AK2 (adenylate kinase 2) - Rat Genome Database

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Gene: AK2 (adenylate kinase 2) Pan paniscus
Analyze
Symbol: AK2
Name: adenylate kinase 2
RGD ID: 11812865
Description: ENCODES a protein that exhibits adenylate kinase activity (ortholog); nucleobase-containing compound kinase activity (ortholog); INVOLVED IN ADP biosynthetic process (ortholog); AMP metabolic process (ortholog); dATP metabolic process (ortholog); PARTICIPATES IN adefovir pharmacokinetics pathway; de novo purine biosynthetic pathway; tenofovir pharmacokinetics pathway; ASSOCIATED WITH Charcot-Marie-Tooth disease dominant intermediate C (ortholog); COVID-19 (ortholog); Deafness (ortholog); FOUND IN sperm flagellum (ortholog); sperm mitochondrial sheath (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: adenylate kinase 2, mitochondrial
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21193,789,141 - 193,817,156 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11192,911,293 - 192,939,311 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0132,295,668 - 32,323,681 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1133,480,074 - 33,508,697 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl133,480,947 - 33,508,621 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
AK2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21193,789,141 - 193,817,156 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11192,911,293 - 192,939,311 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0132,295,668 - 32,323,681 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1133,480,074 - 33,508,697 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl133,480,947 - 33,508,621 (-)Ensemblpanpan1.1panPan2
AK2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38133,007,940 - 33,036,883 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl133,007,986 - 33,080,996 (-)EnsemblGRCh38hg38GRCh38
GRCh37133,473,541 - 33,502,484 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36133,246,173 - 33,275,079 (-)NCBINCBI36Build 36hg18NCBI36
Build 34133,147,675 - 33,171,564NCBI
Celera131,743,797 - 31,772,701 (-)NCBICelera
Cytogenetic Map1p35.1NCBI
HuRef131,590,115 - 31,619,093 (-)NCBIHuRef
CHM1_1133,589,052 - 33,618,018 (-)NCBICHM1_1
T2T-CHM13v2.0132,867,728 - 32,896,675 (-)NCBIT2T-CHM13v2.0
Ak2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394128,887,017 - 128,905,322 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4128,885,751 - 128,905,322 (+)EnsemblGRCm39 Ensembl
GRCm384128,993,224 - 129,011,529 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4128,991,958 - 129,011,529 (+)EnsemblGRCm38mm10GRCm38
MGSCv374128,670,509 - 128,688,773 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364128,495,569 - 128,513,833 (+)NCBIMGSCv36mm8
Celera4127,337,482 - 127,350,601 (+)NCBICelera
Cytogenetic Map4D2.2NCBI
cM Map462.62NCBI
Ak2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85146,609,469 - 146,649,008 (+)NCBIGRCr8
mRatBN7.25141,308,650 - 141,364,633 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5141,346,063 - 141,364,632 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5144,044,192 - 144,062,698 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05145,814,021 - 145,832,527 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05145,813,302 - 145,831,915 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05147,185,474 - 147,204,050 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5147,185,474 - 147,204,050 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05150,910,910 - 150,929,525 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45148,156,751 - 148,176,195 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15148,166,789 - 148,183,198 (+)NCBI
Celera5139,827,913 - 139,846,149 (+)NCBICelera
Cytogenetic Map5q36NCBI
Ak2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495545211,254,853 - 11,275,587 (-)NCBIChiLan1.0ChiLan1.0
AK2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1268,342,769 - 68,371,769 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl268,350,057 - 68,371,090 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha264,922,664 - 64,951,721 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0268,906,961 - 68,936,418 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl268,914,650 - 68,936,416 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1265,719,275 - 65,748,337 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0266,741,685 - 66,770,757 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0267,733,734 - 67,762,814 (+)NCBIUU_Cfam_GSD_1.0
Ak2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505850,062,232 - 50,083,751 (-)NCBIHiC_Itri_2
SpeTri2.0NW_00493647415,887,014 - 15,908,522 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AK2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1689,295,164 - 89,318,169 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
AK2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12099,834,286 - 99,863,071 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2099,834,334 - 99,858,781 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603316,834,347 - 16,863,178 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ak2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476416,089,357 - 16,113,275 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000054972   ⟹   ENSPPAP00000032106
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl133,480,947 - 33,508,621 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000054988   ⟹   ENSPPAP00000032122
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl133,484,191 - 33,508,538 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000054999   ⟹   ENSPPAP00000032133
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl133,485,252 - 33,508,538 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000055003   ⟹   ENSPPAP00000032137
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl133,486,595 - 33,508,538 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000055006   ⟹   ENSPPAP00000032140
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl133,492,165 - 33,508,538 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000055011   ⟹   ENSPPAP00000032145
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl133,503,341 - 33,508,538 (-)Ensembl
RefSeq Acc Id: XM_003812539   ⟹   XP_003812587
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21193,789,151 - 193,817,156 (+)NCBI
NHGRI_mPanPan11192,911,307 - 192,939,311 (+)NCBI
Mhudiblu_PPA_v0132,295,668 - 32,323,670 (-)NCBI
PanPan1.1133,480,947 - 33,508,621 (-)NCBI
Sequence:
RefSeq Acc Id: XM_024928845   ⟹   XP_024784613
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21193,789,141 - 193,811,515 (+)NCBI
NHGRI_mPanPan11192,911,293 - 192,933,670 (+)NCBI
Mhudiblu_PPA_v0132,301,309 - 32,323,681 (-)NCBI
PanPan1.1133,486,595 - 33,508,697 (-)NCBI
Sequence:
RefSeq Acc Id: XM_034960627   ⟹   XP_034816518
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21193,789,153 - 193,817,156 (+)NCBI
NHGRI_mPanPan11192,911,309 - 192,938,270 (+)NCBI
Mhudiblu_PPA_v0132,295,668 - 32,323,668 (-)NCBI
RefSeq Acc Id: XM_034960642   ⟹   XP_034816533
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21193,789,324 - 193,817,156 (+)NCBI
NHGRI_mPanPan11192,911,352 - 192,935,150 (+)NCBI
Mhudiblu_PPA_v0132,299,829 - 32,323,642 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_003812587   ⟸   XM_003812539
- Peptide Label: isoform X2
- UniProtKB: A0A2R9BRP4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_024784613   ⟸   XM_024928845
- Peptide Label: isoform X4
- UniProtKB: A0A2R9BR33 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_034816518   ⟸   XM_034960627
- Peptide Label: isoform X1
RefSeq Acc Id: XP_034816533   ⟸   XM_034960642
- Peptide Label: isoform X3
RefSeq Acc Id: ENSPPAP00000032106   ⟸   ENSPPAT00000054972
RefSeq Acc Id: ENSPPAP00000032122   ⟸   ENSPPAT00000054988
RefSeq Acc Id: ENSPPAP00000032133   ⟸   ENSPPAT00000054999
RefSeq Acc Id: ENSPPAP00000032145   ⟸   ENSPPAT00000055011
RefSeq Acc Id: ENSPPAP00000032140   ⟸   ENSPPAT00000055006
RefSeq Acc Id: ENSPPAP00000032137   ⟸   ENSPPAT00000055003
Protein Domains
Adenylate kinase active site lid


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000038914 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000054972.1 UniProtKB/TrEMBL
  ENSPPAT00000054988.1 UniProtKB/TrEMBL
  ENSPPAT00000054999.1 UniProtKB/TrEMBL
  ENSPPAT00000055003.1 UniProtKB/TrEMBL
  ENSPPAT00000055006.1 UniProtKB/TrEMBL
  ENSPPAT00000055011.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.300 UniProtKB/TrEMBL
InterPro Adenyl_kin_sub UniProtKB/TrEMBL
  Adenylat/UMP-CMP_kin UniProtKB/TrEMBL
  Adenylat_kinase_CS UniProtKB/TrEMBL
  Adenylate_kinase_lid-dom UniProtKB/TrEMBL
  AK2 UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
KEGG Report pps:100984295 UniProtKB/TrEMBL
NCBI Gene AK2 ENTREZGENE
PANTHER ADENYLATE KINASE 2, MITOCHONDRIAL UniProtKB/TrEMBL
  ADENYLATE KINASE 2, MITOCHONDRIAL UniProtKB/TrEMBL
  PTHR23359 UniProtKB/TrEMBL
Pfam ADK UniProtKB/TrEMBL
  ADK_lid UniProtKB/TrEMBL
PRINTS ADENYLTKNASE UniProtKB/TrEMBL
PROSITE ADENYLATE_KINASE UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/TrEMBL
UniProt A0A2R9BR18_PANPA UniProtKB/TrEMBL
  A0A2R9BR33 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9BR36_PANPA UniProtKB/TrEMBL
  A0A2R9BRP4 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9BUL6_PANPA UniProtKB/TrEMBL
  A0A2R9BUM2_PANPA UniProtKB/TrEMBL