P2rx6 (purinergic receptor P2X, ligand-gated ion channel, 6) - Rat Genome Database

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Gene: P2rx6 (purinergic receptor P2X, ligand-gated ion channel, 6) Mus musculus
Analyze
Symbol: P2rx6
Name: purinergic receptor P2X, ligand-gated ion channel, 6
RGD ID: 11045
MGI Page MGI
Description: Predicted to enable extracellularly ATP-gated monoatomic cation channel activity. Predicted to be involved in calcium ion transmembrane transport. Predicted to act upstream of or within excitatory postsynaptic potential and monoatomic cation transmembrane transport. Predicted to be located in cytoplasm; dendritic spine; and neuronal cell body. Predicted to be part of receptor complex. Predicted to be active in glutamatergic synapse; parallel fiber to Purkinje cell synapse; and postsynaptic specialization membrane. Is expressed in central nervous system; heart; parathyroid gland; reproductive system; and respiratory system. Orthologous to human P2RX6 (purinergic receptor P2X 6).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ATP receptor; MGC141601; P2r; P2rxl1; P2x; P2X purinoceptor 6; P2x6; P2xm; purinergic receptor P2X-like 1, orphan receptor
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391617,379,749 - 17,389,879 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1617,379,749 - 17,395,664 (+)EnsemblGRCm39 Ensembl
GRCm381617,561,867 - 17,572,015 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1617,561,885 - 17,577,800 (+)EnsemblGRCm38mm10GRCm38
MGSCv371617,561,978 - 17,572,105 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361617,475,563 - 17,484,828 (+)NCBIMGSCv36mm8
Celera1618,135,205 - 18,145,330 (+)NCBICelera
Cytogenetic Map16A3NCBI
cM Map1610.88NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
4. Mouse MP Annotation Import Pipeline RGD automated import pipeline
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:9852680   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12477932   PMID:16141072   PMID:16141073   PMID:16985003   PMID:17605080   PMID:18657557  
PMID:19076210   PMID:19442872   PMID:21677750   PMID:21873635   PMID:24194600   PMID:25658046   PMID:25874565   PMID:27254077   PMID:27626380   PMID:33125712   PMID:38355793   PMID:38696583  


Genomics

Comparative Map Data
P2rx6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391617,379,749 - 17,389,879 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1617,379,749 - 17,395,664 (+)EnsemblGRCm39 Ensembl
GRCm381617,561,867 - 17,572,015 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1617,561,885 - 17,577,800 (+)EnsemblGRCm38mm10GRCm38
MGSCv371617,561,978 - 17,572,105 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361617,475,563 - 17,484,828 (+)NCBIMGSCv36mm8
Celera1618,135,205 - 18,145,330 (+)NCBICelera
Cytogenetic Map16A3NCBI
cM Map1610.88NCBI
P2RX6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382221,009,799 - 21,028,008 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2221,009,808 - 21,028,013 (+)EnsemblGRCh38hg38GRCh38
GRCh372221,369,454 - 21,382,297 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362219,699,464 - 19,712,302 (+)NCBINCBI36Build 36hg18NCBI36
Build 342219,694,002 - 19,707,673NCBI
Celera224,860,745 - 4,873,604 (+)NCBICelera
Cytogenetic Map22q11.21NCBI
HuRef224,637,727 - 4,650,586 (+)NCBIHuRef
CHM1_12221,369,657 - 21,382,503 (+)NCBICHM1_1
T2T-CHM13v2.02221,423,939 - 21,436,767 (+)NCBIT2T-CHM13v2.0
P2rx6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81196,944,167 - 96,956,424 (-)NCBIGRCr8
mRatBN7.21183,439,922 - 83,450,449 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1183,439,924 - 83,450,481 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1192,167,552 - 92,177,610 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01184,828,716 - 84,838,772 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01183,882,324 - 83,892,380 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01187,434,929 - 87,445,221 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1187,435,185 - 87,445,219 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01190,485,985 - 90,496,515 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41185,431,257 - 85,441,293 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11185,471,855 - 85,481,771 (-)NCBI
Celera1182,208,493 - 82,218,517 (-)NCBICelera
Cytogenetic Map11q23NCBI
P2rx6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544219,264,790 - 19,271,537 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544219,263,544 - 19,272,231 (-)NCBIChiLan1.0ChiLan1.0
P2RX6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22330,721,153 - 30,735,310 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12233,270,081 - 33,284,233 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0223,239,019 - 3,251,966 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12219,728,644 - 19,741,078 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2219,728,644 - 19,741,078 (+)Ensemblpanpan1.1panPan2
P2RX6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12630,456,231 - 30,467,674 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2630,457,014 - 30,466,152 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2630,417,349 - 30,428,575 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02631,867,789 - 31,879,013 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2631,869,314 - 31,879,069 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12629,913,614 - 29,924,837 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02629,537,801 - 29,549,022 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02630,626,779 - 30,638,005 (-)NCBIUU_Cfam_GSD_1.0
P2rx6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118140,186,450 - 140,193,553 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366192,560,759 - 2,566,355 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366192,560,685 - 2,567,612 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
P2RX6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1450,622,938 - 50,633,535 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11450,595,876 - 50,633,536 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21454,043,227 - 54,082,269 (+)NCBISscrofa10.2Sscrofa10.2susScr3
P2RX6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1194,958,713 - 4,969,443 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl194,958,671 - 4,969,724 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660852,001,874 - 2,015,701 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
P2rx6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624945648,499 - 656,075 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624945646,361 - 687,901 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in P2rx6
298 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1656
Count of miRNA genes:692
Interacting mature miRNAs:863
Transcripts:ENSMUST00000023441, ENSMUST00000168383, ENSMUST00000171002
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301970Heal11_mwound healing/regeneration 11 (mouse)Not determined16124263853Mouse
26884376Skwq4_mskull length QTL 4, 5 week (mouse)16841786490896888Mouse
1301841Lrnx9_mlearning-contextual 9 (mouse)Not determined161222536046225471Mouse
4142460Nilac10_mnicotine induced locomotor activity 10 (mouse)Not determined16713690629225471Mouse
38501069Tip4_mtuberculosis immunophenotype 4, IFN-g level (mouse)16431786444520363Mouse
26884432Zlq7_mzygomatic length QTL 7, 10 week (mouse)16381786464620363Mouse
1300632Loca2_mlocomotor activity 2 (mouse)Not determined16122500574Mouse
1301086Lprm5_mlymphoproliferation modifier 5 (mouse)Not determined161184882445848923Mouse
27226768Tibl9_mtibia length 9, 5 week (mouse)16331786451420363Mouse
1301443Mopkd2_mmodifier of polycystic kidney disease progression 2 (mouse)Not determined16464631438646414Mouse
10043978Obq35_mobesity QTL 35 (mouse)Not determined16988163143881631Mouse
1301575Tanidd3_mtally ho associated non-insulin dependednt diabetes mellitus 3 (mouse)Not determined16122897739Mouse
15092082Igly9_mIgG glycosylation 9, GP17b (mouse)161477522320103513Mouse
1357763Lp1_mlymphocyte proliferation 1 (mouse)Not determined16654297965466552Mouse
1301384Dice1_mdetermination of interleukin 4 commitment 1 (mouse)Not determined16128434358Mouse
1300943Skts9_mskin tumor susceptibility 9 (mouse)Not determined16577525239775440Mouse
10402497Lmr23_mleishmaniasis resistance 23 (mouse)Not determined16129674200Mouse
10412289Ppsl_mplasma P-selectin levels (mouse)Not determined16130814572Mouse
4141468Nhdlq10_mnon-HDL QTL 10 (mouse)Not determined16124263853Mouse
1300656Bgeq15_mbody growth early QTL 15 (mouse)Not determined16577525239775440Mouse
4142236Pstc4_mperiosteal circumference 4 (mouse)Not determined161552290949523112Mouse
1301559Bbaa19_mB.burgdorferi-associated arthritis 19 (mouse)Not determined16130066977Mouse
11251724Ewc6_methanol withdrawal and consumption 6 (mouse)16822605242226052Mouse
1300987Skull23_mskull morphology 23 (mouse)Not determined16577525239775440Mouse
1301945Skl7_mskeletal size (tail length) 7 (mouse)Not determined16577525239775440Mouse
4141010Bbq1_mbrain and behavior QTL 1 (mouse)Not determined16647700935021216Mouse
10045614Rapop6_mradiation-induced apoptosis 6 (mouse)Not determined161480292148803032Mouse
27095908Scvln7_msacral vertebrae length 2, 5 week (mouse)16331786439820362Mouse
4141060Pbwg19_mpostnatal body weight growth 19 (mouse)Not determined16120780888Mouse
10043879Adip25_madiposity 25 (mouse)Not determined16122520318Mouse
27226785Feml12_mfemur length 12, 5 week (mouse)16331786464620363Mouse

Markers in Region
AB010883  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381617,571,106 - 17,571,243UniSTSGRCm38
MGSCv371617,571,199 - 17,571,336UniSTSGRCm37
Celera1618,144,424 - 18,144,561UniSTS
Cytogenetic Map16A3UniSTS
Whitehead/MRC_RH16134.28UniSTS
D11Wox5  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381617,571,120 - 17,571,361UniSTSGRCm38
MGSCv371617,571,213 - 17,571,454UniSTSGRCm37
Celera1618,144,438 - 18,144,679UniSTS
Cytogenetic Map16A3UniSTS


Expression


Sequence


RefSeq Acc Id: ENSMUST00000023441   ⟹   ENSMUSP00000023441
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1617,379,749 - 17,389,875 (+)Ensembl
GRCm38.p6 Ensembl1617,561,885 - 17,572,011 (+)Ensembl
RefSeq Acc Id: ENSMUST00000171002   ⟹   ENSMUSP00000132727
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1617,379,749 - 17,388,964 (+)Ensembl
GRCm38.p6 Ensembl1617,561,885 - 17,571,100 (+)Ensembl
RefSeq Acc Id: ENSMUST00000231806   ⟹   ENSMUSP00000156201
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1617,379,797 - 17,395,664 (+)Ensembl
GRCm38.p6 Ensembl1617,561,933 - 17,577,800 (+)Ensembl
RefSeq Acc Id: NM_001159561   ⟹   NP_001153033
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391617,379,749 - 17,389,876 (+)NCBI
GRCm381617,561,885 - 17,572,012 (+)NCBI
MGSCv371617,561,978 - 17,572,105 (+)RGD
Celera1618,135,205 - 18,145,330 (+)RGD
cM Map16 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_011028   ⟹   NP_035158
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391617,379,749 - 17,389,876 (+)NCBI
GRCm381617,561,885 - 17,572,012 (+)NCBI
MGSCv371617,561,978 - 17,572,105 (+)RGD
Celera1618,135,205 - 18,145,330 (+)RGD
cM Map16 ENTREZGENE
Sequence:
RefSeq Acc Id: NR_189665
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391617,379,873 - 17,389,879 (+)NCBI
RefSeq Acc Id: NP_035158   ⟸   NM_011028
- Peptide Label: isoform 1
- UniProtKB: G3X8W3 (UniProtKB/Swiss-Prot),   Q3UUD0 (UniProtKB/Swiss-Prot),   O54803 (UniProtKB/Swiss-Prot),   Q149L9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001153033   ⟸   NM_001159561
- Peptide Label: isoform 2
- UniProtKB: E9PY29 (UniProtKB/TrEMBL),   Q149L9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000156201   ⟸   ENSMUST00000231806
RefSeq Acc Id: ENSMUSP00000132727   ⟸   ENSMUST00000171002
RefSeq Acc Id: ENSMUSP00000023441   ⟸   ENSMUST00000023441

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O54803-F1-model_v2 AlphaFold O54803 1-389 view protein structure

Promoters
RGD ID:6827320
Promoter ID:MM_KWN:20323
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lung
Transcripts:NM_001159561,   NM_011028
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361617,560,876 - 17,561,376 (+)MPROMDB
RGD ID:8685620
Promoter ID:EPDNEW_M20841
Type:initiation region
Name:P2rx6_1
Description:Mus musculus purinergic receptor P2X, ligand-gated ion channel,6 , transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381617,561,981 - 17,562,041EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1337113 AgrOrtholog
Ensembl Genes ENSMUSG00000022758 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000023441 ENTREZGENE
  ENSMUST00000023441.11 UniProtKB/Swiss-Prot
  ENSMUST00000171002 ENTREZGENE
  ENSMUST00000171002.10 UniProtKB/TrEMBL
  ENSMUST00000231806.2 UniProtKB/TrEMBL
Gene3D-CATH 2.60.490.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  atp-gated p2x4 ion channel UniProtKB/Swiss-Prot
InterPro P2X6_purnocptor UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P2X_extracellular_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P2X_purnocptor UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:18440 UniProtKB/Swiss-Prot
MGD MGI:1337113 ENTREZGENE
NCBI Gene 18440 ENTREZGENE
PANTHER P2X PURINOCEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10125:SF21 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam P2X_receptor UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen P2rx6 PhenoGen
PIRSF P2X_purinoceptor UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS P2X6RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P2XRECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE P2X_RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A338P727_MOUSE UniProtKB/TrEMBL
  E9PY29 ENTREZGENE, UniProtKB/TrEMBL
  G3X8W3 ENTREZGENE
  O54803 ENTREZGENE, UniProtKB/Swiss-Prot
  Q149L9 ENTREZGENE, UniProtKB/TrEMBL
  Q3UUD0 ENTREZGENE
UniProt Secondary G3X8W3 UniProtKB/Swiss-Prot
  Q3UUD0 UniProtKB/Swiss-Prot