CHRNA1 (cholinergic receptor nicotinic alpha 1 subunit) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: CHRNA1 (cholinergic receptor nicotinic alpha 1 subunit) Pan paniscus
Analyze
Symbol: CHRNA1
Name: cholinergic receptor nicotinic alpha 1 subunit
RGD ID: 12002776
Description: ENCODES a protein that exhibits acetylcholine binding (ortholog); acetylcholine receptor activity (ortholog); acetylcholine-gated monoatomic cation-selective channel activity (ortholog); INVOLVED IN monoatomic cation transport (ortholog); neuromuscular junction development (ortholog); neuromuscular synaptic transmission (ortholog); PARTICIPATES IN acetylcholine signaling pathway via nicotinic acetylcholine receptor; ASSOCIATED WITH autistic disorder (ortholog); centronuclear myopathy (ortholog); congenital myasthenic syndrome (ortholog); FOUND IN acetylcholine-gated channel complex (ortholog); neuromuscular junction (ortholog); postsynaptic specialization membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: acetylcholine receptor subunit alpha; LOC100986268
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21377,409,788 - 77,422,130 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B77,424,763 - 77,437,105 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B62,022,498 - 62,039,370 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B179,476,147 - 179,509,974 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B179,476,677 - 179,504,763 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
CHRNA1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21377,409,788 - 77,422,130 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B77,424,763 - 77,437,105 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B62,022,498 - 62,039,370 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B179,476,147 - 179,509,974 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B179,476,677 - 179,504,763 (-)Ensemblpanpan1.1panPan2
CHRNA1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382174,747,592 - 174,764,472 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2174,747,592 - 174,787,935 (-)EnsemblGRCh38hg38GRCh38
GRCh372175,612,320 - 175,629,200 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362175,320,566 - 175,337,427 (-)NCBINCBI36Build 36hg18NCBI36
Build 342175,438,113 - 175,454,677NCBI
Celera2169,225,856 - 169,242,726 (-)NCBICelera
Cytogenetic Map2q31.1NCBI
HuRef2167,492,831 - 167,509,717 (-)NCBIHuRef
CHM1_12175,618,423 - 175,635,290 (-)NCBICHM1_1
T2T-CHM13v2.02175,236,308 - 175,253,177 (-)NCBIT2T-CHM13v2.0
Chrna1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39273,393,625 - 73,410,682 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl273,393,559 - 73,410,682 (-)EnsemblGRCm39 Ensembl
GRCm38273,563,281 - 73,580,338 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl273,563,215 - 73,580,338 (-)EnsemblGRCm38mm10GRCm38
MGSCv37273,401,338 - 73,418,363 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36273,364,120 - 73,381,145 (-)NCBIMGSCv36mm8
Celera275,249,906 - 75,266,913 (-)NCBICelera
Cytogenetic Map2C3NCBI
cM Map243.76NCBI
Chrna1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8378,862,286 - 78,877,353 (-)NCBIGRCr8
mRatBN7.2358,454,763 - 58,469,832 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl358,454,744 - 58,469,840 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx361,848,304 - 61,863,363 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0370,431,954 - 70,447,013 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0368,196,984 - 68,212,044 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0360,445,657 - 60,460,724 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl360,445,666 - 60,460,724 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0366,925,891 - 66,940,958 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4356,087,754 - 56,102,821 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1355,984,129 - 55,999,193 (-)NCBI
Celera357,981,902 - 57,996,970 (-)NCBICelera
Cytogenetic Map3q23NCBI
Chrna1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955449661,304 - 683,873 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955449661,310 - 683,873 (+)NCBIChiLan1.0ChiLan1.0
CHRNA1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13618,726,243 - 18,742,505 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3618,726,243 - 18,742,505 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3618,734,972 - 18,751,239 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03618,862,735 - 18,878,999 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3618,860,880 - 18,878,999 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13618,939,222 - 18,955,468 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03618,937,561 - 18,953,818 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03619,048,764 - 19,065,033 (-)NCBIUU_Cfam_GSD_1.0
Chrna1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303135,898,803 - 135,941,651 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365094,452,616 - 4,470,658 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365094,452,382 - 4,470,658 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CHRNA1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1580,673,067 - 80,692,208 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11580,673,072 - 80,692,256 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21589,888,938 - 89,906,230 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CHRNA1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11060,279,837 - 60,298,931 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666040139,305,978 - 139,322,913 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Chrna1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478711,934,433 - 11,950,005 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478711,933,927 - 11,950,017 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSPPAT00000027638   ⟹   ENSPPAP00000006408
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl2B179,476,677 - 179,504,763 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000027649   ⟹   ENSPPAP00000006413
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl2B179,476,677 - 179,492,939 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000027653   ⟹   ENSPPAP00000006416
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl2B179,476,677 - 179,492,939 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000027656   ⟹   ENSPPAP00000006418
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl2B179,476,677 - 179,492,939 (-)Ensembl
RefSeq Acc Id: XM_034954549   ⟹   XP_034810440
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21377,409,788 - 77,421,948 (-)NCBI
NHGRI_mPanPan12B77,424,763 - 77,436,922 (-)NCBI
Mhudiblu_PPA_v02B62,022,504 - 62,034,651 (-)NCBI
RefSeq Acc Id: XM_034954551   ⟹   XP_034810442
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21377,409,796 - 77,422,130 (-)NCBI
NHGRI_mPanPan12B77,424,771 - 77,437,105 (-)NCBI
Mhudiblu_PPA_v02B62,022,504 - 62,034,822 (-)NCBI
RefSeq Acc Id: XM_034954553   ⟹   XP_034810444
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21377,409,796 - 77,421,953 (-)NCBI
NHGRI_mPanPan12B77,424,771 - 77,436,927 (-)NCBI
Mhudiblu_PPA_v02B62,022,504 - 62,039,306 (-)NCBI
Protein Sequences
Protein RefSeqs XP_034810440 (Get FASTA)   NCBI Sequence Viewer  
  XP_034810442 (Get FASTA)   NCBI Sequence Viewer  
  XP_034810444 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000006408.1
  ENSPPAP00000006413.1
  ENSPPAP00000006416.1
  ENSPPAP00000006418.1
RefSeq Acc Id: XP_034810444   ⟸   XM_034954553
- Peptide Label: isoform X3
- UniProtKB: A0A2R8ZN82 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_034810442   ⟸   XM_034954551
- Peptide Label: isoform X2
- UniProtKB: A0A2R8ZN79 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_034810440   ⟸   XM_034954549
- Peptide Label: isoform X1
- UniProtKB: A0A2R8ZN79 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSPPAP00000006418   ⟸   ENSPPAT00000027656
Ensembl Acc Id: ENSPPAP00000006416   ⟸   ENSPPAT00000027653
Ensembl Acc Id: ENSPPAP00000006413   ⟸   ENSPPAT00000027649
Ensembl Acc Id: ENSPPAP00000006408   ⟸   ENSPPAT00000027638
Protein Domains
Neurotransmitter-gated ion-channel ligand-binding   Neurotransmitter-gated ion-channel transmembrane


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000024985 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000027638.1 UniProtKB/TrEMBL
  ENSPPAT00000027649.1 UniProtKB/TrEMBL
  ENSPPAT00000027653.1 UniProtKB/TrEMBL
  ENSPPAT00000027656.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.58.390 UniProtKB/TrEMBL
  2.70.170.10 UniProtKB/TrEMBL
InterPro Neur_chan_lig-bd UniProtKB/TrEMBL
  Neur_chan_lig-bd_sf UniProtKB/TrEMBL
  Neur_channel UniProtKB/TrEMBL
  Neuro-gated_channel_TM_sf UniProtKB/TrEMBL
  Neuro_actylchol_rec UniProtKB/TrEMBL
  Neurotrans-gated_channel_TM UniProtKB/TrEMBL
  Neurotransmitter_ion_chnl_CS UniProtKB/TrEMBL
  Nicotinic_acetylcholine_rcpt UniProtKB/TrEMBL
NCBI Gene CHRNA1 ENTREZGENE
PANTHER PTHR18945 UniProtKB/TrEMBL
Pfam Neur_chan_LBD UniProtKB/TrEMBL
  Neur_chan_memb UniProtKB/TrEMBL
PRINTS NICOTINICR UniProtKB/TrEMBL
  NRIONCHANNEL UniProtKB/TrEMBL
PROSITE NEUROTR_ION_CHANNEL UniProtKB/TrEMBL
Superfamily-SCOP SSF63712 UniProtKB/TrEMBL
  SSF90112 UniProtKB/TrEMBL
UniProt A0A2R8ZN79 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R8ZN82 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R8ZN86_PANPA UniProtKB/TrEMBL
  A0A2R8ZR83_PANPA UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-07-01 CHRNA1  cholinergic receptor nicotinic alpha 1 subunit  LOC100986268  acetylcholine receptor subunit alpha  Symbol and/or name change 5135510 APPROVED
2018-05-08 LOC100986268  acetylcholine receptor subunit alpha  CHRNA1  cholinergic receptor nicotinic alpha 1 subunit  Symbol and/or name change 5135510 APPROVED