RGD Reference Report - Impact of VEGFA -583C > T polymorphism on serum VEGF levels and the susceptibility to acute chest syndrome in pediatric patients with sickle cell disease. - Rat Genome Database
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Impact of VEGFA -583C > T polymorphism on serum VEGF levels and the susceptibility to acute chest syndrome in pediatric patients with sickle cell disease.

Authors: Redha, NA  Mahdi, N  Al-Habboubi, HH  Almawi, WY 
Citation: Redha NA, etal., Pediatr Blood Cancer. 2014 Dec;61(12):2310-2. doi: 10.1002/pbc.25158. Epub 2014 Aug 17.
RGD ID: 11075233
Pubmed: (View Article at PubMed) PMID:25130874
DOI: Full-text: DOI:10.1002/pbc.25158

We investigated the association of VEGFA -583C > T on VEGF serum levels and acute chest syndrome (ACS) in 351 pediatric patients with sickle cell disease (SCD), of whom 90 had ACS, and 261 were ACS-free controls. Significant differences in -583C > T minor allele and genotype frequencies were seen between ACS cases and controls, evidenced by enrichment of -583T/T genotypes in patients with ACS, which were linked with reduction in VEGF serum levels. VEGFA -583C > T and reduced VEGF serum levels may influence ACS risk in patients with SCD, which will aid in identifying patients with SCD who are at high risk of ACS.

Annotation

Disease Annotations    
acute chest syndrome  (IAGP,ISO)

Objects Annotated

Genes (Rattus norvegicus)
Vegfa  (vascular endothelial growth factor A)

Genes (Mus musculus)
Vegfa  (vascular endothelial growth factor A)

Genes (Homo sapiens)
VEGFA  (vascular endothelial growth factor A)


Additional Information