Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 17alpha-ethynylestradiol | decreases expression | ISO | P2rx6 (Rattus norvegicus) | 6480464 | Ethinyl Estradiol results in decreased expression of P2RX6 mRNA | CTD | PMID:29097150 | 17beta-estradiol | multiple interactions | EXP | | 6480464 | [Estradiol co-treated with TGFB1 protein] results in decreased expression of P2RX6 mRNA | CTD | PMID:30165855 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | P2rx6 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of P2RX6 mRNA | CTD | PMID:19933214 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | P2rx6 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of P2RX6 mRNA | CTD | PMID:21570461 | 4-hydroxyphenyl retinamide | decreases expression | ISO | P2rx6 (Mus musculus) | 6480464 | Fenretinide results in decreased expression of P2RX6 mRNA | CTD | PMID:28973697 | 6-propyl-2-thiouracil | decreases expression | ISO | P2rx6 (Rattus norvegicus) | 6480464 | Propylthiouracil results in decreased expression of P2RX6 mRNA | CTD | PMID:24780913 and PMID:25825206 | ammonium chloride | affects expression | ISO | P2rx6 (Rattus norvegicus) | 6480464 | Ammonium Chloride affects the expression of P2RX6 mRNA | CTD | PMID:16483693 | atrazine | increases expression | EXP | | 6480464 | Atrazine results in increased expression of P2RX6 mRNA | CTD | PMID:22378314 | benzo[a]pyrene | increases methylation | EXP | | 6480464 | Benzo(a)pyrene results in increased methylation of P2RX6 exon and Benzo(a)pyrene results in increased methylation of P2RX6 promoter | CTD | PMID:27901495 | bisphenol A | increases expression | ISO | P2rx6 (Rattus norvegicus) | 6480464 | bisphenol A results in increased expression of P2RX6 mRNA | CTD | PMID:27178563 | bisphenol A | increases expression | ISO | P2rx6 (Mus musculus) | 6480464 | bisphenol A results in increased expression of P2RX6 mRNA | CTD | PMID:35598803 | bisphenol A | decreases expression | ISO | P2rx6 (Rattus norvegicus) | 6480464 | bisphenol A results in decreased expression of P2RX6 mRNA | CTD | PMID:25181051 more ... | bisphenol A | multiple interactions | ISO | P2rx6 (Rattus norvegicus) | 6480464 | [bisphenol A co-treated with Testosterone] results in increased expression of P2RX6 mRNA | CTD | PMID:26496021 | carbon nanotube | decreases expression | ISO | P2rx6 (Mus musculus) | 6480464 | Nanotubes and Carbon results in decreased expression of P2RX6 mRNA | CTD | PMID:25554681 | copper atom | increases expression | ISO | P2rx6 (Rattus norvegicus) | 6480464 | Copper deficiency results in increased expression of P2RX6 mRNA | CTD | PMID:26033743 | copper(0) | increases expression | ISO | P2rx6 (Rattus norvegicus) | 6480464 | Copper deficiency results in increased expression of P2RX6 mRNA | CTD | PMID:26033743 | Cuprizon | increases expression | ISO | P2rx6 (Rattus norvegicus) | 6480464 | Cuprizone results in increased expression of P2RX6 mRNA | CTD | PMID:26577399 | endosulfan | decreases expression | ISO | P2rx6 (Rattus norvegicus) | 6480464 | Endosulfan results in decreased expression of P2RX6 mRNA | CTD | PMID:29391264 | epoxiconazole | increases expression | ISO | P2rx6 (Mus musculus) | 6480464 | epoxiconazole results in increased expression of P2RX6 mRNA | CTD | PMID:35436446 | ethanol | decreases expression | ISO | P2rx6 (Rattus norvegicus) | 6480464 | Ethanol results in decreased expression of P2RX6 mRNA | CTD | PMID:17920746 | flavonoids | increases expression | ISO | P2rx6 (Rattus norvegicus) | 6480464 | Flavonoids results in increased expression of P2RX6 mRNA | CTD | PMID:18035473 | ketamine | increases expression | ISO | P2rx6 (Rattus norvegicus) | 6480464 | Ketamine results in increased expression of P2RX6 mRNA | CTD | PMID:20080153 | lead(0) | affects expression | EXP | | 6480464 | Lead affects the expression of P2RX6 mRNA | CTD | PMID:28903495 | methamphetamine | decreases expression | ISO | P2rx6 (Rattus norvegicus) | 6480464 | Methamphetamine results in decreased expression of P2RX6 mRNA | CTD | PMID:19564919 | N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal | increases expression | ISO | P2rx6 (Mus musculus) | 6480464 | benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of P2RX6 mRNA | CTD | PMID:20061341 | ozone | decreases expression | EXP | | 6480464 | Ozone results in decreased expression of P2RX6 mRNA | CTD | PMID:23033980 | ozone | decreases expression | ISO | P2rx6 (Mus musculus) | 6480464 | Ozone results in decreased expression of P2RX6 mRNA | CTD | PMID:33026818 | ozone | multiple interactions | ISO | P2rx6 (Mus musculus) | 6480464 | [Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in decreased expression of P2RX6 mRNA and [Air Pollutants results in increased abundance of Ozone] which results in decreased expression of P2RX6 mRNA | CTD | PMID:27106289 and PMID:34911549 | potassium dichromate | increases expression | ISO | P2rx6 (Mus musculus) | 6480464 | Potassium Dichromate results in increased expression of P2RX6 mRNA | CTD | PMID:23608068 | sodium arsenite | decreases expression | ISO | P2rx6 (Mus musculus) | 6480464 | sodium arsenite results in decreased expression of P2RX6 mRNA | CTD | PMID:37682722 | sotorasib | multiple interactions | EXP | | 6480464 | [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of P2RX6 mRNA | CTD | PMID:36139627 | sunitinib | decreases expression | EXP | | 6480464 | Sunitinib results in decreased expression of P2RX6 mRNA | CTD | PMID:31533062 | temozolomide | decreases expression | EXP | | 6480464 | Temozolomide results in decreased expression of P2RX6 mRNA | CTD | PMID:31758290 | testosterone | multiple interactions | ISO | P2rx6 (Rattus norvegicus) | 6480464 | [bisphenol A co-treated with Testosterone] results in increased expression of P2RX6 mRNA | CTD | PMID:26496021 | tetrachloromethane | decreases expression | ISO | P2rx6 (Rattus norvegicus) | 6480464 | Carbon Tetrachloride results in decreased expression of P2RX6 mRNA | CTD | PMID:16644059 | titanium dioxide | increases expression | ISO | P2rx6 (Mus musculus) | 6480464 | titanium dioxide results in increased expression of P2RX6 mRNA | CTD | PMID:23557971 | trametinib | multiple interactions | EXP | | 6480464 | [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of P2RX6 mRNA | CTD | PMID:36139627 | trichloroethene | increases expression | ISO | P2rx6 (Rattus norvegicus) | 6480464 | Trichloroethylene results in increased expression of P2RX6 mRNA | CTD | PMID:33387578 | troglitazone | decreases expression | ISO | P2rx6 (Mus musculus) | 6480464 | troglitazone results in decreased expression of P2RX6 mRNA | CTD | PMID:28973697 | valproic acid | increases methylation | EXP | | 6480464 | Valproic Acid results in increased methylation of P2RX6 gene | CTD | PMID:29154799 | |