RGD Reference Report - Fibroblast growth factor-16 is a growth factor for embryonic brown adipocytes. - Rat Genome Database

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Fibroblast growth factor-16 is a growth factor for embryonic brown adipocytes.

Authors: Konishi, M  Mikami, T  Yamasaki, M  Miyake, A  Itoh, N 
Citation: Konishi M, etal., J Biol Chem. 2000 Apr 21;275(16):12119-22.
RGD ID: 8553993
Pubmed: PMID:10766846   (View Abstract at PubMed)

In rat embryos, fibroblast growth factor (FGF)-16 is predominantly expressed in brown adipose tissue. To elucidate the role of FGF-16, we examined the expression of FGF-16 mRNA in rat embryonic brown adipose tissue at different developmental stages by Northern blotting analysis and in situ hybridization. FGF-16 mRNA was expressed abundantly in brown adipose tissue during embryonic day 17. 5, embryonic days 17.5-19.5, and thereafter at lower levels into the neonatal period. The expression profile of FGF-16 mRNA well corresponds to the proliferative profile of embryonic brown adipose tissue reported. We also examined the mitogenic activity of recombinant rat FGF-16 for primary brown adipocytes prepared from rat embryonic brown adipose tissue. FGF-16 showed significant mitogenic activity for primary brown adipocytes. The mitogenic activity was found to be exerted by binding and activating FGF receptor-4 in the brown adipose tissue. As a great induction of proliferation of rat brown adipose tissue during cold acclimation was reported, we also examined the expression of FGF-16 mRNA in the brown adipose tissue during cold acclimation by Northern blotting analysis. The expression of FGF-16 mRNA was not increased, but rather decreased. The expression profile of FGF-16 mRNA and the mitogenic activity of FGF-16 reported here indicate that FGF-16 is a unique growth factor involved in proliferation of embryonic brown adipose tissue.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

Molecular Function

Objects Annotated

Genes (Rattus norvegicus)
Fgf16  (fibroblast growth factor 16)
Fgf2  (fibroblast growth factor 2)
Fgfr4  (fibroblast growth factor receptor 4)


Additional Information