SERPINA5 (serpin family A member 5) - Rat Genome Database

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Gene: SERPINA5 (serpin family A member 5) Pan paniscus
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Symbol: SERPINA5
Name: serpin family A member 5
RGD ID: 11937722
Description: ENCODES a protein that exhibits serine-type endopeptidase inhibitor activity (ortholog); INVOLVED IN negative regulation of hydrolase activity (ortholog); negative regulation of proteolysis (ortholog); seminal vesicle development (ortholog); PARTICIPATES IN fibrinolysis pathway; ASSOCIATED WITH amphetamine abuse (ortholog); Arterial Occlusive Diseases (ortholog); cholestasis (ortholog); FOUND IN acrosomal membrane (inferred); external side of plasma membrane (inferred); extracellular exosome (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: plasma serine protease inhibitor
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21595,729,564 - 95,742,189 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11494,946,069 - 94,958,694 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01475,205,446 - 75,217,114 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11494,537,115 - 94,548,803 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1494,537,115 - 94,548,803 (+)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
SERPINA5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21595,729,564 - 95,742,189 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11494,946,069 - 94,958,694 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01475,205,446 - 75,217,114 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11494,537,115 - 94,548,803 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1494,537,115 - 94,548,803 (+)Ensemblpanpan1.1panPan2
SERPINA5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381494,581,426 - 94,593,118 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1494,561,442 - 94,593,118 (+)EnsemblGRCh38hg38GRCh38
GRCh371495,047,763 - 95,059,455 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361494,117,564 - 94,129,205 (+)NCBINCBI36Build 36hg18NCBI36
Build 341494,117,563 - 94,129,204NCBI
Celera1475,103,903 - 75,115,619 (+)NCBICelera
Cytogenetic Map14q32.13NCBI
HuRef1475,228,133 - 75,239,873 (+)NCBIHuRef
CHM1_11494,985,498 - 94,997,214 (+)NCBICHM1_1
T2T-CHM13v2.01488,811,397 - 88,823,118 (+)NCBIT2T-CHM13v2.0
Serpina5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912104,065,572 - 104,072,397 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12104,067,372 - 104,072,396 (+)EnsemblGRCm39 Ensembl
GRCm3812104,099,313 - 104,106,138 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12104,101,113 - 104,106,137 (+)EnsemblGRCm38mm10GRCm38
MGSCv3712105,339,323 - 105,344,347 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3612104,502,163 - 104,507,187 (+)NCBIMGSCv36mm8
Celera12105,318,382 - 105,323,416 (+)NCBICelera
Cytogenetic Map12ENCBI
cM Map1253.3NCBI
Serpina5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86128,774,006 - 128,793,187 (+)NCBIGRCr8
mRatBN7.26123,009,224 - 123,028,412 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6123,023,306 - 123,028,407 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6123,164,246 - 123,169,377 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06123,459,540 - 123,464,673 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06122,796,353 - 122,801,488 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06127,753,152 - 127,772,403 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6127,766,470 - 127,772,420 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06136,972,583 - 136,990,812 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46128,156,901 - 128,161,334 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16128,160,647 - 128,165,080 (+)NCBI
Celera6120,503,068 - 120,508,038 (+)NCBICelera
Cytogenetic Map6q32NCBI
Serpina5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543817,787,399 - 17,796,414 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543817,787,398 - 17,796,013 (-)NCBIChiLan1.0ChiLan1.0
SERPINA5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1863,567,060 - 63,577,015 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl863,566,356 - 63,576,308 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha863,143,801 - 63,153,748 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0863,834,133 - 63,844,074 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl863,833,699 - 63,843,370 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1863,509,369 - 63,519,317 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0863,561,712 - 63,571,667 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0863,892,389 - 63,902,350 (+)NCBIUU_Cfam_GSD_1.0
LOC101958459
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864010,883,273 - 10,897,335 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936846146,116 - 150,438 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936846141,334 - 150,381 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SERPINA5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl7115,802,150 - 115,810,824 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.17115,799,414 - 115,810,825 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.27122,916,002 - 122,927,421 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SERPINA5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12472,369,082 - 72,388,439 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2472,381,119 - 72,384,903 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605359,588,553 - 59,602,023 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Serpina5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247347,236,833 - 7,244,752 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247347,236,833 - 7,245,579 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSPPAT00000043629   ⟹   ENSPPAP00000020832
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1494,537,115 - 94,548,803 (+)Ensembl
Ensembl Acc Id: ENSPPAT00000043635   ⟹   ENSPPAP00000020838
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1494,537,361 - 94,548,152 (+)Ensembl
RefSeq Acc Id: XM_003832820   ⟹   XP_003832868
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21595,729,564 - 95,742,189 (+)NCBI
NHGRI_mPanPan11494,946,069 - 94,958,694 (+)NCBI
Mhudiblu_PPA_v01475,205,497 - 75,217,114 (+)NCBI
PanPan1.11494,537,115 - 94,548,803 (+)NCBI
Sequence:
RefSeq Acc Id: XM_003832821   ⟹   XP_003832869
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21595,730,550 - 95,742,189 (+)NCBI
NHGRI_mPanPan11494,947,055 - 94,958,694 (+)NCBI
Mhudiblu_PPA_v01475,205,509 - 75,217,114 (+)NCBI
PanPan1.11494,537,149 - 94,548,801 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008958263   ⟹   XP_008956511
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21595,730,508 - 95,742,189 (+)NCBI
NHGRI_mPanPan11494,947,013 - 94,958,694 (+)NCBI
Mhudiblu_PPA_v01475,205,446 - 75,217,114 (+)NCBI
PanPan1.11494,537,121 - 94,548,803 (+)NCBI
Sequence:
RefSeq Acc Id: XM_055097983   ⟹   XP_054953958
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21595,731,010 - 95,742,189 (+)NCBI
NHGRI_mPanPan11494,947,515 - 94,958,694 (+)NCBI
Protein Sequences
Protein RefSeqs XP_003832868 (Get FASTA)   NCBI Sequence Viewer  
  XP_003832869 (Get FASTA)   NCBI Sequence Viewer  
  XP_008956511 (Get FASTA)   NCBI Sequence Viewer  
  XP_054953958 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000020832.1
  ENSPPAP00000020838.1
RefSeq Acc Id: XP_003832868   ⟸   XM_003832820
- UniProtKB: A0A2R9AU45 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008956511   ⟸   XM_008958263
- UniProtKB: A0A2R9AU45 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_003832869   ⟸   XM_003832821
- UniProtKB: A0A2R9AU45 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSPPAP00000020832   ⟸   ENSPPAT00000043629
Ensembl Acc Id: ENSPPAP00000020838   ⟸   ENSPPAT00000043635
RefSeq Acc Id: XP_054953958   ⟸   XM_055097983
Protein Domains
SERPIN


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000033644 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000043629.1 UniProtKB/TrEMBL
  ENSPPAT00000043635.1 UniProtKB/TrEMBL
Gene3D-CATH 2.30.39.10 UniProtKB/TrEMBL
  3.30.497.10 UniProtKB/TrEMBL
InterPro Serpin_CS UniProtKB/TrEMBL
  Serpin_dom UniProtKB/TrEMBL
  Serpin_fam UniProtKB/TrEMBL
  Serpin_sf UniProtKB/TrEMBL
  Serpin_sf_1 UniProtKB/TrEMBL
  Serpin_sf_2 UniProtKB/TrEMBL
KEGG Report pps:100992073 UniProtKB/TrEMBL
NCBI Gene SERPINA5 ENTREZGENE
PANTHER PLASMA SERINE PROTEASE INHIBITOR UniProtKB/TrEMBL
  PTHR11461 UniProtKB/TrEMBL
Pfam Serpin UniProtKB/TrEMBL
PROSITE SERPIN UniProtKB/TrEMBL
SMART SERPIN UniProtKB/TrEMBL
Superfamily-SCOP SSF56574 UniProtKB/TrEMBL
UniProt A0A2R9AU45 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9AUG1_PANPA UniProtKB/TrEMBL