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Gene: PYCR2 (pyrroline-5-carboxylate reductase 2) Pan paniscus

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Symbol:

PYCR2

Name:

pyrroline-5-carboxylate reductase 2

RGD ID:

11785573

Description:

ENCODES a protein that exhibits oxidoreductase activity (inferred); pyrroline-5-carboxylate reductase activity (inferred); INVOLVED IN cellular response to oxidative stress (inferred); L-proline biosynthetic process (inferred); proline biosynthetic process (inferred); PARTICIPATES IN AGAT deficiency pathway; arginine and proline metabolic pathway; guanidinoacetate methyltransferase deficiency pathway; ASSOCIATED WITH basal cell carcinoma (ortholog); gastrointestinal stromal tumor (ortholog); genetic disease (ortholog); FOUND IN cytoplasm (inferred); mitochondrion (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

pyrroline-5-carboxylate reductase family member 2

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	23,612,831 - 23,617,694 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	23,561,603 - 23,566,049 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	201,381,270 - 201,385,703 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	206,381,539 - 206,386,002 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	206,381,539 - 206,386,002 (-)	Ensembl	panpan1.1		panPan2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

basal cell carcinoma (ISO)

gastrointestinal stromal tumor (ISO)

genetic disease (ISO)

hypomyelinating leukodystrophy 10 (ISO)

leukodystrophy (ISO)

microcephaly (ISO)

parathyroid carcinoma (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to oxidative stress (IEA)

L-proline biosynthetic process (IEA)

proline biosynthetic process (IEA)

Cellular Component

cytoplasm (IEA)

mitochondrion (IEA)

Molecular Function

oxidoreductase activity (IEA)

protein binding (ISO)

pyrroline-5-carboxylate reductase activity (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

AGAT deficiency pathway (ISO)

arginine and proline metabolic pathway (ISO)

guanidinoacetate methyltransferase deficiency pathway (ISO)

gyrate atrophy pathway (ISO)

hyperprolinemia type I pathway (ISO)

hyperprolinemia type II pathway (ISO)

ornithine translocase deficiency pathway (ISO)

prolidase deficiency pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

PYCR2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	23,612,831 - 23,617,694 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	23,561,603 - 23,566,049 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	201,381,270 - 201,385,703 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	206,381,539 - 206,386,002 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	206,381,539 - 206,386,002 (-)	Ensembl	panpan1.1		panPan2

PYCR2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	225,919,878 - 225,924,250 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	225,919,877 - 225,924,340 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	226,107,578 - 226,111,950 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	224,174,203 - 224,178,588 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	1	222,414,315 - 222,418,700	NCBI
Celera	1	199,298,629 - 199,303,014 (-)	NCBI		Celera
Cytogenetic Map	1	q42.12	NCBI
HuRef	1	196,625,292 - 196,629,755 (-)	NCBI		HuRef
CHM1_1	1	227,379,901 - 227,384,364 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	1	225,107,658 - 225,112,030 (-)	NCBI		T2T-CHM13v2.0

Pycr2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	180,731,839 - 180,735,653 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	1	180,731,858 - 180,735,653 (+)	Ensembl		GRCm39 Ensembl
GRCm38	1	180,904,274 - 180,908,088 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	180,904,293 - 180,908,088 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	1	182,834,405 - 182,838,219 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	1	182,740,984 - 182,744,763 (+)	NCBI		MGSCv36	mm8
Celera	1	187,967,388 - 187,971,204 (+)	NCBI		Celera
Cytogenetic Map	1	H4	NCBI
cM Map	1	84.46	NCBI

Pycr2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	13	95,158,236 - 95,162,030 (+)	NCBI		GRCr8
mRatBN7.2	13	92,626,462 - 92,630,256 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	92,626,471 - 92,634,184 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	13	95,131,781 - 95,135,575 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	13	96,531,710 - 96,535,504 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	13	93,706,406 - 93,710,200 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	13	99,184,624 - 99,188,418 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	99,184,564 - 99,188,431 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	13	104,182,905 - 104,186,734 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	13	96,633,455 - 96,637,249 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	13	96,822,390 - 96,826,184 (+)	NCBI
Celera	13	92,171,198 - 92,174,992 (+)	NCBI		Celera
Cytogenetic Map	13	q26	NCBI

Pycr2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955489	138,600 - 143,112 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955489	138,600 - 143,112 (-)	NCBI	ChiLan1.0	ChiLan1.0

PYCR2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	7	38,902,705 - 38,905,924 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	7	38,384,909 - 38,388,130 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	7	38,736,696 - 38,739,925 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	7	38,736,694 - 38,739,920 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	7	38,576,503 - 38,579,717 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	7	38,584,643 - 38,587,863 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	7	38,854,425 - 38,857,653 (+)	NCBI		UU_Cfam_GSD_1.0

Pycr2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	52,020,591 - 52,025,713 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936526	2,720,521 - 2,726,762 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936526	2,721,579 - 2,726,699 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PYCR2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	10	13,838,085 - 13,845,894 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	10	13,841,755 - 13,845,900 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	10	15,943,366 - 15,947,506 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

PYCR2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	25	3,846,518 - 3,850,976 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	25	3,846,501 - 3,851,856 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666055	3,852,944 - 3,857,403 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Pycr2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624807	31,830 - 63,985 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624807	37,742 - 63,887 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_003814915	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008967800	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JARIFH020000001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSPPAT00000035604 ⟹ ENSPPAP00000012936

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	1	206,381,539 - 206,386,002 (-)	Ensembl

Ensembl Acc Id:

ENSPPAT00000035612 ⟹ ENSPPAP00000012944

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	1	206,382,111 - 206,385,772 (-)	Ensembl

Ensembl Acc Id:

ENSPPAT00000035618 ⟹ ENSPPAP00000012950

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	1	206,382,111 - 206,385,772 (-)	Ensembl

RefSeq Acc Id:

XM_003814915 ⟹ XP_003814963

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	1	23,612,831 - 23,617,694 (+)	NCBI
NHGRI_mPanPan1	1	23,561,603 - 23,566,049 (+)	NCBI
Mhudiblu_PPA_v0	1	201,381,270 - 201,385,703 (-)	NCBI
PanPan1.1	1	206,381,539 - 206,386,002 (-)	NCBI

Sequence:

show sequence

GATTGGTCGCCCGGACGGGGCGGGGCCACGTGGCCTAAGGCGCCATCAGCCGCCCGGGAGATAT
CCGCCGGGGTAGAACAGAGTTGCACCATCCCAGAAGCTGCTGTTAGCTCTTCCGTCCTCGGCAC
GCCGCCCGTTCGCCCCTGCGCTGTCCGCCCTTCCCCTAGCGTTACTTCCGGTCCCGCGCTGAGG
GGGTTTGTGCGGCTGCCAGGAGGCGTGAACCGCGGACCATGAGCGTGGGCTTCATCGGGGCCGG
CCAGCTGGCCTATGCTCTGGCGCGGGGCTTCACGGCCGCAGGCATCCTGTCGGCTCACAAGATA
ATAGCCAGCTCCCCGGAAATGAACCTGCCCACGGTGTCCGCGCTCAGGAAGATGGGTGTGAACC
TGACACGCAGCAACAAGGAGACGGTGAAGCACAGCGACGTCCTGTTTCTGGCTGTGAAGCCACA
TATCATCCCCTTCATCCTGGATGAGATTGGGGCCGACGTGCAAGCCAGACACATCGTGGTCTCC
TGTGCGGCTGGTGTCACCATCAGCTCTGTGGAGAAGAAGCTGATGGCATTCCAGCCAGCCCCCA
AAGTGATTCGCTGCATGACCAACACACCTGTGGTAGTGCGGGAAGGCGCTACGGTGTACGCCAC
GGGCACCCATGCCCTGGTGGAGGATGGGCAGCTCCTGGAGCAGCTCATGAGCAGCGTGGGCTTC
TGCACTGAGGTGGAAGAGGACCTCATCGATGCCGTCACGGGGCTCAGTGGCAGCGGGCCTGCCT
ATGCATTCATGGCTCTGGACGCATTGGCTGATGGTGGGGTGAAGATGGGTTTGCCACGGCGCCT
GGCAATCCAACTCGGGGCCCAGGCTTTGCTGGGAGCTGCCAAGATGCTGCTGGACTCGGAGCAG
CATCCATGCCAGCTTAAGGACAATGTCTGCTCCCCTGGGGGAGCCACCATCCACGCCCTGCACT
TTCTAGAGAGTGGGGGCTTCCGCTCTCTGCTCATCAATGCAGTTGAGGCCTCCTGTATCCGAAC
ACGAGAGCTACAGTCCATGGCCGACCAAGAAAAGATCTCCCCAGCTGCCCTTAAGAAGACCCTC
CTAGACAGAGTGAAGCTGGAATCCCCCACAGTCTCCACACTGACCCCCTCCAGCCCAGGGAAGC
TCCTCACAAGAAGCCTGGCCCTGGGAGGCAAGAAGGACTAAGGCAGCATCTATCCCCTCTGATT
CAGAGCCCTTAGTTGAGAGCCCCTGCCACCCCTGCCACCCCCCTGCCCCGCTCCCACCATTGCC
CCTCCTCAGCTGTGCAAGGAGAAAGCATGCTTAGGAAGTTTTCAGGTCCTTGTGATAAAACCTC
CTTAAATCTGTTCAGACCAAGCAATGCGAGCTTCCTCTCCTGTCCCATGTTGGAAGTTGCTCTG
AAGGGGTGGTAGATGCTGGAAGCCAGACACAACCCTGCGTACGTTGCTCAGTTGGTGGAGACTG
GGGCTGGGACTGGAGTCAGCCCAGCTGGGAGGAGGGGCTGGAGAGGATCTGCAGCTGAAGCCCA
AGGCAGGGTTGGTTTGATGCCAAGGCAAAGTGGTGAGAGAGAAAACAGGAAAGGGGCTTTCTCT
GAATTGGTAAATGGGAAAGAAGTGAGCAACTTAAGATTGTCACAATCACAAGTGTACAGGATTA
GACTGTGTTTATATTTAACTCTTGCTTCATAGGTGTACCATTTAAAGAGTGTTATTTAATGCTA
AGTTTAACTGCTTTAATAAAGTTTATTTTTAAATATC

hide sequence

Protein Sequences


Protein RefSeqs	XP_003814963	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSPPAP00000012936
	ENSPPAP00000012936.1
	ENSPPAP00000012944.1
	ENSPPAP00000012950.1

RefSeq Acc Id:

XP_003814963 ⟸ XM_003814915

- UniProtKB:

A0A2R9ABC1 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MSVGFIGAGQLAYALARGFTAAGILSAHKIIASSPEMNLPTVSALRKMGVNLTRSNKETVKHSD
VLFLAVKPHIIPFILDEIGADVQARHIVVSCAAGVTISSVEKKLMAFQPAPKVIRCMTNTPVVV
REGATVYATGTHALVEDGQLLEQLMSSVGFCTEVEEDLIDAVTGLSGSGPAYAFMALDALADGG
VKMGLPRRLAIQLGAQALLGAAKMLLDSEQHPCQLKDNVCSPGGATIHALHFLESGGFRSLLIN
AVEASCIRTRELQSMADQEKISPAALKKTLLDRVKLESPTVSTLTPSSPGKLLTRSLALGGKKD

hide sequence

Ensembl Acc Id:

ENSPPAP00000012936 ⟸ ENSPPAT00000035604

Ensembl Acc Id:

ENSPPAP00000012944 ⟸ ENSPPAT00000035612

Ensembl Acc Id:

ENSPPAP00000012950 ⟸ ENSPPAT00000035618

Protein Domains

Pyrroline-5-carboxylate reductase catalytic N- Pyrroline-5-carboxylate reductase dimerisation

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000029624	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSPPAT00000035604.1	UniProtKB/TrEMBL
	ENSPPAT00000035612.1	UniProtKB/TrEMBL
	ENSPPAT00000035618.1	UniProtKB/TrEMBL
Gene3D-CATH	NAD(P)-binding Rossmann-like Domain	UniProtKB/TrEMBL
	ProC C-terminal domain-like	UniProtKB/TrEMBL
InterPro	6-PGluconate_DH-like_C_sf	UniProtKB/TrEMBL
	NAD(P)-bd_dom_sf	UniProtKB/TrEMBL
	P5C_Rdtase_cat_N	UniProtKB/TrEMBL
	P5CR-like	UniProtKB/TrEMBL
	P5CR_dimer	UniProtKB/TrEMBL
	Pyrroline-COOH_reductase	UniProtKB/TrEMBL
KEGG Report	pps:100969152	UniProtKB/TrEMBL
NCBI Gene	PYCR2	ENTREZGENE
PANTHER	PTHR11645	UniProtKB/TrEMBL
	PYRROLINE-5-CARBOXYLATE REDUCTASE 2	UniProtKB/TrEMBL
Pfam	F420_oxidored	UniProtKB/TrEMBL
	P5CR_dimer	UniProtKB/TrEMBL
PIRSF	Pyrrol-5-carb_rd	UniProtKB/TrEMBL
PROSITE	P5CR	UniProtKB/TrEMBL
Superfamily-SCOP	SSF48179	UniProtKB/TrEMBL
	SSF51735	UniProtKB/TrEMBL
UniProt	A0A2R9A6N2_PANPA	UniProtKB/TrEMBL
	A0A2R9A7T3_PANPA	UniProtKB/TrEMBL
	A0A2R9ABC1	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2017-03-28	PYCR2	pyrroline-5-carboxylate reductase 2		pyrroline-5-carboxylate reductase family member 2	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - SMPDB

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - SMPDB