PDIA5 (protein disulfide isomerase family A member 5)

Gene: PDIA5 (protein disulfide isomerase family A member 5) Pan paniscus

Analyze

Symbol:

PDIA5

Name:

protein disulfide isomerase family A member 5

RGD ID:

11978851

Description:

ENCODES a protein that exhibits protein disulfide isomerase activity (inferred); protein-disulfide reductase activity (inferred); INVOLVED IN protein folding (inferred); ASSOCIATED WITH alkaptonuria (ortholog); COVID-19 (ortholog); familial hypocalciuric hypercalcemia (ortholog); FOUND IN endoplasmic reticulum (inferred)

Type:

protein-coding

RefSeq Status:

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	2	121,012,763 - 121,107,773 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	3	121,017,569 - 121,112,548 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	3	120,155,981 - 120,250,961 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	3	127,059,751 - 127,154,451 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	3	127,059,751 - 127,154,451 (+)	Ensembl	panpan1.1		panPan2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

alkaptonuria (ISO)

COVID-19 (ISO)

familial hypocalciuric hypercalcemia (ISO)

Primary Lymphedema with Myelodysplasia (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

protein folding (IEA)

Cellular Component

endoplasmic reticulum (IEA)

Molecular Function

protein binding (ISO)

protein disulfide isomerase activity (IEA)

protein-disulfide reductase activity (IEA)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

PDIA5
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	2	121,012,763 - 121,107,773 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	3	121,017,569 - 121,112,548 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	3	120,155,981 - 120,250,961 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	3	127,059,751 - 127,154,451 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	3	127,059,751 - 127,154,451 (+)	Ensembl	panpan1.1		panPan2

PDIA5
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	3	123,067,025 - 123,162,104 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	3	123,067,025 - 123,225,227 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	3	122,785,872 - 122,880,951 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	3	124,268,655 - 124,363,567 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	3	121,192,646 - 121,287,739 (+)	NCBI		Celera
Cytogenetic Map	3	q21.1	NCBI
HuRef	3	120,158,749 - 120,254,205 (+)	NCBI		HuRef
CHM1_1	3	122,749,529 - 122,844,663 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	3	125,787,101 - 125,882,179 (+)	NCBI		T2T-CHM13v2.0

Pdia5
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	16	35,217,678 - 35,311,289 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	16	35,217,682 - 35,311,243 (-)	Ensembl		GRCm39 Ensembl
GRCm38	16	35,397,308 - 35,490,919 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	16	35,397,312 - 35,490,873 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	16	35,397,398 - 35,490,959 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	16	35,317,059 - 35,410,620 (-)	NCBI		MGSCv36	mm8
Celera	16	35,866,403 - 35,959,222 (-)	NCBI		Celera
Cytogenetic Map	16	B3	NCBI
cM Map	16	25.37	NCBI

Pdia5
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	11	78,777,436 - 78,892,370 (+)	NCBI		GRCr8
mRatBN7.2	11	65,272,152 - 65,359,087 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	11	65,272,155 - 65,359,084 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	11	74,095,261 - 74,182,045 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	11	66,757,523 - 66,844,318 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	11	65,788,798 - 65,875,595 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	11	68,493,035 - 68,578,999 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	11	68,493,035 - 68,578,995 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	11	71,580,311 - 71,666,275 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	11	67,117,749 - 67,204,482 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	11	67,175,337 - 67,262,069 (+)	NCBI
Celera	11	64,733,302 - 64,819,377 (+)	NCBI		Celera
Cytogenetic Map	11	q22	NCBI

Pdia5
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955427	22,268,511 - 22,356,181 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955427	22,268,730 - 22,356,123 (+)	NCBI	ChiLan1.0	ChiLan1.0

PDIA5
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	33	26,131,969 - 26,227,256 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	33	26,131,893 - 26,227,253 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	33	26,154,925 - 26,249,690 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	33	26,365,077 - 26,460,503 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	33	26,364,927 - 26,460,501 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	33	26,161,419 - 26,256,156 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	33	26,204,706 - 26,300,729 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	33	26,763,803 - 26,858,825 (+)	NCBI		UU_Cfam_GSD_1.0

Pdia5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	128,116,195 - 128,206,073 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936725	2,024,643 - 2,114,560 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936725	2,024,646 - 2,114,530 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PDIA5
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	13	137,296,883 - 137,398,628 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	13	137,300,086 - 137,398,465 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	13	146,843,483 - 146,941,924 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

PDIA5
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	22	57,711,049 - 57,806,058 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	22	57,711,041 - 57,806,037 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666041	108,540,265 - 108,633,350 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Pdia5
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624912	1,408,645 - 1,523,498 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_003825208	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JARIFH020000002	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSPPAT00000030621 ⟹ ENSPPAP00000007992

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	3	127,059,751 - 127,154,451 (+)	Ensembl

RefSeq Acc Id:

ENSPPAT00000030626 ⟹ ENSPPAP00000007996

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	3	127,081,773 - 127,154,307 (+)	Ensembl

RefSeq Acc Id:

XM_003825208 ⟹ XP_003825256

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	2	121,012,763 - 121,107,773 (+)	NCBI
NHGRI_mPanPan1	3	121,017,569 - 121,112,548 (+)	NCBI
Mhudiblu_PPA_v0	3	120,155,981 - 120,250,961 (+)	NCBI
PanPan1.1	3	127,059,751 - 127,154,451 (+)	NCBI

Sequence:

show sequence

CTGCGCATGCTTTGGCAGACGTGGCACCGGGAACTCGGAGGCGGGGAGCGGCTGGGAAGTGGCC
GTGGTGGTTGGCCGCGGTGGAGCTAGCAGGCGGGCGGGCGGGAGCGGGCGCCGGAGTGGAGAAA
GGAGCCAGCTGTGGGCAGCGCTGCTGGGATGGCGCGGGCCGGGCCGGCGTGGCTGCTGCTGGCA
ATCTGGGTGGTCCTGCCATCATGGCTGTCCTCTGCAAAGGTCTCCTCGCTCATTGAGAGAATCT
CTGACCCCAAGGACTTGAAAAAACTGCTCAGAACCCGGAATAATGTACTGGTGCTTTACTCCAA
ATCTGAGGCGGCAGCTGAAAATCATCTCAGGTTACTGTCCACAGTGGCCCAGGTGGTGAAAGGA
CAAGGGACCATCTGCTGGGTGGACTGTGGTGATGCAGAGAGTAGAAAATTGTGCAAGAAGATGA
AAGTTGACCTGAGCCCGAAGGACAAAAAGGTCGAATTATTCCATTACCAGGATGGTGCATTTCA
TACTGAATATAACCGAGCTGTGACATTTAAGTCCATAGTGGCCTTTTTGAAGGATCCAAAAGGG
CCCCCACTGTGGGAGGAAGATCCTGGAGCCAAAGATGTTGTCCACCTTGACAGTGAAAAGGACT
TCAGACGGCTCCTGAAGAAGGAAGAGAAGCCGCTCCTGATCATGTTTTATGCCCCCTGGTGCAG
CATGTGCAAGAGGATGATGCCGCATTTCCAGAAGGCTGCGACTCAGCTGCGGGGCCACGCCGTG
CTGGCCGGGATGAATGTCTACTCCTCTGAATTTGAAAACATCAAGGAGGAGTACAGCGTGCGCG
GCTTCCCCACCATCTGCTATTTTGAGAAAGGACGGTTCTTGTTCCAGTATGACAACTATGGGTC
CACAGCTGAGGACATTGTGGAGTGGCTGAAGAATCCGCAGCCGCCACAGCCCCAGGTCCCTGAG
ACTCCCTGGGCAGATGAGGGCGGCTCCGTTTATCACCTGACCGATGAAGACTTTGACCAGTTTG
TGAAGGAACACTCCTCTGTCCTCGTCATGTTCCACGCCCCATGGTGTGGCCACTGTAAGAAAAT
GAAGCCGGAGTTTGAGAAGGCAGCAGAAGCCCTCCATGGAGAAGCGGATAGCTCTGGTGTCCTT
GCAGCTGTCGATGCCACTGTCAACAAGGCCCTGGCAGAAAGATTCCACATCTCAGAGTTTCCTA
CGTTGAAGTATTTTAAGAATGGAGAGAAATACGCAGTGCCCGTGCTCAGGACAAAGAAGAAGTT
TCTCGAGTGGATGCAAAACCCTGAGGCCCCCCCACCCCCAGAGCCCACGTGGGAAGAGCAGCAG
ACAAGCTTGTTGCACCTGGTGGGGGACAACTTCCGGGAGACCCTGAAGAAGAAGAAACACACCT
TGGTCATGTTCTACGCCCCTTGGTGCCCACACTGTAAGAAGGTCATTCCGCACTTTACTGCTAC
TGCTGATGCCTTCAAAGATGACCGAAAGATTGCCTGTGCCGCTGTTGACTGTGTCAAAGACAAG
AACCAAGACCTGTGCCAGCAGGAGGCGGTCAAGGGCTACCCCACTTTCCACTACTACCACTATG
GGAAGTTCGCAGAAAAGTATGACAGCGACCGCACAGAATTGGGATTTACCAATTATATTCGAGC
CCTCCGGGAGGGAGACCATGAAAGACTAGGGAAAAAGAAGGAAGAGTTATAATTCCTGCCTCAG
AAAAAGCTTTTCCATTACACTGTGAATGATACCTGTTTTGTTGTTTCTGAATTTCCACATGTTC
TGAAGACAAATTTTTTATAGCCGCTTATGGCCATTTTGTACAATTTTGAAATAAAATTAAACCA
TTTA

hide sequence

Protein Sequences


Protein RefSeqs	XP_003825256	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSPPAP00000007992
	ENSPPAP00000007992.1
	ENSPPAP00000007996.1

RefSeq Acc Id:

XP_003825256 ⟸ XM_003825208

- UniProtKB:

A0A2R8ZYH6 (UniProtKB/TrEMBL), A0A2R8ZVX7 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MARAGPAWLLLAIWVVLPSWLSSAKVSSLIERISDPKDLKKLLRTRNNVLVLYSKSEAAAENHL
RLLSTVAQVVKGQGTICWVDCGDAESRKLCKKMKVDLSPKDKKVELFHYQDGAFHTEYNRAVTF
KSIVAFLKDPKGPPLWEEDPGAKDVVHLDSEKDFRRLLKKEEKPLLIMFYAPWCSMCKRMMPHF
QKAATQLRGHAVLAGMNVYSSEFENIKEEYSVRGFPTICYFEKGRFLFQYDNYGSTAEDIVEWL
KNPQPPQPQVPETPWADEGGSVYHLTDEDFDQFVKEHSSVLVMFHAPWCGHCKKMKPEFEKAAE
ALHGEADSSGVLAAVDATVNKALAERFHISEFPTLKYFKNGEKYAVPVLRTKKKFLEWMQNPEA
PPPPEPTWEEQQTSLLHLVGDNFRETLKKKKHTLVMFYAPWCPHCKKVIPHFTATADAFKDDRK
IACAAVDCVKDKNQDLCQQEAVKGYPTFHYYHYGKFAEKYDSDRTELGFTNYIRALREGDHERL
GKKKEEL

hide sequence

RefSeq Acc Id:

ENSPPAP00000007996 ⟸ ENSPPAT00000030626

RefSeq Acc Id:

ENSPPAP00000007992 ⟸ ENSPPAT00000030621

Protein Domains

Thioredoxin

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000027223	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSPPAT00000030621.1	UniProtKB/TrEMBL
	ENSPPAT00000030626.1	UniProtKB/TrEMBL
Gene3D-CATH	Glutaredoxin	UniProtKB/TrEMBL
InterPro	PDI_a_PDIR	UniProtKB/TrEMBL
	PDIA5_N_PDI_b	UniProtKB/TrEMBL
	Thioredoxin-like_sf	UniProtKB/TrEMBL
	Thioredoxin_CS	UniProtKB/TrEMBL
	Thioredoxin_domain	UniProtKB/TrEMBL
KEGG Report	pps:100988513	UniProtKB/TrEMBL
NCBI Gene	PDIA5	ENTREZGENE
PANTHER	PROTEIN DISULFIDE-ISOMERASE A5	UniProtKB/TrEMBL
	PROTEIN DISULFIDE-ISOMERASE C17H9.14C-RELATED	UniProtKB/TrEMBL
Pfam	Thioredoxin	UniProtKB/TrEMBL
PRINTS	THIOREDOXIN	UniProtKB/TrEMBL
PROSITE	THIOREDOXIN_1	UniProtKB/TrEMBL
	THIOREDOXIN_2	UniProtKB/TrEMBL
Superfamily-SCOP	SSF52833	UniProtKB/TrEMBL
UniProt	A0A2R8ZVX7	ENTREZGENE, UniProtKB/TrEMBL
	A0A2R8ZYH6	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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