APOA4 (apolipoprotein A4) - Rat Genome Database

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Gene: APOA4 (apolipoprotein A4) Canis lupus familiaris
Analyze
Symbol: APOA4
Name: apolipoprotein A4
RGD ID: 12130431
Description: ENCODES a protein that exhibits antioxidant activity (inferred); cholesterol transfer activity (inferred); copper ion binding (inferred); INVOLVED IN peripheral nervous system axon regeneration (ortholog); positive regulation of CoA-transferase activity (ortholog); positive regulation of lipoprotein lipase activity (ortholog); PARTICIPATES IN altered lipoprotein metabolic pathway; lipoprotein metabolic pathway; ASSOCIATED WITH Alzheimer's disease (ortholog); anemia (ortholog); atherosclerosis (ortholog); FOUND IN chylomicron (ortholog); synapse (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: Apo-AIV; ApoA-IV; apolipoprotein A-IV
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1516,751,588 - 16,754,215 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl516,751,799 - 16,754,837 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha516,803,839 - 16,806,395 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0516,698,167 - 16,700,719 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl516,698,240 - 16,701,326 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1516,835,250 - 16,837,800 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0516,737,834 - 16,740,384 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0516,780,743 - 16,783,293 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Alzheimer's disease  (ISO)
anemia  (ISO)
atherosclerosis  (ISO)
cardiovascular system disease  (ISO)
CD3epsilon deficiency  (ISO)
Chemically-Induced Disorders  (ISO)
chromosome 11 partial duplication syndrome  (ISO)
chronic kidney disease  (ISO)
Chronic Pancreatitis  (ISO)
colitis  (ISO)
Coronary Disease  (ISO)
Crohn's disease  (ISO)
diabetic retinopathy  (ISO)
Dwarfism  (ISO)
Experimental Arthritis  (ISO)
Experimental Liver Cirrhosis  (ISO)
Experimental Liver Neoplasms  (ISO)
Familial Pancreatic Carcinoma  (ISO)
glaucoma  (ISO)
graft-versus-host disease  (ISO)
Guillain-Barre syndrome  (ISO)
hepatocellular carcinoma  (ISO)
Huntington's disease  (ISO)
Hyperlipoproteinemia Type II  (ISO)
Hyperlipoproteinemias  (ISO)
Hypertriglyceridemia  (ISO)
immunodeficiency 17  (ISO)
immunodeficiency 18  (ISO)
immunodeficiency 19  (ISO)
Inflammation  (ISO)
inflammatory bowel disease 28  (ISO)
intellectual disability  (ISO)
intermediate coronary syndrome  (ISO)
Intervertebral Disc Displacement  (ISO)
isolated microphthalmia 5  (ISO)
Leber hereditary optic neuropathy  (ISO)
major depressive disorder  (ISO)
myocardial infarction  (ISO)
neovascular inflammatory vitreoretinopathy  (ISO)
nephronophthisis 15  (ISO)
Peripheral Nerve Injuries  (ISO)
peripheral nervous system disease  (ISO)
polyneuropathy  (ISO)
primary hypoalphalipoproteinemia 2  (ISO)
RASopathy  (ISO)
relapsing-remitting multiple sclerosis  (ISO)
retinal detachment  (ISO)
rheumatoid arthritis  (ISO)
schizophrenia  (ISO)
Seasonal Allergic Rhinitis  (ISO)
ulcerative colitis  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
APOA4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1516,751,588 - 16,754,215 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl516,751,799 - 16,754,837 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha516,803,839 - 16,806,395 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0516,698,167 - 16,700,719 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl516,698,240 - 16,701,326 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1516,835,250 - 16,837,800 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0516,737,834 - 16,740,384 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0516,780,743 - 16,783,293 (+)NCBIUU_Cfam_GSD_1.0
APOA4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811116,820,700 - 116,823,304 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11116,820,700 - 116,823,304 (-)EnsemblGRCh38hg38GRCh38
GRCh3711116,691,416 - 116,694,020 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611116,196,628 - 116,199,221 (-)NCBINCBI36Build 36hg18NCBI36
Build 3411116,196,628 - 116,199,162NCBI
Celera11113,849,234 - 113,851,827 (-)NCBICelera
Cytogenetic Map11q23.3NCBI
HuRef11112,623,690 - 112,626,283 (-)NCBIHuRef
CHM1_111116,576,178 - 116,578,767 (-)NCBICHM1_1
T2T-CHM13v2.011116,835,812 - 116,838,412 (-)NCBIT2T-CHM13v2.0
Apoa4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39946,152,142 - 46,154,756 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl946,151,994 - 46,154,757 (+)EnsemblGRCm39 Ensembl
GRCm38946,240,844 - 46,243,458 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl946,240,696 - 46,243,459 (+)EnsemblGRCm38mm10GRCm38
MGSCv37946,048,927 - 46,051,541 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36945,992,149 - 45,994,285 (+)NCBIMGSCv36mm8
Celera943,529,774 - 43,532,388 (+)NCBICelera
Cytogenetic Map9A5.2NCBI
cM Map925.36NCBI
Apoa4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8855,435,779 - 55,438,160 (+)NCBIGRCr8
mRatBN7.2846,539,083 - 46,541,464 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl846,539,082 - 46,541,469 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx852,040,348 - 52,042,728 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0850,319,122 - 50,321,502 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0848,183,398 - 48,185,778 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0850,536,983 - 50,539,371 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl850,537,009 - 50,539,376 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0849,163,055 - 49,165,333 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4849,233,142 - 49,233,431 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1849,245,005 - 49,245,297 (+)NCBI
Celera846,121,074 - 46,123,455 (+)NCBICelera
RH 3.4 Map8473.3RGD
Cytogenetic Map8q22NCBI
Apoa4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541218,155,801 - 18,160,701 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541218,158,095 - 18,160,636 (-)NCBIChiLan1.0ChiLan1.0
APOA4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v29117,524,912 - 117,527,516 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111118,630,121 - 118,632,725 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011111,659,186 - 111,661,790 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111115,591,788 - 115,594,382 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11115,591,788 - 115,594,382 (-)Ensemblpanpan1.1panPan2
Apoa4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494799,177,114 - 99,179,837 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365422,098,683 - 2,101,127 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365422,098,683 - 2,101,127 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
APOA4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl944,201,508 - 44,204,206 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1944,201,587 - 44,204,072 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2949,273,837 - 49,276,322 (-)NCBISscrofa10.2Sscrofa10.2susScr3
APOA4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11108,186,627 - 108,190,508 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1108,186,921 - 108,189,698 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604317,861,078 - 17,863,578 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Apoa4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478412,233,593 - 12,239,763 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478412,237,329 - 12,240,013 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in APOA4
29 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
3 2 1 18 14 6 6 2 6 5 17 9 8 11

Sequence


Ensembl Acc Id: ENSCAFT00000021121   ⟹   ENSCAFP00000019615
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl516,751,799 - 16,754,837 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845007736   ⟹   ENSCAFP00845006125
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl516,698,240 - 16,701,326 (+)Ensembl
RefSeq Acc Id: XM_038474927   ⟹   XP_038330855
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1516,835,250 - 16,837,800 (+)NCBI
RefSeq Acc Id: XM_038536054   ⟹   XP_038391982
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0516,780,743 - 16,783,293 (+)NCBI
RefSeq Acc Id: XM_038600247   ⟹   XP_038456175
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0516,737,834 - 16,740,384 (+)NCBI
RefSeq Acc Id: XM_038664797   ⟹   XP_038520725
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0516,698,167 - 16,700,719 (+)NCBI
RefSeq Acc Id: XM_546510   ⟹   XP_546510
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1516,751,588 - 16,754,215 (+)NCBI
Dog10K_Boxer_Tasha516,803,839 - 16,806,395 (+)NCBI
Sequence:
RefSeq Acc Id: XP_546510   ⟸   XM_546510
- UniProtKB: A0A8C0MIM6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCAFP00000019615   ⟸   ENSCAFT00000021121
RefSeq Acc Id: XP_038330855   ⟸   XM_038474927
RefSeq Acc Id: XP_038456175   ⟸   XM_038600247
RefSeq Acc Id: XP_038520725   ⟸   XM_038664797
- UniProtKB: A0A8C0MIM6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038391982   ⟸   XM_038536054
- UniProtKB: A0A8C0MIM6 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCAFP00845006125   ⟸   ENSCAFT00845007736

Promoters
RGD ID:13683143
Promoter ID:EPDNEW_C1213
Type:single initiation site
Name:APOA4_1
Description:Apolipoprotein A-IV
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1516,751,700 - 16,751,760EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000013306 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030006178 UniProtKB/TrEMBL
  ENSCAFG00040002864 UniProtKB/TrEMBL
  ENSCAFG00845004295 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000021121.5 UniProtKB/TrEMBL
  ENSCAFT00030011362.1 UniProtKB/TrEMBL
  ENSCAFT00040005447.1 UniProtKB/TrEMBL
  ENSCAFT00845007736 ENTREZGENE
  ENSCAFT00845007736.1 UniProtKB/TrEMBL
Gene3D-CATH 6.10.250.2890 UniProtKB/Swiss-Prot
  Apolipoprotein UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ApoA_E UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Apolipoprotein_A1/A4/E UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report cfa:489392 UniProtKB/TrEMBL
NCBI Gene APOA4 ENTREZGENE
PANTHER APOLIPOPROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  APOLIPOPROTEIN A-IV UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Apolipoprotein UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Apolipoprotein UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Apolipoprotein A-I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8C0MIM6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3MKL7_CANLF UniProtKB/TrEMBL
  A0A8P0SHW2_CANLF UniProtKB/TrEMBL
  APOA4_CANLF UniProtKB/Swiss-Prot, ENTREZGENE
VGNC ID VGNC:53263 ENTREZGENE