FGFR4 (fibroblast growth factor receptor 4) - Rat Genome Database

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Gene: FGFR4 (fibroblast growth factor receptor 4) Pan paniscus
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Symbol: FGFR4
Name: fibroblast growth factor receptor 4
RGD ID: 11757967
Description: ENCODES a protein that exhibits ATP binding (inferred); boss receptor activity (inferred); brain-derived neurotrophic factor receptor activity (inferred); INVOLVED IN alveolar secondary septum development (ortholog); cholesterol homeostasis (ortholog); fibroblast growth factor receptor signaling pathway (ortholog); PARTICIPATES IN fibroblast growth factor signaling pathway; ASSOCIATED WITH adenoid cystic carcinoma (ortholog); adult respiratory distress syndrome (ortholog); Breast Neoplasms (ortholog); FOUND IN cell-cell junction (inferred); endoplasmic reticulum (inferred); endosome (inferred)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24172,169,490 - 172,181,379 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15170,308,253 - 170,320,916 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05172,386,443 - 172,400,271 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15179,454,995 - 179,466,114 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5179,454,995 - 179,467,605 (+)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
alveolar secondary septum development  (ISO)
brain-derived neurotrophic factor receptor signaling pathway  (IEA)
cell migration  (IEA)
cell surface receptor protein tyrosine kinase signaling pathway  (IEA)
cellular response to growth factor stimulus  (IEA)
cholesterol homeostasis  (ISO)
chromatin remodeling  (IEA)
collagen-activated tyrosine kinase receptor signaling pathway  (IEA)
ephrin receptor signaling pathway  (IEA)
epidermal growth factor receptor signaling pathway  (IEA)
fibroblast growth factor receptor signaling pathway  (IEA,ISO)
glucose homeostasis  (ISO)
hepatocyte growth factor receptor signaling pathway  (IEA)
insulin receptor signaling pathway  (IEA)
insulin-like growth factor receptor signaling pathway  (IEA)
Kit signaling pathway  (IEA)
lung development  (ISO)
macrophage colony-stimulating factor signaling pathway  (IEA)
negative regulation of fibroblast growth factor production  (ISO)
negative regulation of gene expression  (ISO)
organ induction  (ISO)
peptidyl-tyrosine phosphorylation  (ISO)
phosphate ion homeostasis  (ISO)
platelet-derived growth factor receptor-alpha signaling pathway  (IEA)
platelet-derived growth factor receptor-beta signaling pathway  (IEA)
positive regulation of catalytic activity  (ISO)
positive regulation of cell population proliferation  (IEA,ISO)
positive regulation of DNA biosynthetic process  (IEA)
positive regulation of ERK1 and ERK2 cascade  (IEA)
positive regulation of gene expression  (IEA)
positive regulation of parathyroid hormone secretion  (ISO)
positive regulation of proteolysis  (IEA)
protein autophosphorylation  (ISO)
regulation of bile acid biosynthetic process  (IEA)
regulation of extracellular matrix disassembly  (IEA)
regulation of lipid metabolic process  (ISO)
regulation of phosphate transport  (ISO)
regulation of phosphorus metabolic process  (ISO)
response to bile acid  (ISO)
vascular endothelial growth factor receptor-1 signaling pathway  (IEA)
vascular endothelial growth factor signaling pathway  (IEA)
vitamin D3 metabolic process  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
FGFR4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24172,169,490 - 172,181,379 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15170,308,253 - 170,320,916 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05172,386,443 - 172,400,271 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15179,454,995 - 179,466,114 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5179,454,995 - 179,467,605 (+)Ensemblpanpan1.1panPan2
FGFR4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385177,086,915 - 177,098,144 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5177,086,905 - 177,098,144 (+)EnsemblGRCh38hg38GRCh38
GRCh375176,513,916 - 176,525,145 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365176,446,527 - 176,457,733 (+)NCBINCBI36Build 36hg18NCBI36
Build 345176,446,526 - 176,457,730NCBI
Celera5171,976,184 - 171,987,401 (-)NCBICelera
Cytogenetic Map5q35.2NCBI
HuRef5171,435,609 - 171,446,679 (+)NCBIHuRef
CHM1_15175,946,753 - 175,957,892 (+)NCBICHM1_1
T2T-CHM13v2.05177,630,123 - 177,641,352 (+)NCBIT2T-CHM13v2.0
Fgfr4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391355,300,631 - 55,316,572 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1355,300,453 - 55,316,572 (+)EnsemblGRCm39 Ensembl
GRCm381355,152,818 - 55,168,759 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1355,152,640 - 55,168,759 (+)EnsemblGRCm38mm10GRCm38
MGSCv371355,254,179 - 55,270,120 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361355,162,497 - 55,178,362 (+)NCBIMGSCv36mm8
Celera1356,213,486 - 56,229,296 (+)NCBICelera
Cytogenetic Map13B1NCBI
cM Map1329.8NCBI
Fgfr4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8179,466,686 - 9,481,423 (-)NCBIGRCr8
mRatBN7.2179,461,541 - 9,476,268 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl179,461,547 - 9,476,242 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx179,477,854 - 9,492,597 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01711,007,466 - 11,022,178 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0179,474,258 - 9,489,006 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0179,990,072 - 10,004,339 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl179,990,078 - 10,004,321 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01712,099,383 - 12,113,637 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41715,512,144 - 15,527,348 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11715,512,146 - 15,523,432 (-)NCBI
Celera179,540,006 - 9,554,750 (-)NCBICelera
Cytogenetic Map17p14NCBI
Fgfr4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540829,370,468 - 29,383,971 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540829,370,480 - 29,383,531 (+)NCBIChiLan1.0ChiLan1.0
FGFR4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1436,243,689 - 36,254,636 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl436,244,220 - 36,252,035 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha436,209,722 - 36,220,671 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0436,607,886 - 36,618,835 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl436,607,906 - 36,618,801 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1436,434,871 - 36,445,815 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0436,622,022 - 36,632,969 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0437,130,265 - 37,141,210 (-)NCBIUU_Cfam_GSD_1.0
Fgfr4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213122,360,727 - 122,372,869 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365971,385,624 - 1,397,758 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365971,388,394 - 1,397,731 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FGFR4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl280,841,536 - 80,853,796 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1280,841,536 - 80,853,791 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2282,414,997 - 82,427,239 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FGFR4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12379,095,031 - 79,106,018 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2379,097,429 - 79,105,456 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607510,259,717 - 10,291,447 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fgfr4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473312,964,746 - 12,976,732 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473312,964,893 - 12,979,198 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSPPAT00000050827   ⟹   ENSPPAP00000027984
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl5179,454,995 - 179,466,114 (+)Ensembl
Ensembl Acc Id: ENSPPAT00000050832   ⟹   ENSPPAP00000027988
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl5179,456,359 - 179,466,114 (+)Ensembl
Ensembl Acc Id: ENSPPAT00000050837   ⟹   ENSPPAP00000027993
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl5179,457,678 - 179,467,605 (+)Ensembl
Ensembl Acc Id: ENSPPAT00000050857   ⟹   ENSPPAP00000028013
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl5179,457,731 - 179,465,646 (+)Ensembl
Ensembl Acc Id: ENSPPAT00000050862   ⟹   ENSPPAP00000028018
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl5179,457,731 - 179,465,646 (+)Ensembl
Ensembl Acc Id: ENSPPAT00000050868   ⟹   ENSPPAP00000028024
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl5179,457,731 - 179,458,598 (+)Ensembl
RefSeq Acc Id: XM_003806851   ⟹   XP_003806899
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v24172,169,491 - 172,181,378 (+)NCBI
NHGRI_mPanPan15170,309,031 - 170,320,914 (+)NCBI
Mhudiblu_PPA_v05172,387,147 - 172,399,121 (+)NCBI
PanPan1.15179,454,995 - 179,466,114 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008958181   ⟹   XP_008956429
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v24172,169,491 - 172,181,378 (+)NCBI
NHGRI_mPanPan15170,309,031 - 170,320,914 (+)NCBI
Mhudiblu_PPA_v05172,387,147 - 172,399,105 (+)NCBI
PanPan1.15179,455,002 - 179,466,114 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008958189   ⟹   XP_008956437
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v24172,169,491 - 172,181,378 (+)NCBI
NHGRI_mPanPan15170,309,032 - 170,320,914 (+)NCBI
Mhudiblu_PPA_v05172,387,148 - 172,399,537 (+)NCBI
PanPan1.15179,455,008 - 179,466,114 (+)NCBI
Sequence:
RefSeq Acc Id: XM_034961046   ⟹   XP_034816937
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v24172,172,367 - 172,181,378 (+)NCBI
NHGRI_mPanPan15170,311,909 - 170,320,914 (+)NCBI
Mhudiblu_PPA_v05172,390,014 - 172,399,537 (+)NCBI
RefSeq Acc Id: XM_057302424   ⟹   XP_057158407
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v24172,169,490 - 172,181,379 (+)NCBI
NHGRI_mPanPan15170,309,030 - 170,320,916 (+)NCBI
RefSeq Acc Id: XP_003806899   ⟸   XM_003806851
- Peptide Label: isoform X1
- UniProtKB: A0A2R9BFK6 (UniProtKB/TrEMBL),   A0A2R9BFN1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008956429   ⟸   XM_008958181
- Peptide Label: isoform X1
- UniProtKB: A0A2R9BFK6 (UniProtKB/TrEMBL),   A0A2R9BFN1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008956437   ⟸   XM_008958189
- Peptide Label: isoform X1
- UniProtKB: A0A2R9BFK6 (UniProtKB/TrEMBL),   A0A2R9BFN1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_034816937   ⟸   XM_034961046
- Peptide Label: isoform X3
- UniProtKB: A0A2R9BFN1 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSPPAP00000027988   ⟸   ENSPPAT00000050832
Ensembl Acc Id: ENSPPAP00000027984   ⟸   ENSPPAT00000050827
Ensembl Acc Id: ENSPPAP00000027993   ⟸   ENSPPAT00000050837
Ensembl Acc Id: ENSPPAP00000028018   ⟸   ENSPPAT00000050862
Ensembl Acc Id: ENSPPAP00000028013   ⟸   ENSPPAT00000050857
Ensembl Acc Id: ENSPPAP00000028024   ⟸   ENSPPAT00000050868
RefSeq Acc Id: XP_057158407   ⟸   XM_057302424
- Peptide Label: isoform X2
- UniProtKB: A0A2R9BEB5 (UniProtKB/TrEMBL)
Protein Domains
Ig-like   Protein kinase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000037055 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000050827.1 UniProtKB/TrEMBL
  ENSPPAT00000050832.1 UniProtKB/TrEMBL
  ENSPPAT00000050837.1 UniProtKB/TrEMBL
  ENSPPAT00000050857.1 UniProtKB/TrEMBL
  ENSPPAT00000050862.1 UniProtKB/TrEMBL
  ENSPPAT00000050868.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro FGF_rcpt_fam UniProtKB/TrEMBL
  Ig-like_dom UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig_I-set UniProtKB/TrEMBL
  Ig_sub UniProtKB/TrEMBL
  Ig_sub2 UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  RTK UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/TrEMBL
  Tyr_kinase_AS UniProtKB/TrEMBL
  Tyr_kinase_cat_dom UniProtKB/TrEMBL
KEGG Report pps:100991315 UniProtKB/TrEMBL
NCBI Gene FGFR4 ENTREZGENE
PANTHER FIBROBLAST GROWTH FACTOR RECEPTOR 4 UniProtKB/TrEMBL
  TYROSINE-PROTEIN KINASE RECEPTOR UniProtKB/TrEMBL
Pfam I-set UniProtKB/TrEMBL
  Ig_3 UniProtKB/TrEMBL
  PK_Tyr_Ser-Thr UniProtKB/TrEMBL
PIRSF FGFR UniProtKB/TrEMBL
PRINTS TYRKINASE UniProtKB/TrEMBL
PROSITE IG_LIKE UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_TYR UniProtKB/TrEMBL
SMART IGc2 UniProtKB/TrEMBL
  SM00409 UniProtKB/TrEMBL
  TyrKc UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/TrEMBL
  SSF56112 UniProtKB/TrEMBL
UniProt A0A2R9BEB5 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9BEF9_PANPA UniProtKB/TrEMBL
  A0A2R9BFK6 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9BFN1 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9BFN5_PANPA UniProtKB/TrEMBL