Symbol: |
LIPA |
Name: |
lipase A, lysosomal acid type |
RGD ID: |
12099706 |
Description: |
ENCODES a protein that exhibits lipase activity (ortholog); sterol ester esterase activity (ortholog); INVOLVED IN acute inflammatory response (ortholog); adaptive thermogenesis (ortholog); adipose tissue development (ortholog); PARTICIPATES IN alendronate pharmacodynamics pathway; bile acid biosynthetic pathway; cerebrotendinous xanthomatosis pathway; ASSOCIATED WITH autoimmune lymphoproliferative syndrome (ortholog); cholesterol ester storage disease (ortholog); coronary artery disease (ortholog); FOUND IN cytosol (ortholog); fibrillar center (ortholog); intracellular membrane-bounded organelle (ortholog) |
Type: |
protein-coding
|
RefSeq Status: |
MODEL |
Previously known as: |
lipase A, lysosomal acid, cholesterol esterase (Wolman disease); lysosomal acid lipase/cholesteryl ester hydrolase |
RGD Orthologs |
|
Alliance Orthologs |
|
More Info |
more info ...
|
More Info |
Species |
Gene symbol and name |
Data Source |
Assertion derived from |
less info ...
|
Orthologs 1 |
Homo sapiens (human): |
LIPA (lipase A, lysosomal acid type) |
HGNC |
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OrthoDB, OrthoMCL, Panther, Treefam |
Mus musculus (house mouse): |
Lipa (lysosomal acid lipase A) |
Transitive Ortholog Pipeline |
Transitive Ortholog Pipeline |
Rattus norvegicus (Norway rat): |
Lipa (lipase A, lysosomal acid type) |
Transitive Ortholog Pipeline |
Transitive Ortholog Pipeline |
Chinchilla lanigera (long-tailed chinchilla): |
Lipa (lipase A, lysosomal acid type) |
Transitive Ortholog Pipeline |
Transitive Ortholog Pipeline |
Pan paniscus (bonobo/pygmy chimpanzee): |
LIPA (lipase A, lysosomal acid type) |
Transitive Ortholog Pipeline |
Transitive Ortholog Pipeline |
Sus scrofa (pig): |
LIPA (lipase A, lysosomal acid type) |
Transitive Ortholog Pipeline |
Transitive Ortholog Pipeline |
Chlorocebus sabaeus (green monkey): |
LIPA (lipase A, lysosomal acid type) |
Transitive Ortholog Pipeline |
Transitive Ortholog Pipeline |
Heterocephalus glaber (naked mole-rat): |
Lipa (lipase A, lysosomal acid type) |
Transitive Ortholog Pipeline |
Transitive Ortholog Pipeline |
|
Latest Assembly: |
CanFam3.1 - Dog CanFam3.1 Assembly |
Position: |
Dog Assembly | Chr | Position (strand) | Source | Genome Browsers |
---|
JBrowse | NCBI | UCSC | Ensembl |
---|
CanFam3.1 | 26 | 38,892,771 - 38,918,441 (-) | NCBI | CanFam3.1 | CanFam3.1 | canFam3 | CanFam3.1 | CanFam3.1 Ensembl | 26 | 38,893,337 - 38,918,436 (-) | Ensembl | CanFam3.1 | | canFam3 | CanFam3.1 | Dog10K_Boxer_Tasha | 26 | 38,643,855 - 38,671,678 (-) | NCBI | | Dog10K_Boxer_Tasha | | | ROS_Cfam_1.0 | 26 | 40,476,944 - 40,504,767 (-) | NCBI | | ROS_Cfam_1.0 | | | ROS_Cfam_1.0 Ensembl | 26 | 40,476,940 - 40,505,350 (-) | Ensembl | | ROS_Cfam_1.0 Ensembl | | | UMICH_Zoey_3.1 | 26 | 38,347,241 - 38,375,054 (-) | NCBI | | UMICH_Zoey_3.1 | | | UNSW_CanFamBas_1.0 | 26 | 37,910,947 - 37,938,676 (-) | NCBI | | UNSW_CanFamBas_1.0 | | | UU_Cfam_GSD_1.0 | 26 | 39,180,692 - 39,208,434 (-) | NCBI | | UU_Cfam_GSD_1.0 | | |
|
JBrowse: |
View Region in Genome Browser (JBrowse)
|
Model |
|
Imported Annotations - SMPDB
LIPA (Canis lupus familiaris - dog) |
Dog Assembly | Chr | Position (strand) | Source | Genome Browsers |
---|
JBrowse | NCBI | UCSC | Ensembl |
---|
CanFam3.1 | 26 | 38,892,771 - 38,918,441 (-) | NCBI | CanFam3.1 | CanFam3.1 | canFam3 | CanFam3.1 | CanFam3.1 Ensembl | 26 | 38,893,337 - 38,918,436 (-) | Ensembl | CanFam3.1 | | canFam3 | CanFam3.1 | Dog10K_Boxer_Tasha | 26 | 38,643,855 - 38,671,678 (-) | NCBI | | Dog10K_Boxer_Tasha | | | ROS_Cfam_1.0 | 26 | 40,476,944 - 40,504,767 (-) | NCBI | | ROS_Cfam_1.0 | | | ROS_Cfam_1.0 Ensembl | 26 | 40,476,940 - 40,505,350 (-) | Ensembl | | ROS_Cfam_1.0 Ensembl | | | UMICH_Zoey_3.1 | 26 | 38,347,241 - 38,375,054 (-) | NCBI | | UMICH_Zoey_3.1 | | | UNSW_CanFamBas_1.0 | 26 | 37,910,947 - 37,938,676 (-) | NCBI | | UNSW_CanFamBas_1.0 | | | UU_Cfam_GSD_1.0 | 26 | 39,180,692 - 39,208,434 (-) | NCBI | | UU_Cfam_GSD_1.0 | | |
|
LIPA (Homo sapiens - human) |
Human Assembly | Chr | Position (strand) | Source | Genome Browsers |
---|
JBrowse | NCBI | UCSC | Ensembl |
---|
GRCh38 | 10 | 89,213,572 - 89,251,775 (-) | NCBI | GRCh38 | GRCh38 | hg38 | GRCh38 | GRCh38.p14 Ensembl | 10 | 89,213,569 - 89,414,557 (-) | Ensembl | GRCh38 | | hg38 | GRCh38 | GRCh37 | 10 | 90,973,329 - 91,011,532 (-) | NCBI | GRCh37 | GRCh37 | hg19 | GRCh37 | Build 36 | 10 | 90,963,309 - 91,001,640 (-) | NCBI | NCBI36 | Build 36 | hg18 | NCBI36 | Build 34 | 10 | 90,963,308 - 91,001,640 | NCBI | | | | | Celera | 10 | 84,720,143 - 84,758,472 (-) | NCBI | | Celera | | | Cytogenetic Map | 10 | q23.31 | NCBI | | | | | HuRef | 10 | 84,607,788 - 84,646,145 (-) | NCBI | | HuRef | | | CHM1_1 | 10 | 91,255,383 - 91,293,719 (-) | NCBI | | CHM1_1 | | | T2T-CHM13v2.0 | 10 | 90,097,469 - 90,135,709 (-) | NCBI | | T2T-CHM13v2.0 | | |
|
Lipa (Mus musculus - house mouse) |
Mouse Assembly | Chr | Position (strand) | Source | Genome Browsers |
---|
JBrowse | NCBI | UCSC | Ensembl |
---|
GRCm39 | 19 | 34,469,716 - 34,504,874 (-) | NCBI | GRCm39 | GRCm39 | mm39 | | GRCm39 Ensembl | 19 | 34,469,718 - 34,504,874 (-) | Ensembl | | GRCm39 Ensembl | | | GRCm38 | 19 | 34,492,316 - 34,527,474 (-) | NCBI | GRCm38 | GRCm38 | mm10 | GRCm38 | GRCm38.p6 Ensembl | 19 | 34,492,318 - 34,527,474 (-) | Ensembl | GRCm38 | | mm10 | GRCm38 | MGSCv37 | 19 | 34,566,806 - 34,601,964 (-) | NCBI | GRCm37 | MGSCv37 | mm9 | NCBIm37 | MGSCv36 | 19 | 34,558,313 - 34,593,419 (-) | NCBI | | MGSCv36 | mm8 | | Celera | 19 | 35,267,889 - 35,303,040 (-) | NCBI | | Celera | | | Cytogenetic Map | 19 | C1 | NCBI | | | | | cM Map | 19 | 29.7 | NCBI | | | | |
|
Lipa (Rattus norvegicus - Norway rat) |
Rat Assembly | Chr | Position (strand) | Source | Genome Browsers |
---|
JBrowse | NCBI | UCSC | Ensembl |
---|
GRCr8 | 1 | 241,437,524 - 241,470,936 (-) | NCBI | | GRCr8 | | | mRatBN7.2 | 1 | 232,024,351 - 232,057,735 (-) | NCBI | mRatBN7.2 | mRatBN7.2 | | | mRatBN7.2 Ensembl | 1 | 232,024,356 - 232,057,633 (-) | Ensembl | | mRatBN7.2 Ensembl | | | UTH_Rnor_SHR_Utx | 1 | 240,414,292 - 240,447,547 (-) | NCBI | Rnor_SHR | UTH_Rnor_SHR_Utx | | | UTH_Rnor_SHRSP_BbbUtx_1.0 | 1 | 247,337,140 - 247,370,358 (-) | NCBI | Rnor_SHRSP | UTH_Rnor_SHRSP_BbbUtx_1.0 | | | UTH_Rnor_WKY_Bbb_1.0 | 1 | 240,175,338 - 240,208,560 (-) | NCBI | Rnor_WKY | UTH_Rnor_WKY_Bbb_1.0 | | | Rnor_6.0 | 1 | 252,816,536 - 252,959,348 (-) | NCBI | Rnor6.0 | Rnor_6.0 | rn6 | Rnor6.0 | Rnor_6.0 Ensembl | 1 | 252,816,527 - 252,849,904 (-) | Ensembl | Rnor6.0 | | rn6 | Rnor6.0 | Rnor_5.0 | 1 | 260,038,180 - 260,091,819 (-) | NCBI | Rnor5.0 | Rnor_5.0 | rn5 | Rnor5.0 | RGSC_v3.4 | 1 | 238,466,493 - 238,500,195 (-) | NCBI | RGSC3.4 | RGSC_v3.4 | rn4 | RGSC3.4 | RGSC_v3.1 | 1 | 238,630,381 - 238,664,124 (-) | NCBI | | | | | Celera | 1 | 229,136,934 - 229,170,119 (-) | NCBI | | Celera | | | Cytogenetic Map | 1 | q53 | NCBI | | | | |
|
Lipa (Chinchilla lanigera - long-tailed chinchilla) |
Chinchilla Assembly | Chr | Position (strand) | Source | Genome Browsers |
---|
JBrowse | NCBI | UCSC | Ensembl |
---|
ChiLan1.0 Ensembl | NW_004955425 | 3,718,206 - 3,756,142 (+) | Ensembl | ChiLan1.0 | | | | ChiLan1.0 | NW_004955425 | 3,718,291 - 3,755,942 (+) | NCBI | ChiLan1.0 | ChiLan1.0 | | |
|
LIPA (Pan paniscus - bonobo/pygmy chimpanzee) |
Bonobo Assembly | Chr | Position (strand) | Source | Genome Browsers |
---|
JBrowse | NCBI | UCSC | Ensembl |
---|
NHGRI_mPanPan1-v2 | 8 | 101,231,830 - 101,270,354 (-) | NCBI | | NHGRI_mPanPan1-v2 | | | NHGRI_mPanPan1 | 10 | 101,237,141 - 101,275,629 (-) | NCBI | | NHGRI_mPanPan1 | | | Mhudiblu_PPA_v0 | 10 | 85,938,240 - 85,976,610 (-) | NCBI | Mhudiblu_PPA_v0 | Mhudiblu_PPA_v0 | panPan3 | | PanPan1.1 | 10 | 89,478,502 - 89,516,580 (-) | NCBI | panpan1.1 | PanPan1.1 | panPan2 | | PanPan1.1 Ensembl | 10 | 89,477,082 - 89,516,874 (-) | Ensembl | panpan1.1 | | panPan2 | |
|
LIPA (Sus scrofa - pig) |
Pig Assembly | Chr | Position (strand) | Source | Genome Browsers |
---|
JBrowse | NCBI | UCSC | Ensembl |
---|
Sscrofa11.1 Ensembl | 14 | 101,126,257 - 101,193,614 (-) | Ensembl | Sscrofa11.1 | | susScr11 | Sscrofa11.1 | Sscrofa11.1 | 14 | 101,131,372 - 101,254,739 (-) | NCBI | Sscrofa11.1 | Sscrofa11.1 | susScr11 | Sscrofa11.1 | Sscrofa10.2 | 14 | 110,116,088 - 110,152,009 (-) | NCBI | Sscrofa10.2 | Sscrofa10.2 | susScr3 | |
|
LIPA (Chlorocebus sabaeus - green monkey) |
Green Monkey Assembly | Chr | Position (strand) | Source | Genome Browsers |
---|
JBrowse | NCBI | UCSC | Ensembl |
---|
ChlSab1.1 | 9 | 82,639,220 - 82,677,479 (-) | NCBI | ChlSab1.1 | ChlSab1.1 | chlSab2 | | ChlSab1.1 Ensembl | 9 | 82,638,621 - 82,677,488 (-) | Ensembl | ChlSab1.1 | ChlSab1.1 Ensembl | chlSab2 | | Vero_WHO_p1.0 | NW_023666048 | 43,315,133 - 43,353,408 (-) | NCBI | Vero_WHO_p1.0 | Vero_WHO_p1.0 | | |
|
Lipa (Heterocephalus glaber - naked mole-rat) |
|
.
|
alimentary part of gastrointestinal system
| | | | | | | | | | | | | |
6
|
5
|
5
|
23
|
22
|
16
|
6
|
6
|
6
|
6
|
33
|
22
|
12
|
14
|
10
|
Ensembl Acc Id: |
ENSCAFT00000024907 ⟹ ENSCAFP00000023110 |
Type: |
CODING |
Position: |
Dog Assembly | Chr | Position (strand) | Source |
---|
CanFam3.1 Ensembl | 26 | 38,893,337 - 38,916,913 (-) | Ensembl |
|
Ensembl Acc Id: |
ENSCAFT00000035174 ⟹ ENSCAFP00000030406 |
Type: |
CODING |
Position: |
Dog Assembly | Chr | Position (strand) | Source |
---|
CanFam3.1 Ensembl | 26 | 38,893,337 - 38,918,436 (-) | Ensembl |
|
Ensembl Acc Id: |
ENSCAFT00000064569 ⟹ ENSCAFP00000045987 |
Type: |
CODING |
Position: |
Dog Assembly | Chr | Position (strand) | Source |
---|
CanFam3.1 Ensembl | 26 | 38,893,337 - 38,918,436 (-) | Ensembl |
|
Ensembl Acc Id: |
ENSCAFT00845052971 ⟹ ENSCAFP00845041590 |
Type: |
CODING |
Position: |
Dog Assembly | Chr | Position (strand) | Source |
---|
ROS_Cfam_1.0 Ensembl | 26 | 40,476,940 - 40,504,661 (-) | Ensembl |
|
Ensembl Acc Id: |
ENSCAFT00845053009 ⟹ ENSCAFP00845041619 |
Type: |
CODING |
Position: |
Dog Assembly | Chr | Position (strand) | Source |
---|
ROS_Cfam_1.0 Ensembl | 26 | 40,476,940 - 40,502,602 (-) | Ensembl |
|
Ensembl Acc Id: |
ENSCAFT00845053039 ⟹ ENSCAFP00845041644 |
Type: |
CODING |
Position: |
Dog Assembly | Chr | Position (strand) | Source |
---|
ROS_Cfam_1.0 Ensembl | 26 | 40,476,955 - 40,505,350 (-) | Ensembl |
|
RefSeq Acc Id: |
XM_038437713 ⟹ XP_038293641 |
Type: |
CODING |
Position: |
Dog Assembly | Chr | Position (strand) | Source |
---|
ROS_Cfam_1.0 | 26 | 40,476,944 - 40,504,767 (-) | NCBI |
|
RefSeq Acc Id: |
XM_038437714 ⟹ XP_038293642 |
Type: |
CODING |
Position: |
Dog Assembly | Chr | Position (strand) | Source |
---|
ROS_Cfam_1.0 | 26 | 40,476,944 - 40,504,691 (-) | NCBI |
|
RefSeq Acc Id: |
XM_038437715 ⟹ XP_038293643 |
Type: |
CODING |
Position: |
Dog Assembly | Chr | Position (strand) | Source |
---|
ROS_Cfam_1.0 | 26 | 40,476,944 - 40,504,698 (-) | NCBI |
|
RefSeq Acc Id: |
XM_038459172 ⟹ XP_038315100 |
Type: |
CODING |
Position: |
Dog Assembly | Chr | Position (strand) | Source |
---|
Dog10K_Boxer_Tasha | 26 | 38,643,855 - 38,671,678 (-) | NCBI |
|
RefSeq Acc Id: |
XM_038459174 ⟹ XP_038315102 |
Type: |
CODING |
Position: |
Dog Assembly | Chr | Position (strand) | Source |
---|
Dog10K_Boxer_Tasha | 26 | 38,643,855 - 38,671,602 (-) | NCBI |
|
RefSeq Acc Id: |
XM_038459175 ⟹ XP_038315103 |
Type: |
CODING |
Position: |
Dog Assembly | Chr | Position (strand) | Source |
---|
Dog10K_Boxer_Tasha | 26 | 38,643,855 - 38,671,609 (-) | NCBI |
|
RefSeq Acc Id: |
XM_038512588 ⟹ XP_038368516 |
Type: |
CODING |
Position: |
Dog Assembly | Chr | Position (strand) | Source |
---|
UMICH_Zoey_3.1 | 26 | 38,347,241 - 38,375,054 (-) | NCBI |
|
RefSeq Acc Id: |
XM_038512589 ⟹ XP_038368517 |
Type: |
CODING |
Position: |
Dog Assembly | Chr | Position (strand) | Source |
---|
UMICH_Zoey_3.1 | 26 | 38,347,241 - 38,374,978 (-) | NCBI |
|
RefSeq Acc Id: |
XM_038512590 ⟹ XP_038368518 |
Type: |
CODING |
Position: |
Dog Assembly | Chr | Position (strand) | Source |
---|
UMICH_Zoey_3.1 | 26 | 38,347,241 - 38,374,985 (-) | NCBI |
|
RefSeq Acc Id: |
XM_038576080 ⟹ XP_038432008 |
Type: |
CODING |
Position: |
Dog Assembly | Chr | Position (strand) | Source |
---|
UU_Cfam_GSD_1.0 | 26 | 39,180,692 - 39,208,363 (-) | NCBI |
|
RefSeq Acc Id: |
XM_038576081 ⟹ XP_038432009 |
Type: |
CODING |
Position: |
Dog Assembly | Chr | Position (strand) | Source |
---|
UU_Cfam_GSD_1.0 | 26 | 39,180,692 - 39,208,366 (-) | NCBI |
|
RefSeq Acc Id: |
XM_038576082 ⟹ XP_038432010 |
Type: |
CODING |
Position: |
Dog Assembly | Chr | Position (strand) | Source |
---|
UU_Cfam_GSD_1.0 | 26 | 39,180,692 - 39,208,434 (-) | NCBI |
|
RefSeq Acc Id: |
XM_038640292 ⟹ XP_038496220 |
Type: |
CODING |
Position: |
Dog Assembly | Chr | Position (strand) | Source |
---|
UNSW_CanFamBas_1.0 | 26 | 37,910,947 - 37,938,605 (-) | NCBI |
|
RefSeq Acc Id: |
XM_038640293 ⟹ XP_038496221 |
Type: |
CODING |
Position: |
Dog Assembly | Chr | Position (strand) | Source |
---|
UNSW_CanFamBas_1.0 | 26 | 37,910,947 - 37,938,608 (-) | NCBI |
|
RefSeq Acc Id: |
XM_038640294 ⟹ XP_038496222 |
Type: |
CODING |
Position: |
Dog Assembly | Chr | Position (strand) | Source |
---|
UNSW_CanFamBas_1.0 | 26 | 37,910,947 - 37,938,676 (-) | NCBI |
|
Ensembl Acc Id: |
ENSCAFP00000045987 ⟸ ENSCAFT00000064569 |
|
Ensembl Acc Id: |
ENSCAFP00000030406 ⟸ ENSCAFT00000035174 |
|
Ensembl Acc Id: |
ENSCAFP00000023110 ⟸ ENSCAFT00000024907 |
|
RefSeq Acc Id: |
XP_038368516 ⟸ XM_038512588 |
- Peptide Label: |
isoform X1 |
|
RefSeq Acc Id: |
XP_038368518 ⟸ XM_038512590 |
- Peptide Label: |
isoform X3 |
|
RefSeq Acc Id: |
XP_038368517 ⟸ XM_038512589 |
- Peptide Label: |
isoform X2 |
|
RefSeq Acc Id: |
XP_038496222 ⟸ XM_038640294 |
- Peptide Label: |
isoform X3 |
|
RefSeq Acc Id: |
XP_038496221 ⟸ XM_038640293 |
- Peptide Label: |
isoform X3 |
|
RefSeq Acc Id: |
XP_038496220 ⟸ XM_038640292 |
- Peptide Label: |
isoform X2 |
|
RefSeq Acc Id: |
XP_038293641 ⟸ XM_038437713 |
- Peptide Label: |
isoform X1 |
- UniProtKB: |
A0A8C0SXQ4 (UniProtKB/TrEMBL), A0A8I3SCH6 (UniProtKB/TrEMBL) |
| |
RefSeq Acc Id: |
XP_038293642 ⟸ XM_038437714 |
- Peptide Label: |
isoform X2 |
- UniProtKB: |
A0A8I3Q1T5 (UniProtKB/TrEMBL), A0A8P0SZ18 (UniProtKB/TrEMBL), A0A8C0SXQ4 (UniProtKB/TrEMBL), A0A8I3SCH6 (UniProtKB/TrEMBL) |
|
RefSeq Acc Id: |
XP_038315100 ⟸ XM_038459172 |
- Peptide Label: |
isoform X1 |
- UniProtKB: |
A0A8C0SXQ4 (UniProtKB/TrEMBL), A0A8I3SCH6 (UniProtKB/TrEMBL) |
| |
RefSeq Acc Id: |
XP_038315102 ⟸ XM_038459174 |
- Peptide Label: |
isoform X2 |
- UniProtKB: |
A0A8I3Q1T5 (UniProtKB/TrEMBL), A0A8P0SZ18 (UniProtKB/TrEMBL), A0A8C0SXQ4 (UniProtKB/TrEMBL), A0A8I3SCH6 (UniProtKB/TrEMBL) |
| | |
RefSeq Acc Id: |
XP_038432008 ⟸ XM_038576080 |
- Peptide Label: |
isoform X2 |
- UniProtKB: |
A0A8C0SXQ4 (UniProtKB/TrEMBL), A0A8I3Q1T5 (UniProtKB/TrEMBL), A0A8I3SCH6 (UniProtKB/TrEMBL), A0A8P0SZ18 (UniProtKB/TrEMBL) |
|
Ensembl Acc Id: |
ENSCAFP00845041619 ⟸ ENSCAFT00845053009 |
|
Ensembl Acc Id: |
ENSCAFP00845041590 ⟸ ENSCAFT00845052971 |
|
Ensembl Acc Id: |
ENSCAFP00845041644 ⟸ ENSCAFT00845053039 |
|
|
|