Scn2a (sodium channel, voltage-gated, type II, alpha) - Rat Genome Database

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Gene: Scn2a (sodium channel, voltage-gated, type II, alpha) Mus musculus
Analyze
Symbol: Scn2a
Name: sodium channel, voltage-gated, type II, alpha
RGD ID: 1621393
MGI Page MGI
Description: Exhibits voltage-gated sodium channel activity. Involved in several processes, including intrinsic apoptotic signaling pathway in response to osmotic stress; memory; and sodium ion transmembrane transport. Localizes to several cellular components, including T-tubule; integral component of presynaptic membrane; and paranode region of axon. Is expressed in brain; heart; sciatic nerve; sympathetic ganglion; and telencephalon. Human ortholog(s) of this gene implicated in benign familial neonatal epilepsy; developmental and epileptic encephalopathy 11; and episodic ataxia. Orthologous to human SCN2A (sodium voltage-gated channel alpha subunit 2).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 6430408L10; A230052E19Rik; Nav; Nav1.2; Scn; Scn2a1; sodium channel protein type 2 subunit alpha; sodium channel, voltage-gated, type II, alpha 1; sodium channel, voltage-gated, type II, alpha polypeptide 1; voltage-gated sodium channel Nav1.2 variant a; voltage-gated sodium channel Nav1.2 variant b; voltage-gated sodium channel subunit alpha Nav1.2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39265,451,108 - 65,597,791 (+)NCBIGRCm39mm39
GRCm39 Ensembl265,451,115 - 65,597,791 (+)Ensembl
GRCm38265,620,764 - 65,767,447 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl265,620,771 - 65,767,447 (+)EnsemblGRCm38mm10GRCm38
MGSCv37265,508,502 - 65,605,504 (+)NCBIGRCm37mm9NCBIm37
MGSCv36265,471,335 - 65,568,290 (+)NCBImm8
Celera267,347,826 - 67,445,379 (+)NCBICelera
Cytogenetic Map2C1.3NCBI
cM Map238.61NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

Additional References at PubMed
PMID:1376448   PMID:1679748   PMID:2571571   PMID:8000136   PMID:8094302   PMID:8169823   PMID:8268655   PMID:8751373   PMID:8812438   PMID:8974318   PMID:9726281   PMID:9806833  
PMID:10349636   PMID:10827969   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:14973256   PMID:15123669   PMID:15746173   PMID:15760941   PMID:15907476   PMID:16033895  
PMID:16141072   PMID:16141073   PMID:16245025   PMID:16723544   PMID:17513486   PMID:17537961   PMID:17544618   PMID:17724025   PMID:17804618   PMID:17928448   PMID:18031550   PMID:18601978  
PMID:18799693   PMID:19284629   PMID:19743470   PMID:20956790   PMID:21156207   PMID:21267068   PMID:21339379   PMID:21873635   PMID:22528969   PMID:23652591   PMID:23735284   PMID:24077057  
PMID:25203314   PMID:25378553   PMID:27325115   PMID:28334922   PMID:28734032   PMID:28784306   PMID:29867081   PMID:29991598   PMID:30125271   PMID:30175250   PMID:30962870   PMID:31015467  
PMID:31230762   PMID:31249508   PMID:31501495  


Genomics

Comparative Map Data
Scn2a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39265,451,108 - 65,597,791 (+)NCBIGRCm39mm39
GRCm39 Ensembl265,451,115 - 65,597,791 (+)Ensembl
GRCm38265,620,764 - 65,767,447 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl265,620,771 - 65,767,447 (+)EnsemblGRCm38mm10GRCm38
MGSCv37265,508,502 - 65,605,504 (+)NCBIGRCm37mm9NCBIm37
MGSCv36265,471,335 - 65,568,290 (+)NCBImm8
Celera267,347,826 - 67,445,379 (+)NCBICelera
Cytogenetic Map2C1.3NCBI
cM Map238.61NCBI
SCN2A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2165,194,993 - 165,392,310 (+)EnsemblGRCh38hg38GRCh38
GRCh382165,208,056 - 165,392,310 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372166,095,924 - 166,248,814 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362165,804,158 - 165,957,066 (+)NCBINCBI36hg18NCBI36
Build 342165,976,098 - 166,072,046NCBI
Celera2159,706,512 - 159,859,384 (+)NCBI
Cytogenetic Map2q24.3NCBI
HuRef2157,978,323 - 158,131,089 (+)NCBIHuRef
CHM1_12166,101,845 - 166,254,789 (+)NCBICHM1_1
Scn2a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2350,302,781 - 50,437,504 (+)NCBI
Rnor_6.0 Ensembl351,687,809 - 51,822,250 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0351,687,910 - 51,822,008 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0358,322,640 - 58,456,658 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4347,588,413 - 47,722,800 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1347,484,784 - 47,619,172 (+)NCBI
Celera349,896,043 - 50,030,402 (+)NCBICelera
RH 3.4 Map3613.5RGD
Cytogenetic Map3q21NCBI
Scn2a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554498,721,784 - 8,846,200 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554498,722,043 - 8,846,165 (-)NCBIChiLan1.0ChiLan1.0
SCN2A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12B169,873,992 - 170,026,392 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B169,928,323 - 170,027,509 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02B52,514,918 - 52,667,225 (+)NCBIMhudiblu_PPA_v0panPan3
SCN2A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13610,472,496 - 10,605,055 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3610,472,361 - 10,602,685 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3610,615,273 - 10,749,736 (+)NCBI
ROS_Cfam_1.03610,604,046 - 10,738,882 (+)NCBI
UMICH_Zoey_3.13610,686,329 - 10,820,763 (+)NCBI
UNSW_CanFamBas_1.03610,658,084 - 10,792,902 (+)NCBI
UU_Cfam_GSD_1.03610,770,872 - 10,905,712 (+)NCBI
Scn2a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303127,536,296 - 127,745,013 (+)NCBI
SpeTri2.0NW_00493646913,872,701 - 14,019,170 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LOC100515171
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1571,864,739 - 71,999,212 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11571,864,753 - 71,999,219 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21580,349,224 - 80,429,339 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SCN2A
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11050,717,264 - 50,886,079 (+)NCBI
ChlSab1.1 Ensembl1050,717,271 - 50,888,145 (+)Ensembl
Vero_WHO_p1.0NW_023666040148,625,514 - 148,788,747 (-)NCBI

Position Markers
Scn1a  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map15F1UniSTS
Cytogenetic Map2C1.3UniSTS
cM Map1164.0UniSTS
cM Map236.0UniSTS
cM Map1560.0UniSTS
cM Map236.0UniSTS
Scn2a1   No map positions available.
Scn3a  
Mouse AssemblyChrPosition (strand)SourceJBrowse
cM Map970.0UniSTS
D2Kyo1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map2C1.3UniSTS
cM Map236.0UniSTS
Scn1a  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map2C1.3UniSTS
cM Map236.0UniSTS
Scn1a  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map2C1.3UniSTS
Scn2a1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map2C1.3UniSTS
Scn2a1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map2C1.3UniSTS
Scn3a  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map9F3-F4UniSTS
Cytogenetic Map2C1.3UniSTS
cM Map970.0UniSTS
Scn1a  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11E1UniSTS
Cytogenetic Map2C1.3UniSTS
Scn1a  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map2C1.3UniSTS
Cytogenetic Map15F1UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301769Orgwq2_morgan weight QTL 2 (mouse)Not determined2388608993591306Mouse
8552707Cia23_mcollagen induced arthritis QTL 23 (mouse)Not determined21212472666726109Mouse
1357454Kidq1_mkidney weight QTL 1 (mouse)Not determined220892967119064359Mouse
1357436Splq1_mspleen weight QTL 1 (mouse)Not determined220892967119064359Mouse
1357829Lvrq1_mliver weight QTL 1 (mouse)Not determined220892967119064359Mouse
1558899Egq1_mearly growth QTL 1 (mouse)Not determined220892967119064359Mouse
1558738W6q1_mweight 6 weeks QTL 1 (mouse)Not determined220892967119064359Mouse
1558966W10q9_mweight 10 weeks QTL 9 (mouse)Not determined220892967119064359Mouse
1558915W3q1_mweight 3 weeks QTL 1 (mouse)Not determined220892967119064359Mouse
1357681Hrtq1_mheart weight QTL 1 (mouse)Not determined220892967119064359Mouse
1357881Estoq1_membryo survival total QTL 1 (mouse)Not determined220892967119064359Mouse
39128209Lwq14_mliver weight QTL 14 (mouse)220892967119064359Mouse
1302174Dssc2_mdextran sodium sulfate induced colitis QTL2 (mouse)Not determined224334620148858457Mouse
1300577Capsq1_mcapsaicin sensitivity related QTL 1 (mouse)Not determined22771204884183040Mouse
4141854T2dm2sa_mtype 2 diabetes mellitus 2 in SMXA RI mice (mouse)Not determined229417935148533014Mouse
4141236Hbnr5_mHeligmosomoides bakeri nematode resistance 5 (mouse)Not determined31324555105313225Mouse
4142447Pbwg1.7_mpostnatal body weight growth 1.7 (mouse)Not determined3590731269907394Mouse
4141186Pbwg1.8_mpostnatal body weight growth 1.8 (mouse)Not determined3590731269907394Mouse
4142133Pbwg1.6_mpostnatal body weight growth 1.6 (mouse)Not determined3590731269907394Mouse
1559001Eae33_mexperimental allergic encephalomyelitis susceptibility 33 (mouse)Not determined23610166771779068Mouse
10449145Lanq1_mlanosterol level QTL 1 (mouse)23823971367242263Mouse
10449150Pvldlc1_mplasma VLDL-cholesterol 1 (mouse)23823971367242263Mouse
10449151Hdl8_mhigh density lipoprotein (HDL) level 8 (mouse)23823971367242263Mouse
11038703Ltpr1_mLeishmania tropica response 1 (mouse)24008165374081799Mouse
1301109Dntcs2_mdental caries susceptibility 2 (mouse)Not determined240995481115079684Mouse
1301480Pbwg1_mpostnatal body weight growth 1 (mouse)Not determined24193070775930831Mouse
1301411Pitm1_mprion incubation time 1 (mouse)Not determined24369026877690412Mouse
4141069Pbwg1.5_mpostnatal body weight growth 1.5 (mouse)Not determined4369026877690412Mouse
1301402Ap2q_malcohol preference 2 QTL (mouse)Not determined24369026877690412Mouse
1300788Cia2_mcollagen induced arthritis QTL 2 (mouse)Not determined24369026877690412Mouse
1300671Cia4_mcollagen induced arthritis QTL 4 (mouse)Not determined24369026877690412Mouse
10755532Lymph5_mlymphocyte differential 5 (mouse)24436867378368673Mouse
1300645Alcp1_malcohol preference locus 1 (mouse)Not determined24533811668008524Mouse
1301344Lith1_mlithogenic gene 1 (mouse)Not determined245457623145470727Mouse
4141809Pbwg1.1_mpostnatal body weight growth 1.1 (mouse)Not determined4830206882302151Mouse
11532740Pbwg1.10_mpostnatal body weight growth 1.10 (mouse)24830206882302151Mouse
1301235Alcw4_malcohol withdrawal 4 (mouse)Not determined24843940282439590Mouse
1301747Eae21_mexperimental allergic encephalomyelitis 21 (mouse)Not determined24843940282439590Mouse
1302085Mobe1_mmodifier of obesity 1 (mouse)Not determined24843940282439590Mouse
1300568Hdl1_mhigh density lipoprotein (HDL) level 1 (mouse)Not determined24843940282439590Mouse
1558820Moo1_mmodifier of Odc1 (mouse)Not determined174843940282439590Mouse
10755526Lymph1_mlymphocyte differential 1 (mouse)25098897084988970Mouse
1300875Taste1_mtaste-saccharin preference 1 (mouse)Not determined25109283185092934Mouse
1300761Lgth1_mbody length 1 (mouse)Not determined25187293285873081Mouse
13464141Hbbcq3_mhemoglobin concentration QTL 3 (mouse)25261767586617792Mouse
13463471Hctq6_mhematocrit QTL 6 (mouse)25261767586617792Mouse
4142299Pbwg1.4_mpostnatal body weight growth 1.4 (mouse)Not determined5562407289624172Mouse
4141406Alpq2_malcohol preference QTL 2 (mouse)Not determined25769377391693944Mouse
12738429Lfibq18_mliver fibrosis QTL 18 (mouse)25808964792089647Mouse
1357577Trmq3_mT cell ratio modifier QTL 3 (mouse)Not determined260690268119525037Mouse
13824983Vclq1_mcurvilinear velocity QTL 1 (mouse)262000000137000000Mouse
1300662Etohila_methanol induced locomotor activity (mouse)Not determined26317561097175769Mouse
1301405Etohr_methanol response acute (mouse)Not determined26317561097175769Mouse
1301703Bomd3_mbone mineral density 3 (mouse)Not determined26317561097175769Mouse
10044002Hdl7_mHDL level 7 (mouse)Not determined26317561097175769Mouse
10053681Lith24_mlithogenic gene 24 (mouse)Not determined26317561097175769Mouse
1301048Actre2_mactivity response to ethanol 2 (mouse)Not determined26317561097175769Mouse
1301873Hsl1_mhyperoxia susceptibility locus 1 (mouse)Not determined26373981097739957Mouse
13506939Pbwg1.12_mpostnatal body weight growth 1.12 (mouse)26530206868873081Mouse
5491197Mobq5_mmultigenic obesity QTL 5 (mouse)Not determined265439402162677006Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1668
Count of miRNA genes:481
Interacting mature miRNAs:605
Transcripts:ENSMUST00000028377, ENSMUST00000100067, ENSMUST00000138368, ENSMUST00000144254
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001099298 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001346679 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001346680 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006498583 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017314945 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AJ810516 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK032187 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK038645 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK082598 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK089150 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK143234 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL772235 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AM905319 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX284648 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ993534 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ993535 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KM373687 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KM373688 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L42336 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L42341 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000028377   ⟹   ENSMUSP00000028377
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl265,620,771 - 65,767,447 (+)Ensembl
RefSeq Acc Id: ENSMUST00000100067   ⟹   ENSMUSP00000097645
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl265,670,445 - 65,767,447 (+)Ensembl
RefSeq Acc Id: ENSMUST00000138368
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl265,682,280 - 65,683,866 (+)Ensembl
RefSeq Acc Id: ENSMUST00000144254   ⟹   ENSMUSP00000117955
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl265,620,771 - 65,690,175 (+)Ensembl
RefSeq Acc Id: ENSMUST00000200829   ⟹   ENSMUSP00000143882
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl265,668,765 - 65,765,055 (+)Ensembl
RefSeq Acc Id: ENSMUST00000201378
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl265,620,811 - 65,623,264 (+)Ensembl
RefSeq Acc Id: ENSMUST00000202162   ⟹   ENSMUSP00000143888
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl265,717,576 - 65,728,392 (+)Ensembl
RefSeq Acc Id: ENSMUST00000202508   ⟹   ENSMUSP00000143958
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl265,717,553 - 65,728,441 (+)Ensembl
RefSeq Acc Id: ENSMUST00000202653
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl265,668,686 - 65,671,797 (+)Ensembl
RefSeq Acc Id: ENSMUST00000239325   ⟹   ENSMUSP00000159244
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl265,683,759 - 65,715,745 (+)Ensembl
RefSeq Acc Id: NM_001099298   ⟹   NP_001092768
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39265,499,030 - 65,597,791 (+)NCBI
GRCm38265,668,686 - 65,767,447 (+)NCBI
MGSCv37265,508,502 - 65,605,504 (+)RGD
Celera267,347,826 - 67,445,379 (+)RGD
cM Map2 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001346679   ⟹   NP_001333608
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39265,451,113 - 65,597,791 (+)NCBI
GRCm38265,620,769 - 65,767,447 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001346680   ⟹   NP_001333609
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39265,499,030 - 65,597,791 (+)NCBI
GRCm38265,668,686 - 65,767,447 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006498583   ⟹   XP_006498646
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39265,512,389 - 65,597,533 (+)NCBI
GRCm38265,682,105 - 65,767,189 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017314945   ⟹   XP_017170434
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39265,451,108 - 65,597,533 (+)NCBI
GRCm38265,620,764 - 65,767,189 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001092768   ⟸   NM_001099298
- Peptide Label: isoform 1
- UniProtKB: B1AWN6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006498646   ⟸   XM_006498583
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_017170434   ⟸   XM_017314945
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: NP_001333608   ⟸   NM_001346679
- Peptide Label: isoform 2
- UniProtKB: A0A0J9YTW6 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001333609   ⟸   NM_001346680
- Peptide Label: isoform 3
- UniProtKB: A0A0J9YTW6 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSMUSP00000117955   ⟸   ENSMUST00000144254
RefSeq Acc Id: ENSMUSP00000143958   ⟸   ENSMUST00000202508
RefSeq Acc Id: ENSMUSP00000143888   ⟸   ENSMUST00000202162
RefSeq Acc Id: ENSMUSP00000159244   ⟸   ENSMUST00000239325
RefSeq Acc Id: ENSMUSP00000028377   ⟸   ENSMUST00000028377
RefSeq Acc Id: ENSMUSP00000097645   ⟸   ENSMUST00000100067
RefSeq Acc Id: ENSMUSP00000143882   ⟸   ENSMUST00000200829
Protein Domains
Ion_trans   IQ   Na_trans_assoc   Na_trans_cytopl

Promoters
RGD ID:6832654
Promoter ID:MM_KWN:29457
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain
Transcripts:NM_001099298
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36265,507,891 - 65,508,391 (+)MPROMDB
RGD ID:6832656
Promoter ID:MM_KWN:29459
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain
Transcripts:OTTMUST00000031208
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36265,519,341 - 65,519,841 (+)MPROMDB
RGD ID:6877452
Promoter ID:EPDNEW_M2177
Type:initiation region
Name:Scn2a_1
Description:Mus musculus sodium channel, voltage-gated, type II, alpha ,transcript variant 3, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38265,668,738 - 65,668,798EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:98248 AgrOrtholog
Ensembl Genes ENSMUSG00000075318 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000028377 UniProtKB/Swiss-Prot
  ENSMUSP00000097645 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000117955 UniProtKB/TrEMBL
  ENSMUSP00000143882 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUSP00000143888 UniProtKB/TrEMBL
  ENSMUSP00000143958 UniProtKB/TrEMBL
  ENSMUSP00000159244 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000028377 UniProtKB/Swiss-Prot
  ENSMUST00000100067 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000144254 UniProtKB/TrEMBL
  ENSMUST00000200829 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUST00000202162 UniProtKB/TrEMBL
  ENSMUST00000202508 UniProtKB/TrEMBL
  ENSMUST00000239325 UniProtKB/TrEMBL
Gene3D-CATH 1.20.120.350 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Ion_trans_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IQ_motif_EF-hand-BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Na_channel_asu UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Na_chnl_inactivation_gate UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Na_trans_assoc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Na_trans_cytopl UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VGCC_Ca_Na UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Volt_channel_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:110876 UniProtKB/Swiss-Prot
MGD MGI:98248 ENTREZGENE
NCBI Gene 110876 ENTREZGENE
PANTHER PTHR10037 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Ion_trans UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Na_trans_assoc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Na_trans_cytopl UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB SCN2A RGD
PhenoGen Scn2a PhenoGen
PRINTS NACHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE PS50096 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART SM00015 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0J9YTW6 ENTREZGENE
  A0A0J9YTX0_MOUSE UniProtKB/TrEMBL
  A0A0R5RP28_MOUSE UniProtKB/TrEMBL
  A0A0R5RP29_MOUSE UniProtKB/TrEMBL
  A0A5H1ZRM8_MOUSE UniProtKB/TrEMBL
  A0A668KM74_MOUSE UniProtKB/TrEMBL
  A9JQD3_MOUSE UniProtKB/TrEMBL
  B1AWN6 ENTREZGENE
  F7AMU5_MOUSE UniProtKB/TrEMBL
  Q62242_MOUSE UniProtKB/TrEMBL
  Q68V27_MOUSE UniProtKB/TrEMBL
  Q8C274_MOUSE UniProtKB/TrEMBL
  Q8CAJ8_MOUSE UniProtKB/TrEMBL
  Q8CCS4_MOUSE UniProtKB/TrEMBL
  SCN2A_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary A0A0J9YTW6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-09-02 Scn2a  sodium channel, voltage-gated, type II, alpha  Scn2a1  sodium channel, voltage-gated, type II, alpha 1  Symbol and/or name change 5135510 APPROVED