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Gene: PTGIR (prostaglandin I2 receptor) Pan paniscus

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Symbol:

PTGIR

Name:

prostaglandin I2 receptor

RGD ID:

11926902

Description:

ENCODES a protein that exhibits G protein-coupled receptor activity (inferred); prostacyclin receptor activity (inferred); INVOLVED IN response to lipopolysaccharide (ortholog); PARTICIPATES IN eicosanoid signaling pathway; prostaglandin I2 signaling pathway; ASSOCIATED WITH aspirin-induced respiratory disease (ortholog); heart disease (ortholog); long QT syndrome 1 (ortholog); FOUND IN cytosol (inferred); membrane (inferred); plasma membrane (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

prostacyclin receptor; prostaglandin I2 (prostacyclin) receptor (IP)

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	20	52,770,490 - 52,775,153 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	19	54,641,304 - 54,645,928 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	19	43,613,065 - 43,617,700 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	19	52,141,822 - 52,146,473 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	19	52,141,822 - 52,146,473 (-)	Ensembl	panpan1.1		panPan2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

aspirin-induced respiratory disease (ISO)

heart disease (ISO)

long QT syndrome 1 (ISO)

Walker-Warburg syndrome (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

adenylate cyclase-activating G protein-coupled receptor signaling pathway (IEA)

G protein-coupled receptor signaling pathway (IEA)

inflammatory response (IEA)

negative regulation of platelet-derived growth factor receptor signaling pathway (IEA)

negative regulation of smooth muscle cell proliferation (IEA)

positive regulation of cytosolic calcium ion concentration (IEA)

response to lipopolysaccharide (IEA,ISO)

Cellular Component

cytosol (IEA)

membrane (IEA)

plasma membrane (IEA)

Molecular Function

G protein-coupled receptor activity (IEA)

prostacyclin receptor activity (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

eicosanoid signaling pathway (ISO)

prostaglandin I2 signaling pathway (ISO)

References

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

PTGIR
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	20	52,770,490 - 52,775,153 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	19	54,641,304 - 54,645,928 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	19	43,613,065 - 43,617,700 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	19	52,141,822 - 52,146,473 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	19	52,141,822 - 52,146,473 (-)	Ensembl	panpan1.1		panPan2

PTGIR
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	19	46,610,687 - 46,625,089 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	19	46,618,550 - 46,625,089 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	19	47,123,725 - 47,128,346 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	19	51,815,565 - 51,820,194 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	19	51,815,565 - 51,820,194	NCBI
Celera	19	43,927,252 - 43,931,881 (-)	NCBI		Celera
Cytogenetic Map	19	q13.32	NCBI
HuRef	19	43,548,741 - 43,553,370 (-)	NCBI		HuRef
CHM1_1	19	47,125,572 - 47,130,201 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	19	49,436,301 - 49,450,683 (-)	NCBI		T2T-CHM13v2.0

Ptgir
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	7	16,640,442 - 16,644,828 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	7	16,640,415 - 16,644,830 (+)	Ensembl		GRCm39 Ensembl
GRCm38	7	16,906,490 - 16,910,905 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	7	16,906,490 - 16,910,905 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	7	17,491,839 - 17,496,254 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	7	16,065,012 - 16,069,427 (+)	NCBI		MGSCv36	mm8
Celera	7	14,112,908 - 14,117,323 (+)	NCBI		Celera
Cytogenetic Map	7	A2	NCBI
cM Map	7	9.15	NCBI

Ptgir
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	86,707,690 - 86,710,073 (+)	NCBI		GRCr8
mRatBN7.2	1	77,579,596 - 77,581,979 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	77,579,596 - 77,581,979 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	82,959,574 - 82,961,958 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	91,523,619 - 91,526,003 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	84,714,664 - 84,717,048 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	78,833,449 - 78,835,832 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	78,833,157 - 78,837,623 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	80,080,854 - 80,083,237 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	77,234,538 - 77,236,921 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	77,312,476 - 77,315,005 (+)	NCBI
Celera	1	72,064,851 - 72,067,234 (+)	NCBI		Celera
Cytogenetic Map	1	q21	NCBI

Ptgir
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955574	687,583 - 689,750 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955574	686,156 - 690,126 (-)	NCBI	ChiLan1.0	ChiLan1.0

PTGIR
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	1	109,275,198 - 109,279,463 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	1	109,274,988 - 109,277,584 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	1	108,754,493 - 108,758,755 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	1	109,801,203 - 109,805,465 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	1	109,801,007 - 109,805,132 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	1	109,478,359 - 109,480,898 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	1	109,112,477 - 109,116,738 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	1	109,981,209 - 109,985,471 (+)	NCBI		UU_Cfam_GSD_1.0

Ptgir
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409349	18,866,264 - 18,871,516 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936664	487,125 - 489,414 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936664	487,069 - 489,328 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PTGIR
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	52,522,638 - 52,527,345 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	52,522,639 - 52,527,338 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	47,842,083 - 47,847,155 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

PTGIR
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	6	39,977,057 - 39,983,592 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	6	39,977,864 - 39,980,860 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666073	19,689,063 - 19,693,721 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Ptgir
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624832	6,948,572 - 6,952,719 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624832	6,948,638 - 6,952,664 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_003817487	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_034945671	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JARIFH020000020	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSPPAT00000061388 ⟹ ENSPPAP00000038485

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	19	52,141,822 - 52,146,473 (-)	Ensembl

Ensembl Acc Id:

ENSPPAT00000061392 ⟹ ENSPPAP00000038489

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	19	52,144,551 - 52,145,581 (-)	Ensembl

RefSeq Acc Id:

XM_003817487 ⟹ XP_003817535

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	20	52,770,490 - 52,775,153 (-)	NCBI
NHGRI_mPanPan1	19	54,641,304 - 54,645,928 (-)	NCBI
Mhudiblu_PPA_v0	19	43,613,065 - 43,617,700 (-)	NCBI
PanPan1.1	19	52,141,822 - 52,146,473 (-)	NCBI

Sequence:

show sequence

ACGGAGGGAGGAGGGAAGGAGAAGCTGACACACAGACCGACACAGGCAGCGAGAGACACGCGGA
GCAAAGCAAGTGAAGGCACAGACGCACGGGACAGGAGAGCCTGGGCAAGACTGGAGAGCCCAGA
CCTGGGATGGCGGATTCGTGCAGGAACCTCACCTACGTGCGGGGCTCGGTGGGGCCGGCCACCA
GCACCCTGATGTTCGTGGCCGGCGTGGTGGGCAACGGGCTGGCCCTGGGCATCCTGAGCGCACG
GCGACCAGCGCGCCCCTCGGCCTTCGCGGTGCTGGTCACCGGACTGGCGGCCACCGACCTGCTG
GGCACCAGCTTCCTGAGCCCGGCCGTGTTCGTGGCCTATGCGCGCAACAGCTCTCTGCTGGGCC
TGGCCCGAGGCGGCCCCGCGCTGTGCGATGCCTTCGCCTTCGCCATGACCTTCTTCGGCCTGGC
GTCCATGCTCATCCTCTTTGCCATGGCCGTGGAGCGCTGCCTGGCGCTGAGCCACCCCTACCTC
TACGCGCAGCTGGACGGGCCCCGCTGCGCCCGCCTGGCGCTGCCAGCCATCTACGCCTTCTGCG
TCCTCTTCTGCGCGCTGCCCCTGCTGGGCCTGGGCCAACACCAGCAGTACTGCCCCGGCAGCTG
GTGCTTCCTCCGCATGCGCTGGGCCCAGCCGGGCGGCGCCGCCTTCTCGCTGGCCTACGCCGGC
CTGGTGGCCCTGCTGGTGGCTGCCATCTTCCTCTGCAACGGCTCGGTCACCCTCAGCCTCTGCC
GCATGTACCGCCAGCAGAAGCGCCACCAGGGCTCTCTGGGTCCACGGCCGCGCACTGGAGAGGA
CGAGGTGGACCACCTGATCCTGCTGGCCCTCATGACAGTGGTCATGGCCGTGTGCTCCCTGCCT
CTCACGATCCGCTGCTTCACCCAGGCCGTCGCCCCTGACAGCAGCAGTGAGATGGGGGACCTCC
TTGCCTTCCGCTTCTACGCCTTCAACCCCATCCTGGACCCCTGGGTCTTCATCCTTTTCCGCAA
GGCTGTCTTCCAGCGACTCAAGCTCTGGGTCTGCTGCCTGTGCCTCGGGCCTGCCCACGGCGAC
TCGCAGACACCCCTTTCCCAGCTCGCCTCTGGGAGGAGGGACCCAAGGGCCCCCTCTGCTCCTG
TGGGAAAGGAGGGGAGCTGGGTGCCTTTGTCGGCTTGGGGCGAGGGGCAGGTGGAGCCCTTGCC
TCTCACACAGCAGTCCAGCGGCAGCGCCGTGGGAACGTCGTCCAAAGCAGAAGCCAGCGTCGCC
TGCTCCCTCTGCTGACATTTCGAGCTGACCCTGTGATCTCTGCCCTGTCTTCGGGCGACAGGAG
CCAGAAAATCAGGGACATGGCTGATGGCTGCGGATGCTGGAACCTTGGCCCCCAAACTCTGGGG
CCGATCAGCTGCTGTTTCTCCTGCGGCAGGGCAGTCGCTGCTGGCTCTGGGAAGAGAGTGAGGG
ACAGAGGAAACGTTTATCCTGGAGTGCAGAAAGAATGGTTCTCTCAAAATAACCAGTGGCCTGG
CCAACCTGCTCTGGCCCTGGATTCCCCATCCATCTCACTGTCTAAATATTTAGAAGGCGGAGAA
GTTCCCAGCGGCTTCTGTACACTCAGGTCTGCTCTGGTCTGGGTGCTGGCTCCAATCTGCGTCC
ACTTAGGGGGCCCAACTGCCCACCCCAAGTCCCCAGGGGATGGCCCTCCCCCTCTACCAAGCCA
CTCCAAGAGCCAGCCCCTCTCTGCTCCACAAAAACCACAGTTATTGGAAAAGCTCCCTGCCTTC
CCTTGCCGCTGGTCCCCCATCAGGCTTGGGAGCCCTGGCATCCCAAAGGGGCAACGGGAGGAAG
GGGAGGCTGCTGCATTGTGGGTGATGACGTAGGACATGTGCTTGGTACAAAAAGGGCCTGAGAC
ATTCCACCTAGCTTGACTGGCTGCAAGATGAGAACTGGGGGGGTGCAGGTGGTGGGGAGACAGA
TGGAGAAGCTGGCAGATGAAGGGTGGGGGCTGCGGATCCCAGGGACTGCCCCAGAACACAAACC
TAAGTCCTGTGCCTGTCCCCAGGGTCCTGAATAAATAAAAGCCTCCTTGCAGAGCCTGA

hide sequence

Protein Sequences


Protein RefSeqs	XP_003817535	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSPPAP00000038485.1
	ENSPPAP00000038489.1

RefSeq Acc Id:

XP_003817535 ⟸ XM_003817487

- UniProtKB:

A0A2R9C957 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MADSCRNLTYVRGSVGPATSTLMFVAGVVGNGLALGILSARRPARPSAFAVLVTGLAATDLLGT
SFLSPAVFVAYARNSSLLGLARGGPALCDAFAFAMTFFGLASMLILFAMAVERCLALSHPYLYA
QLDGPRCARLALPAIYAFCVLFCALPLLGLGQHQQYCPGSWCFLRMRWAQPGGAAFSLAYAGLV
ALLVAAIFLCNGSVTLSLCRMYRQQKRHQGSLGPRPRTGEDEVDHLILLALMTVVMAVCSLPLT
IRCFTQAVAPDSSSEMGDLLAFRFYAFNPILDPWVFILFRKAVFQRLKLWVCCLCLGPAHGDSQ
TPLSQLASGRRDPRAPSAPVGKEGSWVPLSAWGEGQVEPLPLTQQSSGSAVGTSSKAEASVACS
LC

hide sequence

Ensembl Acc Id:

ENSPPAP00000038485 ⟸ ENSPPAT00000061388

Ensembl Acc Id:

ENSPPAP00000038489 ⟸ ENSPPAT00000061392

Protein Domains

G-protein coupled receptors family 1 profile

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000041949	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSPPAT00000061388.1	UniProtKB/TrEMBL
	ENSPPAT00000061392.1	UniProtKB/TrEMBL
Gene3D-CATH	Rhodopsin 7-helix transmembrane proteins	UniProtKB/TrEMBL
InterPro	GPCR_Rhodpsn	UniProtKB/TrEMBL
	GPCR_Rhodpsn_7TM	UniProtKB/TrEMBL
	Prostanoid_rcpt	UniProtKB/TrEMBL
	Prostglndn_IP_rcpt	UniProtKB/TrEMBL
KEGG Report	pps:100976681	UniProtKB/TrEMBL
NCBI Gene	PTGIR	ENTREZGENE
PANTHER	PTHR11866	UniProtKB/TrEMBL
	PTHR11866:SF7	UniProtKB/TrEMBL
Pfam	7tm_1	UniProtKB/TrEMBL
PRINTS	GPCRRHODOPSN	UniProtKB/TrEMBL
	PROSTANOIDR	UniProtKB/TrEMBL
	PRSTNOIDIPR	UniProtKB/TrEMBL
PROSITE	G_PROTEIN_RECEP_F1_1	UniProtKB/TrEMBL
	G_PROTEIN_RECEP_F1_2	UniProtKB/TrEMBL
Superfamily-SCOP	Family A G protein-coupled receptor-like	UniProtKB/TrEMBL
UniProt	A0A2R9C957	ENTREZGENE, UniProtKB/TrEMBL
	A0A2R9C9H0_PANPA	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2017-08-15	PTGIR	prostaglandin I2 receptor		prostaglandin I2 (prostacyclin) receptor (IP)	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Annotations - SMPDB

Imported Annotations - PID (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Annotations - SMPDB

Imported Annotations - PID (archival)