FMO1 (flavin containing dimethylaniline monoxygenase 1) - Rat Genome Database

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Gene: FMO1 (flavin containing dimethylaniline monoxygenase 1) Canis lupus familiaris
Analyze
Symbol: FMO1
Name: flavin containing dimethylaniline monoxygenase 1
RGD ID: 12315211
Description: ENCODES a protein that exhibits hypotaurine dehydrogenase activity (ortholog); monooxygenase activity (ortholog); N,N-dimethylaniline monooxygenase activity (ortholog); INVOLVED IN energy homeostasis (ortholog); NADPH oxidation (ortholog); negative regulation of fatty acid oxidation (ortholog); PARTICIPATES IN tamoxifen pharmacodynamics pathway; tamoxifen pharmacokinetics pathway; ASSOCIATED WITH 1q24 Deletion Syndrome (ortholog); amyotrophic lateral sclerosis type 1 (ortholog); autism spectrum disorder (ortholog); FOUND IN endoplasmic reticulum membrane
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: dimethylaniline monooxygenase [N-oxide-forming] 1; dimethylaniline oxidase 1; flavin containing monooxygenase 1; flavin-containing monooxygenase 1; FMO 1; hepatic flavin-containing monooxygenase 1; trimethylamine monooxygenase
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1727,599,230 - 27,623,081 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl727,599,267 - 27,618,237 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha727,120,190 - 27,139,165 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0727,400,502 - 27,424,539 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl727,400,510 - 27,424,542 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1727,251,218 - 27,270,180 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0727,285,744 - 27,304,928 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0727,528,093 - 27,546,971 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:11792679   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
FMO1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1727,599,230 - 27,623,081 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl727,599,267 - 27,618,237 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha727,120,190 - 27,139,165 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0727,400,502 - 27,424,539 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl727,400,510 - 27,424,542 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1727,251,218 - 27,270,180 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0727,285,744 - 27,304,928 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0727,528,093 - 27,546,971 (-)NCBIUU_Cfam_GSD_1.0
FMO1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381171,248,494 - 171,285,978 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1171,248,471 - 171,285,978 (+)EnsemblGRCh38hg38GRCh38
GRCh371171,217,633 - 171,255,117 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361169,484,287 - 169,521,737 (+)NCBINCBI36Build 36hg18NCBI36
Build 341167,949,320 - 167,986,769NCBI
Celera1144,327,502 - 144,364,465 (+)NCBICelera
Cytogenetic Map1q24.3NCBI
HuRef1142,440,949 - 142,478,265 (+)NCBIHuRef
CHM1_11172,639,801 - 172,677,227 (+)NCBICHM1_1
T2T-CHM13v2.01170,604,793 - 170,642,278 (+)NCBIT2T-CHM13v2.0
Fmo1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391162,657,130 - 162,694,170 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1162,657,130 - 162,694,179 (-)EnsemblGRCm39 Ensembl
GRCm381162,829,561 - 162,866,610 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1162,829,561 - 162,866,610 (-)EnsemblGRCm38mm10GRCm38
MGSCv371164,759,692 - 164,796,679 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361164,666,236 - 164,703,223 (-)NCBIMGSCv36mm8
Celera1165,273,712 - 165,303,556 (-)NCBICelera
Cytogenetic Map1H2.1NCBI
cM Map170.34NCBI
Fmo1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81377,715,405 - 77,747,666 (-)NCBIGRCr8
mRatBN7.21375,182,184 - 75,214,439 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1375,182,176 - 75,214,647 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1377,760,307 - 77,792,478 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01379,060,879 - 79,093,009 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01376,320,740 - 76,352,870 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01380,712,885 - 80,745,095 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1380,712,882 - 80,745,347 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01385,607,539 - 85,639,778 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41378,503,770 - 78,536,359 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11378,517,957 - 78,550,547 (-)NCBI
Celera1374,919,415 - 74,951,610 (-)NCBICelera
Cytogenetic Map13q22NCBI
Fmo1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540611,881,882 - 11,916,323 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540611,882,656 - 11,915,875 (+)NCBIChiLan1.0ChiLan1.0
FMO1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2178,472,277 - 78,498,941 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1178,146,459 - 78,173,131 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01146,742,505 - 146,778,560 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11150,456,729 - 150,492,527 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1150,456,729 - 150,492,527 (+)Ensemblpanpan1.1panPan2
FMO1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl963,868,064 - 63,895,076 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1963,860,957 - 63,895,086 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2970,137,610 - 70,171,700 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FMO1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12557,781,273 - 57,819,787 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2557,782,085 - 57,819,408 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605559,419,669 - 59,462,141 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fmo1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477110,357,210 - 10,386,005 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477110,358,422 - 10,386,015 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in FMO1
290 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 6 6 6 5
Low
Below cutoff 5 5 16 6 6 6 12 8 5 6

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000023758   ⟹   ENSCAFP00000022051
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl727,599,267 - 27,618,237 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000062455   ⟹   ENSCAFP00000045766
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl727,599,267 - 27,618,229 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845002360   ⟹   ENSCAFP00845001876
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl727,400,510 - 27,419,732 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845002374   ⟹   ENSCAFP00845001885
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl727,400,510 - 27,419,726 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845002379   ⟹   ENSCAFP00845001890
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl727,414,943 - 27,424,542 (-)Ensembl
RefSeq Acc Id: NM_001003061   ⟹   NP_001003061
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1727,599,267 - 27,618,237 (-)NCBI
Dog10K_Boxer_Tasha727,120,190 - 27,139,165 (-)NCBI
ROS_Cfam_1.0727,400,532 - 27,419,734 (-)NCBI
UMICH_Zoey_3.1727,251,218 - 27,270,180 (-)NCBI
UNSW_CanFamBas_1.0727,285,744 - 27,304,928 (-)NCBI
UU_Cfam_GSD_1.0727,528,093 - 27,546,971 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038670481   ⟹   XP_038526409
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0727,400,502 - 27,424,539 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001003061   ⟸   NM_001003061
- UniProtKB: Q95LA2 (UniProtKB/Swiss-Prot),   A0A8C0LCE1 (UniProtKB/TrEMBL),   A0A8C0SPE7 (UniProtKB/TrEMBL),   A0A8I3MPB1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000045766   ⟸   ENSCAFT00000062455
RefSeq Acc Id: ENSCAFP00000022051   ⟸   ENSCAFT00000023758
RefSeq Acc Id: XP_038526409   ⟸   XM_038670481
- Peptide Label: isoform X1
- UniProtKB: Q95LA2 (UniProtKB/Swiss-Prot),   A0A8C0LCE1 (UniProtKB/TrEMBL),   A0A8C0SPE7 (UniProtKB/TrEMBL),   A0A8I3MPB1 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845001876   ⟸   ENSCAFT00845002360
RefSeq Acc Id: ENSCAFP00845001890   ⟸   ENSCAFT00845002379
RefSeq Acc Id: ENSCAFP00845001885   ⟸   ENSCAFT00845002374

Promoters
RGD ID:13683944
Promoter ID:EPDNEW_C2014
Type:single initiation site
Name:FMO1_1
Description:flavin containing monooxygenase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1727,618,237 - 27,618,297EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000014982 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSCAFG00030000236 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSCAFG00040015175 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSCAFG00845001369 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000023758.3 UniProtKB/Swiss-Prot
  ENSCAFT00000062455.2 UniProtKB/TrEMBL
  ENSCAFT00000096697.1 UniProtKB/TrEMBL
  ENSCAFT00030000380.1 UniProtKB/Swiss-Prot
  ENSCAFT00030000390.1 UniProtKB/TrEMBL
  ENSCAFT00040028004.1 UniProtKB/Swiss-Prot
  ENSCAFT00040028070.1 UniProtKB/TrEMBL
  ENSCAFT00845002360 ENTREZGENE
  ENSCAFT00845002360.1 UniProtKB/Swiss-Prot
  ENSCAFT00845002374.1 UniProtKB/TrEMBL
  ENSCAFT00845002379.1 UniProtKB/TrEMBL
Gene3D-CATH 3.50.50.60 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro FAD/NAD-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Flavin_mOase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Flavin_mOase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Flavin_mOase_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report cfa:403604 UniProtKB/Swiss-Prot
NCBI Gene FMO1 ENTREZGENE
PANTHER DIMETHYLANILINE MONOOXYGENASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DIMETHYLANILINE MONOOXYGENASE [N-OXIDE-FORMING] 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam FMO-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NAD_binding_8 UniProtKB/TrEMBL
PIRSF FMO UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS FMOXYGENASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FMOXYGENASE1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF51905 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8C0LCE1 ENTREZGENE
  A0A8C0SPE7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3MKC8_CANLF UniProtKB/TrEMBL
  A0A8I3MPB1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0PGE9_CANLF UniProtKB/TrEMBL
  FMO1_CANLF UniProtKB/Swiss-Prot, ENTREZGENE
VGNC ID VGNC:40916 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-08-06 FMO1  flavin containing dimethylaniline monoxygenase 1  FMO1  flavin containing monooxygenase 1  Symbol and/or name change 5135510 APPROVED