CLDN3 (claudin 3) - Rat Genome Database

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Gene: CLDN3 (claudin 3) Pan paniscus
Analyze
Symbol: CLDN3
Name: claudin 3
RGD ID: 11841711
Description: ENCODES a protein that exhibits cell-cell adhesion mediator activity (inferred); identical protein binding (inferred); structural molecule activity (inferred); INVOLVED IN response to ethanol (ortholog); response to Gram-positive bacterium (ortholog); ASSOCIATED WITH allergic rhinitis (ortholog); autism spectrum disorder (ortholog); autistic disorder (ortholog); FOUND IN bicellular tight junction (ortholog); lateral plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: claudin-3
RGD Orthologs
Human
Mouse
Rat
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2691,123,883 - 91,130,587 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17139,393,595 - 139,395,219 (+)NCBINHGRI_mPanPan1
PanPan1.1780,924,338 - 80,925,761 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl780,924,731 - 80,925,393 (-)Ensemblpanpan1.1panPan2



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
CLDN3BonoboIntestinal Reperfusion Injury  ISOCldn3 (Rattus norvegicus)9068941protein:decreased expression:colon:RGDPMID:19929946 and REF_RGD_ID:2325127
CLDN3Bonobopeptic esophagitis  ISOCldn3 (Rattus norvegicus)9068941protein:altered expression:epithelial cell and esophagus:RGDPMID:21373849 and REF_RGD_ID:11344880
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Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
CLDN3Bonoboautism spectrum disorder  ISOCLDN3 (Homo sapiens)8554872ClinVar Annotator: match by term: Autism spectrum disorderClinVarPMID:21658581 more ...
CLDN3Bonoboautistic disorder  ISOCLDN3 (Homo sapiens)8554872ClinVar Annotator: match by term: AutismClinVarPMID:21681106 and PMID:30208311
CLDN3Bonobointestinal volvulus  ISOCLDN3 (Homo sapiens)8554872ClinVar Annotator: match by term: INTESTINAL MALROTATION and FAMILIALClinVarPMID:25741868
CLDN3BonoboNeurodevelopmental Disorders  ISOCLDN3 (Homo sapiens)8554872ClinVar Annotator: match by term: Neurodevelopmental disorderClinVarPMID:25741868
CLDN3Bonobopleomorphic xanthoastrocytoma  ISOCLDN3 (Homo sapiens)8554872ClinVar Annotator: match by term: Pleomorphic xanthoastrocytomaClinVarPMID:28299358
CLDN3Bonoboschizophrenia  ISOCLDN3 (Homo sapiens)8554872ClinVar Annotator: match by term: SchizophreniaClinVarPMID:21681106 and PMID:30208311
CLDN3Bonobosupravalvular aortic stenosis  ISOCLDN3 (Homo sapiens)8554872ClinVar Annotator: match by term: Supravalvar aortic stenosisClinVarPMID:10627943 more ...
CLDN3BonoboVolvulus Of Midgut  ISOCLDN3 (Homo sapiens)8554872ClinVar Annotator: match by term: Volvulus of midgutClinVarPMID:25741868
CLDN3BonoboWilliams-Beuren syndrome  ISOCLDN3 (Homo sapiens)8554872ClinVar Annotator: match by term: Williams syndromeClinVarPMID:25741868
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Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
CLDN3Bonoboallergic rhinitis  ISOCLDN3 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:33441633
CLDN3BonoboProstatic Neoplasms  ISOCLDN3 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:17013881
CLDN3BonoboStomach Neoplasms  ISOCLDN3 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:16367923


Biological Process
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Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
CLDN3Bonoboactin cytoskeleton organization involved_inIEAUniProtKB:O15551 and ensembl:ENSP00000378577150520179 EnsemblGO_REF:0000107
CLDN3Bonobobicellular tight junction assembly involved_inIEAUniProtKB:O15551 and ensembl:ENSP00000378577150520179 EnsemblGO_REF:0000107
CLDN3Bonobocalcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules involved_inIEAUniProtKB:Q9Z0G9 and ensembl:ENSMUSP00000091799150520179 EnsemblGO_REF:0000107
CLDN3Bonobocell junction assembly involved_inIEAUniProtKB:O15551 and ensembl:ENSP00000378577150520179 EnsemblGO_REF:0000107
CLDN3Bonobocell junction maintenance involved_inIEAUniProtKB:Q9Z0G9 and ensembl:ENSMUSP00000091799150520179 EnsemblGO_REF:0000107
CLDN3Bonobocell-cell junction maintenance involved_inIEAUniProtKB:O15551 and ensembl:ENSP00000378577150520179 EnsemblGO_REF:0000107
CLDN3Bonoboepithelial cell morphogenesis involved_inIEAUniProtKB:Q9Z0G9 and ensembl:ENSMUSP00000091799150520179 EnsemblGO_REF:0000107
CLDN3Bonoboestablishment of endothelial blood-brain barrier involved_inIEAUniProtKB:Q9Z0G9 and ensembl:ENSMUSP00000091799150520179 EnsemblGO_REF:0000107
CLDN3Bonobonegative regulation of cell migration involved_inIEAUniProtKB:O15551 and ensembl:ENSP00000378577150520179 EnsemblGO_REF:0000107
CLDN3Bonobonegative regulation of cell population proliferation involved_inIEAUniProtKB:O15551 and ensembl:ENSP00000378577150520179 EnsemblGO_REF:0000107
CLDN3Bonobonegative regulation of gene expression involved_inIEAUniProtKB:O15551 and ensembl:ENSP00000378577150520179 EnsemblGO_REF:0000107
CLDN3Bonobonegative regulation of phosphate transmembrane transport involved_inIEAUniProtKB:O15551 and ensembl:ENSP00000378577150520179 EnsemblGO_REF:0000107
CLDN3Bonobopositive regulation of cell migration involved_inIEAUniProtKB:O15551 and ensembl:ENSP00000378577150520179 EnsemblGO_REF:0000107
CLDN3Bonobopositive regulation of gene expression involved_inIEAUniProtKB:O15551 and ensembl:ENSP00000378577150520179 EnsemblGO_REF:0000107
CLDN3Bonobopositive regulation of wound healing involved_inIEAUniProtKB:O15551 and ensembl:ENSP00000378577150520179 EnsemblGO_REF:0000107
CLDN3Bonoboregulation of cell morphogenesis involved_inIEAUniProtKB:O15551 and ensembl:ENSP00000378577150520179 EnsemblGO_REF:0000107
CLDN3Bonoboregulation of membrane permeability involved_inIEAUniProtKB:O15551 and ensembl:ENSP00000378577150520179 EnsemblGO_REF:0000107
CLDN3Bonoboregulation of transepithelial transport involved_inIEAUniProtKB:O15551 and ensembl:ENSP00000378577150520179 EnsemblGO_REF:0000107
CLDN3Bonoboresponse to ethanol  ISOCldn3 (Rattus norvegicus)9068941 RGDPMID:17889313 and REF_RGD_ID:11344881
CLDN3Bonoboresponse to Gram-positive bacterium  ISOCldn3 (Rattus norvegicus)9068941Bifidobacterium bifidumRGDPMID:20501441 and REF_RGD_ID:2324672
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Cellular Component
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Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
CLDN3Bonoboanchoring junction located_inIEAUniProtKB-KW:KW-0965150520179 UniProtGO_REF:0000043
CLDN3Bonoboapical junction complex located_inIEAUniProtKB:O15551 and ensembl:ENSP00000378577150520179 EnsemblGO_REF:0000107
CLDN3Bonoboapicolateral plasma membrane located_inIEAUniProtKB:Q9Z0G9 and ensembl:ENSMUSP00000091799150520179 EnsemblGO_REF:0000107
CLDN3Bonobobicellular tight junction  ISOCldn3 (Rattus norvegicus)9068941 RGDPMID:11159882 and REF_RGD_ID:727233
CLDN3Bonobobicellular tight junction located_inIEAUniProtKB:O15551 more ...150520179 EnsemblGO_REF:0000107
CLDN3Bonobobicellular tight junction located_inIEAInterPro:IPR003549 and InterPro:IPR006187150520179 InterProGO_REF:0000002
CLDN3Bonobobicellular tight junction located_inIEAUniRule:UR000060637150520179 UniProtGO_REF:0000104
CLDN3Bonobobicellular tight junction located_inIEAUniProtKB-KW:KW-0796150520179 UniProtGO_REF:0000043
CLDN3Bonobobicellular tight junction located_inIEAUniProtKB-SubCell:SL-0265150520179 UniProtGO_REF:0000044
CLDN3Bonobocell-cell junction located_inIEAUniProtKB:O15551 more ...150520179 EnsemblGO_REF:0000107
CLDN3Bonobolateral plasma membrane  ISOCldn3 (Rattus norvegicus)9068941 RGDPMID:19929946 and REF_RGD_ID:2325127
CLDN3Bonobolateral plasma membrane located_inIEAUniProtKB:Q9Z0G9 and ensembl:ENSMUSP00000091799150520179 EnsemblGO_REF:0000107
CLDN3Bonobomembrane located_inIEAInterPro:IPR004031150520179 InterProGO_REF:0000002
CLDN3Bonobomembrane located_inIEAUniProtKB-KW:KW-0472150520179 UniProtGO_REF:0000043
CLDN3Bonobomembrane located_inIEAUniRule:UR000060637150520179 UniProtGO_REF:0000104
CLDN3Bonoboplasma membrane located_inIEAUniProtKB-SubCell:SL-0039150520179 UniProtGO_REF:0000044
CLDN3Bonoboplasma membrane located_inIEAUniProtKB:Q9Z0G9 and ensembl:ENSMUSP00000091799150520179 EnsemblGO_REF:0000107
CLDN3Bonoboplasma membrane located_inIEAUniProtKB-KW:KW-1003150520179 UniProtGO_REF:0000043
CLDN3Bonoboprotein-containing complex part_ofIEAUniProtKB:O15551 and ensembl:ENSP00000378577150520179 EnsemblGO_REF:0000107
CLDN3Bonobotight junction located_inIEAUniProtKB:O15551 more ...150520179 EnsemblGO_REF:0000107
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Molecular Function
1 to 10 of 10 rows

  
1 to 10 of 10 rows

PMID:22301074   PMID:30032202  



CLDN3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2691,123,883 - 91,130,587 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17139,393,595 - 139,395,219 (+)NCBINHGRI_mPanPan1
PanPan1.1780,924,338 - 80,925,761 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl780,924,731 - 80,925,393 (-)Ensemblpanpan1.1panPan2
CLDN3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38773,768,997 - 73,770,270 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl773,768,997 - 73,770,270 (-)EnsemblGRCh38hg38GRCh38
GRCh37773,183,327 - 73,184,600 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36772,821,263 - 72,822,512 (-)NCBINCBI36Build 36hg18NCBI36
Build 34772,627,978 - 72,629,227NCBI
Celera768,661,514 - 68,662,787 (-)NCBICelera
Cytogenetic Map7q11.23NCBI
HuRef769,065,982 - 69,067,255 (-)NCBIHuRef
CHM1_1773,329,029 - 73,330,302 (-)NCBICHM1_1
T2T-CHM13v2.0774,969,874 - 74,971,147 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2772,516,399 - 72,517,672 (-)NCBI
Cldn3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395135,015,068 - 135,016,330 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5135,015,068 - 135,016,326 (+)EnsemblGRCm39 Ensembl
GRCm385134,986,214 - 134,987,476 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5134,986,214 - 134,987,472 (+)EnsemblGRCm38mm10GRCm38
MGSCv375135,462,084 - 135,463,342 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365135,270,841 - 135,272,099 (+)NCBIMGSCv36mm8
Celera5131,997,044 - 131,998,302 (+)NCBICelera
Cytogenetic Map5G2NCBI
cM Map574.93NCBI
Cldn3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81227,345,075 - 27,346,547 (-)NCBIGRCr8
mRatBN7.21221,708,538 - 21,710,010 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1221,708,398 - 21,711,001 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1222,849,399 - 22,850,871 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01223,461,727 - 23,463,199 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01222,529,747 - 22,531,219 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01221,831,341 - 21,832,813 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1221,831,342 - 21,832,813 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01223,849,259 - 23,850,731 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1223,471,431 - 23,472,903 (-)NCBICelera
Cytogenetic Map12q12NCBI
CLDN3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.166,534,229 - 6,535,237 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha68,231,695 - 8,232,703 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.066,349,000 - 6,350,005 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl66,348,948 - 6,350,256 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.166,338,822 - 6,339,825 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.066,286,583 - 6,287,588 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.066,450,257 - 6,451,264 (+)NCBIUU_Cfam_GSD_1.0
Cldn3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344131,083,239 - 131,084,510 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365432,951,086 - 2,953,956 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365432,952,054 - 2,953,313 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CLDN3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl311,019,073 - 11,020,102 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1311,019,073 - 11,020,102 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2310,715,404 - 10,716,250 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CLDN3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1289,301,312 - 9,303,496 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl289,302,446 - 9,303,108 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660707,203,761 - 7,205,348 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cldn3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474014,065,478 - 14,066,137 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474014,065,172 - 14,066,432 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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RefSeq Transcripts XM_003815566 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JARIFH020000006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSPPAT00000011329   ⟹   ENSPPAP00000002314
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl780,924,731 - 80,925,393 (-)Ensembl
RefSeq Acc Id: XM_003815566   ⟹   XP_003815614
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2691,123,883 - 91,130,587 (+)NCBI
NHGRI_mPanPan17139,393,595 - 139,395,219 (+)NCBI
PanPan1.1780,924,338 - 80,925,761 (-)NCBI
Sequence:
Protein RefSeqs XP_003815614 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000002314.1
RefSeq Acc Id: XP_003815614   ⟸   XM_003815566
- UniProtKB: A0A2R8ZHZ2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSPPAP00000002314   ⟸   ENSPPAT00000011329



1 to 15 of 15 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSPPAG00000010463 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000011329.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.140.150 UniProtKB/TrEMBL
InterPro Claudin UniProtKB/TrEMBL
  Claudin3 UniProtKB/TrEMBL
  Claudin_CS UniProtKB/TrEMBL
  PMP22/EMP/MP20/Claudin UniProtKB/TrEMBL
KEGG Report pps:100975200 UniProtKB/TrEMBL
NCBI Gene CLDN3 ENTREZGENE
PANTHER PTHR12002 UniProtKB/TrEMBL
Pfam PMP22_Claudin UniProtKB/TrEMBL
PRINTS CLAUDIN UniProtKB/TrEMBL
  CLAUDIN3 UniProtKB/TrEMBL
PROSITE CLAUDIN UniProtKB/TrEMBL
UniProt A0A2R8ZHZ2 ENTREZGENE, UniProtKB/TrEMBL
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