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GENE - TERM ANNOTATION REPORT

RGD ID: 12718861
Species: Ictidomys tridecemlineatus
RGD Object: Gene
Symbol: Edn1
Name: endothelin 1
Acc ID: DOID:5199
Term: ureteral obstruction
Definition: Blockage in any part of the URETER causing obstruction of urine flow from the kidney to the URINARY BLADDER. The obstruction may be congenital, acquired, unilateral, bilateral, complete, partial, acute, or chronic. Depending on the degree and duration of the obstruction, clinical features vary greatly such as HYDRONEPHROSIS and obstructive nephropathy.
Definition Source(s): MESH:D014517
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Edn1 ISOEdn1 (Rattus norvegicus)9068941RGDmRNA, protein:increased expression:renal tubule, renal interstitium (rat)PMID:12887768 REF_RGD_ID:8662268
Edn1 ISOEDN1 (Homo sapiens)9068941CTDCTD Direct Evidence: marker/mechanismPMID:26207612
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