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GENE - TERM ANNOTATION REPORT

RGD ID: 12718861
Species: Ictidomys tridecemlineatus
RGD Object: Gene
Symbol: Edn1
Name: endothelin 1
Acc ID: DOID:8947
Term: diabetic retinopathy
Definition: Disease of the RETINA as a complication of DIABETES MELLITUS. It is characterized by the progressive microvascular complications, such as ANEURYSM, interretinal EDEMA, and intraocular PATHOLOGIC NEOVASCULARIZATION.
Definition Source(s): MESH:D003930
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Edn1 ISOEdn1 (Rattus norvegicus)9068941RGDmRNA:increased expression:retina (rat)PMID:20628425 REF_RGD_ID:9068929
Edn1 ISOEDN1 (Homo sapiens)9068941RGDassociated with Diabetes Mellitus, Insulin-Dependent;protein:increased secretion:plasmaPMID:19293263 REF_RGD_ID:2313279
Edn1 ISOEDN1 (Homo sapiens)9068941RGDassociated with Diabetes Mellitus, Non-Insulin-Dependent;DNA:polymorphism:exon:p.K198N (human)PMID:18806884 REF_RGD_ID:2313281
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