TLR8 (toll like receptor 8) - Rat Genome Database

TLR8 (toll like receptor 8) - Rat Genome Database

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Gene: TLR8 (toll like receptor 8) Pan paniscus

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Symbol:

TLR8

Name:

toll like receptor 8

RGD ID:

12040647

Description:

ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN regulation of protein phosphorylation (ortholog); PARTICIPATES IN Toll-like receptor signaling pathway; ASSOCIATED WITH alcohol use disorder (ortholog); anogenital venereal wart (ortholog); autistic disorder (ortholog); FOUND IN endomembrane system (inferred); endosome (inferred); external side of plasma membrane (inferred)

Type:

protein-coding

RefSeq Status:

Previously known as:

toll-like receptor 8

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	TLR8 (toll like receptor 8)	NCBI	Ortholog
Mus musculus (house mouse):	Tlr8 (toll-like receptor 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Tlr8 (toll-like receptor 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Tlr8 (toll like receptor 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	TLR8 (toll like receptor 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Tlr8 (toll like receptor 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	TLR8 (toll like receptor 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	TLR8 (toll like receptor 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Tlr8 (toll like receptor 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	X	14,690,911 - 14,707,471 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	X	14,694,577 - 14,711,137 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	X	5,518,742 - 5,535,304 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	X	12,808,144 - 12,824,720 (+)	NCBI	panpan1.1	PanPan1.1	panPan2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
TLR8	Bonobo	alcohol use disorder		ISO	TLR8 (Homo sapiens)	9068941	mRNA:increased expression:orbitofrontal cortex	RGD	PMID:34415075 and REF_RGD_ID:597538499
TLR8	Bonobo	anogenital venereal wart		ISO	TLR8 (Homo sapiens)	9068941	mRNA and protein:increased expression:multiple (human)	RGD	PMID:23754510 and REF_RGD_ID:40400714
TLR8	Bonobo	membranoproliferative glomerulonephritis		ISO	Tlr8 (Mus musculus)	9068941	mRNA:increased expression:renal glomerulus (mouse)	RGD	PMID:18256364 and REF_RGD_ID:7246909
TLR8	Bonobo	respiratory syncytial virus infectious disease		ISO	TLR8 (Homo sapiens)	9068941	associated with Bronchiolitis and mRNA:increased expression:nasopharynx (human)	RGD	PMID:19386802 and REF_RGD_ID:5129471

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
TLR8	Bonobo	autistic disorder		ISO	TLR8 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Autism	ClinVar	PMID:21681106 and PMID:30208311
TLR8	Bonobo	autoimmune hemolytic anemia		ISO	TLR8 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Autoimmune hemolytic anemia	ClinVar	PMID:25741868 more ...
TLR8	Bonobo	immunodeficiency 98		ISO	TLR8 (Homo sapiens)	8554872	ClinVar more ...	ClinVar	PMID:25741868 more ...
TLR8	Bonobo	Joubert syndrome 1		ISO	TLR8 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Familial aplasia of the vermis	ClinVar	PMID:11349230 more ...
TLR8	Bonobo	Neurodevelopmental Disorders		ISO	TLR8 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Neurodevelopmental disorder	ClinVar	PMID:25741868
TLR8	Bonobo	osteoarthritis		ISO	TLR8 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Osteoarthritis	ClinVar

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
TLR8	Bonobo	contact dermatitis		ISO	TLR8 (Homo sapiens)	9068941	CTD Direct Evidence: marker/mechanism	CTD	PMID:25724174
TLR8	Bonobo	hepatitis C		ISO	TLR8 (Homo sapiens)	9068941	CTD Direct Evidence: marker/mechanism	CTD	PMID:27385120

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
TLR8	Bonobo	immunodeficiency 98		ISO	TLR8 (Homo sapiens)	7240710		OMIM

Biological Process

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
TLR8	Bonobo	canonical NF-kappaB signal transduction	involved_in	IEA	PANTHER:PTN000687301	150520179		TreeGrafter	GO_REF:0000118
TLR8	Bonobo	cellular response to mechanical stimulus	involved_in	IEA	UniProtKB:Q9NR97 and ensembl:ENSP00000218032	150520179		Ensembl	GO_REF:0000107
TLR8	Bonobo	defense response to other organism	involved_in	IEA	ARBA:ARBA00027395	150520179		UniProt	GO_REF:0000117
TLR8	Bonobo	defense response to virus	involved_in	IEA	PANTHER:PTN000687301	150520179		TreeGrafter	GO_REF:0000118
TLR8	Bonobo	defense response to virus	involved_in	IEA	UniProtKB:Q9NR97 and ensembl:ENSP00000218032	150520179		Ensembl	GO_REF:0000107
TLR8	Bonobo	immune system process	involved_in	IEA	UniProtKB-KW:KW-0391	150520179		UniProt	GO_REF:0000043
TLR8	Bonobo	inflammatory response	involved_in	IEA	UniProtKB-KW:KW-0395	150520179		UniProt	GO_REF:0000043
TLR8	Bonobo	innate immune response	involved_in	IEA	UniProtKB-KW:KW-0399	150520179		UniProt	GO_REF:0000043
TLR8	Bonobo	negative regulation of interleukin-12 production	involved_in	IEA	UniProtKB:Q9NR97 and ensembl:ENSP00000218032	150520179		Ensembl	GO_REF:0000107
TLR8	Bonobo	pattern recognition receptor signaling pathway	involved_in	IEA	ARBA:ARBA00033911	150520179		UniProt	GO_REF:0000117
TLR8	Bonobo	positive regulation of canonical NF-kappaB signal transduction	involved_in	IEA	UniProtKB:Q9NR97 and ensembl:ENSP00000218032	150520179		Ensembl	GO_REF:0000107
TLR8	Bonobo	positive regulation of innate immune response	involved_in	IEA	UniProtKB:Q9NR97 and ensembl:ENSP00000218032	150520179		Ensembl	GO_REF:0000107
TLR8	Bonobo	positive regulation of interferon-alpha production	involved_in	IEA	UniProtKB:Q9NR97 and ensembl:ENSP00000218032	150520179		Ensembl	GO_REF:0000107
TLR8	Bonobo	positive regulation of interferon-beta production	involved_in	IEA	UniProtKB:Q9NR97 and ensembl:ENSP00000218032	150520179		Ensembl	GO_REF:0000107
TLR8	Bonobo	positive regulation of interleukin-1 beta production	involved_in	IEA	UniProtKB:Q9NR97 and ensembl:ENSP00000218032	150520179		Ensembl	GO_REF:0000107
TLR8	Bonobo	positive regulation of interleukin-6 production	involved_in	IEA	PANTHER:PTN000687301	150520179		TreeGrafter	GO_REF:0000118
TLR8	Bonobo	positive regulation of interleukin-6 production	involved_in	IEA	UniProtKB:Q9NR97 and ensembl:ENSP00000218032	150520179		Ensembl	GO_REF:0000107
TLR8	Bonobo	positive regulation of interleukin-8 production	involved_in	IEA	UniProtKB:Q9NR97 and ensembl:ENSP00000218032	150520179		Ensembl	GO_REF:0000107
TLR8	Bonobo	positive regulation of intracellular signal transduction	involved_in	IEA	ARBA:ARBA00027124	150520179		UniProt	GO_REF:0000117
TLR8	Bonobo	positive regulation of type I interferon production	involved_in	IEA	ARBA:ARBA00049826	150520179		UniProt	GO_REF:0000117
TLR8	Bonobo	positive regulation of type II interferon production	involved_in	IEA	UniProtKB:Q9NR97 and ensembl:ENSP00000218032	150520179		Ensembl	GO_REF:0000107
TLR8	Bonobo	regulation of protein phosphorylation	acts_upstream_of_or_within	ISO	MGI:2176882	9068941	PMID:24740015	MGI	PMID:24740015
TLR8	Bonobo	response to virus	involved_in	IEA	UniProtKB:Q9NR97 and ensembl:ENSP00000218032	150520179		Ensembl	GO_REF:0000107
TLR8	Bonobo	signal transduction	involved_in	IEA	InterPro:IPR000157	150520179		InterPro	GO_REF:0000002
TLR8	Bonobo	toll-like receptor 8 signaling pathway	involved_in	IEA	UniProtKB:Q9NR97 and ensembl:ENSP00000218032	150520179		Ensembl	GO_REF:0000107
TLR8	Bonobo	toll-like receptor signaling pathway	involved_in	IEA	PANTHER:PTN000687301	150520179		TreeGrafter	GO_REF:0000118

Cellular Component

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
TLR8	Bonobo	endomembrane system	located_in	IEA	UniProtKB-SubCell:SL-0147	150520179		UniProt	GO_REF:0000044
TLR8	Bonobo	endosome	located_in	IEA	UniProtKB-KW:KW-0967	150520179		UniProt	GO_REF:0000043
TLR8	Bonobo	endosome	located_in	IEA	UniProtKB-SubCell:SL-0101	150520179		UniProt	GO_REF:0000044
TLR8	Bonobo	external side of plasma membrane	located_in	IEA	UniProtKB:Q9NR97 and ensembl:ENSP00000218032	150520179		Ensembl	GO_REF:0000107
TLR8	Bonobo	lysosome	located_in	IEA	ARBA:ARBA00028565	150520179		UniProt	GO_REF:0000117
TLR8	Bonobo	membrane	located_in	IEA	UniProtKB-KW:KW-0472	150520179		UniProt	GO_REF:0000043
TLR8	Bonobo	plasma membrane	located_in	IEA	PANTHER:PTN000687301	150520179		TreeGrafter	GO_REF:0000118

Molecular Function

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
TLR8	Bonobo	DNA binding	enables	IEA	UniProtKB:Q9NR97 and ensembl:ENSP00000218032	150520179		Ensembl	GO_REF:0000107
TLR8	Bonobo	double-stranded RNA binding	enables	IEA	UniProtKB:Q9NR97 and ensembl:ENSP00000218032	150520179		Ensembl	GO_REF:0000107
TLR8	Bonobo	identical protein binding	enables	ISO	UniProtKB:Q9NR97-1	9068941	PMID:23520111 and PMID:25599397	IntAct	PMID:23520111 and PMID:25599397
TLR8	Bonobo	pattern recognition receptor activity	enables	IEA	PANTHER:PTN000687301	150520179		TreeGrafter	GO_REF:0000118
TLR8	Bonobo	protein binding	enables	ISO	UniProtKB:Q9H1C4	9068941	PMID:22164301 and PMID:33961781	IntAct	PMID:22164301 and PMID:33961781
TLR8	Bonobo	protein binding	enables	ISO	UniProtKB:P58242	9068941	PMID:26095358	UniProt	PMID:26095358
TLR8	Bonobo	single-stranded RNA binding	enables	IEA	UniProtKB:Q9NR97 and ensembl:ENSP00000218032	150520179		Ensembl	GO_REF:0000107

RGD Manual Annotations

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
TLR8	Bonobo	Toll-like receptor signaling pathway		ISO	TLR8 (Homo sapiens)	9068941		RGD	PMID:21235323 and REF_RGD_ID:5685014

PMID:18810425	PMID:22301074	PMID:30032202

TLR8
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	X	14,690,911 - 14,707,471 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	X	14,694,577 - 14,711,137 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	X	5,518,742 - 5,535,304 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	X	12,808,144 - 12,824,720 (+)	NCBI	panpan1.1	PanPan1.1	panPan2

TLR8
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	X	12,906,620 - 12,923,169 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	X	12,906,620 - 12,923,169 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	X	12,924,739 - 12,941,288 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	X	12,834,679 - 12,851,209 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	X	17,038,744 - 17,055,292 (+)	NCBI		Celera
Cytogenetic Map	X	p22.2	NCBI
HuRef	X	10,691,356 - 10,708,478 (+)	NCBI		HuRef
CHM1_1	X	12,955,183 - 12,971,731 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	X	12,488,083 - 12,504,631 (+)	NCBI		T2T-CHM13v2.0

Tlr8
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	X	166,024,119 - 166,047,325 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	X	166,025,692 - 166,047,325 (-)	Ensembl		GRCm39 Ensembl
GRCm38	X	167,241,123 - 167,264,329 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	X	167,242,696 - 167,264,329 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	X	163,680,664 - 163,701,720 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	X	162,580,693 - 162,607,911 (-)	NCBI		MGSCv36	mm8
Celera	X	150,416,046 - 150,437,421 (-)	NCBI		Celera
Cytogenetic Map	X	F5	NCBI
cM Map	X	78.29	NCBI

Tlr8
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	X	30,708,714 - 30,733,104 (+)	NCBI		GRCr8
mRatBN7.2	X	27,091,780 - 27,116,092 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	X	27,091,778 - 27,116,549 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	X	28,164,972 - 28,187,831 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	X	31,566,484 - 31,589,384 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	X	27,779,612 - 27,802,461 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	X	28,539,158 - 28,562,803 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	X	28,539,158 - 28,562,803 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	X	28,932,434 - 28,956,373 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Celera	X	27,503,122 - 27,525,908 (+)	NCBI		Celera
Cytogenetic Map	X	q13	NCBI

Tlr8
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955544	303,319 - 306,426 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955544	302,027 - 317,110 (-)	NCBI	ChiLan1.0	ChiLan1.0

TLR8
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	X	9,381,159 - 9,399,938 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	X	9,337,717 - 9,356,229 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	X	9,333,237 - 9,351,758 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	X	9,347,575 - 9,351,742 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	X	9,317,807 - 9,336,322 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	X	9,357,237 - 9,375,770 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	X	9,349,380 - 9,367,898 (+)	NCBI		UU_Cfam_GSD_1.0

Tlr8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	X	2,638,020 - 2,642,609 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936470	2,638,014 - 2,641,133 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936470	2,638,020 - 2,642,201 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TLR8
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	X	9,597,604 - 9,616,757 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	X	9,551,284 - 9,616,762 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	X	10,451,110 - 10,512,940 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

TLR8
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	X	11,387,933 - 11,405,056 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	X	11,400,907 - 11,404,029 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666056	13,179,722 - 13,196,707 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Tlr8
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624882	1,240,626 - 1,312,468 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624882	1,240,519 - 1,247,311 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.


RefSeq Transcripts	XM_008973908	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_034950154	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_055106521	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AB445668	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JARIFH020000024	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

XM_008973908 ⟹ XP_008972156

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	X	14,690,911 - 14,707,471 (+)	NCBI
NHGRI_mPanPan1	X	14,694,577 - 14,711,137 (+)	NCBI
Mhudiblu_PPA_v0	X	5,518,742 - 5,535,304 (+)	NCBI
PanPan1.1	X	12,808,144 - 12,824,720 (+)	NCBI

Sequence:

show sequence

AGTTTCTCTTCTCGGCCACCTCCTGCATAGAGGGTACCATTCTGCGTTGCTGCAAGTTATGGAATGAAAAATTAGAACAACAGAAACGTGGAAAACATGTTCCTTCAGTCGTCAATGCTGACCTGCAT
TTTCCTGCTAATATCTGGTTCCTGTGAGTTATGCGCCGAAGAAAATTTTTCTAGAAGCTATCCTTGTGATGAGAAAAAGCAAAATGACTCAGTTATTGCAGAGTGCAGCAATCGTCGACTACGGGAAG
TTCCCCAAACGGTGGGCAAATATGTGACAGAACTAGACCTGTCTGATAATTTCATCACACACATAACGAATGAATCATTTCAAGGGCTGCAAAATCTCACTAAAATAAATCTAAACCACAACCCCAAT
GTACAGCACCAGAACGGAAATCCTGGTATACAATCAAATGGCTTGAATATCACAGACGGGGCATTCCTCAACCTAAAAAACCTAAGGGAGTTACTGCTTGAAGACAACCAGTTACCCCAAATACCCTC
TGGTTTGCCAGAGTCTTTGACAGAACTTAGTCTAATTCAAAACAATATATACAACATAACTAAAGAGGGCATTTCAAGACTTATAAACTTGAAAAATCTCTATTTGGCCTGGAACTGCTATTTTAACA
AAGTTTGCGAGAAAACTAACATAGAAGATGGAGTATTTGAAACGCTGACAAATTTGGAGTTGCTATCACTATCTTTCAATTCTCTTTCACATGTGCCACCCAAACTGCCAAGCTCCCTACGTAAACTT
TTTCTGAGCAACACCCAGATCAAATACATTAGTGAAGAAGATTTCAAGGGATTGATAAATTTAACATTACTAGATTTAAGCGGGAACTGTCCGAGGTGCTTCAATGCCCCATTTCCATGCGTGCCTTG
TGATGGTGGTGCTTCAATTAATATAGATCGTTTTGCTTTTCAAAACTTGACCCAACTTCGATACCTAAACCTCTCTAGCACTTCCCTCAGGAAGATTAATGCTGCCTGGTTTAAAAATATGCCTCATC
TGAAGGTGCTGGATCTTGAATTCAACTATTTAGTGGGAGAAATAGCCTCTGGGGCATTTTTAACGATGCTGCCCCGCTTAGAAATACTTGACTTGTCTTTTAACTACATAAAGGGGAGTTATCCACAG
CATATTAATATTTCCAAAAACTTCTCTAAACTTTTGTCTCTACGGGCATTGCATTTAAGAGGTTATGTGTTCCAGGAACTCAGAGAAGATGATTTCCAGCCCCTGATGCAGCTTCCAAACTTATCGAC
TATCAACTTGGGTATTAATTTTATTAAGCAAATCGATTTCAAACTTTTCCAAAATTTCTCCAATCTGGAAATCATTTACTTGTCAGAAAACAGAATATCACCGTTGGTAAAAGATACCAGGCAGAGTT
ATGCAAATAGTTCCTCTTTTCAACGTCATATCCTGAAACGACGCTCAACAGATTTTGAGTTTGACCCACATTCGAACTTTTATCATTTCACCCGTCCTTTAATAAAGCCACAATGTGCTGCTTATGGA
AAAGCCTTAGATTTAAGCCTCAACAGTATTTTCTTCATTGGGCCAAACCAATTTGAAAATCTTCCTGACATTGCCTGTTTAAATCTGTCTGCAAATAGCAACGCTCAAGTGTTAAGTGGAACTGAATT
TTCAGCCATTCCTCATGTCAAATATTTGGATTTGACAAACAATAGACTAGACTTTGATAATGCTAGTGCTCTTACTGAATTGTCCGACTTGGAAGTTCTAGATCTCAGCTATAATTCACACTATTTCA
GAATAGCAGGCGTAACACATCATCTAGAATTTATTCAAAATTTCACAAATCTAAAAGTTTTAAACTTGAGCCACAACAACATTTATACTTTAACAGATAAGTATAACCTGGAAAGCAAGTCCCTGGTA
GAATTAGTTTTCAGTGGCAATCGCCTTGACATTTTGTGGAATGATGATGACAACAGGTATATCTCCATTTTCAAAGGTCTCAAGAATCTGACACGTCTGGATTTATCCCTTAATAGGCTCAAGCACAT
CCCAAATGAAGCATTCCTTAATTTGCCAGCGAGTCTCACTGAACTACATATAAATGATAATATGTTAAAGTTTTTTAACTGGACATTACTCCAGCAGTTTCCTCGTCTCGAGTTGCTCGACTTACGTG
GAAACAAACTACTCTTTTTAACTGATAGCCTATCTGACTTTACATCTTCCCTTCGGACACTGCTGCTGAGTCATAACAGGATTTCCCACCTACCCTCTGGCTTTCTTTCTGAAGTCAGTAGTCTGAAG
CACCTCGATTTAAGTTCCAATCTGCTAAAAACAATCAATAAATCCGCACTCGAAACTAAGACCACCACCAAATTATCTATGTTGGAACTACACGGAAACCCCTTTGAATGCACCTGTGACATTGGAGA
TTTCCGAAGATGGATGGATGAACATCTGAACGTCAAAATTCCCAGACTGGTAGATGTCATTTGTGCCAGTCCTGGGGATCAAAGAGGGAAGAGTATTGTGAGTCTGGAGCTAACAACTTGTGTTTCAG
ATGTCACTGCAGTGATATTATTTTTCTTCACGTTCTTTATCACCACCATGGTTATGTTGGCTGCCCTGGCTCACCATTTGTTTTACTGGGATGTTTGGTTTATATATAATGTGTGTTTAGCTAAGGTA
AAAGGCTACAGGTCTCTTTCCACATCCCAAACTTTCTATGATGCTTACATTTCTTATGACACCAAAGATGCCTCTGTTACTGACTGGGTGATAAATGAGCTGCGCTACCACCTTGAAGAGAGCCGAGA
CAAAAACGTTCTCCTTTGTCTAGAGGAGAGGGATTGGGACCCGGGATTGGCCATCATCGACAACCTCATGCAGAGCATCAACCAAAGCAAGAAAACAGTATTTGTTTTAACCAAAAAATATGCAAAAA
GCTGGAACTTTAAAACAGCTTTTTACTTGGCTTTGCAGAGGCTAATGGATGAGAACATGGATGTGATTATATTTATCCTGCTGGAGCCAGTGTTACAGCATTCTCAGTATTTGAGGCTACGGCAGCGG
ATCTGTAAGAGCTCCATCCTCCAGTGGCCTGACAACCCGAAGGCAGAAGGCTTGTTTTGGCAAACTCTGAGAAATGTGGTCTTAACTGAAAATGATTCACGGTATAACAATATGTATGTTGATTCCAT
TAAGCAATACTAACTGACGTTAAGTCATGATTTCGCGCCATAATACAGATGCAAAGGAATGACATTTCTGTCTTAGTTATCTATTGCTATGTAACAAATTATCCCAAAACTTAGTGGTTTAAAACAAC
ACATTTGCTAGCCCACAGTTTTTGAGGGTCAGGAGTCCAGGCCCAGCATAACTGGGTCCTCTGCTCAGGGTGTCTCAGAGGCTGCAATGTAGGTGTTCACCAGAGACATAGGCATCTCTGGGGTCACA
CTCATGTGGTTGTTTTCCGGATTCAATTCCTCCTGGGCTATTGGCCAAAGGCTATACTCATGTAAGCCATGCAAGCCTCGCCCACAAGGCAGCTTGCTTCATCAGAGCTAGCAAAAAAGAGAGGTTGC
TAGCAAGATGAAGTCACAATCTTTTGTAATCGAATCAAAAAAGTGATATCTCATCACTTTGGCCATATTCTATTTGCTAGAAGTAAACCACAGGTCCCACCAGCTCCATGGGAGTGACCACCTCAGTC
CAGGGAAAACAGCTGAAGACCAAGATGGTGAGCTCTGATTGCTTCAGTTGGTCATCAACTATTTTCCCTTGACTGCTGTCCTGGGATGGCCTGCTATCTTGATCATAGATTGTGAATATCAGGAGGCA
GGGATCACTGTGGACCATCTTAGCAGTTGACCTAATACACCTTCTTTTCAATATCTAAGAACTTTTGCCACTGTGACTAATGGTCCTAATATTAAGCTGTTGTTTATATTTATCATATATCTATGGCT
ACATGGTTATATTATGCTGTGGTTGCGTTCGGTTTTATTTACAGTTGCTTTTACAAATATTTGCTGTAACATTTGACTTCTAAGGTTTAGATGCCATTTAAGAACTGAGATGGATAGCTTTTAAAGCA
TCTTTTACTTCTTAACCATTTTTAAAAAGTATGCAGCTAAATTCGAAGCTTTTGGTCTATATTGTTAATTGCCATTGCTGTAAATCTTAAAATGAATGAATAAAAATGTTTCATTTTACAA

hide sequence

RefSeq Acc Id:

XM_055106521 ⟹ XP_054962496

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	X	14,694,674 - 14,707,471 (+)	NCBI
NHGRI_mPanPan1	X	14,698,340 - 14,711,137 (+)	NCBI


Protein RefSeqs	XP_008972156	(Get FASTA)	NCBI Sequence Viewer
	XP_054962496	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	BAG55065	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSPPAP00000033784.1

RefSeq Acc Id:	XP_008972156 ⟸ XM_008973908
- Peptide Label:	isoform X1
- UniProtKB:	B3Y656 (UniProtKB/TrEMBL)
- Sequence:	show sequence MFLQSSMLTCIFLLISGSCELCAEENFSRSYPCDEKKQNDSVIAECSNRRLREVPQTVGKYVTELDLSDNFITHITNESFQGLQNLTKINLNHNPNVQHQNGNPGIQSNGLNITDGAFLNLKNLRELL LEDNQLPQIPSGLPESLTELSLIQNNIYNITKEGISRLINLKNLYLAWNCYFNKVCEKTNIEDGVFETLTNLELLSLSFNSLSHVPPKLPSSLRKLFLSNTQIKYISEEDFKGLINLTLLDLSGNCPR CFNAPFPCVPCDGGASINIDRFAFQNLTQLRYLNLSSTSLRKINAAWFKNMPHLKVLDLEFNYLVGEIASGAFLTMLPRLEILDLSFNYIKGSYPQHINISKNFSKLLSLRALHLRGYVFQELREDDF QPLMQLPNLSTINLGINFIKQIDFKLFQNFSNLEIIYLSENRISPLVKDTRQSYANSSSFQRHILKRRSTDFEFDPHSNFYHFTRPLIKPQCAAYGKALDLSLNSIFFIGPNQFENLPDIACLNLSAN SNAQVLSGTEFSAIPHVKYLDLTNNRLDFDNASALTELSDLEVLDLSYNSHYFRIAGVTHHLEFIQNFTNLKVLNLSHNNIYTLTDKYNLESKSLVELVFSGNRLDILWNDDDNRYISIFKGLKNLTR LDLSLNRLKHIPNEAFLNLPASLTELHINDNMLKFFNWTLLQQFPRLELLDLRGNKLLFLTDSLSDFTSSLRTLLLSHNRISHLPSGFLSEVSSLKHLDLSSNLLKTINKSALETKTTTKLSMLELHG NPFECTCDIGDFRRWMDEHLNVKIPRLVDVICASPGDQRGKSIVSLELTTCVSDVTAVILFFFTFFITTMVMLAALAHHLFYWDVWFIYNVCLAKVKGYRSLSTSQTFYDAYISYDTKDASVTDWVIN ELRYHLEESRDKNVLLCLEERDWDPGLAIIDNLMQSINQSKKTVFVLTKKYAKSWNFKTAFYLALQRLMDENMDVIIFILLEPVLQHSQYLRLRQRICKSSILQWPDNPKAEGLFWQTLRNVVLTEND SRYNNMYVDSIKQY hide sequence

RefSeq Acc Id:	XP_054962496 ⟸ XM_055106521
- Peptide Label:	isoform X2
- UniProtKB:	B3Y656 (UniProtKB/TrEMBL)

Protein Domains

TIR

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000039752	UniProtKB/TrEMBL
Ensembl Transcript	ENSPPAT00000056661.1	UniProtKB/TrEMBL
Gene3D-CATH	Ribonuclease Inhibitor	UniProtKB/TrEMBL
	Toll/interleukin-1 receptor homology (TIR) domain	UniProtKB/TrEMBL
InterPro	Cys-rich_flank_reg_C	UniProtKB/TrEMBL
	Leu-rich_rpt	UniProtKB/TrEMBL
	Leu-rich_rpt_typical-subtyp	UniProtKB/TrEMBL
	LRR_dom_sf	UniProtKB/TrEMBL
	TIR_dom	UniProtKB/TrEMBL
	Toll_tir_struct_dom_sf	UniProtKB/TrEMBL
NCBI Gene	TLR8	ENTREZGENE
PANTHER	TOLL-LIKE RECEPTOR 7-RELATED	UniProtKB/TrEMBL
	TOLL-LIKE RECEPTOR 8	UniProtKB/TrEMBL
Pfam	LRR_8	UniProtKB/TrEMBL
	TIR	UniProtKB/TrEMBL
PROSITE	LRR	UniProtKB/TrEMBL
	TIR	UniProtKB/TrEMBL
SMART	LRR_SD22	UniProtKB/TrEMBL
	LRR_TYP	UniProtKB/TrEMBL
	LRRCT	UniProtKB/TrEMBL
	TIR	UniProtKB/TrEMBL
Superfamily-SCOP	L domain-like	UniProtKB/TrEMBL
	Toll/Interleukin receptor TIR domain	UniProtKB/TrEMBL
UniProt	B3Y656	ENTREZGENE, UniProtKB/TrEMBL