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Gene: PYCR2 (pyrroline-5-carboxylate reductase 2) Sus scrofa

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Symbol:

PYCR2

Name:

pyrroline-5-carboxylate reductase 2

RGD ID:

13994552

Description:

ENCODES a protein that exhibits oxidoreductase activity (inferred); pyrroline-5-carboxylate reductase activity (inferred); INVOLVED IN cellular response to oxidative stress (inferred); L-proline biosynthetic process (inferred); proline biosynthetic process (inferred); PARTICIPATES IN AGAT deficiency pathway; arginine and proline metabolic pathway; guanidinoacetate methyltransferase deficiency pathway; ASSOCIATED WITH basal cell carcinoma (ortholog); gastrointestinal stromal tumor (ortholog); genetic disease (ortholog); FOUND IN cytoplasm (inferred); mitochondrion (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

pyrroline-5-carboxylate reductase family member 2

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

Sscrofa11.1 - Pig Sscrofa11.1 Assembly

Position:

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	10	13,838,085 - 13,845,894 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	10	13,841,755 - 13,845,900 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	10	15,943,366 - 15,947,506 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

basal cell carcinoma (ISO)

gastrointestinal stromal tumor (ISO)

genetic disease (ISO)

hypomyelinating leukodystrophy 10 (ISO)

leukodystrophy (ISO)

microcephaly (ISO)

parathyroid carcinoma (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to oxidative stress (IEA)

L-proline biosynthetic process (IBA,IEA)

proline biosynthetic process (IEA)

Cellular Component

cytoplasm (IEA)

mitochondrion (IEA)

Molecular Function

oxidoreductase activity (IEA)

protein binding (ISO)

pyrroline-5-carboxylate reductase activity (IBA,IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

AGAT deficiency pathway (ISO)

arginine and proline metabolic pathway (ISO)

guanidinoacetate methyltransferase deficiency pathway (ISO)

gyrate atrophy pathway (ISO)

hyperprolinemia type I pathway (ISO)

hyperprolinemia type II pathway (ISO)

ornithine translocase deficiency pathway (ISO)

prolidase deficiency pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

PYCR2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	10	13,838,085 - 13,845,894 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	10	13,841,755 - 13,845,900 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	10	15,943,366 - 15,947,506 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

PYCR2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	225,919,878 - 225,924,250 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	225,919,877 - 225,924,340 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	226,107,578 - 226,111,950 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	224,174,203 - 224,178,588 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	1	222,414,315 - 222,418,700	NCBI
Celera	1	199,298,629 - 199,303,014 (-)	NCBI		Celera
Cytogenetic Map	1	q42.12	NCBI
HuRef	1	196,625,292 - 196,629,755 (-)	NCBI		HuRef
CHM1_1	1	227,379,901 - 227,384,364 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	1	225,107,658 - 225,112,030 (-)	NCBI		T2T-CHM13v2.0

Pycr2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	180,731,839 - 180,735,653 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	1	180,731,858 - 180,735,653 (+)	Ensembl		GRCm39 Ensembl
GRCm38	1	180,904,274 - 180,908,088 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	180,904,293 - 180,908,088 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	1	182,834,405 - 182,838,219 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	1	182,740,984 - 182,744,763 (+)	NCBI		MGSCv36	mm8
Celera	1	187,967,388 - 187,971,204 (+)	NCBI		Celera
Cytogenetic Map	1	H4	NCBI
cM Map	1	84.46	NCBI

Pycr2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	13	95,158,236 - 95,162,030 (+)	NCBI		GRCr8
mRatBN7.2	13	92,626,462 - 92,630,256 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	92,626,471 - 92,634,184 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	13	95,131,781 - 95,135,575 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	13	96,531,710 - 96,535,504 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	13	93,706,406 - 93,710,200 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	13	99,184,624 - 99,188,418 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	99,184,564 - 99,188,431 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	13	104,182,905 - 104,186,734 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	13	96,633,455 - 96,637,249 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	13	96,822,390 - 96,826,184 (+)	NCBI
Celera	13	92,171,198 - 92,174,992 (+)	NCBI		Celera
Cytogenetic Map	13	q26	NCBI

Pycr2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955489	138,600 - 143,112 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955489	138,600 - 143,112 (-)	NCBI	ChiLan1.0	ChiLan1.0

PYCR2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	23,612,831 - 23,617,694 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	23,561,603 - 23,566,049 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	201,381,270 - 201,385,703 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	206,381,539 - 206,386,002 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	206,381,539 - 206,386,002 (-)	Ensembl	panpan1.1		panPan2

PYCR2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	7	38,902,705 - 38,905,924 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	7	38,384,909 - 38,388,130 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	7	38,736,696 - 38,739,925 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	7	38,736,694 - 38,739,920 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	7	38,576,503 - 38,579,717 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	7	38,584,643 - 38,587,863 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	7	38,854,425 - 38,857,653 (+)	NCBI		UU_Cfam_GSD_1.0

Pycr2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	52,020,591 - 52,025,713 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936526	2,720,521 - 2,726,762 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936526	2,721,579 - 2,726,699 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PYCR2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	25	3,846,518 - 3,850,976 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	25	3,846,501 - 3,851,856 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666055	3,852,944 - 3,857,403 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Pycr2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624807	31,830 - 63,985 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624807	37,742 - 63,887 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in PYCR2
136 total Variants

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	circulatory system	ectoderm	endocrine system	endoderm	hemolymphoid system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
10	4	23	3	2	5	14	12	23	3	6	3

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_003130542	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_005653785	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_021064411	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AEMK02000071	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CU914379	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GFLN01055079	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSSSCT00000011877 ⟹ ENSSSCP00000011573

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1 Ensembl	10	13,838,085 - 13,845,894 (-)	Ensembl

Ensembl Acc Id:

ENSSSCT00000085777 ⟹ ENSSSCP00000065170

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1 Ensembl	10	13,838,085 - 13,845,894 (-)	Ensembl

Ensembl Acc Id:

ENSSSCT00000098089 ⟹ ENSSSCP00000080639

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1 Ensembl	10	13,838,085 - 13,845,894 (-)	Ensembl

RefSeq Acc Id:

XM_003130542 ⟹ XP_003130590

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1	10	13,841,755 - 13,845,900 (-)	NCBI

Sequence:

show sequence

TGGGGCCCTGCGGCGCGGTCCCAGAATGAGGGAGTGAGGAGTCGGCTGGGGGACTCGTCCCGGA
AGTTGCCGCCTACCCCCAGAATCCGGCTCCGGGGCGCGTCGCCCGCTCAGTTCTCCGCTTTTCG
CCTTTCCTCGCTGCGCGGACTCCCCAGGCTGCTCGGCAGACGCGGAGCGAACCATGAGCGTGGG
CTTCATCGGCGCCGGCCAGCTGGCCTGCGCCCTGGCGCGGGGCTTCACGGCTGCAGGCATCCTG
TCGGCTCACAAGATAATAGCCAGCTCCCCGGAAATGGACCTGCCCACGGTGGCCGCGCTCAGGA
AGATGGGGGTGAACCTGACCCGGAGCAACAAGGAGACAGTGAGGCACAGCGATGTCCTGTTCCT
GGCCGTGAAGCCACACATCATCCCCTTCATCCTGGACGAGATTGGGGCCGATGTCCAGGCCAGG
CACATTGTGGTCTCCTGTGCGGCCGGTGTCACCATCAGCTCTGTGGAGAAGAAACTGCAGGCGT
TCCAGCCGGCGCCCAAAGTCATCCGCTGTATGACCAACACGCCCGTGGTGGTGCGGGAGGGCGC
CACGGTGTACGCCACGGGCACGCATGCCCTGGTGGAGGACGGGCAGCTCCTGGAGCAGCTCATG
AGCAGCGTGGGCTTCTGCACCGAGGTGGAGGAGGACCTGATTGATGCCGTCACAGGCCTCAGTG
GCAGTGGGCCTGCCTATGCGTTCATGGCCCTGGACGCCCTGGCCGATGGTGGGGTGAAGATGGG
CCTGCCGCGGCGCCTGGCCGTCCGACTGGGGGCCCAGGCCTTGCTGGGTGCTGCCAAGATGCTA
CTGGACTCTGAGCAGCATCCGGGCCAGCTCAAGGACAATGTCTGCTCCCCCGGGGGGGCCACCA
TCCATGCTCTGCACTTTCTAGAGAGCGGCGGCTTCCGCTCCCTGCTCATCAACGCCGTGGAGGC
CTCCTGCATCCGCACAAGAGAGCTGCAGTCCATGGCGGACCAAGAAAAGGTCCCCGCAGCTGCC
CTCAAGAAGACCCTCCTGGACAGAGTGAAACTGGAGTCCCCCACGGTGTCCACGTTGACCCCCT
CCAGCTCCGGGAAGCTCCTCACAAGAAGCCCAGCCCCAGGAGGCAAGAAGGACTGAGGCTGCCT
CAGGCGACCCTCCTCTCTGACCAGACCCTCGGCCGAGGGGGCCGCGCAGGGCCAGGGTGGGCTC
AGGGAGTCTTCAGGTCCTTGTGATAAAACCTCCTGAAACCTCTTCGGACCAGGCAGCGCTAGTT
TCCCCTCATGTCTCATGCTGTAAGGTGCTCTGACATGGTGATGCCAAGAAACAGGTACAGCCCA
ACACGCCGCACACGGATGGAAGAGAGAGGCTGGCAGTCCCGTCAGAGCCCCAGCTCTGCGGGGA
GGGCTGAGGCCCCTTCACCTGGGATCCTCCAGCTGGAGCCCAGGGCAGGGTTCCTTTGATGCTA
AGTCAAGGCAAGTGACTTGGAATTACCACACTTAATCAGAGAGGCACATATTAGTCTGTGTTAC
ATTTAACTCTTGCTTCATAGATGTACAGTGGAAAAAGTGTCATTCAATGCTGTTAAGGTTAGCT
GCTTTAATAAAGTGTTATTTTTTAGCACCCTC

hide sequence

RefSeq Acc Id:

XM_005653785 ⟹ XP_005653842

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1	10	13,841,755 - 13,845,900 (-)	NCBI

Sequence:

show sequence

TGGGGCCCTGCGGCGCGGTCCCAGAATGAGGGAGTGAGGAGTCGGCTGGGGGACTCGTCCCGGA
AGTTGCCGCCTACCCCCAGAATCCGGCTCCGGGGCGCGTCGCCCGCTCAGTTCTCCGCTTTTCG
CCTTTCCTCGCTGCGCGGACTCCCCAGGCTGCTCGGCAGACGCGGAGCGAACCATGAGCGTGGG
CTTCATCGGCGCCGGCCAGCTGGCCTGCGCCCTGGCGCGGGGCTTCACGGCTGCAGGTGAGCGT
GTGGAGGCGGCCGCGCGGGCGGTTCGTAGCTTAGGCGGTGAACGTGAATGATTGAAGAAAGGGG
AATTTGCATCTGCTGGGGAAGAAGAGACTCCTCTTAAGCCTGCAAAAGCGATTGAGAGGAGGAG
AACGCCAGCAACCGTCTCCACAACGGAGTGTTGCATCCTGTCGGCTCACAAGATAATAGCCAGC
TCCCCGGAAATGGACCTGCCCACGGTGGCCGCGCTCAGGAAGATGGGGGTGAACCTGACCCGGA
GCAACAAGGAGACAGTGAGGCACAGCGATGTCCTGTTCCTGGCCGTGAAGCCACACATCATCCC
CTTCATCCTGGACGAGATTGGGGCCGATGTCCAGGCCAGGCACATTGTGGTCTCCTGTGCGGCC
GGTGTCACCATCAGCTCTGTGGAGAAGAAACTGCAGGCGTTCCAGCCGGCGCCCAAAGTCATCC
GCTGTATGACCAACACGCCCGTGGTGGTGCGGGAGGGCGCCACGGTGTACGCCACGGGCACGCA
TGCCCTGGTGGAGGACGGGCAGCTCCTGGAGCAGCTCATGAGCAGCGTGGGCTTCTGCACCGAG
GTGGAGGAGGACCTGATTGATGCCGTCACAGGCCTCAGTGGCAGTGGGCCTGCCTATGCGTTCA
TGGCCCTGGACGCCCTGGCCGATGGTGGGGTGAAGATGGGCCTGCCGCGGCGCCTGGCCGTCCG
ACTGGGGGCCCAGGCCTTGCTGGGTGCTGCCAAGATGCTACTGGACTCTGAGCAGCATCCGGGC
CAGCTCAAGGACAATGTCTGCTCCCCCGGGGGGGCCACCATCCATGCTCTGCACTTTCTAGAGA
GCGGCGGCTTCCGCTCCCTGCTCATCAACGCCGTGGAGGCCTCCTGCATCCGCACAAGAGAGCT
GCAGTCCATGGCGGACCAAGAAAAGGTCCCCGCAGCTGCCCTCAAGAAGACCCTCCTGGACAGA
GTGAAACTGGAGTCCCCCACGGTGTCCACGTTGACCCCCTCCAGCTCCGGGAAGCTCCTCACAA
GAAGCCCAGCCCCAGGAGGCAAGAAGGACTGAGGCTGCCTCAGGCGACCCTCCTCTCTGACCAG
ACCCTCGGCCGAGGGGGCCGCGCAGGGCCAGGGTGGGCTCAGGGAGTCTTCAGGTCCTTGTGAT
AAAACCTCCTGAAACCTCTTCGGACCAGGCAGCGCTAGTTTCCCCTCATGTCTCATGCTGTAAG
GTGCTCTGACATGGTGATGCCAAGAAACAGGTACAGCCCAACACGCCGCACACGGATGGAAGAG
AGAGGCTGGCAGTCCCGTCAGAGCCCCAGCTCTGCGGGGAGGGCTGAGGCCCCTTCACCTGGGA
TCCTCCAGCTGGAGCCCAGGGCAGGGTTCCTTTGATGCTAAGTCAAGGCAAGTGACTTGGAATT
ACCACACTTAATCAGAGAGGCACATATTAGTCTGTGTTACATTTAACTCTTGCTTCATAGATGT
ACAGTGGAAAAAGTGTCATTCAATGCTGTTAAGGTTAGCTGCTTTAATAAAGTGTTATTTTTTA
GCACCCTC

hide sequence

RefSeq Acc Id:

XM_021064411 ⟹ XP_020920070

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1	10	13,841,755 - 13,845,900 (-)	NCBI

Sequence:

show sequence

TGGGGCCCTGCGGCGCGGTCCCAGAATGAGGGAGTGAGGAGTCGGCTGGGGGACTCGTCCCGGA
AGTTGCCGCCTACCCCCAGAATCCGGCTCCGGGGCGCGTCGCCCGCTCAGTTCTCCGCTTTTCG
CCTTTCCTCGCTGCGCGGACTCCCCAGGCTGCTCGGCAGACGCGGAGCGAACCATGAGCGTGGG
CTTCATCGGCGCCGGCCAGCTGGCCTGCGCCCTGGCGCGGGGCTTCACGGCTGCAGGGAACGCA
TGGGAACGGGATAGACCGGGACCCTCAGTTAAAAAGCCTTACCTTCTGCAGGCATCCTGTCGGC
TCACAAGATAATAGCCAGCTCCCCGGAAATGGACCTGCCCACGGTGGCCGCGCTCAGGAAGATG
GGGGTGAACCTGACCCGGAGCAACAAGGAGACAGTGAGGCACAGCGATGTCCTGTTCCTGGCCG
TGAAGCCACACATCATCCCCTTCATCCTGGACGAGATTGGGGCCGATGTCCAGGCCAGGCACAT
TGTGGTCTCCTGTGCGGCCGGTGTCACCATCAGCTCTGTGGAGAAGAAACTGCAGGCGTTCCAG
CCGGCGCCCAAAGTCATCCGCTGTATGACCAACACGCCCGTGGTGGTGCGGGAGGGCGCCACGG
TGTACGCCACGGGCACGCATGCCCTGGTGGAGGACGGGCAGCTCCTGGAGCAGCTCATGAGCAG
CGTGGGCTTCTGCACCGAGGTGGAGGAGGACCTGATTGATGCCGTCACAGGCCTCAGTGGCAGT
GGGCCTGCCTATGCGTTCATGGCCCTGGACGCCCTGGCCGATGGTGGGGTGAAGATGGGCCTGC
CGCGGCGCCTGGCCGTCCGACTGGGGGCCCAGGCCTTGCTGGGTGCTGCCAAGATGCTACTGGA
CTCTGAGCAGCATCCGGGCCAGCTCAAGGACAATGTCTGCTCCCCCGGGGGGGCCACCATCCAT
GCTCTGCACTTTCTAGAGAGCGGCGGCTTCCGCTCCCTGCTCATCAACGCCGTGGAGGCCTCCT
GCATCCGCACAAGAGAGCTGCAGTCCATGGCGGACCAAGAAAAGGTCCCCGCAGCTGCCCTCAA
GAAGACCCTCCTGGACAGAGTGAAACTGGAGTCCCCCACGGTGTCCACGTTGACCCCCTCCAGC
TCCGGGAAGCTCCTCACAAGAAGCCCAGCCCCAGGAGGCAAGAAGGACTGAGGCTGCCTCAGGC
GACCCTCCTCTCTGACCAGACCCTCGGCCGAGGGGGCCGCGCAGGGCCAGGGTGGGCTCAGGGA
GTCTTCAGGTCCTTGTGATAAAACCTCCTGAAACCTCTTCGGACCAGGCAGCGCTAGTTTCCCC
TCATGTCTCATGCTGTAAGGTGCTCTGACATGGTGATGCCAAGAAACAGGTACAGCCCAACACG
CCGCACACGGATGGAAGAGAGAGGCTGGCAGTCCCGTCAGAGCCCCAGCTCTGCGGGGAGGGCT
GAGGCCCCTTCACCTGGGATCCTCCAGCTGGAGCCCAGGGCAGGGTTCCTTTGATGCTAAGTCA
AGGCAAGTGACTTGGAATTACCACACTTAATCAGAGAGGCACATATTAGTCTGTGTTACATTTA
ACTCTTGCTTCATAGATGTACAGTGGAAAAAGTGTCATTCAATGCTGTTAAGGTTAGCTGCTTT
AATAAAGTGTTATTTTTTAGCACCCTC

hide sequence

Protein Sequences


Protein RefSeqs	XP_003130590	(Get FASTA)	NCBI Sequence Viewer
	XP_005653842	(Get FASTA)	NCBI Sequence Viewer
	XP_020920070	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSSCP00000011573
	ENSSSCP00000011573.5
	ENSSSCP00000065170.1
	ENSSSCP00000080639.1
	ENSSSCP00015019280.1
	ENSSSCP00015019303.1
	ENSSSCP00025046590.1
	ENSSSCP00025046610.1
	ENSSSCP00030031301.1
	ENSSSCP00030031305.1
	ENSSSCP00035029507.1
	ENSSSCP00035029509.1
	ENSSSCP00040025380.1
	ENSSSCP00040025429.1
	ENSSSCP00050041771.1
	ENSSSCP00050041773.1
	ENSSSCP00055021874.1
	ENSSSCP00055021912.1
	ENSSSCP00060041322.1
	ENSSSCP00060041324.1
	ENSSSCP00065017692.1
	ENSSSCP00065017694.1
	ENSSSCP00070011408.1
	ENSSSCP00070011510.1

RefSeq Acc Id:	XP_003130590 ⟸ XM_003130542
- Peptide Label:	isoform X1
- UniProtKB:	A0A4X1T9C4 (UniProtKB/TrEMBL), A0A8X9AEK2 (UniProtKB/TrEMBL), A0A480F2F7 (UniProtKB/TrEMBL), F1S8R2 (UniProtKB/TrEMBL)
- Sequence:	show sequence MSVGFIGAGQLACALARGFTAAGILSAHKIIASSPEMDLPTVAALRKMGVNLTRSNKETVRHSD VLFLAVKPHIIPFILDEIGADVQARHIVVSCAAGVTISSVEKKLQAFQPAPKVIRCMTNTPVVV REGATVYATGTHALVEDGQLLEQLMSSVGFCTEVEEDLIDAVTGLSGSGPAYAFMALDALADGG VKMGLPRRLAVRLGAQALLGAAKMLLDSEQHPGQLKDNVCSPGGATIHALHFLESGGFRSLLIN AVEASCIRTRELQSMADQEKVPAAALKKTLLDRVKLESPTVSTLTPSSSGKLLTRSPAPGGKKD hide sequence

RefSeq Acc Id:	XP_020920070 ⟸ XM_021064411
- Peptide Label:	isoform X2
- UniProtKB:	A0A480K6U0 (UniProtKB/TrEMBL), A0A480YHC0 (UniProtKB/TrEMBL)
- Sequence:	show sequence MDLPTVAALRKMGVNLTRSNKETVRHSDVLFLAVKPHIIPFILDEIGADVQARHIVVSCAAGVT ISSVEKKLQAFQPAPKVIRCMTNTPVVVREGATVYATGTHALVEDGQLLEQLMSSVGFCTEVEE DLIDAVTGLSGSGPAYAFMALDALADGGVKMGLPRRLAVRLGAQALLGAAKMLLDSEQHPGQLK DNVCSPGGATIHALHFLESGGFRSLLINAVEASCIRTRELQSMADQEKVPAAALKKTLLDRVKL ESPTVSTLTPSSSGKLLTRSPAPGGKKD hide sequence

RefSeq Acc Id:	XP_005653842 ⟸ XM_005653785
- Peptide Label:	isoform X2
- UniProtKB:	A0A480K6U0 (UniProtKB/TrEMBL), A0A480YHC0 (UniProtKB/TrEMBL)
- Sequence:	show sequence MDLPTVAALRKMGVNLTRSNKETVRHSDVLFLAVKPHIIPFILDEIGADVQARHIVVSCAAGVT ISSVEKKLQAFQPAPKVIRCMTNTPVVVREGATVYATGTHALVEDGQLLEQLMSSVGFCTEVEE DLIDAVTGLSGSGPAYAFMALDALADGGVKMGLPRRLAVRLGAQALLGAAKMLLDSEQHPGQLK DNVCSPGGATIHALHFLESGGFRSLLINAVEASCIRTRELQSMADQEKVPAAALKKTLLDRVKL ESPTVSTLTPSSSGKLLTRSPAPGGKKD hide sequence

Ensembl Acc Id:

ENSSSCP00000065170 ⟸ ENSSSCT00000085777

Ensembl Acc Id:

ENSSSCP00000080639 ⟸ ENSSSCT00000098089

Ensembl Acc Id:

ENSSSCP00000011573 ⟸ ENSSSCT00000011877

Protein Domains

Pyrroline-5-carboxylate reductase catalytic N- Pyrroline-5-carboxylate reductase dimerisation

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSSCG00000010855	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
	ENSSSCG00015036438	UniProtKB/TrEMBL
	ENSSSCG00025075804	UniProtKB/TrEMBL
	ENSSSCG00030049102	UniProtKB/TrEMBL
	ENSSSCG00035054514	UniProtKB/TrEMBL
	ENSSSCG00040045047	UniProtKB/TrEMBL
	ENSSSCG00050071075	UniProtKB/TrEMBL
	ENSSSCG00055013925	UniProtKB/TrEMBL
	ENSSSCG00060069958	UniProtKB/TrEMBL
	ENSSSCG00065030849	UniProtKB/TrEMBL
	ENSSSCG00070007182	UniProtKB/TrEMBL
Ensembl Transcript	ENSSSCT00000011877	ENTREZGENE
	ENSSSCT00000011877.5	UniProtKB/TrEMBL
	ENSSSCT00000085777.2	UniProtKB/TrEMBL
	ENSSSCT00000098089.1	UniProtKB/TrEMBL
	ENSSSCT00015048459.1	UniProtKB/TrEMBL
	ENSSSCT00015048507.1	UniProtKB/TrEMBL
	ENSSSCT00025104679.1	UniProtKB/TrEMBL
	ENSSSCT00025104704.1	UniProtKB/TrEMBL
	ENSSSCT00030068511.1	UniProtKB/TrEMBL
	ENSSSCT00030068519.1	UniProtKB/TrEMBL
	ENSSSCT00035072739.1	UniProtKB/TrEMBL
	ENSSSCT00035072741.1	UniProtKB/TrEMBL
	ENSSSCT00040060454.1	UniProtKB/TrEMBL
	ENSSSCT00040060548.1	UniProtKB/TrEMBL
	ENSSSCT00050096939.1	UniProtKB/TrEMBL
	ENSSSCT00050096942.1	UniProtKB/TrEMBL
	ENSSSCT00055027482.1	UniProtKB/TrEMBL
	ENSSSCT00055027529.1	UniProtKB/TrEMBL
	ENSSSCT00060095529.1	UniProtKB/TrEMBL
	ENSSSCT00060095542.1	UniProtKB/TrEMBL
	ENSSSCT00065041715.1	UniProtKB/TrEMBL
	ENSSSCT00065041718.1	UniProtKB/TrEMBL
	ENSSSCT00070013838.1	UniProtKB/TrEMBL
	ENSSSCT00070013963.1	UniProtKB/TrEMBL
Gene3D-CATH	NAD(P)-binding Rossmann-like Domain	UniProtKB/TrEMBL
	ProC C-terminal domain-like	UniProtKB/TrEMBL
InterPro	6-PGluconate_DH-like_C_sf	UniProtKB/TrEMBL
	NAD(P)-bd_dom_sf	UniProtKB/TrEMBL
	P5C_Rdtase_cat_N	UniProtKB/TrEMBL
	P5CR-like	UniProtKB/TrEMBL
	P5CR_dimer	UniProtKB/TrEMBL
	Pyrroline-COOH_reductase	UniProtKB/TrEMBL
KEGG Report	ssc:100524702	UniProtKB/TrEMBL
NCBI Gene	PYCR2	ENTREZGENE
PANTHER	PTHR11645	UniProtKB/TrEMBL
	PYRROLINE-5-CARBOXYLATE REDUCTASE	UniProtKB/TrEMBL
	PYRROLINE-5-CARBOXYLATE REDUCTASE 2	UniProtKB/TrEMBL
Pfam	F420_oxidored	UniProtKB/TrEMBL
	P5CR_dimer	UniProtKB/TrEMBL
PIRSF	Pyrrol-5-carb_rd	UniProtKB/TrEMBL
PROSITE	P5CR	UniProtKB/TrEMBL
Superfamily-SCOP	SSF48179	UniProtKB/TrEMBL
	SSF51735	UniProtKB/TrEMBL
UniProt	A0A480F2F7	ENTREZGENE
	A0A480K6U0	ENTREZGENE, UniProtKB/TrEMBL
	A0A480YHC0	ENTREZGENE, UniProtKB/TrEMBL
	A0A4X1T6E4_PIG	UniProtKB/TrEMBL
	A0A4X1T9C4	ENTREZGENE, UniProtKB/TrEMBL
	A0A8D1ENJ7_PIG	UniProtKB/TrEMBL
	A0A8W4FQH6_PIG	UniProtKB/TrEMBL
	A0A8X9AEK2	ENTREZGENE, UniProtKB/TrEMBL
	F1S8R2	ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary	A0A480F2F7	UniProtKB/TrEMBL
	A0A5G2QMA7	UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - OMIM

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