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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68977
Species: Homo sapiens
RGD Object: Gene
Symbol: AGTR1
Name: angiotensin II receptor type 1
Acc ID: CHEBI:9434
Term: telmisartan
Definition: A member of the class of benzimidazoles used widely in the treatment of hypertension.
Chemical ID: MESH:C084178
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
AGTR1decreases expression ISOAgtr1a (Rattus norvegicus)329956421RGDtelmisartan decreases expression of mRNA in mandible of rats with periodontal disease 
AGTR1multiple interactionsEXP 6480464CTDtelmisartan binds to and results in decreased activity of AGTR1 proteinPMID:21557540
AGTR1affects bindingISOAgtr1a (Rattus norvegicus)6480464CTDtelmisartan binds to AGTR1 proteinPMID:8220885
AGTR1decreases expressionISOAgtr1a (Rattus norvegicus)6480464CTDtelmisartan results in decreased expression of AGTR1A mRNAPMID:19171132
AGTR1increases expressionISOAgtr1a (Rattus norvegicus)6480464CTDtelmisartan results in increased expression of AGTR1 mRNAPMID:9533614
AGTR1multiple interactionsISOAgtr1a (Rattus norvegicus)6480464CTDTelmisartan binds to and results in decreased activity of AGTR1 protein; Telmisartan inhibits the reaction [AGT protein results in increased expression of AGTR1A mRNA]; Telmisartan inhibits the reaction [Daunorubicin results in increased expression of AGTR1A protein]; Telmisartan inhibits the reaction [Pregabalin results in increased expression of AGTR1 protein]PMID:19706694 PMID:20888384 PMID:31629013 PMID:9728324
AGTR1multiple interactionsISOAgtr1a (Mus musculus)6480464CTDtelmisartan inhibits the reaction [[AGT protein modified form co-treated with AGTR1A co-treated with AGTR1B] results in increased expression of SERPINE1 mRNA]; telmisartan inhibits the reaction [Streptozocin results in increased expression of AGTR1A protein]PMID:17620961 PMID:21381899
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