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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2199
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bcl2
Name: BCL2, apoptosis regulator
Acc ID: CHEBI:28445
Term: vincristine
Definition: A vinca alkaloid with formula C46H56N4O10 found in the Madagascar periwinkle, Catharanthus roseus. It is used (commonly as the corresponding sulfate salt)as a chemotherapy drug for the treatment of leukaemia, lymphoma, myeloma, breast cancer and head and neck cancer.
Chemical ID: MESH:D014750
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bcl2decreases expressionEXP 6480464CTDVincristine results in decreased expression of BCL2 mRNAPMID:33038355 PMID:36808657
Bcl2multiple interactionsEXP 6480464CTDQuercetin inhibits the reaction [Vincristine results in decreased expression of BCL2 mRNA]PMID:33038355
Bcl2decreases expressionISOBcl2 (Mus musculus)6480464CTDVincristine results in decreased expression of BCL2 mRNA; Vincristine results in decreased expression of BCL2 proteinPMID:34286406
Bcl2decreases response to substanceISOBCL2 (Homo sapiens)6480464CTDBCL2 protein results in decreased susceptibility to VincristinePMID:20162574
Bcl2increases phosphorylationISOBCL2 (Homo sapiens)6480464CTDVincristine results in increased phosphorylation of BCL2 proteinPMID:15907805
Bcl2multiple interactionsISOBcl2 (Mus musculus)6480464CTDKN 93 inhibits the reaction [Vincristine results in decreased expression of BCL2 mRNA]; KN 93 inhibits the reaction [Vincristine results in decreased expression of BCL2 protein]PMID:34286406
Bcl2multiple interactionsISOBCL2 (Homo sapiens)6480464CTD[Doxorubicin co-treated with Dexamethasone co-treated with Vincristine co-treated with Cytarabine co-treated with Mercaptopurine co-treated with Methotrexate co-treated with Cyclophosphamide co-treated with Enzymes and Coenzymes] results in increased expression of BCL2 protein; [Doxorubicin co-treated with Vincristine co-treated with Etoposide co-treated with Mitotane] results in decreased expression of BCL2 protein; [MIR497 results in decreased expression of BCL2 protein] which results in increased susceptibility to Vincristine; TYMP inhibits the reaction [Vincristine results in increased phosphorylation of BCL2 protein]PMID:15907805 PMID:21182165 PMID:21258880 PMID:9815696
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