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GENE - TERM ANNOTATION REPORT

RGD ID: 14230826
Species: Sus scrofa
RGD Object: Gene
Symbol: VEGFA
Name: vascular endothelial growth factor A
Acc ID: DOID:1584
Term: acute chest syndrome
Definition: A lung disease that involves a vasoocclusive crisis of the pulmonary vasculature seen in patients with sickle cell anemia. The crisis is initiated by a lung infection, and the resulting inflammation and loss of oxygen tension leads to sickling of red cells and further vasoocclusion. The disease has_symptom fever, has_symptom pleuritic chest pain, has_symptom tachypnea, has_symptom cough, has_symptom hypoxemia, has_symptom marked leukocytosis, and has_symptom diffuse infiltrates on chest radiograph. (DO)
Definition Source(s): http://en.wikipedia.org/wiki/Acute_chest_syndrome "DO" "DO"
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
VEGFAsusceptibilityISOVEGFA (Homo sapiens)9068941RGDassociated with Anemia, Sickle Cell;DNA:polymorphism:583C > T (human)PMID:25130874 REF_RGD_ID:11075233
VEGFAsusceptibilityISOVEGFA (Homo sapiens)9068941RGDassociated with Anemia, Sickle Cell;DNA:SNPs: : rs2010963, rs833068,rs3025020(human)PMID:22925497 REF_RGD_ID:11075235
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