GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Ccn2 | increases expression | EXP | | 6480464 | CTD | Paraquat results in increased expression of CCN2 mRNA; Paraquat results in increased expression of CCN2 protein | PMID:23433149 PMID:25815693 PMID:33000210 | Ccn2 | increases secretion | EXP | | 6480464 | CTD | Paraquat results in increased secretion of CCN2 protein | PMID:33000210 | Ccn2 | multiple interactions | EXP | | 6480464 | CTD | LY2109761 inhibits the reaction [Paraquat results in increased expression of CCN2 mRNA]; LY2109761 inhibits the reaction [Paraquat results in increased secretion of CCN2 protein]; prolinedithiocarbamate inhibits the reaction [Paraquat results in increased expression of CCN2 mRNA]; prolinedithiocarbamate inhibits the reaction [Paraquat results in increased expression of CCN2 protein]; Tacrolimus inhibits the reaction [Paraquat results in increased expression of CCN2 mRNA]; Tacrolimus inhibits the reaction [Paraquat results in increased secretion of CCN2 protein] | PMID:23433149 PMID:33000210 | Ccn2 | increases expression | ISO | CCN2 (Homo sapiens) | 6480464 | CTD | Paraquat results in increased expression of CCN2 mRNA; Paraquat results in increased expression of CCN2 protein | PMID:15728566 PMID:16767377 PMID:20035857 PMID:25815693 PMID:26129822 PMID:27682480 PMID:33737140 PMID:35182771 | Ccn2 | increases expression | ISO | Ccn2 (Mus musculus) | 6480464 | CTD | Paraquat results in increased expression of CCN2 mRNA; Paraquat results in increased expression of CCN2 protein | PMID:12595580 PMID:25945502 PMID:26758514 PMID:30744607 PMID:32462952 | Ccn2 | multiple interactions | ISO | CCN2 (Homo sapiens) | 6480464 | CTD | [CCN2 protein co-treated with Paraquat] affects the expression of MMP2 mRNA; [CCN2 protein co-treated with Paraquat] affects the expression of MMP9 mRNA; [CCN2 protein co-treated with Paraquat] affects the expression of TIMP1 mRNA; [Paraquat co-treated with TGFB1 protein] results in increased expression of CCN2 mRNA; Saralasin inhibits the reaction [Paraquat results in increased expression of CCN2 mRNA]; Saralasin inhibits the reaction [Paraquat results in increased expression of CCN2 protein]; TGFB1 protein promotes the reaction [Paraquat results in increased expression of CCN2 protein]; Triamcinolone Acetonide promotes the reaction [Paraquat results in increased expression of CCN2 mRNA]; tricarbonylchloro(glycinato)ruthenium(II) inhibits the reaction [Paraquat results in increased expression of CCN2 protein] | PMID:15728566 PMID:20035857 PMID:26129822 PMID:27682480 PMID:33737140 | Ccn2 | multiple interactions | ISO | Ccn2 (Mus musculus) | 6480464 | CTD | ADIPOQ protein inhibits the reaction [Paraquat results in increased expression of CCN2 mRNA]; plant extract, Puerariae Radix inhibits the reaction [Paraquat results in increased expression of CCN2 mRNA]; plant extract, Puerariae Radix inhibits the reaction [Paraquat results in increased expression of CCN2 protein]; tetramethylpyrazine inhibits the reaction [Paraquat results in increased expression of CCN2 protein] | PMID:25945502 PMID:26758514 PMID:30744607 | | ||||||||||||||||||||||
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