GKN1 (gastrokine 1) - Rat Genome Database

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Gene: GKN1 (gastrokine 1) Canis lupus familiaris
Analyze
Symbol: GKN1
Name: gastrokine 1
RGD ID: 12135324
Description: ENCODES a protein that exhibits growth factor activity (inferred); INVOLVED IN positive regulation of cell population proliferation (inferred); signal transduction (inferred); ASSOCIATED WITH adenocarcinoma (ortholog); ovarian cyst (ortholog); Stomach Neoplasms (ortholog); FOUND IN extracellular region (inferred); secretory granule (inferred); INTERACTS WITH masitinib
Type: protein-coding
RefSeq Status: MODEL
Previously known as: gastrokine-1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11067,788,329 - 67,793,445 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1067,788,110 - 67,793,589 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1067,677,625 - 67,682,902 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01068,810,000 - 68,815,276 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1068,809,829 - 68,815,215 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11068,491,450 - 68,496,462 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01068,792,706 - 68,797,978 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01069,087,881 - 69,092,894 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
GKN1Dogadenocarcinoma  ISOGKN1 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:15378696
GKN1Dogovarian cyst  ISOGKN1 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:21239663
GKN1DogStomach Neoplasms  ISOGKN1 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:15378696


  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
GKN1Dogmasitinib increases expressionEXP 6480464masitinib results in increased expression of GKN1 mRNACTDPMID:22747577


Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
GKN1Dogpositive regulation of cell population proliferation acts_upstream_of_or_withinIEAUniProtKB:Q9CR36 and ensembl:ENSMUSP00000032129150520179 EnsemblGO_REF:0000107
GKN1Dogregulation of cell population proliferation involved_inIBAMGI:1913533 more ...150520179 GO_CentralGO_REF:0000033
GKN1Dogsignal transduction involved_inIEAGO:0008083150520179 GOCGO_REF:0000108

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
GKN1Dogextracellular region located_inIEAUniProtKB:Q9NS71 and ensembl:ENSP00000367172150520179 EnsemblGO_REF:0000107
GKN1Dogextracellular space is_active_inIBAMGI:1916138 and PANTHER:PTN001046815150520179 GO_CentralGO_REF:0000033
GKN1Dogsecretory granule located_inIEAUniProtKB:Q9CR36 and ensembl:ENSMUSP00000032129150520179 EnsemblGO_REF:0000107

Molecular Function

  

PMID:30032202  



GKN1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11067,788,329 - 67,793,445 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1067,788,110 - 67,793,589 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1067,677,625 - 67,682,902 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01068,810,000 - 68,815,276 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1068,809,829 - 68,815,215 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11068,491,450 - 68,496,462 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01068,792,706 - 68,797,978 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01069,087,881 - 69,092,894 (+)NCBIUU_Cfam_GSD_1.0
GKN1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38268,974,636 - 68,980,976 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl268,974,573 - 68,980,980 (+)EnsemblGRCh38hg38GRCh38
GRCh37269,201,768 - 69,208,108 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36269,055,209 - 69,061,616 (+)NCBINCBI36Build 36hg18NCBI36
Build 34269,113,417 - 69,119,763NCBI
Celera269,052,436 - 69,058,843 (+)NCBICelera
Cytogenetic Map2p13.3NCBI
HuRef268,937,927 - 68,944,334 (+)NCBIHuRef
CHM1_1269,131,023 - 69,137,429 (+)NCBICHM1_1
T2T-CHM13v2.0268,987,051 - 68,993,391 (+)NCBIT2T-CHM13v2.0
Gkn1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39687,322,635 - 87,327,897 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl687,322,632 - 87,327,924 (-)EnsemblGRCm39 Ensembl
GRCm38687,345,653 - 87,350,915 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl687,345,650 - 87,350,942 (-)EnsemblGRCm38mm10GRCm38
MGSCv37687,295,647 - 87,300,909 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36687,311,287 - 87,316,549 (-)NCBIMGSCv36mm8
Celera689,284,666 - 89,289,929 (-)NCBICelera
Cytogenetic Map6D1NCBI
cM Map637.96NCBI
Gkn1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84121,347,417 - 121,352,705 (-)NCBIGRCr8
mRatBN7.24119,790,101 - 119,795,389 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4119,790,101 - 119,795,389 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4125,261,663 - 125,267,030 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04121,036,416 - 121,041,783 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04119,660,661 - 119,666,028 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04119,143,070 - 119,148,358 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4119,143,070 - 119,148,358 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04183,711,680 - 183,717,243 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44121,496,151 - 121,501,439 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14121,740,631 - 121,745,920 (-)NCBI
Celera4108,760,377 - 108,765,665 (-)NCBICelera
Cytogenetic Map4q34NCBI
Gkn1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542416,046,662 - 16,049,687 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542416,046,662 - 16,051,235 (-)NCBIChiLan1.0ChiLan1.0
GKN1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21257,434,605 - 57,478,862 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A57,438,553 - 57,444,940 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A69,015,692 - 69,022,155 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A70,137,447 - 70,143,918 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A70,137,447 - 70,144,040 (+)Ensemblpanpan1.1panPan2
Gkn1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629215,306,926 - 15,312,244 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649113,259,073 - 13,264,213 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649113,259,073 - 13,264,213 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GKN1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl373,420,359 - 73,426,592 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1373,420,359 - 73,426,472 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2376,861,574 - 76,867,686 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GKN1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11438,145,076 - 38,291,187 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1438,145,559 - 38,152,126 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604573,838,684 - 73,847,183 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

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Variants in GKN1
95 total Variants



adipose tissue
alimentary part of gastrointestinal system
ectoderm
endocrine system
endoderm
hemolymphoid system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
3 1 10 5 6 6 2 8 7 7 2 6



Ensembl Acc Id: ENSCAFT00000005245   ⟹   ENSCAFP00000004854
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1067,788,110 - 67,793,589 (+)Ensembl
Ensembl Acc Id: ENSCAFT00000074190   ⟹   ENSCAFP00000050663
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1067,788,110 - 67,793,589 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845042410   ⟹   ENSCAFP00845033250
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1068,809,829 - 68,815,215 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845042464   ⟹   ENSCAFP00845033288
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1068,809,829 - 68,815,215 (+)Ensembl
RefSeq Acc Id: XM_005626250   ⟹   XP_005626307
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11067,788,329 - 67,793,445 (+)NCBI
Dog10K_Boxer_Tasha1067,677,625 - 67,682,902 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038489646   ⟹   XP_038345574
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11068,491,450 - 68,496,462 (+)NCBI
RefSeq Acc Id: XM_038549548   ⟹   XP_038405476
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01069,087,881 - 69,092,894 (+)NCBI
RefSeq Acc Id: XM_038615423   ⟹   XP_038471351
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01068,792,706 - 68,797,978 (+)NCBI
RefSeq Acc Id: XM_038680814   ⟹   XP_038536742
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01068,810,000 - 68,815,276 (+)NCBI
1 to 10 of 10 rows
Protein RefSeqs XP_005626307 (Get FASTA)   NCBI Sequence Viewer  
  XP_038345574 (Get FASTA)   NCBI Sequence Viewer  
  XP_038405476 (Get FASTA)   NCBI Sequence Viewer  
  XP_038471351 (Get FASTA)   NCBI Sequence Viewer  
  XP_038536742 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCAFP00000004854.4
  ENSCAFP00000050663.2
  ENSCAFP00845033250.1
  ENSCAFP00845033288
  ENSCAFP00845033288.1
1 to 10 of 10 rows
RefSeq Acc Id: XP_005626307   ⟸   XM_005626250
- UniProtKB: A0A8I3PKG9 (UniProtKB/TrEMBL),   A0A8P0N661 (UniProtKB/TrEMBL),   A0A8C0JFX9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCAFP00000004854   ⟸   ENSCAFT00000005245
Ensembl Acc Id: ENSCAFP00000050663   ⟸   ENSCAFT00000074190
RefSeq Acc Id: XP_038345574   ⟸   XM_038489646
RefSeq Acc Id: XP_038471351   ⟸   XM_038615423
BRICHOS

RGD ID:13685100
Promoter ID:EPDNEW_C3168
Type:multiple initiation site
Name:GKN1_1
Description:gastrokine 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11067,788,425 - 67,788,485EPDNEW


1 to 22 of 22 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSCAFG00000003275 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00845024000 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000005245.5 UniProtKB/TrEMBL
  ENSCAFT00000074190.2 UniProtKB/TrEMBL
  ENSCAFT00845042410.1 UniProtKB/TrEMBL
  ENSCAFT00845042464 ENTREZGENE
  ENSCAFT00845042464.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.390.150 UniProtKB/TrEMBL
InterPro BRICHOS_dom UniProtKB/TrEMBL
  Gastrokine UniProtKB/TrEMBL
KEGG Report cfa:612599 UniProtKB/TrEMBL
NCBI Gene GKN1 ENTREZGENE
PANTHER GASTROKINE 1 UniProtKB/TrEMBL
Pfam BRICHOS UniProtKB/TrEMBL
PROSITE BRICHOS UniProtKB/TrEMBL
SMART BRICHOS UniProtKB/TrEMBL
UniProt A0A8C0JFX9 ENTREZGENE
  A0A8I3PKG9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3PQC0_CANLF UniProtKB/TrEMBL
  A0A8P0N661 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0T3B3_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:41246 ENTREZGENE
1 to 22 of 22 rows