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GENE - TERM ANNOTATION REPORT

RGD ID: 14181661
Species: Sus scrofa
RGD Object: Gene
Symbol: TNF
Name: tumor necrosis factor
Acc ID: DOID:9002165
Term: Diabetic Nephropathies
Definition: KIDNEY injuries associated with diabetes mellitus and affecting KIDNEY GLOMERULUS; ARTERIOLES; KIDNEY TUBULES; and the interstitium. Clinical signs include persistent PROTEINURIA, from microalbuminuria progressing to ALBUMINURIA of greater than 300 mg/24 h, leading to reduced GLOMERULAR FILTRATION RATE and END-STAGE RENAL DISEASE.
Definition Source(s): MESH:D003928
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
TNF ISOTNF (Homo sapiens)9068941RGD PMID:16141456 REF_RGD_ID:1580311
TNF ISOTnf (Rattus norvegicus)9068941RGD PMID:16336586 REF_RGD_ID:1580208
TNF ISOTnf (Rattus norvegicus)9068941RGDassociated with Diabetes Mellitus, ExperimentalPMID:12969138 REF_RGD_ID:1580296
TNF ISOTnf (Rattus norvegicus)9068941RGDassociated with Diabetes Mellitus, Experimental;protein:increased expression:urinePMID:21441310 REF_RGD_ID:5135032
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