GKN1 (gastrokine 1) - Rat Genome Database

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Gene: GKN1 (gastrokine 1) Sus scrofa
Analyze
Symbol: GKN1
Name: gastrokine 1
RGD ID: 13884561
Description: ENCODES a protein that exhibits growth factor activity (inferred); INVOLVED IN positive regulation of cell population proliferation (ortholog); ASSOCIATED WITH adenocarcinoma (ortholog); genetic disease (ortholog); ovarian cyst (ortholog); FOUND IN extracellular region (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 18 kDa antrum mucosa protein; AMP-18; AMP18; gastrokine-1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl373,420,359 - 73,426,592 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1373,420,359 - 73,426,472 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2376,861,574 - 76,867,686 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:12851218   PMID:30032202  


Genomics

Comparative Map Data
GKN1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl373,420,359 - 73,426,592 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1373,420,359 - 73,426,472 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2376,861,574 - 76,867,686 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GKN1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38268,974,636 - 68,980,976 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl268,974,573 - 68,980,980 (+)EnsemblGRCh38hg38GRCh38
GRCh37269,201,768 - 69,208,108 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36269,055,209 - 69,061,616 (+)NCBINCBI36Build 36hg18NCBI36
Build 34269,113,417 - 69,119,763NCBI
Celera269,052,436 - 69,058,843 (+)NCBICelera
Cytogenetic Map2p13.3NCBI
HuRef268,937,927 - 68,944,334 (+)NCBIHuRef
CHM1_1269,131,023 - 69,137,429 (+)NCBICHM1_1
T2T-CHM13v2.0268,987,051 - 68,993,391 (+)NCBIT2T-CHM13v2.0
Gkn1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39687,322,635 - 87,327,897 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl687,322,632 - 87,327,924 (-)EnsemblGRCm39 Ensembl
GRCm38687,345,653 - 87,350,915 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl687,345,650 - 87,350,942 (-)EnsemblGRCm38mm10GRCm38
MGSCv37687,295,647 - 87,300,909 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36687,311,287 - 87,316,549 (-)NCBIMGSCv36mm8
Celera689,284,666 - 89,289,929 (-)NCBICelera
Cytogenetic Map6D1NCBI
cM Map637.96NCBI
Gkn1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84121,347,417 - 121,352,705 (-)NCBIGRCr8
mRatBN7.24119,790,101 - 119,795,389 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4119,790,101 - 119,795,389 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4125,261,663 - 125,267,030 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04121,036,416 - 121,041,783 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04119,660,661 - 119,666,028 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04119,143,070 - 119,148,358 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4119,143,070 - 119,148,358 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04183,711,680 - 183,717,243 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44121,496,151 - 121,501,439 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14121,740,631 - 121,745,920 (-)NCBI
Celera4108,760,377 - 108,765,665 (-)NCBICelera
Cytogenetic Map4q34NCBI
Gkn1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542416,046,662 - 16,049,687 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542416,046,662 - 16,051,235 (-)NCBIChiLan1.0ChiLan1.0
GKN1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21257,434,605 - 57,478,862 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A57,438,553 - 57,444,940 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A69,015,692 - 69,022,155 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A70,137,447 - 70,143,918 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A70,137,447 - 70,144,040 (+)Ensemblpanpan1.1panPan2
GKN1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11067,788,329 - 67,793,445 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1067,788,110 - 67,793,589 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1067,677,625 - 67,682,902 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01068,810,000 - 68,815,276 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1068,809,829 - 68,815,215 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11068,491,450 - 68,496,462 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01068,792,706 - 68,797,978 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01069,087,881 - 69,092,894 (+)NCBIUU_Cfam_GSD_1.0
Gkn1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629215,306,926 - 15,312,244 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649113,259,073 - 13,264,213 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649113,259,073 - 13,264,213 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GKN1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11438,145,076 - 38,291,187 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1438,145,559 - 38,152,126 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604573,838,684 - 73,847,183 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in GKN1
86 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 3
Low 2 3 2 4 2 2 2 1 1
Below cutoff 1 1 1 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000026236   ⟹   ENSSSCP00000021568
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl373,420,359 - 73,426,592 (-)Ensembl
RefSeq Acc Id: NM_001195779   ⟹   NP_001182708
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1373,420,359 - 73,426,472 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_001182708   ⟸   NM_001195779
- Peptide Label: precursor
- UniProtKB: Q8HYA9 (UniProtKB/Swiss-Prot),   A0A8D1HUD6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000021568   ⟸   ENSSSCT00000026236
Protein Domains
BRICHOS


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000035529 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00005041747 UniProtKB/TrEMBL
  ENSSSCG00015064440 UniProtKB/Swiss-Prot
  ENSSSCG00025039204 UniProtKB/Swiss-Prot
  ENSSSCG00030032415 UniProtKB/Swiss-Prot
  ENSSSCG00035061301 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSSSCG00040016461 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSSSCG00045018774 UniProtKB/TrEMBL
  ENSSSCG00050038456 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSSSCG00055014920 UniProtKB/Swiss-Prot
  ENSSSCG00060030827 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSSSCG00065016859 UniProtKB/Swiss-Prot
  ENSSSCG00070029929 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000026236 ENTREZGENE
  ENSSSCT00000026236.4 UniProtKB/TrEMBL
  ENSSSCT00005066928.1 UniProtKB/TrEMBL
  ENSSSCT00015086283.1 UniProtKB/Swiss-Prot
  ENSSSCT00025053252.1 UniProtKB/Swiss-Prot
  ENSSSCT00030044818.1 UniProtKB/Swiss-Prot
  ENSSSCT00035082342.1 UniProtKB/TrEMBL
  ENSSSCT00035082356.1 UniProtKB/Swiss-Prot
  ENSSSCT00040022126.1 UniProtKB/TrEMBL
  ENSSSCT00040022153.1 UniProtKB/Swiss-Prot
  ENSSSCT00045031959.1 UniProtKB/TrEMBL
  ENSSSCT00045032024.1 UniProtKB/TrEMBL
  ENSSSCT00050051869.1 UniProtKB/TrEMBL
  ENSSSCT00050051879.1 UniProtKB/Swiss-Prot
  ENSSSCT00055029418.1 UniProtKB/Swiss-Prot
  ENSSSCT00060041663.1 UniProtKB/TrEMBL
  ENSSSCT00060041674.1 UniProtKB/Swiss-Prot
  ENSSSCT00065022377.1 UniProtKB/Swiss-Prot
  ENSSSCT00070060136.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.390.150 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro BRICHOS_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report ssc:100502561 UniProtKB/Swiss-Prot
NCBI Gene GKN1 ENTREZGENE
PANTHER GASTROKINE 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GASTROKINE-1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam BRICHOS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE BRICHOS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART BRICHOS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8D1HUD6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1V0X6_PIG UniProtKB/TrEMBL
  A0A8I8JIU3_PIG UniProtKB/TrEMBL
  GKN1_PIG UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary A0A8Q9BHK6 UniProtKB/TrEMBL
VGNC ID VGNC:88472 ENTREZGENE