Gkn1 (gastrokine 1) - Rat Genome Database

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Gene: Gkn1 (gastrokine 1) Mus musculus
Analyze
Symbol: Gkn1
Name: gastrokine 1
RGD ID: 1549983
MGI Page MGI
Description: Enables growth factor activity. Acts upstream of or within positive regulation of cell population proliferation. Located in secretory granule. Is expressed in several structures, including aorta; gut; quadriceps femoris muscle; reproductive system; and sciatic nerve. Orthologous to human GKN1 (gastrokine 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 18 kDa antrum mucosa protein; 2200002K21Rik; AMP-; AMP-18; BRIC; BRICD1; Fov; foveolin; gastrokine-1; protein CA11 homolog
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39687,322,635 - 87,327,897 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl687,322,632 - 87,327,924 (-)EnsemblGRCm39 Ensembl
GRCm38687,345,653 - 87,350,915 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl687,345,650 - 87,350,942 (-)EnsemblGRCm38mm10GRCm38
MGSCv37687,295,647 - 87,300,909 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36687,311,287 - 87,316,549 (-)NCBIMGSCv36mm8
Celera689,284,666 - 89,289,929 (-)NCBICelera
Cytogenetic Map6D1NCBI
cM Map637.96NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2. A novel mitogenic protein that is highly expressed in cells of the gastric antrum mucosa. Martin TE, etal., Am J Physiol Gastrointest Liver Physiol 2003 Aug;285(2):G332-43.
3. MGDs mouse GO annotations MGD data from the GO Consortium
4. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
5. Mouse MP Annotation Import Pipeline RGD automated import pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:12477932   PMID:16141072   PMID:16141073   PMID:17277741   PMID:18558092   PMID:21873635   PMID:24194600   PMID:25919700   PMID:27626380  
PMID:33947892   PMID:35082384   PMID:38355793  


Genomics

Comparative Map Data
Gkn1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39687,322,635 - 87,327,897 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl687,322,632 - 87,327,924 (-)EnsemblGRCm39 Ensembl
GRCm38687,345,653 - 87,350,915 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl687,345,650 - 87,350,942 (-)EnsemblGRCm38mm10GRCm38
MGSCv37687,295,647 - 87,300,909 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36687,311,287 - 87,316,549 (-)NCBIMGSCv36mm8
Celera689,284,666 - 89,289,929 (-)NCBICelera
Cytogenetic Map6D1NCBI
cM Map637.96NCBI
GKN1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38268,974,636 - 68,980,976 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl268,974,573 - 68,980,980 (+)EnsemblGRCh38hg38GRCh38
GRCh37269,201,768 - 69,208,108 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36269,055,209 - 69,061,616 (+)NCBINCBI36Build 36hg18NCBI36
Build 34269,113,417 - 69,119,763NCBI
Celera269,052,436 - 69,058,843 (+)NCBICelera
Cytogenetic Map2p13.3NCBI
HuRef268,937,927 - 68,944,334 (+)NCBIHuRef
CHM1_1269,131,023 - 69,137,429 (+)NCBICHM1_1
T2T-CHM13v2.0268,987,051 - 68,993,391 (+)NCBIT2T-CHM13v2.0
Gkn1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84121,347,417 - 121,352,705 (-)NCBIGRCr8
mRatBN7.24119,790,101 - 119,795,389 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4119,790,101 - 119,795,389 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4125,261,663 - 125,267,030 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04121,036,416 - 121,041,783 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04119,660,661 - 119,666,028 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04119,143,070 - 119,148,358 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4119,143,070 - 119,148,358 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04183,711,680 - 183,717,243 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44121,496,151 - 121,501,439 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14121,740,631 - 121,745,920 (-)NCBI
Celera4108,760,377 - 108,765,665 (-)NCBICelera
Cytogenetic Map4q34NCBI
Gkn1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542416,046,662 - 16,049,687 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542416,046,662 - 16,051,235 (-)NCBIChiLan1.0ChiLan1.0
GKN1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21257,434,605 - 57,478,862 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A57,438,553 - 57,444,940 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A69,015,692 - 69,022,155 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A70,137,447 - 70,143,918 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A70,137,447 - 70,144,040 (+)Ensemblpanpan1.1panPan2
GKN1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11067,788,329 - 67,793,445 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1067,788,110 - 67,793,589 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1067,677,625 - 67,682,902 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01068,810,000 - 68,815,276 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1068,809,829 - 68,815,215 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11068,491,450 - 68,496,462 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01068,792,706 - 68,797,978 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01069,087,881 - 69,092,894 (+)NCBIUU_Cfam_GSD_1.0
Gkn1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629215,306,926 - 15,312,244 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649113,259,073 - 13,264,213 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649113,259,073 - 13,264,213 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GKN1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl373,420,359 - 73,426,592 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1373,420,359 - 73,426,472 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2376,861,574 - 76,867,686 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GKN1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11438,145,076 - 38,291,187 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1438,145,559 - 38,152,126 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604573,838,684 - 73,847,183 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Gkn1
341 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:204
Count of miRNA genes:165
Interacting mature miRNAs:183
Transcripts:ENSMUST00000032129
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4142271Egq8_mearly growth QTL 8 (mouse)Not determined450382396633110Mouse
10043864T2dm4sa_mtype 2 diabetes mellitus 4 in SMXA RI mice (mouse)Not determined683690851146954059Mouse
1301521Pas1c_mpulmonary adenoma susceptibility 1c (mouse)Not determined671958006105958152Mouse
14697704Stsl4_mSalmonella typhimurium susceptibility locus 4 (mouse)67707698389976982Mouse
10412119Stv_mstriatal volumne (mouse)Not determined660026991100026967Mouse
1300954Fcsa1_mfemoral cross-sectional area 1 (mouse)Not determined671958006105958152Mouse
13824985Alh1_mamplitude of lateral head displacement 1 (mouse)67797698396976961Mouse
4142259Tabw2_mtally ho associated body weight 2 (mouse)Not determined46912919136400690Mouse
25314319Histh6_mhistamine hypersensitivity 6 (mouse)648696934125336963Mouse
12792979Fbmd2_mfemoral bone mineral density 2, females only (mouse)675026989115026943Mouse
1301571Arrd1_mage-related retinal degeneration 1 (mouse)Not determined67552133992584431Mouse
4142126W3q3_mweight 3 weeks QTL 3 (mouse)Not determined450382396633110Mouse
1300674Nidd3n_mnon-insulin-dependent diabetes mellitus 3 in NSY (mouse)Not determined67552133994202936Mouse
25314320Histh5_mhistamine hypersensitivity 5 (mouse)648696934148351498Mouse
1558977Skmw10_mskeletal muscle weight 10 (mouse)Not determined65842456692424693Mouse
1300869Stheal5_msoft tissue heal 5 (mouse)Not determined671552042105552160Mouse
1302020Bbaa20_mB.burgdorferi-associated arthritis 20 (mouse)Not determined67129960593441074Mouse
1300618Pgia19_mproteoglycan induced arthritis 19 (mouse)Not determined64529099387403016Mouse
1301962Eila2_methanol induced locomotor activity 2 (mouse)Not determined648703490125333748Mouse
4141028Mclr_mmethylcholanthrene lymphoma resistance (mouse)Not determined5435041188356155Mouse
1301320Ots1_movarian teratoma susceptibility 1 (mouse)Not determined675424566104480516Mouse
10043972Obq28_mobesity QTL 28 (mouse)Not determined65851741692517416Mouse
1300556Cia6_mcollagen induced arthritis QTL 6 (mouse)Not determined6446488487403016Mouse
1558984Cplaq9_mcircadian period of locomotor activity 9 (mouse)Not determined63864656092584431Mouse
10412157Fl1n_mfatty liver 1 in NSY (mouse)Not determined645290993128811995Mouse
11251720Ewc4_methanol withdrawal and consumption 4 (mouse)684099474118099474Mouse
25440480Moaq2_mmodifier of alien QTL 2 (mouse)63050001117476961Mouse
26884414Bzwq12_mbi-zygomatic width QTL 12, 16 week (mouse)63400000139076998Mouse
10043901Pfat5_mpredicted fat percentage 5 (mouse)Not determined675584287109584431Mouse
1301687Mnic2_mmacronutrient intake (mouse)Not determined686783787113521563Mouse
4142361W10q11_mweight 10 weeks QTL 11 (mouse)Not determined450382396633110Mouse
1301813Skl3_mskeletal size (tail length) 3 (mouse)Not determined670402880104403016Mouse
4142232W6q4_mweight 6 weeks QTL 4 (mouse)Not determined450382396633110Mouse
1357683Igf1sl1_mIGF-1 serum levels 1 (mouse)Not determined652138693116132228Mouse
1301876Bits2_mbitterness sensitivity 2 (mouse)Not determined670402880104403016Mouse
1357875Pfat2_mpredicted fat percentage 2 (mouse)Not determined676440930110441074Mouse
15039373Adip28_madiposity 28 (mouse)65628519490285194Mouse
15039375Bw41_mbody weight QTL 41 (mouse)65628519490285194Mouse
1301369Im4_mimmunoregulatory 4 (mouse)Not determined66346172197461888Mouse
10412208Cypr4_mcytokine production 4 (mouse)Not determined675693484109693678Mouse
1300650Bw18_mbody weight QTL 18 (mouse)Not determined666690851100691013Mouse
1301034Egrm2_mearly growth rate (mouse)Not determined670402880104403016Mouse
14696731Pairq1_mP. aeruginosa infection resistance QTL 1 (mouse)681476981102176961Mouse
13506930Recrq9_mrecombination rate in male meiosis QTL 9 (mouse)673476983134676963Mouse
10412195Efw_mepididymal fat weight (mouse)Not determined67552133994202936Mouse
1301740Bwq2_mbody weight QTL 2 (mouse)Not determined66003466394034782Mouse
4141376Dbm1_mdiabetes modifier 1 (mouse)Not determined678606487121092347Mouse


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_025466 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC153853 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK008622 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK008640 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK008641 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK008647 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK008722 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK008745 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK008933 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK008956 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK008990 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK009145 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK019050 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK028136 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY139183 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY456960 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC099446 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC132540 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC132542 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466523 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000032129   ⟹   ENSMUSP00000032129
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl687,322,632 - 87,327,924 (-)Ensembl
GRCm38.p6 Ensembl687,345,650 - 87,350,942 (-)Ensembl
RefSeq Acc Id: NM_025466   ⟹   NP_079742
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39687,322,635 - 87,327,897 (-)NCBI
GRCm38687,345,653 - 87,350,915 (-)ENTREZGENE
MGSCv37687,295,647 - 87,300,909 (-)RGD
Celera689,284,666 - 89,289,929 (-)RGD
cM Map6 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_079742   ⟸   NM_025466
- Peptide Label: precursor
- UniProtKB: Q9CTZ5 (UniProtKB/Swiss-Prot),   Q9D7K7 (UniProtKB/Swiss-Prot),   Q9CR36 (UniProtKB/Swiss-Prot),   Q53YU8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000032129   ⟸   ENSMUST00000032129
Protein Domains
BRICHOS

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9CR36-F1-model_v2 AlphaFold Q9CR36 1-184 view protein structure

Promoters
RGD ID:6890322
Promoter ID:EPDNEW_M8612
Type:multiple initiation site
Name:Gkn1_1
Description:Mus musculus gastrokine 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38687,350,911 - 87,350,971EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1913533 AgrOrtholog
Ensembl Genes ENSMUSG00000030050 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000032129 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUST00000032129.3 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.390.150 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro BRICHOS_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Gastrokine UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:66283 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1913533 ENTREZGENE
NCBI Gene 66283 ENTREZGENE
PANTHER GASTROKINE 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam BRICHOS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Gkn1 PhenoGen
PROSITE BRICHOS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART BRICHOS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt GKN1_MOUSE UniProtKB/Swiss-Prot
  Q53YU8 ENTREZGENE, UniProtKB/TrEMBL
  Q9CR36 ENTREZGENE
  Q9CTZ5 ENTREZGENE
  Q9D7K7 ENTREZGENE
UniProt Secondary Q9CTZ5 UniProtKB/Swiss-Prot
  Q9D7K7 UniProtKB/Swiss-Prot