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GENE - TERM ANNOTATION REPORT

RGD ID: 18901054
Species: Heterocephalus glaber
RGD Object: Gene
Symbol: Il10
Name: interleukin 10
Acc ID: DOID:2841
Term: asthma
Definition: A bronchial disease that is characterized by chronic inflammation and narrowing of the airways, which is caused by a combination of environmental and genetic factors. The disease has_symptom recurring periods of wheezing (a whistling sound while breathing), has_symptom chest tightness, has_symptom shortness of breath, has_symptom mucus production and has_symptom coughing. (DO)
Definition Source(s): http://www.nhlbi.nih.gov/health/dci/Diseases/Asthma/Asthma_WhatIs.html "DO" "DO", https://www.ncbi.nlm.nih.gov/books/NBK430901/ "DO" "DO", https://www.ncbi.nlm.nih.gov/books/NBK7223/ "DO" "DO"
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il10 ISOIl10 (Mus musculus)9068941RGD PMID:20237464 PMID:20644177 REF_RGD_ID:4140459 REF_RGD_ID:4140471
Il10 ISODpp4 (Rattus norvegicus)9068941RGD PMID:20560982 REF_RGD_ID:5131623
Il10 ISOIl10 (Rattus norvegicus)9068941RGDprotein:decreased expression:plasmaPMID:20230687 REF_RGD_ID:4140421
Il10 ISOIL10 (Homo sapiens)9068941RGD PMID:20121766 REF_RGD_ID:4140451
Il10susceptibilityISOIL10 (Homo sapiens)9068941RGDDNA:polymorphism: :-627C>A (human)PMID:12938145 REF_RGD_ID:4143221
Il10treatmentISOIl10 (Mus musculus)9068941RGD PMID:21998459 REF_RGD_ID:11046261
Il10 ISOIL10 (Homo sapiens)9068941CTDCTD Direct Evidence: marker/mechanismPMID:29317916
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