Pdia5 (protein disulfide isomerase associated 5) - Rat Genome Database
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Gene: Pdia5 (protein disulfide isomerase associated 5) Mus musculus
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Symbol: Pdia5
Name: protein disulfide isomerase associated 5
RGD ID: 1550584
Description: Predicted to have peptide disulfide oxidoreductase activity. Predicted to be involved in cell redox homeostasis. Predicted to localize to endoplasmic reticulum. Is expressed in clavicle; mandible; maxilla; orbito-sphenoid; and rib. Orthologous to human PDIA5 (protein disulfide isomerase family A member 5); INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; benzo[a]pyrene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: 2700053F16Rik; AU015525; P; Pdir; protein disulfide isomerase-associated 5; protein disulfide isomerase-related protein; protein disulfide-isomerase A5
Orthologs:
Homo sapiens (human) : PDIA5 (protein disulfide isomerase family A member 5)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Pdia5 (protein disulfide isomerase family A, member 5)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pdia5 (protein disulfide isomerase family A member 5)
Pan paniscus (bonobo/pygmy chimpanzee) : PDIA5 (protein disulfide isomerase family A member 5)
Canis lupus familiaris (dog) : PDIA5 (protein disulfide isomerase family A member 5)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pdia5 (protein disulfide isomerase family A member 5)
Sus scrofa (pig) : PDIA5 (protein disulfide isomerase family A member 5)
Chlorocebus sabaeus (African green monkey) : PDIA5 (protein disulfide isomerase family A member 5)
Heterocephalus glaber (naked mole-rat) : Pdia5 (protein disulfide isomerase family A member 5)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391635,217,678 - 35,311,289 (-)NCBI
GRCm381635,397,308 - 35,490,919 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1635,397,312 - 35,490,873 (-)EnsemblGRCm38mm10GRCm38
MGSCv371635,397,398 - 35,490,959 (-)NCBIGRCm37mm9NCBIm37
MGSCv361635,317,059 - 35,410,620 (-)NCBImm8
Celera1635,866,403 - 35,959,222 (-)NCBICelera
Cytogenetic Map16B3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
COVID-19  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,4-dinitrotoluene  (ISO)
4-amino-2,6-dinitrotoluene  (ISO)
6-propyl-2-thiouracil  (ISO)
acetamide  (ISO)
acrylamide  (ISO)
adefovir pivoxil  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (ISO)
bromobenzene  (ISO)
buspirone  (ISO)
cadmium dichloride  (ISO)
captan  (EXP)
carbon nanotube  (EXP)
chloroacetaldehyde  (ISO)
chlorpromazine  (ISO)
cidofovir anhydrous  (ISO)
cisplatin  (ISO)
clodronic acid  (ISO)
clofibrate  (EXP)
clofibric acid  (ISO)
cobalt dichloride  (ISO)
cyclosporin A  (ISO)
diazinon  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
endosulfan  (ISO)
entinostat  (ISO)
fenofibrate  (ISO)
flutamide  (ISO)
folic acid  (EXP)
folpet  (EXP)
genistein  (ISO)
ibuprofen  (ISO)
ifosfamide  (ISO)
ketamine  (ISO)
lithium chloride  (ISO)
menadione  (ISO)
metformin  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (ISO)
nefazodone  (ISO)
nickel dichloride  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (EXP)
propiconazole  (EXP)
SB 431542  (ISO)
tert-butyl hydroperoxide  (EXP)
thapsigargin  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
troglitazone  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vinclozolin  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

Additional References at PubMed
PMID:7556671   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:12477932   PMID:12520002   PMID:12904583   PMID:14610273   PMID:15163632   PMID:15489334   PMID:16141072  
PMID:16141073   PMID:18799693   PMID:21267068   PMID:22002444   PMID:30196744   PMID:32325033  


Genomics

Comparative Map Data
Pdia5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391635,217,678 - 35,311,289 (-)NCBI
GRCm381635,397,308 - 35,490,919 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1635,397,312 - 35,490,873 (-)EnsemblGRCm38mm10GRCm38
MGSCv371635,397,398 - 35,490,959 (-)NCBIGRCm37mm9NCBIm37
MGSCv361635,317,059 - 35,410,620 (-)NCBImm8
Celera1635,866,403 - 35,959,222 (-)NCBICelera
Cytogenetic Map16B3NCBI
PDIA5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl3123,067,025 - 123,225,227 (+)EnsemblGRCh38hg38GRCh38
GRCh383123,067,025 - 123,162,104 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh373122,785,856 - 122,880,953 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363124,268,655 - 124,363,567 (+)NCBINCBI36hg18NCBI36
Celera3121,192,646 - 121,287,739 (+)NCBI
Cytogenetic Map3q21.1NCBI
HuRef3120,158,749 - 120,254,205 (+)NCBIHuRef
CHM1_13122,749,529 - 122,844,663 (+)NCBICHM1_1
Pdia5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01168,493,035 - 68,578,999 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1168,493,035 - 68,578,995 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01171,580,311 - 71,666,275 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41167,117,749 - 67,204,482 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11167,175,337 - 67,262,069 (+)NCBI
Celera1164,733,302 - 64,819,377 (+)NCBICelera
Cytogenetic Map11q22NCBI
Pdia5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542722,268,511 - 22,356,181 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542722,268,730 - 22,356,123 (+)NCBIChiLan1.0ChiLan1.0
PDIA5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.13127,059,751 - 127,154,451 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3127,059,751 - 127,154,451 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v03120,155,981 - 120,250,961 (+)NCBIMhudiblu_PPA_v0panPan3
PDIA5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl3326,131,893 - 26,227,253 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.13326,131,969 - 26,227,256 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Pdia5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049367252,024,646 - 2,114,530 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PDIA5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13137,296,856 - 137,398,471 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113137,300,086 - 137,398,465 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213146,843,483 - 146,941,924 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PDIA5
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl2257,711,041 - 57,806,037 (-)Ensembl
ChlSab1.12257,711,049 - 57,806,058 (-)NCBI
Pdia5
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046249121,408,645 - 1,523,498 (+)NCBI

Position Markers
AU015525  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381635,397,391 - 35,398,334UniSTSGRCm38
MGSCv371635,397,477 - 35,398,420UniSTSGRCm37
Celera1635,866,482 - 35,867,425UniSTS
Cytogenetic Map16B3UniSTS
Whitehead/MRC_RH16357.51UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
27095908Scvln7_msacral vertebrae length 2, 5 week (mouse)16350000040000000Mouse
27226768Tibl9_mtibia length 9, 5 week (mouse)16350000051600000Mouse
27226785Feml12_mfemur length 12, 5 week (mouse)16350000064800000Mouse
26884432Zlq7_mzygomatic length QTL 7, 10 week (mouse)16400000064800000Mouse
38501069Tip4_mtuberculosis immunophenotype 4, IFN-g level (mouse)16450000044700000Mouse
1301443Mopkd2_mmodifier of polycystic kidney disease progression 2 (mouse)Not determined16482756438827664Mouse
1300656Bgeq15_mbody growth early QTL 15 (mouse)Not determined16595650239956690Mouse
1301945Skl7_mskeletal size (tail length) 7 (mouse)Not determined16595650239956690Mouse
1300987Skull23_mskull morphology 23 (mouse)Not determined16595650239956690Mouse
1300943Skts9_mskin tumor susceptibility 9 (mouse)Not determined16595650239956690Mouse
1357763Lp1_mlymphocyte proliferation 1 (mouse)Not determined16672511565669666Mouse
11251724Ewc6_methanol withdrawal and consumption 6 (mouse)16840730242407302Mouse
26884376Skwq4_mskull length QTL 4, 5 week (mouse)16860000091100000Mouse
10043978Obq35_mobesity QTL 35 (mouse)Not determined161006288144062881Mouse
1301086Lprm5_mlymphoproliferation modifier 5 (mouse)Not determined161203007246030171Mouse
1301841Lrnx9_mlearning-contextual 9 (mouse)Not determined161240654246406653Mouse
10045614Rapop6_mradiation-induced apoptosis 6 (mouse)Not determined161498410348984214Mouse
4142236Pstc4_mperiosteal circumference 4 (mouse)Not determined161570409149704294Mouse
1357517Bwtn1_mbody weight at necropsy 1 (mouse)Not determined162020057985803938Mouse
1300534Bmd15_mbone mineral density 15 (mouse)Not determined162211802156118212Mouse
4141179Ipng3_mimprinted postnatal growth 3 (mouse)Not determined2295650257773713Mouse
1300915Lmr12_mleishmaniasis resistance 12 (mouse)Not determined162897245062972589Mouse
11059559Lmr12a_mleishmaniasis resistance 12a (mouse)162897245062972589Mouse
11059560Lmr12b_mleishmaniasis resistance 12b (mouse)162897245062972589Mouse
11049571Lmr12c_mleishmaniasis resistance 12c (mouse)162897245062972589Mouse
25671380Hrsq2_mhost response to SARS QTL 2, titer (mouse)163158368336719911Mouse
1301070Cypr1_mcytokine production 1 (mouse)Not determined163249243266492570Mouse
4142187Arrd3_mage-related retinal degeneration 3 (mouse)Not determined3270409165669666Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:266
Count of miRNA genes:216
Interacting mature miRNAs:229
Transcripts:ENSMUST00000023550
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000023550   ⟹   ENSMUSP00000023550
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1635,397,312 - 35,490,873 (-)Ensembl
RefSeq Acc Id: ENSMUST00000231406
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1635,410,473 - 35,413,185 (-)Ensembl
RefSeq Acc Id: ENSMUST00000231595
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1635,453,471 - 35,490,589 (-)Ensembl
RefSeq Acc Id: ENSMUST00000231779
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1635,398,319 - 35,413,175 (-)Ensembl
RefSeq Acc Id: NM_028295   ⟹   NP_082571
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391635,217,682 - 35,311,243 (-)NCBI
GRCm381635,397,312 - 35,490,873 (-)NCBI
MGSCv371635,397,398 - 35,490,959 (-)RGD
Celera1635,866,403 - 35,959,222 (-)RGD
cM Map16 ENTREZGENE
Sequence:
RefSeq Acc Id: XR_004939233
RefSeq Status:
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391635,217,678 - 35,311,289 (-)NCBI
RefSeq Acc Id: XR_384603
RefSeq Status:
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391635,217,678 - 35,311,289 (-)NCBI
GRCm381635,397,308 - 35,490,919 (-)NCBI
Sequence:
RefSeq Acc Id: XR_384604
RefSeq Status:
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391635,217,678 - 35,311,289 (-)NCBI
GRCm381635,397,308 - 35,490,919 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_082571   ⟸   NM_028295
- Peptide Label: precursor
- UniProtKB: Q921X9 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000023550   ⟸   ENSMUST00000023550
Protein Domains
Thioredoxin

Promoters
RGD ID:6827335
Promoter ID:MM_KWN:20872
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   Spleen
Transcripts:NM_028295
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361635,490,654 - 35,491,154 (-)MPROMDB
RGD ID:8686074
Promoter ID:EPDNEW_M21068
Type:initiation region
Name:Pdia5_1
Description:Mus musculus protein disulfide isomerase associated 5 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381635,490,883 - 35,490,943EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1919849 AgrOrtholog
Ensembl Genes ENSMUSG00000022844 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000023550 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000023550 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.30.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro PDIA5_N_PDI_b UniProtKB/Swiss-Prot
  Thioredoxin-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thioredoxin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thioredoxin_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:72599 UniProtKB/Swiss-Prot
MGD MGI:1919849 ENTREZGENE
NCBI Gene 72599 ENTREZGENE
Pfam Thioredoxin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Pdia5 PhenoGen
PROSITE ER_TARGET UniProtKB/Swiss-Prot
  THIOREDOXIN_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  THIOREDOXIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52833 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Mm.71015 ENTREZGENE
UniProt PDIA5_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q9CSM8_MOUSE UniProtKB/TrEMBL