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GENE - TERM ANNOTATION REPORT

RGD ID: 2070
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Agtr1a
Name: angiotensin II receptor, type 1a
Acc ID: GO:0007186
Term: G protein-coupled receptor signaling pathway
Definition: The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane.
Definition Source(s): GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Agtr1a IMP 629553RGD  
Agtr1a IMP 1582440RGD  
Agtr1ainvolved_inISOAGTR1 (Homo sapiens)1624291RGD PMID:1378723

PMID:1378723
Agtr1ainvolved_inIBAFB:FBgn0025631 or MGI:1346086 or MGI:2441843 or MGI:87966 or PANTHER:PTN001200905 or Agtr1a (Rattus norvegicus) or Agtr1b (Rattus norvegicus) or Aplnr (Rattus norvegicus) or UniProtKB:P30556 or UniProtKB:P35414 or UniProtKB:P48039 or UniProtKB:P49685 or ZFIN:ZDB-GENE-030131-43471600115GO_CentralGO_REF:0000033

GO_REF:0000033
Agtr1ainvolved_inIEAInterPro:IPR000190 or InterPro:IPR000248 or InterPro:IPR0002761600115InterProGO_REF:0000002

GO_REF:0000002
Agtr1ainvolved_inIEAUniProtKB-KW:KW-02971600115UniProtGO_REF:0000043

GO_REF:0000043
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