PYCR2 (pyrroline-5-carboxylate reductase 2) - Rat Genome Database
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Gene: PYCR2 (pyrroline-5-carboxylate reductase 2) Sus scrofa
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Symbol: PYCR2
Name: pyrroline-5-carboxylate reductase 2
RGD ID: 13994552
Description: ENCODES a protein that exhibits pyrroline-5-carboxylate reductase activity (inferred); INVOLVED IN cellular response to oxidative stress (ortholog); proline biosynthetic process (ortholog); PARTICIPATES IN AGAT deficiency pathway; arginine and proline metabolic pathway; guanidinoacetate methyltransferase deficiency pathway; ASSOCIATED WITH hypomyelinating leukodystrophy 10 (ortholog); microcephaly (ortholog); FOUND IN mitochondrion (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: pyrroline-5-carboxylate reductase family member 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11013,841,755 - 13,845,900 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21015,943,366 - 15,947,506 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

Genomics

Comparative Map Data
PYCR2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11013,841,755 - 13,845,900 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21015,943,366 - 15,947,506 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PYCR2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1225,919,877 - 225,924,340 (-)EnsemblGRCh38hg38GRCh38
GRCh381225,919,878 - 225,924,250 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371226,107,578 - 226,111,950 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361224,174,203 - 224,178,588 (-)NCBINCBI36hg18NCBI36
Build 341222,414,315 - 222,418,700NCBI
Celera1199,298,629 - 199,303,014 (-)NCBI
Cytogenetic Map1q42.12NCBI
HuRef1196,625,292 - 196,629,755 (-)NCBIHuRef
CHM1_11227,379,901 - 227,384,364 (-)NCBICHM1_1
Pycr2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391180,731,839 - 180,735,653 (+)NCBIGRCm39mm39
GRCm39 Ensembl1180,731,858 - 180,735,653 (+)Ensembl
GRCm381180,904,274 - 180,908,088 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1180,904,293 - 180,908,088 (+)EnsemblGRCm38mm10GRCm38
MGSCv371182,834,405 - 182,838,219 (+)NCBIGRCm37mm9NCBIm37
MGSCv361182,740,984 - 182,744,763 (+)NCBImm8
Celera1187,967,388 - 187,971,204 (+)NCBICelera
Cytogenetic Map1H4NCBI
Pycr2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21392,626,462 - 92,630,256 (+)NCBI
Rnor_6.0 Ensembl1399,184,564 - 99,188,431 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01399,184,624 - 99,188,418 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.013104,182,905 - 104,186,734 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41396,633,455 - 96,637,249 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11396,822,390 - 96,826,184 (+)NCBI
Celera1392,171,198 - 92,174,992 (+)NCBICelera
Cytogenetic Map13q26NCBI
Pycr2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_004955489138,600 - 143,112 (-)NCBIChiLan1.0ChiLan1.0
PYCR2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11206,381,539 - 206,386,002 (-)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v01201,381,270 - 201,385,703 (-)NCBIMhudiblu_PPA_v0panPan3
PYCR2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1738,902,705 - 38,905,924 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Pycr2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365262,721,579 - 2,726,699 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PYCR2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1253,846,518 - 3,850,976 (+)NCBI
Pycr2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462480737,742 - 63,887 (-)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 1 2 3 8
Low 10 3 1 2 2 15 2 3 3
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: XM_003130542   ⟹   XP_003130590
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11013,841,755 - 13,845,900 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005653785   ⟹   XP_005653842
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11013,841,755 - 13,845,900 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021064411   ⟹   XP_020920070
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11013,841,755 - 13,845,900 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_003130590 (Get FASTA)   NCBI Sequence Viewer  
  XP_005653842 (Get FASTA)   NCBI Sequence Viewer  
  XP_020920070 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_003130590   ⟸   XM_003130542
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_020920070   ⟸   XM_021064411
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_005653842   ⟸   XM_005653785
- Peptide Label: isoform X2
- UniProtKB: F1S8R2 (UniProtKB/TrEMBL)
- Sequence:
Protein Domains
F420_oxidored   P5CR_dimer


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000010855 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070007182 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000011573 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000065170 UniProtKB/TrEMBL
  ENSSSCP00070011408 UniProtKB/TrEMBL
  ENSSSCP00070011510 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000011877 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000085777 UniProtKB/TrEMBL
  ENSSSCT00070013838 UniProtKB/TrEMBL
  ENSSSCT00070013963 UniProtKB/TrEMBL
InterPro 6-PGluconate_DH-like_C_sf UniProtKB/TrEMBL
  NAD(P)-bd_dom_sf UniProtKB/TrEMBL
  P5C_Rdtase_cat_N UniProtKB/TrEMBL
  P5CR_dimer UniProtKB/TrEMBL
  Pyrroline-COOH_reductase UniProtKB/TrEMBL
KEGG Report ssc:100524702 UniProtKB/TrEMBL
NCBI Gene PYCR2 ENTREZGENE
Pfam F420_oxidored UniProtKB/TrEMBL
  P5CR_dimer UniProtKB/TrEMBL
PIRSF Pyrrol-5-carb_rd UniProtKB/TrEMBL
PROSITE P5CR UniProtKB/TrEMBL
Superfamily-SCOP SSF48179 UniProtKB/TrEMBL
  SSF51735 UniProtKB/TrEMBL
TIGRFAMs proC UniProtKB/TrEMBL
UniProt A0A480K6U0_PIG UniProtKB/TrEMBL
  A0A4X1T6E4_PIG UniProtKB/TrEMBL
  A0A4X1T9C4_PIG UniProtKB/TrEMBL
  A0A5G2QMA7_PIG UniProtKB/TrEMBL
  F1S8R2 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary A0A480F2F7 UniProtKB/TrEMBL