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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732211
Species: Homo sapiens
RGD Object: Gene
Symbol: KCNB1
Name: potassium voltage-gated channel subfamily B member 1
Acc ID: CHEBI:6809
Term: methamphetamine
Definition: A member of the class of amphetamines in which the amino group of (S)-amphetamine carries a methyl substituent.
Chemical ID: MESH:D008694
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
KCNB1increases expressionISOKcnb1 (Rattus norvegicus)6480464CTDMethamphetamine results in increased expression of KCNB1 proteinPMID:29297590
KCNB1increases expressionISOKcnb1 (Mus musculus)6480464CTDMethamphetamine results in increased expression of KCNB1 mRNAPMID:26307267
KCNB1multiple interactionsISOKcnb1 (Rattus norvegicus)6480464CTD2-(4-morpholino)ethyl-1-phenylcyclohexane-1-carboxylate inhibits the reaction [Methamphetamine results in increased expression of KCNB1 protein]; pyrazolanthrone inhibits the reaction [Methamphetamine results in increased expression of KCNB1 protein]; SB 203580 inhibits the reaction [Methamphetamine results in increased expression of KCNB1 protein]PMID:29297590
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