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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1620890
Species: Mus musculus
RGD Object: Gene
Symbol: Abcb1a
Name: ATP-binding cassette, sub-family B member 1A
Acc ID: CHEBI:37941
Term: clopidogrel
Definition: A thienopyridine that is 4,5,6,7-tetrahydrothieno[3,2-c]pyridine in which the hydrogen attached to the nitrogen is replaced by an o-chlorobenzyl group, the methylene hydrogen of which is replaced by a methoxycarbonyl group (the S enantiomer). A P2Y12 receptor antagonist, it is used to inhibit blood clots and prevent heart attacks.
Chemical ID: MESH:C055162
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcb1aaffects response to substanceISOABCB1 (Homo sapiens)6480464CTDABCB1 gene affects the susceptibility to clopidogrel; ABCB1 gene polymorphism affects the susceptibility to clopidogrel; ABCB1 gene SNP affects the susceptibility to clopidogrelPMID:17112805 PMID:19106083 PMID:20180610
Abcb1adecreases activityISOABCB1 (Homo sapiens)6480464CTDclopidogrel results in decreased activity of ABCB1 proteinPMID:17112805
Abcb1adecreases expressionISOABCB1 (Homo sapiens)6480464CTDclopidogrel results in decreased expression of ABCB1 mRNA; clopidogrel results in decreased expression of ABCB1 proteinPMID:17112805
Abcb1adecreases uptakeISOABCB1 (Homo sapiens)6480464CTDABCB1 protein results in decreased uptake of clopidogrelPMID:17112805
Abcb1aincreases secretionISOABCB1 (Homo sapiens)6480464CTDABCB1 protein results in increased secretion of clopidogrelPMID:17112805
Abcb1amultiple interactionsISOAbcb1a (Rattus norvegicus)6480464CTD[Aspirin results in increased expression of ABCB1 protein] which results in decreased uptake of clopidogrelPMID:21900887
Abcb1amultiple interactionsISOABCB1 (Homo sapiens)6480464CTDABCB1 gene affects the reaction [CYP2C19 gene affects the susceptibility to clopidogrel]PMID:19934793
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