCAFT00000068235
RefSeq Acc Id: ENSCAFP00000016416   ⟸   ENSCAFT00000017733
RefSeq Acc Id: XP_038376933   ⟸   XM_038521005
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038376934   ⟸   XM_038521006
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038376935   ⟸   XM_038521007
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038376936   ⟸   XM_038521008
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038505044   ⟸   XM_038649116
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038505045   ⟸   XM_038649117
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038505046   ⟸   XM_038649118
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038505047   ⟸   XM_038649119
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038302857   ⟸   XM_038446929
- Peptide Label: isoform X1
- UniProtKB: A0A8C0TTQ7 (UniProtKB/TrEMBL),   A0A8I3NWP9 (UniProtKB/TrEMBL),   A0A8I3NV34 (UniProtKB/TrEMBL),   A0A8P0TFJ4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038302858   ⟸   XM_038446930
- Peptide Label: isoform X1
- UniProtKB: A0A8C0TTQ7 (UniProtKB/TrEMBL),   A0A8I3NWP9 (UniProtKB/TrEMBL),   A0A8I3NV34 (UniProtKB/TrEMBL),   A0A8P0TFJ4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038302859   ⟸   XM_038446931
- Peptide Label: isoform X2
- UniProtKB: A0A8I3NV34 (UniProtKB/TrEMBL),   A0A8P0TFJ4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038302860   ⟸   XM_038446932
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038319343   ⟸   XM_038463415
- Peptide Label: isoform X2
- UniProtKB: A0A8I3NV34 (UniProtKB/TrEMBL),   A0A8P0TFJ4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038440626   ⟸   XM_038584698
- Peptide Label: isoform X1
- UniProtKB: A0A8C0TTQ7 (UniProtKB/TrEMBL),   A0A8I3NV34 (UniProtKB/TrEMBL),   A0A8I3NWP9 (UniProtKB/TrEMBL),   A0A8P0TFJ4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038440627   ⟸   XM_038584699
- Peptide Label: isoform X1
- UniProtKB: A0A8C0TTQ7 (UniProtKB/TrEMBL),   A0A8I3NV34 (UniProtKB/TrEMBL),   A0A8I3NWP9 (UniProtKB/TrEMBL),   A0A8P0TFJ4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038440628   ⟸   XM_038584700
- Peptide Label: isoform X2
- UniProtKB: A0A8I3NV34 (UniProtKB/TrEMBL),   A0A8P0TFJ4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038440629   ⟸   XM_038584701
- Peptide Label: isoform X3
RefSeq Acc Id: ENSCAFP00845022818   ⟸   ENSCAFT00845029009
RefSeq Acc Id: ENSCAFP00845023077   ⟸   ENSCAFT00845029357
RefSeq Acc Id: ENSCAFP00845022975   ⟸   ENSCAFT00845029212
RefSeq Acc Id: ENSCAFP00845022905   ⟸   ENSCAFT00845029123
Protein Domains
Ion transport   Sodium ion transport-associated   Voltage-gated Na+ ion channel cytoplasmic


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000011130 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030019437 UniProtKB/TrEMBL
  ENSCAFG00040024312 UniProtKB/TrEMBL
  ENSCAFG00845016291 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000017733.6 UniProtKB/TrEMBL
  ENSCAFT00000068896.2 UniProtKB/TrEMBL
  ENSCAFT00000073386.2 UniProtKB/TrEMBL
  ENSCAFT00000109002.1 UniProtKB/TrEMBL
  ENSCAFT00030035737.1 UniProtKB/TrEMBL
  ENSCAFT00030035904.1 UniProtKB/TrEMBL
  ENSCAFT00030035940.1 UniProtKB/TrEMBL
  ENSCAFT00040045316.1 UniProtKB/TrEMBL
  ENSCAFT00040045375.1 UniProtKB/TrEMBL
  ENSCAFT00040045394.1 UniProtKB/TrEMBL
  ENSCAFT00845029009 ENTREZGENE
  ENSCAFT00845029009.1 UniProtKB/TrEMBL
  ENSCAFT00845029123.1 UniProtKB/TrEMBL
  ENSCAFT00845029212.1 UniProtKB/TrEMBL
  ENSCAFT00845029357.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.70 UniProtKB/TrEMBL
  1.20.120.350 UniProtKB/TrEMBL
  EF-hand UniProtKB/TrEMBL
  iswi atpase UniProtKB/TrEMBL
InterPro Ion_trans_dom UniProtKB/TrEMBL
  IQ_motif_EF-hand-BS UniProtKB/TrEMBL
  Na_channel_asu UniProtKB/TrEMBL
  Na_chnl_inactivation_gate UniProtKB/TrEMBL
  Na_trans_assoc UniProtKB/TrEMBL
  Na_trans_cytopl UniProtKB/TrEMBL
  VGCC_Ca_Na UniProtKB/TrEMBL
  Volt_channel_dom_sf UniProtKB/TrEMBL
KEGG Report cfa:478773 UniProtKB/TrEMBL
NCBI Gene LOC478773 ENTREZGENE
PANTHER PTHR10037 UniProtKB/TrEMBL
  SODIUM CHANNEL PROTEIN TYPE 2 SUBUNIT ALPHA UniProtKB/TrEMBL
Pfam Ion_trans UniProtKB/TrEMBL
  Na_trans_assoc UniProtKB/TrEMBL
  Na_trans_cytopl UniProtKB/TrEMBL
PRINTS NACHANNEL UniProtKB/TrEMBL
PROSITE PS50096 UniProtKB/TrEMBL
SMART SM00015 UniProtKB/TrEMBL
Superfamily-SCOP Voltage-gated potassium channels UniProtKB/TrEMBL
UniProt A0A8C0TQ61_CANLF UniProtKB/TrEMBL
  A0A8C0TTQ7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0Z634_CANLF UniProtKB/TrEMBL
  A0A8I3NQG4_CANLF UniProtKB/TrEMBL
  A0A8I3NV34 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3NWP9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3S265_CANLF UniProtKB/TrEMBL
  A0A8P0PMS0_CANLF UniProtKB/TrEMBL
  A0A8P0TFJ4 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:53105 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-02-27 SCN2A  sodium voltage-gated channel alpha subunit 2  LOC478773  sodium channel protein type 2 subunit alpha  Symbol and/or name change 5135510 APPROVED