FMO1 (flavin containing dimethylaniline monoxygenase 1) - Rat Genome Database

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Gene: FMO1 (flavin containing dimethylaniline monoxygenase 1) Pan paniscus
Analyze
Symbol: FMO1
Name: flavin containing dimethylaniline monoxygenase 1
RGD ID: 11726394
Description: ENCODES a protein that exhibits monooxygenase activity (ortholog); N,N-dimethylaniline monooxygenase activity (ortholog); INVOLVED IN response to lipopolysaccharide (ortholog); PARTICIPATES IN tamoxifen pharmacodynamics pathway; tamoxifen pharmacokinetics pathway; ASSOCIATED WITH 1q24 Deletion Syndrome (ortholog); amyotrophic lateral sclerosis type 1 (ortholog); autism spectrum disorder (ortholog); FOUND IN endoplasmic reticulum (inferred); endoplasmic reticulum membrane (inferred); membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: dimethylaniline monooxygenase [N-oxide-forming] 1; flavin containing monooxygenase 1; flavin-containing monooxygenase 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2178,472,277 - 78,498,941 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1178,146,459 - 78,173,131 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01146,742,505 - 146,778,560 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11150,456,729 - 150,492,527 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1150,456,729 - 150,492,527 (+)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
FMO1Bonobo1q24 Deletion Syndrome  ISOFMO1 (Homo sapiens)8554872ClinVar Annotator: match by term: 1q24q25 microdeletion syndromeClinVarPMID:25741868
FMO1Bonobogastrointestinal stromal tumor  ISOFMO1 (Homo sapiens)8554872ClinVar Annotator: match by term: Gastrointestinal stromal tumorClinVarPMID:28492532
FMO1Bonoboparathyroid carcinoma  ISOFMO1 (Homo sapiens)8554872ClinVar Annotator: match by term: Parathyroid carcinomaClinVarPMID:28492532
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
FMO1Bonoboamyotrophic lateral sclerosis type 1  ISOFMO1 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:17127561
FMO1Bonoboautism spectrum disorder  ISOFMO1 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:35663546
FMO1BonoboExperimental Liver Cirrhosis  ISOFMO1 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:17072980 and PMID:25380136


Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
FMO1Bonoboenergy homeostasis acts_upstream_of_or_withinIEAUniProtKB:P50285 and ensembl:ENSMUSP00000037259150520179 EnsemblGO_REF:0000107
FMO1Bonobonegative regulation of fatty acid oxidation acts_upstream_of_or_withinIEAUniProtKB:P50285 and ensembl:ENSMUSP00000037259150520179 EnsemblGO_REF:0000107
FMO1Bonoboorganic acid metabolic process involved_inIEAUniProtKB:Q01740 and ensembl:ENSP00000481732150520179 EnsemblGO_REF:0000107
FMO1Bonoboresponse to lipopolysaccharide  ISOFmo1 (Rattus norvegicus)9068941 RGDPMID:19779138 and REF_RGD_ID:2316301
FMO1Bonobotaurine biosynthetic process involved_inIEAUniProtKB:P50285 more ...150520179 EnsemblGO_REF:0000107
FMO1Bonobotoxin metabolic process involved_inIEAUniProtKB:Q01740 and ensembl:ENSP00000481732150520179 EnsemblGO_REF:0000107
FMO1Bonoboxenobiotic metabolic process acts_upstream_of_or_withinIEAUniProtKB:P50285 and ensembl:ENSMUSP00000037259150520179 EnsemblGO_REF:0000107

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
FMO1Bonoboendoplasmic reticulum located_inIEAUniProtKB-KW:KW-0256150520179 UniProtGO_REF:0000043
FMO1Bonoboendoplasmic reticulum membrane located_inIEAUniRule:UR000011949150520179 UniProtGO_REF:0000104
FMO1Bonoboendoplasmic reticulum membrane located_inIEAUniProtKB-SubCell:SL-0097150520179 UniProtGO_REF:0000044
FMO1Bonobomembrane located_inIEAUniProtKB-KW:KW-0472150520179 UniProtGO_REF:0000043

Molecular Function
1 to 16 of 16 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
FMO1Bonoboflavin adenine dinucleotide binding enablesIEAInterPro:IPR000960 and InterPro:IPR020946150520179 InterProGO_REF:0000002
FMO1Bonobohypotaurine monooxygenase activity enablesIEAUniProtKB:P50285 more ...150520179 EnsemblGO_REF:0000107
FMO1Bonobohypotaurine monooxygenase activity enablesIEARHEA:69819150520179 RHEAGO_REF:0000116
FMO1Bonobomonooxygenase activity  ISOFmo1 (Rattus norvegicus)9068941 RGDPMID:8504165 and REF_RGD_ID:728615
FMO1Bonobomonooxygenase activity enablesIEAUniProtKB:P50285 more ...150520179 EnsemblGO_REF:0000107
FMO1Bonobomonooxygenase activity enablesIEAUniProtKB-KW:KW-0503150520179 UniProtGO_REF:0000043
FMO1BonoboN,N-dimethylaniline monooxygenase activity  ISOFmo1 (Rattus norvegicus)9068941 RGDPMID:8504165 and REF_RGD_ID:728615
FMO1BonoboN,N-dimethylaniline monooxygenase activity enablesIEAInterPro:IPR002253 and InterPro:IPR020946150520179 InterProGO_REF:0000002
FMO1BonoboN,N-dimethylaniline monooxygenase activity enablesIEAUniRule:UR000011949150520179 UniProtGO_REF:0000104
FMO1BonoboN,N-dimethylaniline monooxygenase activity enablesIEARHEA:24468150520179 RHEAGO_REF:0000116
FMO1BonoboN,N-dimethylaniline monooxygenase activity enablesIEAUniProtKB:Q01740 and ensembl:ENSP00000481732150520179 EnsemblGO_REF:0000107
FMO1BonoboNADP binding enablesIEAInterPro:IPR000960 and InterPro:IPR020946150520179 InterProGO_REF:0000002
FMO1Bonobooxidoreductase activity enablesIEAUniProtKB-KW:KW-0560150520179 UniProtGO_REF:0000043
FMO1Bonoboprotein binding enablesISOUniProtKB:O43889-29068941 PMID:25910212IntActPMID:25910212
FMO1Bonoboprotein binding enablesISOUniProtKB:O95214 more ...9068941 PMID:32296183IntActPMID:32296183
FMO1Bonobotrimethylamine monooxygenase activity enablesIEARHEA:31979150520179 RHEAGO_REF:0000116
1 to 16 of 16 rows

Imported Annotations - SMPDB

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
FMO1Bonobotamoxifen pharmacodynamics pathway   ISOFMO1 (Homo sapiens)9068941 SMPDBSMP:00471
FMO1Bonobotamoxifen pharmacokinetics pathway   ISOFMO1 (Homo sapiens)9068941 SMPDBSMP:00606
PMID:22301074   PMID:30032202  



FMO1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2178,472,277 - 78,498,941 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1178,146,459 - 78,173,131 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01146,742,505 - 146,778,560 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11150,456,729 - 150,492,527 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1150,456,729 - 150,492,527 (+)Ensemblpanpan1.1panPan2
FMO1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381171,248,494 - 171,285,978 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1171,248,471 - 171,285,978 (+)EnsemblGRCh38hg38GRCh38
GRCh371171,217,633 - 171,255,117 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361169,484,287 - 169,521,737 (+)NCBINCBI36Build 36hg18NCBI36
Build 341167,949,320 - 167,986,769NCBI
Celera1144,327,502 - 144,364,465 (+)NCBICelera
Cytogenetic Map1q24.3NCBI
HuRef1142,440,949 - 142,478,265 (+)NCBIHuRef
CHM1_11172,639,801 - 172,677,227 (+)NCBICHM1_1
T2T-CHM13v2.01170,604,793 - 170,642,278 (+)NCBIT2T-CHM13v2.0
Fmo1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391162,657,130 - 162,694,170 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1162,657,130 - 162,694,179 (-)EnsemblGRCm39 Ensembl
GRCm381162,829,561 - 162,866,610 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1162,829,561 - 162,866,610 (-)EnsemblGRCm38mm10GRCm38
MGSCv371164,759,692 - 164,796,679 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361164,666,236 - 164,703,223 (-)NCBIMGSCv36mm8
Celera1165,273,712 - 165,303,556 (-)NCBICelera
Cytogenetic Map1H2.1NCBI
cM Map170.34NCBI
Fmo1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81377,715,405 - 77,747,666 (-)NCBIGRCr8
mRatBN7.21375,182,184 - 75,214,439 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1375,182,176 - 75,214,647 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1377,760,307 - 77,792,478 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01379,060,879 - 79,093,009 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01376,320,740 - 76,352,870 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01380,712,885 - 80,745,095 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1380,712,882 - 80,745,347 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01385,607,539 - 85,639,778 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41378,503,770 - 78,536,359 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11378,517,957 - 78,550,547 (-)NCBI
Celera1374,919,415 - 74,951,610 (-)NCBICelera
Cytogenetic Map13q22NCBI
Fmo1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540611,881,882 - 11,916,323 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540611,882,656 - 11,915,875 (+)NCBIChiLan1.0ChiLan1.0
FMO1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1727,599,230 - 27,623,081 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl727,599,267 - 27,618,237 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha727,120,190 - 27,139,165 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0727,400,502 - 27,424,539 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl727,400,510 - 27,424,542 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1727,251,218 - 27,270,180 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0727,285,744 - 27,304,928 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0727,528,093 - 27,546,971 (-)NCBIUU_Cfam_GSD_1.0
FMO1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl963,868,064 - 63,895,076 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1963,860,957 - 63,895,086 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2970,137,610 - 70,171,700 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FMO1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12557,781,273 - 57,819,787 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2557,782,085 - 57,819,408 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605559,419,669 - 59,462,141 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fmo1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477110,357,210 - 10,386,005 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477110,358,422 - 10,386,015 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.






Ensembl Acc Id: ENSPPAT00000062723   ⟹   ENSPPAP00000039811
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1150,456,729 - 150,492,527 (+)Ensembl
Ensembl Acc Id: ENSPPAT00000062728   ⟹   ENSPPAP00000039816
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1150,466,300 - 150,477,192 (+)Ensembl
Ensembl Acc Id: ENSPPAT00000062732   ⟹   ENSPPAP00000039820
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1150,466,519 - 150,492,098 (+)Ensembl
Ensembl Acc Id: ENSPPAT00000062734   ⟹   ENSPPAP00000039822
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1150,466,519 - 150,492,098 (+)Ensembl
RefSeq Acc Id: XM_008978300   ⟹   XP_008976548
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2178,472,277 - 78,498,941 (-)NCBI
NHGRI_mPanPan1178,146,459 - 78,173,131 (-)NCBI
Mhudiblu_PPA_v01146,742,505 - 146,778,560 (+)NCBI
PanPan1.11150,456,729 - 150,492,527 (+)NCBI
Sequence:
RefSeq Acc Id: XM_055111665   ⟹   XP_054967640
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2178,472,277 - 78,498,895 (-)NCBI
NHGRI_mPanPan1178,146,476 - 78,173,085 (-)NCBI
RefSeq Acc Id: XM_063603969   ⟹   XP_063460039
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2178,472,277 - 78,489,294 (-)NCBI
Protein RefSeqs XP_008976548 (Get FASTA)   NCBI Sequence Viewer  
  XP_054967640 (Get FASTA)   NCBI Sequence Viewer  
  XP_063460039 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000039811.1
  ENSPPAP00000039816.1
  ENSPPAP00000039820.1
  ENSPPAP00000039822.1
RefSeq Acc Id: XP_008976548   ⟸   XM_008978300
- Peptide Label: isoform X1
- UniProtKB: A0A2R9CCZ4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSPPAP00000039816   ⟸   ENSPPAT00000062728
Ensembl Acc Id: ENSPPAP00000039820   ⟸   ENSPPAT00000062732
Ensembl Acc Id: ENSPPAP00000039822   ⟸   ENSPPAT00000062734
Ensembl Acc Id: ENSPPAP00000039811   ⟸   ENSPPAT00000062723



1 to 23 of 23 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSPPAG00000042572 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000062723.1 UniProtKB/TrEMBL
  ENSPPAT00000062728.1 UniProtKB/TrEMBL
  ENSPPAT00000062732.1 UniProtKB/TrEMBL
  ENSPPAT00000062734.1 UniProtKB/TrEMBL
Gene3D-CATH 3.50.50.60 UniProtKB/TrEMBL
InterPro FAD/NAD-bd_sf UniProtKB/TrEMBL
  Flavin_mOase UniProtKB/TrEMBL
  Flavin_mOase-like UniProtKB/TrEMBL
  Flavin_mOase_1 UniProtKB/TrEMBL
  FMO UniProtKB/TrEMBL
KEGG Report pps:100992347 UniProtKB/TrEMBL
NCBI Gene FMO1 ENTREZGENE
PANTHER DIMETHYLANILINE MONOOXYGENASE UniProtKB/TrEMBL
Pfam FMO-like UniProtKB/TrEMBL
PIRSF FMO UniProtKB/TrEMBL
PRINTS FMOXYGENASE UniProtKB/TrEMBL
  FMOXYGENASE1 UniProtKB/TrEMBL
Superfamily-SCOP SSF51905 UniProtKB/TrEMBL
UniProt A0A2R9CCZ4 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9CCZ8_PANPA UniProtKB/TrEMBL
  A0A2R9CD02_PANPA UniProtKB/TrEMBL
  A0A2R9CNJ8 ENTREZGENE, UniProtKB/TrEMBL
1 to 23 of 23 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-04-30 FMO1  flavin containing dimethylaniline monoxygenase 1    flavin containing monooxygenase 1  Symbol and/or name change 5135510 APPROVED