GKN1 (gastrokine-1) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: GKN1 (gastrokine-1) Pan paniscus
Analyze
Symbol: GKN1
Name: gastrokine-1 (Ensembl:gastrokine 1)
RGD ID: 11974721
Description: ENCODES a protein that exhibits growth factor activity (inferred); INVOLVED IN positive regulation of cell population proliferation (ortholog); ASSOCIATED WITH adenocarcinoma (ortholog); genetic disease (ortholog); ovarian cyst (ortholog); FOUND IN extracellular region (inferred); extracellular space (inferred); secretory granule (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: gastrokine 1; LOC100993461
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21257,434,605 - 57,478,862 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A57,438,553 - 57,444,940 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A69,015,692 - 69,022,155 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A70,137,447 - 70,143,918 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A70,137,447 - 70,144,040 (+)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
GKN1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21257,434,605 - 57,478,862 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A57,438,553 - 57,444,940 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A69,015,692 - 69,022,155 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A70,137,447 - 70,143,918 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A70,137,447 - 70,144,040 (+)Ensemblpanpan1.1panPan2
GKN1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38268,974,636 - 68,980,976 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl268,974,573 - 68,980,980 (+)EnsemblGRCh38hg38GRCh38
GRCh37269,201,768 - 69,208,108 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36269,055,209 - 69,061,616 (+)NCBINCBI36Build 36hg18NCBI36
Build 34269,113,417 - 69,119,763NCBI
Celera269,052,436 - 69,058,843 (+)NCBICelera
Cytogenetic Map2p13.3NCBI
HuRef268,937,927 - 68,944,334 (+)NCBIHuRef
CHM1_1269,131,023 - 69,137,429 (+)NCBICHM1_1
T2T-CHM13v2.0268,987,051 - 68,993,391 (+)NCBIT2T-CHM13v2.0
Gkn1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39687,322,635 - 87,327,897 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl687,322,632 - 87,327,924 (-)EnsemblGRCm39 Ensembl
GRCm38687,345,653 - 87,350,915 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl687,345,650 - 87,350,942 (-)EnsemblGRCm38mm10GRCm38
MGSCv37687,295,647 - 87,300,909 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36687,311,287 - 87,316,549 (-)NCBIMGSCv36mm8
Celera689,284,666 - 89,289,929 (-)NCBICelera
Cytogenetic Map6D1NCBI
cM Map637.96NCBI
Gkn1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84121,347,417 - 121,352,705 (-)NCBIGRCr8
mRatBN7.24119,790,101 - 119,795,389 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4119,790,101 - 119,795,389 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4125,261,663 - 125,267,030 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04121,036,416 - 121,041,783 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04119,660,661 - 119,666,028 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04119,143,070 - 119,148,358 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4119,143,070 - 119,148,358 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04183,711,680 - 183,717,243 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44121,496,151 - 121,501,439 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14121,740,631 - 121,745,920 (-)NCBI
Celera4108,760,377 - 108,765,665 (-)NCBICelera
Cytogenetic Map4q34NCBI
Gkn1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542416,046,662 - 16,049,687 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542416,046,662 - 16,051,235 (-)NCBIChiLan1.0ChiLan1.0
GKN1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11067,788,329 - 67,793,445 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1067,788,110 - 67,793,589 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1067,677,625 - 67,682,902 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01068,810,000 - 68,815,276 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1068,809,829 - 68,815,215 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11068,491,450 - 68,496,462 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01068,792,706 - 68,797,978 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01069,087,881 - 69,092,894 (+)NCBIUU_Cfam_GSD_1.0
Gkn1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629215,306,926 - 15,312,244 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649113,259,073 - 13,264,213 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649113,259,073 - 13,264,213 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GKN1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl373,420,359 - 73,426,592 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1373,420,359 - 73,426,472 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2376,861,574 - 76,867,686 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GKN1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11438,145,076 - 38,291,187 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1438,145,559 - 38,152,126 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604573,838,684 - 73,847,183 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000048383   ⟹   ENSPPAP00000025555
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl2A70,137,447 - 70,144,040 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000048389   ⟹   ENSPPAP00000025561
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl2A70,140,045 - 70,143,765 (+)Ensembl
RefSeq Acc Id: XM_003830924   ⟹   XP_003830972
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21257,434,719 - 57,440,983 (-)NCBI
NHGRI_mPanPan12A57,438,553 - 57,444,940 (-)NCBI
Mhudiblu_PPA_v02A69,015,692 - 69,022,155 (+)NCBI
PanPan1.12A70,137,447 - 70,143,918 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063595071   ⟹   XP_063451141
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21257,434,605 - 57,478,862 (-)NCBI
Protein Sequences
Protein RefSeqs XP_003830972 (Get FASTA)   NCBI Sequence Viewer  
  XP_063451141 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000025555
  ENSPPAP00000025555.1
  ENSPPAP00000025561.1
Reference Protein Sequences
RefSeq Acc Id: XP_003830972   ⟸   XM_003830924
- Peptide Label: isoform X2
- UniProtKB: A0A2R9BBA6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSPPAP00000025555   ⟸   ENSPPAT00000048383
RefSeq Acc Id: ENSPPAP00000025561   ⟸   ENSPPAT00000048389
RefSeq Acc Id: XP_063451141   ⟸   XM_063595071
- Peptide Label: isoform X1
Protein Domains
BRICHOS


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000035903 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000048383.1 UniProtKB/TrEMBL
  ENSPPAT00000048389.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.390.150 UniProtKB/TrEMBL
InterPro BRICHOS_dom UniProtKB/TrEMBL
NCBI Gene GKN1 ENTREZGENE
PANTHER GASTROKINE 1 UniProtKB/TrEMBL
  GASTROKINE-1 UniProtKB/TrEMBL
Pfam BRICHOS UniProtKB/TrEMBL
PROSITE BRICHOS UniProtKB/TrEMBL
SMART BRICHOS UniProtKB/TrEMBL
UniProt A0A2R9B8Z5_PANPA UniProtKB/TrEMBL
  A0A2R9BBA6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2024-03-13 GKN1  gastrokine-1  GKN1  gastrokine 1  Symbol and/or name change 5135510 APPROVED
2023-04-25 GKN1  gastrokine 1  GKN1  gastrokine-1  Symbol and/or name change 5135510 APPROVED
2022-05-10 GKN1  gastrokine-1  LOC100993461  gastrokine-1  Symbol and/or name change 5135510 APPROVED
2018-05-08 LOC100993461  gastrokine-1  GKN1  gastrokine 1  Symbol and/or name change 5135510 APPROVED